Andrew McEwen and Robert Cockburn, David Wade, Chris Petit, Clifford Longley, Andrew Billen, C. M. Money, H. B. Dunning, DJM, Linda Franklin, Daniel Ward, Motor Industry Correspondent, Patricia Davies, Stephen Leather, Michael Clark and Carol Leonard, Andrew Morgan, Ronald Faux and Edward Gorman, Gordon Allan, Andrew J. Plater, Steven Dickman, Cliff Feltham, Ivo Tennant, Hilary Finch, Findlay Davidson, Mark Ellis, Richard Evans, Media Editor, Christopher, Thomas, Carol Leonard, Dessa Trevisan, Richard Streeton, Richard Eaton, Stuart Jones Football Correspondent, J. C. Edward, Roddy Forsyth, John Spicer, Employment Affairs Correspondent, Michael Hamlyn, Khanaqin Sector, Bernard Levin, Brian P. Smith, Mitchell Platts, Golf Correspondent, Martin Waller and Geoffrey Foster, P. J. Freeman, Michael J. Tooley, Anthony Grant, Michael Haynes, Jill Sherman, Social Services Correspondent, John Sergeant, Andrew Moger, Irene V. Duchenne, Mick Cleary, Alan Hamilton, Richard Bassett and Our Correspondent and Andrew McEwen, Hugh Montefiore, Dr Richard Golding, Charles Bremner, David Sapsted and Michael Evans, Enoch Powell, Edward Gorman, John Hennessy, David Lowry Director, Nigel Seymer, Rex Bellamy Tennis Correspondent, Paul Vallely, Stephen Johnson, Sydney Friskin, Dennis Signy, David Miller, Chris Thau, Celia Brayfield, William Greaves, Christopher Goulding, Peter Davalle, Alan Lee, Cricket Correspondent, Nicholas Beeston, Peter Bryan, Alexandra Jackson, W. J. Burroughs, Heather Kirby, Robin Russell Jones, Cathy Harris, Martin Searby, Barry Pickthall, Pat Butcher, Joyce Whitehead, Maxwell Newton, Raymond Keen, Chess Correspondent, David Tremayne, Geoffrey Foster, Richard Bassett, David Brewerton, Daniel Ward Motor Industry Correspondent, F. R. Badcock, R. B. Cruse, Jason D. Shaw, Graham Searjeant, Financial Editor, Robert Matthews, Technology Correspondent, Clive White, Mary Stewart-Wallance, John Gloucester, Alan Lee Cricket Correspondent, David Walker, David Tytler, Education Editor, Michael Evans Defence Correspondent, John Curtiss, Jack Bailey, Pat Butcher Athletics Correspondent, Sam Kiley, Keith Macklin, Derek Harris Industrial Editor, F. M. M. Lewes, Colin Campbell, Michael Evans and David Sapsted, Michael Coleman, Clement Freud, Mary Dejevsky, Richard Battley,
... Saturday's Scoreboards Cycling Drug test reprieve for Longo record Cycling Inspiring challenge by Spoor Bowls (AP): ...
1988 - Gale Group | TDA
Walter E. Longo, Rabie N. Stephan, Lawrence D. True, David A. August, William B. McCullough,
Longo, Walter E. M.D.1; Stephan, Rabie N. M.D.1; True, Lawrence D. M.D.2; ...
Tópico(s): Metastasis and carcinoma case studies
1986 - Lippincott Williams & Wilkins | Journal of Clinical Gastroenterology
Sara McConnell Personal Finance Writer, Liz Dolan, Ted O'toole, Paul Heiney, Clifford Longley, Caroline Ricketts (Executive committee member), Patricia Davies, Simon Barnes, Paul Bompard, John Bowis, Bill Frost, Caroline Davis (Executive Secretary), David Rhys Jones, Harvey Elliott, Angela Mackay, Ivo Tennant, Norman Howell, Robin Oakley, Sally Brompton, Philip Howard, Hilary Finch, P. J. Patrick, Director, Laura Thompson, Jeremy Kingston, Anna Reynolds, Quentin Cowdry and Peter Mulligan, Carol Leonard, Ronald J. MacDonald, David Thurlow, Lynne Truss, Carol Sarler, Jeremy Lee-Potter, Chairman of Council, Richard Streeton, Stuart Jones Football Correspondent, Geoff Brown, David Watts, Diplomatic Correspondent, Callum Murray, Ray Clancy, Michael Seely Racing Correspondent, Martin Fletcher, Deborah Coles (Co-director), Peter Davenport, John McCarthy, Norman Hammond, Archaeology Correspondent, Alan Lorimer, Jill Sherman, Social Services Correspondent, Robert Dashwood, Huon Mallalieu, Lawrence Dex, Martin Barrow, Neil Bennett and Lulu Yu, Chris Smart, Alan Hamilton, Jenny MacArthur, Katharine Minchin, Frances Bissell, Kevin Eason Motoring Correspondent, Roy Strong, Neil Bennett Banking Correspondent, John Percival, Francis Ponsonby, Jonathan Meaeds, Fiona MacCarthy, William Peto, Nicole Swengley, Gavin Bell, John Woodcock, Edward Gorman, Irish Affairs Correspondent, David Miller, Lin Jenkins, Rupert Bruce, Peter Dormer, Mitchell Platts Golf Correspondent, Geoffrey Wheeler, R. J. Post, Celia Goodhart (Principal), William Greaves, Ali Jaber and Richard Beeston, John O'leary Higher Education Correspondent, Raymond Keene, Jonathan Prynn, Simon Tait Arts Correspondent, Alan Lee, Cricket Correspondent, John Russell Taylor, Raymond Keene, Chess Correspondent, Ali Jaber, Alix Ramsay, Hindle wakes, Michael Bell, Peter Bryan, Iain R. Redpath, Ken Lawrence, David Powell, Athletics Correspondent, John Bell, Barry Pickthall, E. E. Cooper, Roger McGough, Roger Boyes, Alastair Robertson, William Cash and Rupert Steiner, O. W. H. Clark, Sue Moore, Michael Pitfield, D. R. Chandler, David Young, Jane Macquitty, Ross Tieman Industrial Correspondent, Sara McConnell, R. Larkin, Clive White, Charles Nevin, Matthew Parris, Gerard Davies, Mapp and Lucia, John Shaw, John Bell, Business Editor, R. A. Baker, Timothy Clarke, Philip Pangalos, Tim Jones, Peter Mulligan, Michael Horsnell, Benedict Nightingale, Lloyd Bracey, Quentin Cowdry, Home Affairs Correspondent, Jack Bailey, Anatole Kaletsky Economics Editor, Rupert Steiner, Anne McElvoy, Richard Ford, Political Correspondent, John Phillips, Adam Kelliher, Gwen Powell, Matthew Bond, Judy Froshaug, H. D. Berman, Clement Freud, David Lindsay, Legal adviser,
... Tokyo Results from Gateshed Green keeps his title Longo in dispute In Brief O'Connor's two- ... Bentley Ornamental Gates Columba Dovecotes Connoisseur Sun Dials Walter Blom & Son Ltd. Insushade The Times Country Property ...
1991 - Gale Group | TDA
Frank W. Longo, Walter E. Longo, Philip Tomashefsky, John K. Lattimer, Bernard D. Rivin, Myron Tannenbaum,
Ultrasonic irradiation was employed by direct administration to the skin overlying subcutaneously implanted Furth-Columbia rat Wilms' tumors. Treated tumors were flattened and excavated and demonstrated no stigmata of hemorrhage or infection. There was a marked decrease in growth rate of the tumors with an increase in survival time of the host. Histologic assessment with the light microscope exhibited a sharp line of demarcation between the necrosed sonicated portion of tumor and the viable intact ...
Tópico(s): Ultrasound and Hyperthermia Applications
1975 - Elsevier BV | Urology
Andrew Robson, Mark Hall, Jon Ashworth, John Denham, David Adams, Nick Nuttall Environment Correspondent, David Charter Health Correspondent, Helen Studd, Helen Daniel, Michael Aylwin, Robert Hands, Andrew Pierce, DJM, Joanna Coles, Frances Gibb Legal Editor, Simon Barnes, Peter Lansley, Paul Hoggart, Claire McDonald, Mark Souster, Richard Hobson, Michael Evans Defence Editor, Philip Howard, Hilary Finch, Jeremy Kingston, James Bone, Gabrielle Starkey, Erich Steiner, Srikumar Sen, Morag Preston, Geoff Brown, Gerald Davies, William a Anderson, Anthony Seldon, Laura Campbell, Ben Webster Transport Correspondent, Conal Urquhart, David McVay, Pat Gibson, Donald Hutera, Stewart Tendler Crime Correspondent, John Redwood, Dominic Walsh, Steve Bird, Victoria Segal, Raymond Keene Chess Correspondent, Alix Ramsay Tennis Correspondent, Graham Speake (Honorary Secretary), Tony Keable-Elliott, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Martin Barrow, Anita Chaudhuri, Richard Ford Home Correspondent, Robin Young, Clare Whitehead, Leslie Turnberg, Chairman, Andy Stephens, Rodney Milnes, Jennifer Riley, Simon Baddeley, David Collins, Nick Wyke, Phil Gordon, Keith Pike, Mike Bradley, David Hands, D. C, Chris Moss, Greg Hurst, Patience Wheatcroft Business Editor, Arthur Leathley City Correspondent, Caroline Merrell Banking Correspondent, Cyril Chantler (Chairman), Russell Kempson, Dan Whitcombe, Daniel McGrory, Oliver Kay, Lisa Armstrong, Michael Theodoulou, Rick Broadbent, Jeremy Pound, Anna Söderblom, John Hopkins, Marit Hargie, Umberto Bossi (Federal Secretary), John Hopkins Golf Correspondent, Rob Wright, Celia Brayfield, Raymond Keene, Adam Sage, Peter Davalle, Sean MacAulay, Christine Buckley Industrial Editor, Nigel Cliff, Chris Ayres Media Business Correspondent, Cathy Harris, Richard Owen, Damian Whitworth, Mick Hume, John Carr, Roger Boyes, Martin Woods, Nick Hasell, Richard Holledge, David Hands Rugby Correspondent, Christopher Martin-Jenkins Chief Cricket Correspondent and Stephen Farrell, Ben Hammersley, John Allison, William Rees-Mogg, Nick Szczepanik, Nigel Hawkes Health Editor and Helen Studd, John Goodbody, Philip Webster Political Editor, Jeremy Griffiths, Alan Copps, Ian Johns, Michael Fitzpatrick, Linus Gregoriadis, Nancy Jo Sales, Richard Hoare, Chris McGrath, Tim Wapshott, Michael Austin, Alan Lee, Anjana Abuja, Walter Gammie, Peter Riddell, Ben MacIntyre, Lea Paterson Economics Editor, Jenny Eclair, Ian Brodie, Tony Dawe, Richard Beeston Diplomatic Editor, Michael Dynes, Fraser Nelson, Lea Paterson, Lewis Stuart, Michael Horsnell, Malcolm Field, Chairman, Chris Ayres, Kathleen Wyatt, Mark Baldwin, Edgar Andrews, Dr Thomas Stuttaford, Lindsay Nicolle, Alyson Rudd, Bill Edgar, Robert Whymant, Alan Lee Racing Correspondent, Sally Patten, Brian Clarke Fishing Correspondent, Edward Gorman Sailing Correspondent, Giles Tremlett and Daniel McGrory, Sally Patten Retail Correspondent, Christopher Irvine, Rebecca Goldsmith, Cyril Townsend, Director,
... New York crown Oakwood shoot way to victory Longo breaks one-hour record Hartlepool bowl over holders ...
2000 - Gale Group | TDA
Ronald I. Shorr, Walter Longo, Terry D. Oberley, Marek J. Bozdech, Duard L. Walker,
... Bone Marrow Transplant RecipientRONALD I. SHORR, M.D., WALTER L. LONGO, M.D., TERRY D. OBERLEY, M.D., MAREK ... WALKER, M.D.RONALD I. SHORR, M.D., WALTER L. LONGO, M.D., TERRY D. OBERLEY, M.D., MAREK ... and Disclosure InformationAuthors: RONALD I. SHORR, M.D.; WALTER L. LONGO, M.D.; TERRY D. OBERLEY, M.D.; MAREK ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
1987 - American College of Physicians | Annals of Internal Medicine
Waldemar Januszczak, Tim Tezisler, Hilary Mantel, Michael Prescott, John Dugdale, Graham Thomas, Barbara Hall, Nigel Botherway, Sebastian Faulks, Colin Kitt, Ken Green, Rebecca Butlin, Fred Redwood, Allan Palmer, James Clark, Anthony Clare, John Peter, MacMillan, Dan Pearson, Pam Barrett, Emma Moore, Amanda Ursell, Lilian Nduta, John Jay, J D, Ed Owen, Mark Souster, Gareth Walsh, Frank Whitford, Ivo Tennant, David Landers, Dr Russell Reid, Patricia Ellis, Alex Todorovic, Eve MacSWEENEY, Alistair Scott, Peter Kirrage, P D, Sally Payne, David Smith, John Harlow Social Affairs Editor, Kirstie Hamilton City Editor, John Goetz, Melanie Phillips, Nick Pitt, Michael Walbank, Ian Christie, Brian Pedley, E P, Andrew Sullivan, Clive Davis, Neil Wormald, Deborah Moggach, Stephen Grey, Mary Wilson, Karen Robinson, Prince Ernst, Lynne Truss, Ronald Bergan The Guardian, Tony Allen-Mills, Simon Wilde, Jerome Burn, Martin James, Noel Lawlor, Tom Walker, Anthony Sattin, Vanessa Feltz, Robert Winnett, Alison Brace, Irwin Stelzer, Robert Hewison, Peter Wilson, Roger Anderson, Curt Howland, David Dougill, Lily Savage, York Membery, Vivien Greene, John Evans, Dr Andrew Bamji, Robert Mugabe, Martin Copsey, Thrasy Petropoulos, Jean-Pierre Garnier, Kathryn Gyngell, Sarah Toyne, David Hewson, Tania Alexander, Margaret Coles, Hugh Canning, Alasdair Reid, Margarette Driscoll, Peter Watson, Jeremy Clarkson, Nigel Williams, Edward Porter, Stewart Lee, David Cairns, Louise Taylor, John Waples Deputy City Editor, David Coleman, Jane Renton, Eben Black, Stuart Husband, Glaxo Wellcome, Robin Taylor, Peter Millar, Chris Woodruff, Phil Craigie, Andrea Webster, Bob Clay, Nick Gardner, Peter Ogden, Stuart Wavell, Paul Donovan, Alastair Hendy, Digby Hildreth, John Platt, James Clark Home Affairs Correspondent, Smita Talati, Paul Driver, Steven Norris, Boris Schapiro, John Humphrys, Ann McFerran, Nicholas Hellen, Richard Brooks, John Follain, Kushal Banerjee, Ian Hawkey, Steven Downes, Neil MacLEAN, Christopher Morgan, David Leppard, Shelley Von Strunckel, Dave Hannigan, Sue Beenstock, Mike Katz, Kirstie Hamilton, Mark Edwards, Michael Sheridan Banaue, David Lawrenson, Eben Black Chief Political Correspondent, Danny O'Brien, Phil Baker, Michael Riding, Hugo Barnacle, Marion Meade, Lois Rogers, Alan Combes, Sean Newsom, Raymond Keene, C L, John Wakeham, Norman Silver, Senay Boztas, Cosmo Landesman, Michale Woodhead, A A Gih, David Walton, Andy Knott, Peter Lampl, Chris Partridge, Michael Prescott Political Editor, Stephen Jones, Laurel Ives, Richard Evans, Reuben Girling, Alex Ross, Nick Cain, Peta Bee, Paul Nuki, M J, Rob Ryan, Jemimah Bailey, Claire Oldfield, Colin McDOWELL, David Walsh, Jeremy Paxman, Liam Fay, S P, Lois Rogers Medical Correspondent, Stephen Armstrong, Dr Adrian Tibbitts, Loulse Taylor, Christopher Goodwin, Paul Kavanagh, Nicholas Walter, Mark Prigg, Nick Harvey, David Selbourne, Roland White, David Windle, Kerry Chodera, Borodin Quartet, Kim Fletcher, Maurice Chittenden, Kevin Pratt, Andrew Mueller, Sean Connolly, Andrew Lorenz Business Editor, Richard Rae, Mark Franchetti, Jonathan Powell, Moira Myers, Jon Ungoed-Thomas, Ray Hutton, Frankfurt, Tim Anderson, Susan Elkin, Jonathan Leake, Christine Webb, John Harlow, Godfrey Smith, Michael Austin, Dipesh Gadher, Elizo Virzaladze, John Waples, R Susan Clark, Jeremy Hart, A A Gill, Matthew Campbell, Brian Glanville, John Carey, Tom Robbins, Stephen Pettitt, Mark Thompson, Robert Johnston, Jeremy Langmead, Sally Kinnes, Andrew Lorenz, John Noble, Naomi Caine, Nigel Powell, Nicholas Hellen Media Editor, David Wickers, Hazel Courteney, Roger Dobson, Tom Rhodes, Richard Harris, Smithkline Beecham, John Aizlewood, Clifford Bishop, John Cornwell, Andrew Frankel, Jonathan Futrell, Rupert Steiner, Hugh Pearman, Dan Cairns, David Parsley, David Smith Economics Editor, Simon Crerar, Anthony Howard, Max Nottingham, Joanna Simon, Stephen Boyd, India Knight, Mike Tyson, Steve Grant, Simon Howard, Pamela Coleman, Barry Newcombe, Dominic Rushe, Chris Lynam, Bob Latham,
... in some pond life, says Dan Pearson Gardening Longo Vital NordicTrack Multiple Display Advertising Items Glucosamine Glucosamine ...
2000 - Gale Group | Sunday Times HA GDA
Eric Tran, Dan L. Longo, Walter J. Urba,
More than 7 years have passed since the regression of advanced lymphoma was first reported in a patient who had undergone the infusion of T cells engineered to express a chimeric antigen receptor (CAR) targeting the CD19 antigen expressed on the surface of both normal and malignant B cells.1 Subsequent trials of CD19-targeted CAR T-cell therapy showed a complete response in some patients with relapsed or chemotherapy-refractory hematologic cancers for which there were no effective therapies.2-5 This ...
Tópico(s): Virus-based gene therapy research
2017 - Massachusetts Medical Society | New England Journal of Medicine
John Dugdale, Michael Prescott, Bill Kirkwood, J K Rowling, Mark Stretton, Andrea Routley, Christopher Morgan Religious Affairs Correspondent, Cloin McDOWELL, Jon Swain, James Clark, Nicholas Rufford, Rob Hughes, John Peter, Liam Clarke Northern Ireland Editor, Pam Barrett, Emma Moore, Amanda Ursell, Hamish Stevenson, Derek Hodgson, Debbie Foskett, David Pryce-Jones, Lesley White, John Jay, Christopher Somerville, Alan Craig, Martin Jay, George Dobre, Ivo Tennant, Terence Blacker, Dr Patricia Ready, Tanla Alexander, Lucy Hughes-Hallett, David Smith, Alex Attwood Mla, Jane Dorward, Melanie Phillips, Nick Pitt, E P, Andrew Sullivan, Clive Davis, Mary Wilson, Kathy Brewis, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, David Martin Hird, Anthony Sattin, Melissa Gibson, Robert Winnett, Irwin Stelzer, Jane Moore, Tom English, Robert Hewison, Peter Wilson, David Dougill, Andy Potts, John Evans, Philip Kingsley, Jo Martin, Steve Curry, Sarah Toyne, David Hewson, Margaret Coles, Hugh Canning, Hugh Mcllvanney, Margarette Driscoll, Nigel Williams, Jeremy Clarkson, David Cairns, Edward Porter, Peter Conradi, Louise Taylor, Rachel Shabi, Ben Pailthorpe, Stuart Coulson, Venetia Williamson-Noble, Eben Black, Baroness Hayman, Roberto Di Matteo, David Eimer, Simon Bendall, Lisa Skyes, Nick Gardner, Mark Franchetti Moscow, William Nagel, Phillip Oppenheim, Stuart Wavell, Josephine Smit, Paul Donovan, Alastair Hendy, Steve Boyd, James Clark Home Affairs Correspondent, Paul Driver, John Humphrys, Peter Howard, Ian Hawkey, Jerome Burne, Alex Clark, Christopher Morgan, David Leppard, John Eggleston, Shelley Von Strunckel, Chris Dedicoat vice-president and managing director of Uk, Mark Edwards, Frank Leboeuf, Susan Clark, David Cooper, Danny O'Brien, Anne Thomas, Jonathan Abrahams, Phil Baker, Susan Greenfield, Charlotte Black, Matthew Kalman, Lois Rogers, Sean Newsom, Frank Biln, Lady Helen Taylor, Raymond Keene, Gianluca Vialli, Senay Boztas, Cosmo Landesman, Marie Colvin, Andrew Holdsworth, Diana Wright, June Ducas, Andy Knott, Eilcen de Bruin, Chris Partridge, Stephen Jones, Guy Bellairs, John Gregory, Paul Emerson, Uzi Mahnaimi, Nick Cain, A E Hopkins President, Richard Evans, Bronek Masojada, Ray Perry director of marketing, Dominic Rushe, Don Edwards, Caroline Donald, Jemimah Bailey, Claire Oldfield, David Walsh, John Stern, Trevor Lewis, Gareth Southgate, Lois Rogers Medical Correspondent, Stephen Armstrong, Bjork, Jane Winter, Mark Macaskill, Paul Kavanagh, Mark Prigg, Bethan Cole, Garth Alexander, D P, Maurice Chittenden, Richard Brooks Arts Editor, Stephen Hiatt, Andrew Lorenz Business Editor, Peter Coad, Ray Hutton, Jonathan Powell, Jon Ungoed-Thomas, Susan Elkin, John Crossland, Michael Sheridan, D J Taylor, Amanda Craig, John Harlow, Peter Clarke, Godfrey Smith, John Urbanek, Ed de Goey, John Offord, David Gregson, Peter Morris, T Wilson, John Waples, Boy George, A A Gill, Brian Glanville, David James, Tom Robbins, David Sumner Smith, Nick Fielding, Michael Brunson, Stephen Pettitt, Jonathan Leake Science Editor, Kevin Goldstein-Jackson, Jeremy Langmead, Rw Johnson, Tom Walker Diplomatic Correspondent, Andrew Lorenz, Sally Kinnes, Naomi Caine, Liam Clarke, Nicholas Hellen Media Editor, Geoffrey Hoon, David Wickers, Roger Dobson, Tom Rhodes, Jane Hardy, Nigel Powell, John Aizlewood, Jeremy Lazell, John Cornwell, Mark Hodson, Hugh Pearman, Brian Pendreigh, Dan Cairns, David Parsley, Michael Riding managing director, George de Randich, Neil MacLean, Penny Perrick, Emilla Fox, Simon Crerar, Peter Roebuck, Walter Ellis, India Knight, James Park, Steve Grant, Simon Howard, Dan Pearson, Rosie Waterhouse, Boris Schapiro, Karen Robinson, Sheena Lane,
... Advertising Items Healthspan Dry Itchy Skin? Pharmavita Ltd. Longo Vital Glucosamine Sulphate To Place your Own Advertisement ...
2000 - Gale Group | Sunday Times HA GDA
Dario Livio Longo, Walter Dastrù, Lorena Consolino, Miklos Espak, Maddalena Arigoni, Federica Cavallo, Silvio Aime,
The objective of this study was to compare a clustering approach to conventional analysis methods for assessing changes in pharmacokinetic parameters obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during antiangiogenic treatment in a breast cancer model. BALB/c mice bearing established transplantable her2+ tumors were treated with a DNA-based antiangiogenic vaccine or with an empty plasmid (untreated group). DCE-MRI was carried out by administering a dose of 0.05 mmol/ ...
Tópico(s): Advanced MRI Techniques and Applications
2015 - Elsevier BV | Magnetic Resonance Imaging
Jannick Clemens, Anja Seckinger, Dirk Hose, Dirk Theile, Magdalena Longo, Walter E. Haefeli, Jürgen Burhenne, Johanna Weiß,
Tópico(s): HIV/AIDS drug development and treatment
2014 - Springer Science+Business Media | Cancer Chemotherapy and Pharmacology
Dario Livio Longo, Walter Dastrù, Giuseppe Digilio, Jochen Keupp, Sander Langereis, Stefania Lanzardo, Simone Prestigio, Oliver C Steinbach, Enzo Terreno, Fulvio Uggeri, Silvio Aime,
Iopamidol (Isovue®-Bracco Diagnostic Inc.) is a clinically approved X-Ray contrast agent used in the last 30 years for a wide variety of diagnostic applications with a very good clinical acceptance. Iopamidol contains two types of amide functionalities that can be exploited for the generation of chemical exchange saturation transfer effect. The exchange rate of the two amide proton pools is markedly pH-dependent. Thus, a ratiometric method for pH assessment has been set-up based on the comparison ...
Tópico(s): MRI in cancer diagnosis
2010 - Wiley | Magnetic Resonance in Medicine
M.R. Giofré, Giuseppe Meduri, Socrate Pallio, Salvatore Calandra, Antonio Magnano, Domenico Niceforo, Maurizio Cinquegrani, Vincenza Di Leo, Emanuela Mazzon, Giacomo Carlo Sturniolo, Giuseppe Longo, Walter Fries,
Portal hypertensive gastropathy (PHG) is frequently found among patients with hepatic cirrhosis and at present the only way to detect and follow PHG is via endoscopy.To assess gastric and intestinal permeability and investigate its relationship to endoscopic findings and indices of portal hypertension and hepatic function.Thirty-one non-diabetic patients with hepatic cirrhosis and PHG (PHG+) were studied and compared with 17 cirrhotic patients without PHG (PHG-). All patients underwent endoscopy for ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2000 - Lippincott Williams & Wilkins | European Journal of Gastroenterology & Hepatology
William C. Kopp, John W. Smith, C. Ewel, W. Gregory Alvord, Cheryl Main, Paul M. Guyre, Ronald G. Steis, Dan L. Longo, Walter J. Urba,
Summary: Interferon-γ (IFN-γ) is a potent monocyte/macrophage activating agent that in animal models exhibits a bell-shaped dose-response curve of immunomodulatory activity and antitumor efficacy. Previous clinical trials of IFN-γ conducted at the maximal tolerated dose (MTD) have been associated with low response rates that may have been due to failure to treat at an optimal immunomodulatory dose (OID). The objective of this study was to test the hypothesis that optimal immunomodulatory activity of ...
Tópico(s): Immune Response and Inflammation
1993 - Lippincott Williams & Wilkins | Journal of Immunotherapy
Juan B. Ochoa, Brendan D. Curti, Andrew B. Peitzman, R L Simmons, Timothy R. Billiar, Robert P. Hoffman, Raymond Rault, DL Longo, Walter J. Urba, Augusto C. Ochoa,
Toxicity to interleukin-2 (IL-2) tumor immunotherapy is manifested principally by the vascular leak syndrome, hypotension, and a hyperdynamic response with low systemic vascular resistance. Nitric oxide (.N = O), a recently discovered biological mediator of vascular smooth muscle relaxation, is produced in increased amounts by numerous cell types exposed to a number of inflammatory cytokines.Our purpose was to determine if there is an increased production of .N = O in patients receiving IL-2 tumor immunotherapy, ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
1992 - Oxford University Press | JNCI Journal of the National Cancer Institute
George Wilding, Harry L. Green, Dan L. Longo, Walter J. Urba,
Tumor invasion of the heart and pericardium accounts for a significant degree ofmorbidity in cancer patients. Although present in only 107; of all cancer patients, fully one-third of patients with pericardial or cardiac metastases will die as a direct result ofthis involvement. Malignant tumors of the heart and pericardium can be divided into primary tumors of the heart and pericardium and those arising as metastatic or direct extensions of tumors originating in other organs. Primary tumors are ...
Tópico(s): Lymphoma Diagnosis and Treatment
1988 - Elsevier BV | Cancer Treatment Reviews
Herbert Schuel, Frank J. Longo, Walter L. Wilson, Walter Troll,
The normal elevation of the fertilization membrane and the establishment of the block to polyspermy are retarded in Arbacia punctulata eggs by specific protease inhibitors, soybean trypsin inhibitor (SBTI), leupeptin, and antipain. Ultrastructural observations show that the vitelline layer remains attached to the plasma membrane of fertilized SBTI treated eggs at numerous sites (cortical projections). Quantitive morphometric analysis indicates that the vitelline layer elevates from about 65% of the ...
Tópico(s): Crustacean biology and ecology
1976 - Elsevier BV | Developmental Biology
Lorena Consolino, Dario Livio Longo, Walter Dastrù, Juan Carlos Cutrìn, Daniela Dettori, Stefania Lanzardo, Salvatore Oliviero, Federica Cavallo, Silvio Aime,
Tumour progression depends on several sequential events that include the microenvironment remodelling processes and the switch to the angiogenic phenotype, leading to new blood vessels recruitment. Non-invasive imaging techniques allow the monitoring of functional alterations in tumour vascularity and cellularity. The aim of this work was to detect functional changes in vascularisation and cellularity through Dynamic Contrast Enhanced (DCE) and Diffusion Weighted (DW) Magnetic Resonance Imaging (MRI) ...
Tópico(s): Breast Lesions and Carcinomas
2016 - Wiley | International Journal of Cancer
Muhammad Bilal Abid, Micah Rubin, Nathan A. Ledeboer, Anikó Szabó, Walter Longo, Meera Mohan, Nirav N. Shah, Timothy S. Fenske, Sameem Abedin, Lyndsey Runaas, Anita D’Souza, Saurabh Chhabra, Binod Dhakal, Mehdi Hamadani,
Hematopoietic cell transplantation (HCT) and cellular therapy (CT) recipients have poor outcomes after developing COVID-19 (Spanjaart et al., 2021Spanjaart A.M. Ljungman P. de La Camara R. Tridello G. Ortiz-Maldonado V. Urbano-Ispizua A. Barba P. Kwon M. Caballero D. Sesques P. et al.Poor outcome of patients with COVID-19 after CAR T-cell therapy for B-cell malignancies: results of a multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working ...
Tópico(s): Immunotherapy and Immune Responses
2022 - Cell Press | Cancer Cell
Sameem Abedin, Edward McKenna, Saurabh Chhabra, Marcelo C. Pasquini, Nirav N. Shah, James H. Jerkins, Arielle Baim, Lyndsey Runaas, Walter Longo, William R. Drobyski, Parameswaran Hari, Mehdi Hamadani,
Corticosteroid-refractory graft-versus-host disease (SR-GVHD) remains a significant source of morbidity after allogeneic hematopoietic cell transplantation. No standard therapy exists in this setting; however, recent studies have demonstrated a very promising role for ruxolitinib, an oral Janus kinase 1/2 inhibitor. With increasing evidence of efficacy for SR-GVHD, limited data exist describing complications of ruxolitinib use, specifically infectious complications during use in SR-GVHD. In this ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2019 - Elsevier BV | Biology of Blood and Marrow Transplantation
Nirav N. Shah, Fenlu Zhu, Dina Schneider, Carolyn Taylor, Winfried Krueger, Andrew Worden, Walter Longo, Mehdi Hamadani, Timothy S. Fenske, Bryon D. Johnson, Boro Dropulić, Rimas J. Orentas, Parameswaran Hari,
2510 Background: Anti-CD19 CAR-T cell therapy is a breakthrough treatment (tx) for patients (pts) with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL). Despite impressive outcomes, non-response and relapse with CD19 negative disease remain challenges. Through dual B-cell antigen targeting of CD20 and CD19, with a first-in-human bispecific lentiviral CAR-T cell (LV20.19CAR), we aim to improve response rates while limiting CD19 negative relapse. Methods: Pts were treated on a Phase 1 dose escalation + ...
Tópico(s): Biosimilars and Bioanalytical Methods
2019 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Michael A. Pulsipher, Brent R. Logan, Pintip Chitphakdithai, Deidre M. Kiefer, Marcie L. Riches, J. Douglas Rizzo, Paolo Anderlini, Susan F. Leitman, James W. Varni, Hati Kobusingye, RaeAnne M. Besser, J. Philip Miller, Rebecca Drexler, Aly Abdel‐Mageed, Ibrahim Ahmed, Luke P. Akard, Andrew Artz, Edward D. Ball, Ruthee-Lu Bayer, Carolyn Bigelow, Brian J. Bolwell, E. Randolph Broun, Nancy Bunin, David Delgado, Katharine E. Duckworth, Christopher C. Dvorak, Theresa Hahn, Ann E. Haight, Parameswaran Hari, Brandon Hayes‐Lattin, David A. Jacobsohn, Ann A. Jakubowski, Kimberly A. Kasow, Hillard M. Lazarus, Jane L. Liesveld, Michael Linenberger, Mark R. Litzow, Walter Longo, Margarida Magalhaes‐Silverman, John M. McCarty, Joseph P. McGuirk, Shahram Mori, Vinod K. Prasad, Scott D. Rowley, Witold B. Rybka, Indira Sahdev, Jeffrey Schriber, George B. Selby, Paul Shaughnessy, Shalini Shenoy, Thomas R. Spitzer, William T. Tse, Joseph P. Uberti, Madhuri Vusirikala, Edmund K. Waller, Daniel J. Weisdorf, Gregory A. Yanik, Willis H. Navarro, Mary M. Horowitz, Galen E. Switzer, Bronwen E. Shaw, Dennis L. Confer,
The development of reduced-intensity approaches for allogeneic hematopoietic cell transplantation has resulted in growing numbers of older related donors (RDs) of peripheral blood stem cells (PBSCs). The effects of age on donation efficacy, toxicity, and long-term recovery in RDs are poorly understood. To address this we analyzed hematologic variables, pain, donation-related symptoms, and recovery in 1211 PBSC RDs aged 18 to 79 enrolled in the Related Donor Safety Study. RDs aged > 60 had a lower median ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2018 - Elsevier BV | Biology of Blood and Marrow Transplantation
Michael A. Pulsipher, Brent R. Logan, Deidre M. Kiefer, Pintip Chitphakdithai, Marcie L. Riches, J. Douglas Rizzo, Paolo Anderlini, O’Susan F. Leitman, Hati Kobusingye, RaeAnne M. Besser, J. Philip Miller, Rebecca Drexler, Aly Abdel‐Mageed, Ibrahim Ahmed, Luke P. Akard, Andrew Artz, Edward D. Ball, Ruthee-Lu Bayer, Carolyn Bigelow, Brian J. Bolwell, E. Randolph Broun, David Delgado, Katharine E. Duckworth, Christopher C. Dvorak, Theresa Hahn, Ann E. Haight, Parameswaran Hari, Brandon Hayes‐Lattin, David A. Jacobsohn, Ann A. Jakubowski, Kimberly A. Kasow, Hillard M. Lazarus, Jane L. Liesveld, Michael Linenberger, Mark R. Litzow, Walter Longo, Margarida Magalhaes‐Silverman, John M. McCarty, Joseph P. McGuirk, Shahram Mori, Vinod Parameswaran, Vinod K. Prasad, Scott D. Rowley, Witold B. Rybka, Indira Sahdev, Jeffrey Schriber, George B. Selby, Paul Shaughnessy, Shalini Shenoy, Thomas R. Spitzer, William T. Tse, Joseph P. Uberti, Madhuri Vusirikala, Edmund K. Waller, Daniel J. Weisdorf, Gregory A. Yanik, Willis H. Navarro, Mary M. Horowitz, Galen E. Switzer, Dennis L. Confer, Bronwen E. Shaw,
Unlike unrelated donor registries, transplant centers lack uniform approaches to related donor assessment and deferral. To test whether related donors are at increased risk for donation-related toxicities, we conducted a prospective observational trial of 11,942 related and unrelated donors aged 18–60 years. Bone marrow (BM) was collected at 37 transplant and 78 National Marrow Donor Program centers, and peripheral blood stem cells (PBSC) were collected at 42 transplant and 87 unrelated donor centers ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2018 - Ferrata Storti Foundation | Haematologica
Amir A. Azari, Remzi Karadağ, Mozhgan Rezaei Kanavi, Sarah Nehls, Neal P. Barney, KyungMann Kim, Walter Longo, Peiman Hematti, Mark Juckett,
To evaluate the treatment of autologous serum eye drops (ASED) on dry eyes in patients with graft-versus-host disease (GVHD).A retrospective chart review of 35 patients with a history of ocular GVHD following hematopoietic stem cell transplantation that used ASED to alleviate dry eye symptoms was performed. Patients were categorized into three different groups. If patients had available ophthalmic data before and after starting treatment was group 1 (n = 14), had available ophthalmic data after starting ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2016 - Taylor & Francis | Cutaneous and Ocular Toxicology
Ginna G. Laport, Juan Wu, Brent R. Logan, Veronika Bachanová, Chitra Hosing, Timothy S. Fenske, Walter Longo, Steven M. Devine, Auayporn Nademanee, Iris D. Gersten, Mary M. Horowitz, Hillard M. Lazarus, Marcie L. Riches,
Allogeneic (allo) hematopoietic cell transplantation (HCT) can induce long-term remissions in chemosensitive relapsed follicular lymphoma (FL). The Blood and Marrow Transplant Clinical Trials Network conducted a multicenter phase 2 trial to examine the efficacy of alloHCT using reduced-intensity conditioning with rituximab (RTX) in multiply relapsed, chemosensitive FL. The primary endpoint was 2-year progression-free survival (PFS). The conditioning regimen consisted of fludarabine, cyclophosphamide, ...
Tópico(s): Immune Cell Function and Interaction
2016 - Elsevier BV | Biology of Blood and Marrow Transplantation
Natalie S. Callander, Stephanie Markovina, Jens C. Eickhoff, Paul R. Hutson, Toby C. Campbell, Peiman Hematti, Ronald S. Go, Robert Hegeman, Walter Longo, Eliot C. Williams, Fotis Asimakopoulos, Shigeki Miyamoto,
Retreatment with bortezomib (B) is often considered for patients with relapsed multiple myeloma (MM), but this strategy is hindered by uncertainty of response and emergence of B-induced peripheral neuropathy (PN). We incorporated acetyl-l-carnitine (ALCAR) to prevent PN and allow for adequate dosing. We also investigated the correlation between B-inducible NF-κB activation and response to therapy. Nineteen patients with relapsed/refractory MM received up to 8 cycles of intravenous bortezomib, doxorubicin ...
Tópico(s): Peptidase Inhibition and Analysis
2014 - Springer Science+Business Media | Cancer Chemotherapy and Pharmacology
Elizabeth Chang, Christopher G. Peterson, Sangbum Choi, Jens C. Eickhoff, KyungMann Kim, David T. Yang, L Gilbert, Eric S. Rogers, Jae Werndli, Michael S. Huie, Thomas McFarland, Michael Volk, Jules H. Blank, Natalie S. Callander, Walter Longo, Brad S. Kahl,
Summary Intensive chemotherapy regimens are not feasible in many adults with mantle cell lymphoma (MCL). We sought to build upon our previous experience with a non‐intensive regimen, modified R‐hyperCVAD chemotherapy (rituximab, cyclophosphamide, vincristine, doxorubicin, dexamethasone) with maintenance rituximab (MR), by the incorporation of bortezomib (VcR‐CVAD) and the extension of MR beyond 2 years. Patients with previously untreated MCL received VcR‐CVAD chemotherapy every 21 d for six cycles. ...
Tópico(s): Cardiac tumors and thrombi
2011 - Wiley | British Journal of Haematology
Natalie S. Callander, Stephanie Markovina, Mark Juckett, Elizabeth M. Wagner, Jill Kolesar, Walter Longo, Eliot C. Williams, KyungMann Kim, Jae Werndli, Shigeki Miyamoto,
Abstract Abstract 3885 Poster Board III-821 The interaction between malignant plasma cells and non malignant bone marrow microenvironment has been recognized as both an important feature of MM propagation and a therapeutic target. One critical pathway appears to involve neoangiogenesis as evidenced by increased blood vessel density in areas of myeloma cell proliferation. The potent anti MM compound lenalidomide may work partly through down regulation of VEGF expression by bone marrow stromal cells. ...
Tópico(s): Peptidase Inhibition and Analysis
2009 - Elsevier BV | Blood
Julie Chang, Stephen Medlin, Brad S. Kahl, Walter Longo, Eliot C. Williams, Jack M. Lionberger, KyungMann Kim, Jihoon Kim, Elizabeth Esterberg, Mark Juckett,
The augmented Berlin–Frankfurt–Münster (aBFM) regimen has demonstrated improved outcomes in children with acute lymphomblastic leukemia (ALL), but efficacy in adults is unknown. In this retrospective study, we evaluated clinical outcomes in 29 adult ALL patients (aged 19–70) treated with standard BFM (sBFM) or dose-intensive aBFM. Patients were stratified into risk groups based on age, cytogenetic abnormalities, peripheral leukocytosis and response to induction chemotherapy. Inter-mediate risk patients ...
Tópico(s): Acute Myeloid Leukemia Research
2008 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Muhammad Wasif Saif, Walter Longo, Gary M. Israel,
Bevacizumab is the fi rst vascular endothelial growth factor-targeted agent shown to increase survival in patients receiving first- and second-line intravenous 5-FU-based chemotherapy for the treatment of metastatic colorectal cancer. Bevacizumab is typically well tolerated and its major side effects include hypertension, proteinuria, bleeding, gastrointestinal perforation and arterial thrombotic events. Although exfoliative dermatitis has been described as a side effect in 19% of patients, skin ...
Tópico(s): Chemotherapy-related skin toxicity
2008 - Elsevier BV | Clinical Colorectal Cancer