Louis Blom-Cooper, Liz Dolan, John Terraine, Paul Heiney, Sara Jane Checkland, Tony Travers, Clifford Longley, Martin Fletcher and Paul Adams, Fred Wright, M. F. Cullis, Philip Gross, Anthony Maggs, Simon Barnes, B. M. Lahee, Bill Frost, S. J. C, Sheila Gunn, Political Correspondent, Norman Howell, Angela MacKay, Ross Tieman, Industrial Correspondent, Philip Howard, Laura Thompson, Adam Taussik, Ian Murray, Tom Gibb, Clive Davis, Melinda Wittstock, Media Correspondent, Lynne Truss, Wolfgang Münchau, European Business Correspondent, Albert Dormer, Richard Streeton, Liz Smith, Fashion Editor, Geoff Brown, Gerald Davies, Ray Clancy, Joe Joseph, Michael Seely Racing Correspondent, Martin Fletcher, Peter Davenport, Stewart Tendler Crime Correspondent, Peter Stothard, US Editor, Raymond Gubbay, Hugh Leggatt, Ivor Crewe, Wrenbury, Anne Caborn, Christopher Price, Ray Kennedy, Anthony Quinton, Martin Cropper, Alan Hamilton, Michael Clark, Antony Gold, Byron Rogers, Frances Bissell, David Hands, John Percival, Vivien Asquith, J. R. Lowerson, Graham Wood, Quentin Cowdry Home Affairs Correspondent, Robert Cockburn, C. Lancaster, Harvey Elliott, Air Correspondent, Gavin Bell, Peter Birch, Douglas Broom Local Government Correspondent, George Brock, Sydney Friskin, Raymond Blackburn, Martin Hoyle, William Jackson, Gillian Bowditch, (Michael Phillips), David Powell Athletics Correspondent, Hugh Hanning, Eluned Price, Lindsay Cook, Money Editor, Kerry Gill, Raymond Keene, Jonathan Prynn, John Russell Taylor, Craig Brown, Alix Ramsay, Paul Griffiths, E. Rosenstiel, Peter Bryan, Liz Gill, Martin Fletcher and Bruce Clark, G. A. Goodeve, Alice Thomson, Megan Tresidder, Craig Seton, Jill Sherman, Marc Weller, N. R. MacNICOL, William Cook, C. L. Torrero, M. G. Griffith, Betty Powell, Brian Beel, Keith MacKlin, E. Halton, Richard Duce, Christopher Thomas, Sir Christopher Hogg, Joanna Pitman, Ross Tieman Industrial Correspondent, Sara McConnell, G. Ellenbogen, George Hill, Colin Narbrough, Economics Correspondent, Sean O'Hagan, Clive White, Richard Ford and Douglas Broom, Michael Seely, Gillian E. Balmforth, Walter Gammie, Helen Pridham, Peter Victor, John Herbecq, John C. de la T. Davies, J. W. Saunders, Mark Le Fanu, David Sinclair, Michael Horovitz, Michael Binyon, Diplomatic Editor, Charles Hennessy, Hamilton of Dalzell, Benedict Nightingale, Margaret Wiedemann, Richard Morrison, Michael Evans, John Phillips, Tamara Stokes, Harvey Elliott Air Correspondent, Matthew Bond, Colin Campbell, Susan Ellicott, Judy Froshaug, David Hands, Rugby Correspondent, Andrew Longmore, Tennis Correspondent,
... He was born on October 7,1906 Casimir Lewy Casimir Lewy, philosopher, has died aged 71. He was born ...
1991 - Gale Group | TDA
Walter Maetzler, Stefan P. Schmid, Isabel Wurster, Inga Liepelt, Alexandra Gaenslen, Thomas Gasser, Daniela Berg,
Abstract Reduced (GSH R ) but not oxidized glutathione (GSSG) has been shown to be dramatically altered in the substantia nigra (SN) of Lewy body disease (LBD) patients post mortem; but up to now, there is no convincing evidence that these changes can be monitored in vivo. We investigated GSH R and GSSG in rapidly processed cerebrospinal fluid (CSF) and plasma samples of 80 LBD and 35 control subjects and detected reduced CSF GSH R levels in LBD subjects. The reduction was negatively associated with age ...
Tópico(s): Alzheimer's disease research and treatments
2010 - Wiley | Movement Disorders
S. C. Leslie, Terence Reese, Elizabeth Jennings, Frank W. Bradbrook, Abraham Lincoln, Quentin Bell, Geoffrey Lewis, K. W. Gransden, Garfield Clack, Peter Green, Alfred Sherman, E. R. Patton, Stanley Mayes, R. B. Kitaj, Edmond Sollberger, Raymond Williams, Barbara H. Nuttall, Deryck Cooke, C. Fleetwood-Walker, Derrick Sington, Walter Allen, J. M. Cameron, John Russell Taylor, Susan Bradshaw, Doghouse, Charles Thomas, John Brooke, Robin Skelton, Ivan Roots, H. B. Acton, J. N. L. Myres, Stanley Hyland, W. G. Good, John Pringle, Margaret Cole, Edward Lockspeiser, Laurence Lerner, Citizen Getty, W. J. M. Mackenzie, Martin Shuttleworth, Harold Franklin, Kay Smallshaw,
... G. E. Moore, 1919-1953. Edited by Casimir Lewy Allen and Unwin. 42s. The Souterrains of Southern ...
1963 - Gale Group | The Listener GDA
Walter Maetzler, Velichka Stoycheva, Benjamin Schmid, Claudia Schulte, Ann‐Kathrin Hauser, Kathrin Brockmann, Arthur Melms, Thomas Gasser, Daniela Berg,
Lewy body disease, defined by the occurrence of α-synuclein aggregates as fibrils in Lewy bodies and Lewy neurites, is associated with increased probabilities for both co-occurrence of dementia, and co-occurrence of Alzheimer's disease (AD)-like path
Tópico(s): Dementia and Cognitive Impairment Research
2010 - IOS Press | Journal of Alzheimer s Disease
By Giles Smith Business News Staff, From Our Correspondent, From Paul Martin, By a Staff Reporter, U S Economic Correspondent, By David Wood Political Correspondent, From David Bonavia, From John Chartres, By Christopher Warman, By Tony Aldous Environment Reportor, By Philip Howard, By Our Medical reporter, By Our Political Staff, By Our Local Government Correspondent, Leonard Amey, By Our Social Services Correspondent, By Innis Macbeath Labour Editor, By Marcel Berlins Legal Correspondent, From Peter Strafford, From Sue Masterman, By George Clark Political Staff, From Michael Knipe, From Michael Hornsby, From Peter Hazelhurst, From Our Own Correspondent, From Fred Emery, From Leo Goodstadt, From Mario Modiano, From Julian Mounter Motoring Correspondent, From Stewart Harris, By Alan Gibson, By Neil Allen Athletics Correspondent, From Jim Railton, By Our Rifle Shooting Correspondent, By Peter Ryde Golf Correspondent, By Michael Phillips Racing Corespondent, From Terry McLean, By Andrew porter, By John Nicholls, David Wade, Loenard Buckley, John Percival, Joan Chissell, Michael Billington, Michael Glenny, Max Harrison, David Williams, Gerald Ely, Stewart Harris, Patrick Brogan, PHS, Ernest A. Payne, Walter J. Martin, C. Desmond Ford, SJ, T. Corbishley, SJ, H. G. Townsend, SJ, Emest J. Edwards, Harry Morton, Michael Scott, S. Booth-Clibborn, Kenneth Skelton, Kenneth Sansbury, Gordon Evans, Tom Baird, Nigel L. Gilson, Hagh E. Wilcox, Albert W. Mosley, Paul Oestreicher, Sydney D. Bailey, Herbert Waddams, R. Elliott Kendall, K. S. RYLE, , B. LEVENE, DAVID BARRAN, VAL DUNCAN, REAY GEDDES, KEARTON, NETHERTHORPE, PLOWDEN, POOLE, E. J. CALLARD, DEREK EZRA, A. A. HALL, KENNETH, KEITH, ARTHUR, NORMAN, MICHAEL ANCRAM (Conservative Candidate, West Lothian 1970) MALCOLM RIFKIND (Conservative Candidate, Central Edinburgh 1970) W. M. REID (Labour Candidate, Orkney and Zetland 1970) GEORGE FOULKES (Labour Candidate, West Edinburgh 1970) DONALD GORRIE (Liberal Candidate, West Edinburgh 1970) DONALD CLARKE (Liberal Candidate, Edinburgh Pentlands 1970), K. W. CATTERMOLE., JIM SILLARS., WILL HOWIE., C. LEWY., CICELY MORGAN., H. J. G. Renwick, P. J. Williams, K. M. Fitzpatrick, A. J. Rutland, P. W. R. Bull, D. Cox, P. G. Clinkskel, N. Brook, L. G. Neville, A. P. D. Williams, R. Saunders, J. D. Lang, S. J. Tucker, A. G. Bedford, L. B. Turner, P. L. Sibree, T. Forbes, J. Vela, E. B. Bell, D. J. Bigden, B. Donaghue, A. R. W. Grimsley, G. F. Cope, D. B. Jewell, L. Castle, D. Cussen, D. G. Knight, R. Good, M. Doughty, D. E. Cook, G. Price, R. Freeman, P. Jutton, P. Geen, M. Parsley, M. Farmer, G. W. Piper, D. Edwards, S. Garner, P. Kellett, F. Ramsey, I. Price, R. H. Goodall, B. Marshall, M. A. Cornish, P. Walters, A. Witherick, J. Louis-Marc, E. F. Elgie, K. Hart, R. Raybould, J. W. Bayley, A. L. Brand, F. W. Twiss, P. W. R. Denning, A. J. Laister, G. Everett, J. R. H. Minter, D. Evans, B. M. S. W. Emery, F. W. T. Bowell, M. C. Page, J. Jupe, P. J. Dent, D. G. Knight., A. H. LUSCOMBE., PHILIP NOEL-BAKER, , FLORIAN O. P. BRANN., H. A. GUY, From Our Special Correspondent, By Pearce Wright, Science Correspondent, By Malcolm Brown, By Paul Routledge Labour Staff, By Clifford Webb Midlands Industrial Correspondent, By Arthur Reed Air Correspondent, By Andrew Goodrick-Clarke, By Kenneth Owen Technology Correspondent, By Patricia Tisdall, From John Earle, From Frank Vogl, By Michael Baily Shipping Correspondent, By Leonard Amey, By John Woodland, BY THE FINANCIAL EDITOR, By Richard Spiegelberg, ERIC COCKERAM, , D. R. OFFORD., By Joe Roeber, Innis Macbeath, W. H. LAITHWAITE, MARK OTTAWAY., R. A. HILL, M. E. WALKER, R. F. COOK, M. R. E. HUTTON., ADRIAN FISHER., By Anthony Thomas, Guy Hawtin, John Armytage,
News: Viewpoint, Unsafe seats upset MPs, Peers propose closer links with Commons, Pressure query to BBC, Myths that start at Calais Agriculture, Nationwide ...
1971 - Gale Group | TDA
Walter Maetzler, Benjamin Schmid, Matthis Synofzik, Claudia Schulte, Karin Riester, Heiko Huber, Kathrin Brockmann, Thomas Gasser, Daniela Berg, Arthur Melms,
A large proportion of demented Lewy body disease patients have Alzheimer's disease (AD)- like pathology, in particular amyloid-β (Aβ) plaques. Cystatin C (CysC) is a carrier of soluble Aβ42 in the cerebrospinal fluid (CSF) and reduces Aβ plaque forma
Tópico(s): Folate and B Vitamins Research
2010 - IOS Press | Journal of Alzheimer s Disease
Andrea Dunaif, Georgette Green, Robert Phelps, Mark Lebwohl, Walter Futterweit, LORENA LEWY,
Acanthosis nigricans (AN) is a freguent clinical finding in hyperandrogenic women. Its presence has been used to subgroup such women. We performed this study in order to determine the actual histological prevalence of AN and its relationship to sex hormone levels and insulin action. Insulinmediated glucose disposal was determined by the euglycemic clamp technique, and neck or axillary skin biopsies were graded blind for the presence and severity of AN in lean and obese women with the polycystic ovary ...
Tópico(s): Cancer and Skin Lesions
1991 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Walter Maetzler, Stefanie Keller, Joan Michelis, Niklas Koehler, Elke Stransky, Clemens Becker, Claudia Schulte, Arthur Melms, Thomas Gasser, Daniela Berg,
Butyrylcholinesterase (BChE) genotypes and protein (BuChE) activity, especially in combination with Apolipoprotein E4 (ApoE4), have been investigated as risk factors for developing Alzheimer disease (AD) and may be associated with the rate of progression of cognitive decline. Despite similar pathologic (e.g. amyloid deposition) and neurochemical (e.g. cholinergic deficits) aspects between AD and Lewy body diseases (LBD), scarce data is obtainable about BChE genotypes and BuChE activity in LBD. We measured ...
Tópico(s): Computational Drug Discovery Methods
2009 - Elsevier BV | Neurobiology of Disease
Walter Maetzler, Daniela Berg, Matthis Synofzik, Kathrin Brockmann, Jana Godau, Arthur Melms, Thomas Gasser, Stephanie Hörnig, Markus Langkamp,
There is increasing evidence that in Lewy body-associated dementias (encompassing Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB)), the adaptive immune system is altered and the degenerative process includes glial cells in
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2011 - IOS Press | Journal of Alzheimer s Disease
Walter Maetzler, Willy Deleersnijder, Valérie Hanssens, Alice Bernard, Kathrin Brockmann, Justus Marquetand, Isabel Wurster, Tim W. Rattay, Lorenzo Pietro Roncoroni, Eva Schaeffer, Stefanie Lerche, Anja Apel, Christian Deuschle, Daniela Berg,
Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers for Lewy body disorders, i.e. Parkinson's disease with (PDD) and without dementia (PDND) and Lewy body dementia (DLB). GDF15 has a prominent role in development, cell proliferation, differentiation, and repair, ...
Tópico(s): Macrophage Migration Inhibitory Factor
2016 - Public Library of Science | PLoS ONE
Silvia Favaretto, Uwe Walter, Claudio Baracchini, Sara Pompanin, Cinzia Bussè, Giovanni Zorzi, Mario Ermani, Annachiara Cagnin,
Background and purpose Transcranial sonography ( TCS ) of the brain parenchyma is used to visualize alterations in the substantia nigra ( SN ) and it is applied for early diagnosis of Parkinson's disease. Our aim was to explore specific echogenic alterations of the SN in dementia with Lewy bodies ( DLB ) compared to Alzheimer's disease ( AD ). Methods Seventy‐one subjects underwent TCS : 22 DLB , 28 AD and 21 healthy elderly controls. Cognitive impairment, extrapyramidal signs, visual hallucinations, fluctuations and ...
Tópico(s): Neurological disorders and treatments
2016 - Wiley | European Journal of Neurology
Walter Maetzler, Joan Michelis, Juergen Tomiuk, Arthur Melms, Clemens Becker, Thomas Gasser, Claudia Schulte, Daniela Berg,
Tópico(s): Trace Elements in Health
2009 - Springer Science+Business Media | Journal of Neural Transmission
M. Kramer, Walter Schulz‐Schaeffer,
Lewy bodies, the pathological hallmark of dementia with Lewy bodies (DLB), are large juxtanuclear inclusions of aggregated alpha-synuclein. However, the small number of cortical Lewy bodies relative to the total neuron count does not correlate with the extent of cognitive impairment. In contrast to dopaminergic neurons in Parkinson's disease, nerve cell loss is usually less prevalent in the cortex of DLB, suggesting a different mechanism of neurodegeneration. Because antibodies used for immunodetection ...
Tópico(s): Nerve injury and regeneration
2007 - Society for Neuroscience | Journal of Neuroscience
Michela Deleidi, Walter Maetzler,
Protein clearance is critical for the maintenance of the integrity of neuronal cells, and there is accumulating evidence that in most-if not all-neurodegenerative disorders, impaired protein clearance fundamentally contributes to functional and structural alterations eventually leading to clinical symptoms. Dysfunction of protein clearance leads to intra- and extraneuronal accumulation of misfolded proteins and aggregates. The pathological hallmark of Lewy body disorders (LBDs) is the abnormal accumulation ...
Tópico(s): Neurological diseases and metabolism
2012 - Hindawi Publishing Corporation | International Journal of Alzheimer s Disease
Raffaella Franciotti, Nicola Walter Falasca, Laura Bonanni, Francesca Anzellotti, Valerio Maruotti, Silvia Comani, Astrid Thomas, Armando Tartaro, John‐Paul Taylor, Marco Onofrj,
Tópico(s): Neural dynamics and brain function
2012 - Elsevier BV | Neurobiology of Aging
H.J. Tschampa, Walter Schulz‐Schaeffer, Jens Wiltfang, S. Poser, Markus Otto, M. Neumann, H. A. Kretzschmar,
Tópico(s): Prion Diseases and Protein Misfolding
2001 - Lippincott Williams & Wilkins | Neurology
Alberto Raggi, Walter Neri, Raffaele Ferri,
Abstract Prevalence studies suggest that Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the most common dementing illnesses in the elderly. The aim of this narrative review was to provide data on sleep-related behaviors in AD and DLB. This paper contains arguments, with a clinical approach, on both circadian rhythm changes and dissociated states of wakefulness and sleep in these two conditions.
Tópico(s): Circadian rhythm and melatonin
2014 - De Gruyter | Reviews in the Neurosciences
Christopher E. Ellis, Pamela L. Schwartzberg, Teresa L. Grider, Donald W. Fink, Robert L. Nussbaum,
... onset disease and pathologically through its presence in Lewy bodies. α-Syn is phosphorylated on serine residues; however, tyrosine phosphorylation of α-Syn has not been established (1Okochi M. Walter J. Koyama A. Nakajo S. Baba M. Iwatsubo ... onset disease and pathologically through its presence in Lewy bodies. α-Syn is phosphorylated on serine residues; however, tyrosine phosphorylation of α-Syn has not been established (1Okochi M. Walter J. Koyama A. Nakajo S. Baba M. Iwatsubo ...
Tópico(s): Alzheimer's disease research and treatments
2001 - Elsevier BV | Journal of Biological Chemistry
Walter G. Williams, Immanuel Lewy,
... the Pentateuch The Growth of the Pentateuch, Immanuel Lewy. Walter G. Williams Walter G. Williams Search for other ...
Tópico(s): Archaeology and Historical Studies
1959 - Society of Biblical Literature | Journal of Biblical Literature
Walter Maetzler, Inga Liepelt, Matthias Reimold, Gerald Reischl, Christoph Solbach, Clemens Becker, Claudia Schulte, Thomas Leyhe, Stefanie Keller, Arthur Melms, Thomas Gasser, Daniela Berg,
About one fourth of Lewy body disease (LBD) patients show cortical beta-amyloid load, basically a hallmark of Alzheimer disease (AD). Using [11C]PIB-PET, we tested whether LBD patients with beta-amyloid burden differ from those without with respect to demographic, clinical, biochemical and genetic parameters. Thirty-five LBD subjects (9 patients with Lewy body dementia, DLB; 12 demented Parkinson patients, PDD; 14 non-demented PD, PDND) underwent [11C]PIB-PET, and were classified as either PIB(+) or ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2009 - Elsevier BV | Neurobiology of Disease
Walter Maetzler, You‐Yong Tian, S. Baur, Tina Gauger, Bartholomäus Odoj, Benjamin Schmid, Claudia Schulte, Christian Deuschle, Susanna A. Heck, Anja Apel, Arthur Melms, Thomas Gasser, Daniela Berg,
Parkinson's disease (PD) without (non-demented, PDND) and with dementia (PDD), and dementia with Lewy bodies (DLB) are subsumed under the umbrella term Lewy body disorders (LBD). The main component of the underlying pathologic substrate, i.e. Lewy bodies and Lewy neurites, is misfolded alpha-synuclein (Asyn), and--in particular in demented LBD patients--co-occurring misfolded amyloid-beta (Abeta). Lowered blood and cerebrospinal fluid (CSF) levels of transthyretin (TTR)--a clearance protein mainly produced ...
Tópico(s): Cellular transport and secretion
2012 - Public Library of Science | PLoS ONE
Swetha Vijayaraghavan, Walter Maetzler, Matthias Reimold, Christina Unger Lithner, Inga Liepelt‐Scarfone, Daniela Berg, Taher Darreh‐Shori,
Apolipoprotein E ε4 allele (APOE ε4) increases the apolipoprotein E (apoE) protein levels in Alzheimer's disease (AD) cerebrospinal fluid (CSF). Thus, we hypothesized that apoE levels were also associated with the APOE genotype, and amyloid-β (Aβ)-associated clinical, functional, and imaging parameters in patients with Lewy body-associated disorders (LBD). Indeed, similar to AD, patients with LBD displayed high CSF apoE levels (greatest in patients with dementia with LBD), and this was linked to APOE ε4. ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2013 - Wiley | Alzheimer s & Dementia
Stephan Theiss, Walter Maetzler, Christian Deuschle, Holger Lerche, Henner Koch, Marcel Dihné,
One of the core clinical criteria of Dementia with Lewy bodies (DLB) are fluctuations of cognition. Underlying processes may be rather functional than neurodegenerative, reflected by, for example, factors present in cerebrospinal fluid (CSF). The aim of this study was to identify in-vitro neuronal network activity (ivNNA) changes of CSF from DLB patients compared with patients with Parkinson’s disease (PD) and controls. Primary neuronal mouse cultures were grown on microelectrode arrays to record ivNNA ...
Tópico(s): Neuroscience and Neuropharmacology Research
2017 - Lippincott Williams & Wilkins | Neuroreport
Walter Maetzler, Anne Kathrin Stapf, Claudia Schulte, Ann‐Kathrin Hauser, Stefanie Lerche, Isabel Wurster, Erwin Schleicher, Arthur Melms, Daniela Berg,
Recent studies have provided evidence that uric acid (UA), a natural antioxidant, may play a role in the development and progression of Parkinson's disease (PD) and of dementia. In this clinical study we were therefore interested in the role of UA in
Tópico(s): Alzheimer's disease research and treatments
2011 - IOS Press | Journal of Alzheimer s Disease
Uwe Walter, Dirk Dressler, Alexander Wolters, Matthias Wittstock, B. Greim, R. Benecke,
Tópico(s): RNA regulation and disease
2005 - Springer Science+Business Media | Journal of Neurology
Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are usually associated with loss of dopaminergic neurons. Loss of substantia nigra neurons and presence of Lewy body inclusions in some of the remaining neurons are the hallmark pathology seen in the final stages of the disease. Attempts to correlate Lewy body pathology to either cell death or severity of clinical symptoms, however, have not been successful. While the pathophysiology of the neurodegenerative process can hardly be explained ...
Tópico(s): Nuclear Receptors and Signaling
2010 - Springer Science+Business Media | Acta Neuropathologica
Brit Mollenhauer, Lukas Cepek, Mirko Bibl, Jens Wiltfang, Walter Schulz‐Schaeffer, Barbara Ciesielczyk, Manuela Neumann, Petra Steinacker, Hans A. Kretzschmar, S. Poser, Claudia Trenkwalder, Markus Otto,
The intra vitam diagnosis of dementia with Lewy bodies (DLB) is still based on clinical grounds. So far no technical investigations have been available to support this diagnosis. As for tau protein and beta-amyloid(1-42) (Abeta42), promising results for the diagnosis of Alzheimer's disease (AD) have been reported; we evaluated these markers and S-100B protein in cerebrospinal fluid (CSF), using a set of commercially available assays, of 71 patients with DLB, 67 patients with AD and 41 nondemented controls ( ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2005 - Karger Publishers | Dementia and Geriatric Cognitive Disorders
Colette Walter, Nancy E. Edwards, Rosanne Griggs, Karen S. Yehle,
Dementia is a growing problem with global, social, and financial repercussions. Early screening, diagnosis, education, planning, and treatment of dementia in primary care may reduce this burden. Presently, dementia is often diagnosed relatively late in the disease process, resulting in greater financial and caregiver burden. Primary care providers are often most likely to encounter patients with cognitive impairment early. The new guidelines outlined in the Diagnostic and Statistical Manual of Mental ...
Tópico(s): Mental Health and Psychiatry
2014 - Elsevier BV | The Journal for Nurse Practitioners
Brit Mollenhauer, H. Esselmann, Claudia Trenkwalder, Walter Schulz‐Schaeffer, Hans A. Kretzschmar, Markus Otto, Jens Wiltfang, Mirko Bibl,
Appropriate treatment of dementia requires biomarkers that provide an exact and differential diagnosis. We recently presented differentially expressed amyloid-β (Aβ) peptide patterns in cerebrospinal fluid (CSF) as biomarker candidates for neurochemical diagnosis of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). The objective of the present study was to investigate CSF Aβ peptide patterns in both neuropathologically and clinically defined diagnostic groups of AD and DLB. Using the quantitative ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2011 - IOS Press | Journal of Alzheimer s Disease
Laura de Boni, Sascha Tierling, Sigrun Roeber, Jörn Walter, Armin Giese, Hans A. Kretzschmar,
Tópico(s): Autism Spectrum Disorder Research
2011 - Springer Science+Business Media | NeuroMolecular Medicine