Jakob Skjold‐Jørgensen, Jesper Vind, Allan Svendsen, Morten J. Bjerrum,
... we have investigated the activation of TlL (Lipase_W89) and certain lid mutants, containing either a single positive charge mutation, E87K (Lipase_K87_W89), within the lid region or a lid residue composition of both lipase and esterase character (Hybrid_W89) as a function of solvent polarity. Activation differences ... results show that the lid in Lipase_K87_W89 undergoes a pronounced structural transition toward an open ... whereas only small changes are detected for Lipase_W89 ascribed to the stabilizing effect of the positive ...
Tópico(s): Electrochemical sensors and biosensors
2015 - American Chemical Society | Biochemistry
Yue Li, Jarosław Błaszczyk, Yan Wu, Genbin Shi, Xinhua Ji, Honggao Yan,
... due to the interactions between residues R84 and W89 and the two substrates has been addressed by ... for either substrate binding or catalysis. Substitution of W89 with alanine increases the K(d) for the ... biochemical results of the W89A mutation indicate that W89 contributes somewhat to the binding of HP and ... interactions of the R84 guanidinium group or the W89 indole ring with the substrates.
Tópico(s): HIV/AIDS drug development and treatment
2005 - American Chemical Society | Biochemistry
Jinguang Huang, Yanxiang Zhao, Huaian Liu, Dan Huang, Xiankun Cheng, Wensheng Zhao, Ian A. Taylor, Junfeng Liu, You‐Liang Peng,
... multiple functions in transcription and DNA repair. Residue W89, is engaged in stacking interactions with DNA in ... of oligo DNA. By comparison, the equivalent residue, W89 in wild type PC4 interacts with two nucleotides ... of the first one. A hydrophobic patch around W89 that favours interaction with two nucleotides is not ... indicate that the conserved Y74 in MoSub1 or W89 in PC4, are not only key residues in ...
Tópico(s): Genomics and Chromatin Dynamics
2015 - Nature Portfolio | Scientific Reports
Padmavati Venkataraman, Prasad Joshi, Srinivasan P Venkatachalan, Mani Muthalagi, Harish Parihar, Karen S. Kirschbaum, Marvin K. Schulte,
... binding affinity to wildtype 5-HT3ASRs. Mutations at W89, R91, Y142 and Y152 produced significant decreases in ... and 2 were altered only by mutations at W89, and Y152.Based on the data obtained for ... with R91 while the benzimidazole group interacts with W89. Our data support an interaction of the distal ...
Tópico(s): Chemical Synthesis and Analysis
2002 - BioMed Central | BMC Biochemistry
Yusuke Matsui, Keisuke Shindo, Kayoko Nagata, Katsuhiro Io, Kohei Tada, Fumie Iwai, Masayuki Kobayashi, Norimitsu Kadowaki, Reuben S. Harris, Akifumi Takaori‐Kondo,
... We now demonstrate that Vif conserved residues E88/W89 are crucial for CBFβ binding. Substitution of E88/W89 to alanines impaired binding to CBFβ, degradation of ... model in which HIV-1 Vif residues E88/W89 may participate in binding CBFβ.
Tópico(s): Immune Cell Function and Interaction
2013 - Elsevier BV | Virology
Camille Pineau, Natalia Guschinskaya, Isabelle Gonçalves, Florence Ruaudel, Xavier Robert, Patrice Gouet, Lionel Ballut, Vladimir E. Shevchik,
... Q59, which is sandwiched between two tryptophan residues, W89 from the same monomer B and W89∗ from monomer A. A similar conformation with a ... by a polar-π interaction between Q59 and W89 in the same monomer (Fig. 4C and Fig. ...
Tópico(s): Biochemical and Structural Characterization
2021 - Elsevier BV | Journal of Biological Chemistry
A.J. Visser, L. Ganzeveld, Ignacio Goded, Maarten Krol, Ivan Mammarella, Giovanni Manca, K. F. Boersma,
... uptake parameterizations – a commonly applied big leaf parameterization (W89; Wesely, 1989) and a multi-layer model (MLC- ... Ispra, Italy, and Hyytiälä, Finland). We find that W89 cannot reproduce the diurnal cycle in ozone deposition ... misrepresentation of stomatal versus non-stomatal uptake in W89 results in an overestimation of growing season cumulative ...
Tópico(s): Atmospheric Ozone and Climate
2021 - Copernicus Publications | Atmospheric chemistry and physics
Rui-yue ZHANG, Zhao‐Shi Xu, Liancheng Li, Ming Chen, You‐Zhi Ma,
... plant resistance. A putative water stress-induced gene, W89, was cloned from the cDNA library of drought- ... reaction (RT-PCR). The full-length cDNA of W89 consists of 2392 bp and contains a 1896 ... amino acid protein. Southern blot analysis indicated that W89 was a single-copy gene. RT-PCR analysis revealed that the expression of W89 was upregulated by drought, cold, and abscisic acid (ABA). Amino acid sequence analysis discovered that W89 had a conserved region of DUF248 (pfam03141), which ... motif (SAM)-binding motif. Phylogenetic analysis showed that W89 was 66% identical to Oryza sativa dehydration-responsive ...
Tópico(s): Plant responses to water stress
2007 - Elsevier BV | Agricultural Sciences in China
Steven Groák, Frederick Krimgold,
... Working Commission coordinator on Building Research and Education W89, Frederick Krimgold, Associate Dean of Research and Extension, ... and the implications for education were discussed at W89's London meeting in the autumn of 1988.
Tópico(s): Architecture and Computational Design
1989 - Taylor & Francis | Batiment International Building Research and Practice
Essentials of Nuclear Medicine Imaging, 6th ed.Neal P. PassanteAudio Available | Share
Tópico(s): Medical Imaging Techniques and Applications
2012 - American Roentgen Ray Society | American Journal of Roentgenology
Sudip Das, Tarak Karmakar, Sundaram Balasubramanian,
... studied. A special orientation of the lid residue, W89, in the closed form, which enables an optimal ... fluorescence spectroscopy. The flipping and consequent exposure of W89 in the open form of TLL induce a ...
Tópico(s): Ionic liquids properties and applications
2016 - American Chemical Society | The Journal of Physical Chemistry B
Amir Qaseem, Jennifer Yost, Itziar Etxeandia‐Ikobaltzeta, Linda L. Humphrey,
... 1 September 2020Volume 173, Issue 5 Page: W88-W89 Keywords Chloroquine Cohort studies COVID-19 Disclosure Hydroxychloroquine ...
Tópico(s): Sepsis Diagnosis and Treatment
2020 - American College of Physicians | Annals of Internal Medicine
Robert W. Seifert, Mark Rukavina,
Medical bankruptcy, whatever its actual frequency, is an extreme example of a much broader phenomenon. Medical debt is surprisingly common, affecting about twenty-nine million nonelderly adult Americans, with and without health insurance. The presence of medical debt, even for the insured, appears to create health care access barriers akin to those faced by the uninsured. Policymakers, researchers, and medical providers should consider medical debt a risk factor for reduced health access and poorer ...
Tópico(s): Global Health Care Issues
2006 - Project HOPE | Health Affairs
Paul G. Yock, David T. Linker,
... 10.2214/AJR.08.1381, 192:3, (W84-W89), Online publication date: 1-Mar-2009. Brodoefel H, ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
1990 - Lippincott Williams & Wilkins | Circulation
Robert H. Webb, Patrick T. Pringle, G.R. Rink,
... rapids and riffles below tributary mouths. (See also W89-09239) (Lantz-PTT)
Tópico(s): Landslides and related hazards
1987 - United States Department of the Interior | Antarctica A Keystone in a Changing World
Harald Brodoefel, Christof Burgstahler, Adeel Sabir, Chun-Shan Yam, Faisal Khosa, Claus D. Claussen, Melvin E. Clouse,
The purpose of this study was to evaluate a voxel-based analytic technique for quantification of noncalcified coronary artery plaque with intravascular sonography as a standard of reference.Intravascular sonography and dual-source MDCT angiography prospectively performed on 12 patients resulted in identification of 20 segments containing noncalcified plaque. Four of these segments were used to establish reference measurements of 0.6-mm proximal wall thickness with a 0-HU cutoff between the epicardial ...
Tópico(s): Advanced MRI Techniques and Applications
2009 - American Roentgen Ray Society | American Journal of Roentgenology
Ruchira S. Datta, Christopher A. Meacham, Bushra Samad, Christoph Neyer, Kimmen Sjölander,
Ortholog detection is essential in functional annotation of genomes, with applications to phylogenetic tree construction, prediction of protein–protein interaction and other bioinformatics tasks. We present here the PHOG web server employing a novel algorithm to identify orthologs based on phylogenetic analysis. Results on a benchmark dataset from the TreeFam-A manually curated orthology database show that PHOG provides a combination of high recall and precision competitive with both InParanoid ...
Tópico(s): Gene expression and cancer classification
2009 - Oxford University Press | Nucleic Acids Research
Patricia E. Cowell, Laura S. Allen, Nadia Zalatimo, Victor H. Denenberg,
... W22-39, W49-62, W65-74, W77-85, W89-94, and W95-99. Trend analyses were performed ...
Tópico(s): Cognitive Abilities and Testing
1992 - Elsevier BV | Developmental Brain Research
Jarosław Błaszczyk, Yue Li, Genbin Shi, Honggao Yan, Xinhua Ji,
... as well as the conformation of nearby residue W89.
Tópico(s): HIV/AIDS drug development and treatment
2003 - American Chemical Society | Biochemistry
Sze Yiun Teo, Shih-chang Wang,
The objective of our study was to describe the imaging features of polyacrylamide gel breast implants in women with and those without complications from mammoplasty.Although polyacrylamide gel implants may mimic conventional implants on both sonography and MRI in women who do not have complications from mammoplasty, polyacrylamide gel implants have some distinguishing features. The imaging appearance of polyacrylamide gel implants is related to the technique of injection and whether there are any ...
Tópico(s): Metastasis and carcinoma case studies
2008 - American Roentgen Ray Society | American Journal of Roentgenology
Tong Yang, Zheng Wang, Fang Wu, Jingwei Tan, Yijun Shen, Erguang Li, Dai Jing-zhi, Ronghai Shen, Gang Li, Jinsong Wu, Luochun Wang, Haibo Wang, Yanjun Liu,
... using computational protein design, we found that residue W89 and E92 of TNFR2 were critical for ligand ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2010 - Public Library of Science | PLoS Computational Biology
Ying Dang, Roderick W. Davis, Ian A. York, Yong‐Hui Zheng,
... G84, and, to a lesser extent, I87 and W89 play very critical roles in A3G/A3F neutralization. ...
Tópico(s): Cytomegalovirus and herpesvirus research
2010 - American Society for Microbiology | Journal of Virology
Christopher Lee, Robert D. Suh, Mayil S. Krishnam, Chi Lai, Michael C. Fishbein, W. Dean Wallace, Alice Chen, Rajeev Saggar, Rajan Saggar, John A. Belperio, A. Ardehali, David J. Ross,
Pulmonary capillary hemangiomatosis (PCH) is a rare cause of pulmonary hypertension characterized by uncontrolled capillary proliferation in the pulmonary interstitium and alveolar walls. Lung transplantation remains the only definitive treatment. To date, there have been no reported cases of recurrent PCH after lung transplantation. We present a case that describes important radiologic and clinical features of PCH and raises questions about its pathogenesis.
Tópico(s): Vascular Anomalies and Treatments
2010 - Lippincott Williams & Wilkins | Journal of Thoracic Imaging
Ayşe Erden, Necati Örmecı, Suat Fítöz, İlhan Erden, Sumru Tanju, Yasemin Genç,
The purpose of this study was to establish the role of MR cholangiopancreatography (MRCP) in the diagnosis of biliary rupture in hepatic hydatid disease. We sought to determine whether the morphologic features of cysts and bile duct abnormalities detected on MRCP are specific enough for identification of intrabiliary rupture.If one of the following MRCP findings of apparent connection between hydatid cyst and biliary system, deformation of cyst, focal defect in cyst wall, or beaklike projection extending ...
Tópico(s): Parasitic Infections and Diagnostics
2007 - American Roentgen Ray Society | American Journal of Roentgenology
Laura Cendron, R. Berni, Claudia Folli, Ileana Ramazzina, Riccardo Percudani, Giuseppe Zanotti,
... Thornton J.M. Nucleic Acids Res. 2005; 33: W89-W93Crossref PubMed Scopus (505) Google Scholar) and DALI ( ...
Tópico(s): Biochemical and Molecular Research
2007 - Elsevier BV | Journal of Biological Chemistry
Laura Cendron, Elisabetta Tasca, Tommaso Seraglio, Anke Seydel, Alessandro Angelini, Roberto Battistutta, Cesare Montecucco, Giuseppe Zanotti,
... from 3D structure. Nucl Acids Res 2005; 33: W89–W93. 10.1093/nar/gki414 CASPubMedWeb of Science® ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2007 - Wiley | Proteins Structure Function and Bioinformatics
Harini Mohanram, Alyssa Nip, Prerna N. Domadia, Anirban Bhunia, Surajit Bhattacharjya,
... for most of the residues, whereby residues M88-W89-G90-G91 adopt a type I β-turn ...
Tópico(s): Viral Infections and Vectors
2012 - American Chemical Society | Biochemistry
Qinghua Fang, Ying Zhao, Manfred Lindau,
... transmembrane domain. Here we show that 2 tryptophans (W89/W90) located in the juxtamembrane domain of Syb2, ...
Tópico(s): Erythrocyte Function and Pathophysiology
2012 - Wiley | FEBS Letters
Roman A. Laskowski, James D. Watson, Janet M. Thornton,
ProFunc ( http://www.ebi.ac.uk/thornton-srv/databases/ProFunc ) is a web server for predicting the likely function of proteins whose 3D structure is known but whose function is not. Users submit the coordinates of their structure to the server in PDB format. ProFunc makes use of both existing and novel methods to analyse the protein's sequence and structure identifying functional motifs or close relationships to functionally characterized proteins. A summary of the analyses provides an at-a-glance view ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2005 - Oxford University Press | Nucleic Acids Research
Kyungdo Han, Byong-Hyon Ju, Hojin Jung,
Molecular interaction networks, such as those involving protein-protein and protein-DNA interactions, often consist of thousands of nodes or even more, which severely limits the usefulness of many graph drawing tools because they become too slow for interactive analysis of the networks and because they produce cluttered drawings with many edge crossings. We present a new, fast-layout algorithm and its implementation called WebInterViewer for visualizing large-scale molecular interaction networks. ...
Tópico(s): Biomedical Text Mining and Ontologies
2004 - Oxford University Press | Nucleic Acids Research