Mikael Libert, Gráinne Gilmore, Dr Rosamunde Codling, Andrew Robson, Giles Smith, Matt Dickinson Chief Sports Correspondent, Matthew Hilton, Professor Roger Francis Chairman, Sir Peter Viggers, MP, Colin Firth, Susannah Hickling, Andrew Billen, Zahid Hussain, Tudor Spencer, Stephen Hockman, QC, Gary Duncan, David Aaronovitch, John Howard, Robin Pagnamenta Energy and Environment Editor, John Whitwell, Patrick Watson, Alexandra Frean Education Editor, Richard Gerver, Mark Lynas, Carol Midgley, Ian King, Christine Seib, David Chater, James Ducker, Rachel Campbell-Johnston, Murad Ahmed, Missy Higgins, Michael Johnstone, Patrick Kidd, Deborah Dugan, Sam Marlowe, Kaya Burgess, Martin Samuel Chief Football Correspondent, David Sharrock, Sathnam Sanghera, Angelique Kidjo, Valerie Elliott, Dr Susan Lanham-New, Rachel Sylvester, Bruce Clark, David Ryder, Donald Hutera, Robert Peston, Deborah Haynes, Jack Malvern, Dominic Walsh, Dan Sabbagh Media Editor, Ken Russell, Peter Stiff, Alice Wilkinson, Dan Sabbagh, Chloe Lambert, George Walker, Gael GarcÍa Bernal, Rhys Blakely, Miguel Bose, David Charter, Lilly Peel, Susan Thompson, Derwent May, David Reynolds, Russell Kempson, Sheila Watt-Cloutier, Suzy Jagger, Gary Duncan Economics Editor, Oliver Kay, Annie Lennox, Gerard Baker, Paul McCann, Sarah Vine, Iain Banks, John Westerby, Tom Baldwin, Marc Cox, Sam Coates, Gok Wan, Ann Treneman, David Robertson Business Correspondent, Rob Wright, Raymond Keene, Matt Hughes, Rebecca O'Connor, Kristin Davis, Professor Tanya Byron, David Ross, John Kapranos Huntley Professor, Jeremy Page, Chris Campling, Bronwen Maddox, Fran Yeoman, Jill Sherman, Helen Nugent, Lindsey Bareham, Marcus Leroux, Mick Hume, Nick Hasell, Allan Mallinson, Bill Nighy, Colin McDowell, Tony Cascarino, Tom Dart, Rosemary Bennett Social Affairs Correspondent, Paul Simons, Michael Herman, Kathryn Hone, Philip Webster Political Editor, Christian Preston, Emily Ford, Emily Gosden, Helen Power, Angus MacLeod, George Caulkin, Russell Jenkins, Neil Fisher, Alan Lee, Vinnie Jones, Thom Yorke, Jeremy Page South Asia Correspondent, Tony Dawe, Richard Beeston, Philip Webster, Charles Shepherd, David Sinclair, Catherine Stearn, Dr Helen Wallace Director, Martin Waller, Lewis Smith Environment Reporter, Chris Ayres, Shaun McKenna, Veronica Schmidt, Scarlett Johansson, Benedict Nightingale, Rick Broadbent Athletics Correspondent, Stephen Dalton, Nicola Woolcock, Bill Edgar, Frances Gibb, Jarvis Cocker, Valerie Grove, Adam Sherwin, Rahul Bose, Benedict Birnberg, Chris Smyth, Professor David Reid Chairman, Olav Bjortomt, Janina Ochojska, Archbishop Emeritus Desmond Tutu, Christopher Irvine, Sarah Thornton, Ian McEwan, David Attenborough,
Farewell, casino economics The Times The party's over for Carphone playboy Brown's recovery gathers pace with new poll boost Voters switch back to Labour ...
2008 - Gale Group | TDA
Arash Joushaghani, Rajiv Iyer, Joyce K. S. Poon, J. Stewart Aitchison, C. Martijn de Sterke, Jun Wan, Marc M. Dignam,
We report the observation of quasi-Bloch oscillations, a recently proposed, new type of dynamic localization in the spatial evolution of light in a curved coupled optical waveguide array. By spatially resolving the optical intensity at various propagation distances, we show the delocalization and final relocalization of the beam in the waveguide array. Through comparisons with other structures, we show that this dynamic localization is robust beyond the nearest-neighbor tight-binding approximation ...
Tópico(s): Photonic and Optical Devices
2009 - American Physical Society | Physical Review Letters
Jonathan Northcroft, Dan Mitchell, Waldemar Januszczak, John Dugdale, Patrick French, Matthew Wall, Julian Corolett, Barbara Hall, Nigel Botherway, Will Young, Dominc Rushe, Clare Ward MP, Fred Redwood, David Brown, Helen Davies, Nicholas Rufford, Rob Hughes, Graeme Wright, John Peter, V S, Emma Moore, Rebecca Abrams, Teresa Keane, Amanda Ursell, Jonathan Miller, David Pryce-Jones, J D, Susan d'Arcy, Lucy Adams, Frank Whitford, Nicholas Coleridge, Steve Bord, Sam Gilpin, Kathryn Cooper, Mia Ogden, David Smith, Humphrey Carpenter, Tim Richards, Ian Murray, Rory Godson, David Cracknell Political Editor, Nick Pitt, Frederic Raphael, Neil Wormald, E P, Andrew Sullivan, Loe Lovejoy, Don Pettingale, Guy Dennis, Lynne Truss, Neil Davy, Leslie Fraser-Mitchell, Kathy Brewis, Mark Blumberg, Tony Allen-Mills, Simon Wilde, Martin James, Anthony Sattin, Robert Winnett, Irwin Stelzer, Adrian Furnham, Peter Wilson, Rosie Millard, Lawrence Dallaglio, David Dougill, Sir Nigel Hawthorne, John Arlidge, Thrasy Petropoulos, H C, David Hewson, Adam Duritz, Cally Law, Rakesh Rawal, Hugh Canning, Alasdair Reid, Margarette Driscoll, Graham Duffill, Jeremy Clarkson, Andrew Stone, Trevor Drury, Edward Porter, Stewart Lee, Victoria Segal, Lisa Miller, Fiona Berry, Helen Kenny, Anita Chaudhuri, John O'Donnell, Nick Caln, Travis Elborough, Liz Edwards, George Perry, Karena Batstone, Nick Gardner, Peter Parker, Mike Laws, Paul Ham, Roger Eglin, Paul Donovan, Kathryan Cooper, Alastair Hendy, Chris Woodhead, Stan Labovitch, Lucinda Kemeny, Jasper Gerard, Derek Clements, Michael Woodhead, Paul Driver, John Humphrys, Nicholas Hellen, Richard Brooks, Johan Cruyff, Ian Hawkey, Shelley Von Strunckel, Alex Clark, Christopher Morgan, David Leppard, Lynne Franks, Paul Durman, Mark Edwards, Keith Rider, Sarah Gracie, George Kelly, Alan Allbright, Tilly Bagshawe, David Lawrenson, Andy Knett, Susan Clark, Angus Deayton, Nick Raynsford Mp, Danny O'Brien, Phil Baker, Christina Patterson, Victoria O'Brien, Raymond Keene, Joe Lovjoy, Gareth Huw Davies, David Cracknell, Cosmo Landesman, Zoe Brennan, Robbie Hudson, Marie Colvin, Diana Wright, Norman Parkinson, David Orr, Stephen Jones, Dominic O'Connell, Alexis Giles, Richard Evans, Uzi Mahnaimi, Nick Cain, Michael Wright, Peta Bee, Jonathan Davies, Luci Hoe, M J, Lois Rogers Medical correspondent, Nick Rennison, Damaris Graham, Miranda Seymour, David Walsh, Caroline Gascoigne, David Lodge, Trevor Lewis, Jack Grimston, Colin McDowell, Bryan Appleyard, Lois Rogers Medical Correspondent, Stephen Armstrong, John Elliott, John O'brien, Richard Woods, Danny Roth, William Burrows, Rory Godson Business Editor, John Lloyd, Maurice Chittenden, Les Snowdon, Matthew Williamson, Nick Hanna, Stephen Jay Gould, Richard Brooks Arts Editor, Tom Brett, Richard Rae, Mark Franchetti, Ray Hutton, James Hughes, Martin Ivens, Ian G Mace, Frank Fitzgibbon, Winner Dinners, Huw Richards, Alexandra Dawe, Jeff Bell, Hazel Prouse, Ria Higgins, Michael Sheridan, Godfrey Smith, Barry Collins, John Waples, Paul Rowan, Hunter Davies, Marc Zakian, A A Gill, Matthew Campbell, R Tomlinson, Natalle Graham, Nick Fielding, James Beechey, Claudia Croft, Maria McErlane, Jonathan Leake Science Editor, Jonathan Calvert, Cherry Norton, Sally Kinnes, Janet Crawford, Naomi Caine, David Wickers, Nigel Powell, Jeremy Lazell, Mark Hodson, Andrew Frankel, Graham Norwood, Elizabeth Buchan, Joe Lovejoy, Jonathan Futrell, Rupert Steiner, Hugh Pearman, Ian Hawkey European football correspondent, Dan Cairns, David Harbord, David Smith Economics Editor, Tom Deveson, Mrs Mills, Simon Crerar, Sarah Baxter, Kate Spicer, Essop Pahad Minister in the Presidency, Matthew Goodman, India Knight, Steve Grant, Nicola Gill, Kingston Smith, Simon Howard, Dan Pearson, Toyah Wilicox, Dominic Rushe, Karen Robinson, Peter Stanford,
... women in war Openplan Reassuring, Mr Average Obi-Wan Kenobi doesn't understand Sheriff Bush Vive la ... it's a lot easier on the wallet. Marc Zakian says the undiscovered reaches of Umbria can ...
2002 - Gale Group | Sunday Times HA GDA
Daming Gao, Hiroyuki Inuzuka, Michael Korenjak, Alan Tseng, Tao Wu, Lixin Wan, Marc W. Kirschner, Nicholas J. Dyson, Wenyi Wei,
APC/Cdh1 is a major cell cycle regulator and its function has been implicated in DNA damage repair; however, its exact role remains unclear. Using affinity purification coupled with mass spectrometry, we identified Claspin as a novel Cdh1-interacting protein and further demonstrated that Claspin is a novel Cdh1 ubiquitin substrate. As a result, inactivation of Cdh1 leads to activation of the Claspin/Chk1 pathway. Previously, we demonstrated that Rb interacts with Cdh1 to influence its ability to ...
Tópico(s): DNA Repair Mechanisms
2009 - American Society for Cell Biology | Molecular Biology of the Cell
Jonathan Northcroft, Ron Sweet, Hala Jaber, John Dugdale, Georgina Harland, Barbara Hall, Paulo Sutch, Michael Horgan, Iasper Gerard, J B, Jim Munro, Peter Whittle, Helen Davies, Sally Brock, Katie Bowman, Nicholas Rufford, Mario Melchiot, Rob Hughes, John Peter, Pam Barrett, Colin Brennan, Professor Gideon Garter, William Lewis Business Editor, Jonathan Miller, Andrew Longmore, Lesley White, Chris Lane, Jane Mulkerrins, Richard Harries, Terry Hope, Gareth Walsh, Frank Whitford, Ivo Tennant, Stephen Pettit, Nicolette Jones, David Gower, Matt Wolf, Kathryn Cooper, Sam Gilpin, Susan Bell, William Lewis, Alison Davies, P D, Peter Done, Michael Kilcommons, Neil Wormald, E P, Andrew Sullivan, Clive Davis, Nicholas Alexander, Jane Warren, Claive Davis, Andrew Porter, Joseph Dunn, Tony Allen-Mills, Simon Wilde, Martin James, Claire Moore, Robert Winnett, Ben Ainslie, Karina Bryant, Irwin Stelzer, Michael Johnson, Keri Allan, Peter Wilson, Tim Richard, Rosie Millard, Peter Wood's, Emily Woof, David Dougill, Giles Coren, Hazel Evans, Burlington Bartie, Dan Caims, Craig Fallon, John Gribbin, John Rcilly, Claudio Ranieri, Nick Speed, Rob Maul, Elizabeth Robertson, David Bond, Hugh Canning, Alasdair Reid, Micheal Clarke, Geraldine Hackett Education Correspondent, Sir Alexander MacAra Chairman, Jeremy Clarkson, Victoria Segal, Edward Porter, Diego Maradona, Peter Waterfield, David Cairns, Stewart Lee, Michael Portillo, Helen Kenny, Patricia Nicol, Linda Hunter, Sarah Dempster, Zahid Kasim, Dave Pollard, Michael Slane, Peter Black, Stella Tillyard, Dr Andrew Wakefield, Jenny Dale, Lydia Slater, Adam Nathan, Mark Crivelli, David Burke, Shelley von Strunckel, Andrew Porter Deputy Political Editor, Josh West, Paula Robinson, Geoffrey Dicks, Chris Johnston, Raymond Blanc, Stuart Wavell, Leon Taylor, Robert Whitaker, Paul Donovan, Peter Hounam, Matthew Pinsent, Edward Gorman, Chris Woodhead, Vaneisa Baksh, Lucinda Kemeny, Keith Elliott, Derek Clements, Paul Driver, Garth Pearce, John Humphrys, Gordon Douglas, Nicholas Hellen, Katy Sexton, Roy Bullock, Richard Brooks, Ian Hawkey, Ross Hamilton, Christopher Morgan, David Leppard, Debbie TAYLOR's, Paul Durman, Alex Clark, Phill Baker, Lisa Grainger, Alicia Wyllie, Tony Shellium, Mark Edwards, Rachel Bridge, Steve Williams, Miss Hannan Davies, Susan Clark, Mike Towndrow, Phil Baker, Paul Green, Christina Lamb, Douglas Dalby, James Gibson, Marian Marshall, Julia Llewellyn, Raymond Keene, David Cracknell, Barbara Gill, Robbie Hudson, Cosmo Landesman, Gavin Conway, Diana Wright, Paul Ratcliffe, Francis Gilbert, Stephen Jones, Dominic O'Connell, Jemima Khan, Barry Flatman, Uzi Mahnaimi, Nick Cain, Louise Armitstead, Michael Wright, Natalie Graham, Kieran Moriarty, Jennifer Lewandowski, Caroline Donald, Nick Rennison, Hugh Cairns, Miranda Seymour, David Walsh, Helen Brown, Trevor Lewis, Karen Armstrong, Helen Stewart, Robert Ballantyne, Frank Sweatman, Paul Thomas, Bryan Appleyard, Christopher Gill, John Elliott, Stephen Armstrong, Colin McDowell, …att Roberts, Ned Parker, J C Morris, Nicholas Milton, R W Johnson, Victoria O'brien, Tim Heaton, Richard Woods, Roland White, Elizabeth Jenkins, Bethan Cole, Ruth Rendell, Nick Ray, Shane Watson, Amrit Dhillon, Maurice Chittenden, Dr Tony Margiotta, Body Matters, Judith O'Reilly, Mark Franchetti, Richard Rae, Ray Hutton, Jon Ungoed-Thomas, Brendan Simms, Naomi Wolf, Dan Box, James Cracknell, Niall Ferguson, John Harlow, Dileep Premachandran, Andy Summers, Brian Smyth, Barry Collins, Andrew Warner, James Foxall, Hunter Davies, Jeremy Hart, A A Gill, Andrew Turnbull, Melanie McDonagh, Matthew Campbell, Steve Fossett, John Carey, Alan Strachan, Neal Bascomb, Nick Fielding, Rory MacLean, Lauris Morgan-Griffiths, Claudia Croft, Jonathan Leake Science Editor, Sir Peter Smithers, Richard Faulds, Hazel Curry, Ciaran Hancock, Maria McErlane, Sally Kinnes, Naomi Caine, Daniel Emery, Keri Ailan, Roger Dobson, Peter Almond, Brian Doogan, John Aizlewood, Kate Battersby, Clifford Bishop, Mark Hodson, Daniel Box, Graham Norwood, John Cornwell, Joe Lovejoy, Victor Bryant, David Budworth, Hugh Pearman, Andrew Davidson, Dan Cairns, C Topham, Susannah Price, Ian Sutherland, Sarah Baxter, Alex Bellos, Chris Feetenby, Dave Stevens, David Robertson, Matthew Goodman, India Knight, Kingston Smith, Nina Goswami, Jason Dawe, Richard Lewis, Karen Robinson, Chris Tomlinson,
... re on a hamster wheel and it just wan't stop? A of diet constant stress could ...
2004 - Gale Group | Sunday Times HA GDA
Adam M. Bayless, Sisi Chen, Sam C. Ogden, Xiaoyan Xu, John D. Sidda, M.K. Manik, Sulin Li, Boštjan Kobe, Thomas Ve, Lijiang Song, Murray Grant, Li Wan, Marc T. Nishimura,
Toll/interleukin-1 receptor (TIR) domain proteins function in cell death and immunity. In plants and bacteria, TIR domains are often enzymes that produce isomers of cyclic adenosine 5′-diphosphate–ribose (cADPR) as putative immune signaling molecules. The identity and functional conservation of cADPR isomer signals is unclear. A previous report found that a plant TIR could cross-activate the prokaryotic Thoeris TIR–immune system, suggesting the conservation of plant and prokaryotic TIR-immune signals. ...
Tópico(s): Plant-Microbe Interactions and Immunity
2023 - American Association for the Advancement of Science | Science Advances
Raymond Snoddy and Jon Ashworth, Helen Johnstone, Portia Colwell, Robert Spellman, R. W. Leon, Business Editor Patience Wheatcroft, Sally Brock, Adrian Lee, Grace Bradberry, Rob Hughes, John Morgan, Clive King, Paul Hoggart, Andrew Purvis, Karen Woolfson, Paula Hawkins and Elizabeth Judge, Robert Lea, Raymond Snoddy, Media Editor, Michael Evans Defence Editor, Douglas Friedli, C. P. Headdon, General Manager, Jeremy Kingston, Thomas Cook, Alison Kervin, Clive Davis, Joyce Blake, Sharon Linnard, Dominic Bradbury, Nick Nuttall, Environment Correspondent, David McVay and Craig Lord, Stewart Tendler, Crime Correspondent, Alexei Sayle, Fraser Nelson, Retail Correspondent, Raymond Snoddy, Clare Stewart, Alice Lagnado and Simon Saradzhyan, C. S. Guest, Tony Alexander, Mark Barrowcliffe, Pat Gibson, David McVay, Tish McPhilemy, Janet Simmons, Stephen McClarence, Henry Harris, Donald Hutera, D. R., Melanie Tringham, John Hopkins, Golf Correspondent, Jerome Boyd Maunsell, Rob Penn, E. C., Tim Reid, Peter Hughes, Susie Steiner, Property Correspondent, Jo Morris, Alan Hamilton, Oliver Wright, Mark Inglefield, Rodney Milnes, Robin Young, George Lees, Alice Lagnado, Doug Sager, Roland Watson, Frances Bissell, Alix Ramsay, Tennis Correspondent, P. B., Charles Bremner, Imogen Aylen, Helen Rumbelow, Chris Barton, Martin Symington, David Jones, Jonathan Sacks, Peter Barnard, David Charter, Simon Beckett, Tim Teeman, Derwent May, Jasper Gerard, Clare Colvin, robert whymant, Paula Hawkins, Michael Drewett, Nigel Williamson, Daniel McGrory, Paul Armstrong, Ed Potton, Richard Colwill, Stephen Anderton, Paul Durman, Amber Cowan, David Lister, Lisa Armstrong, Tom Baldwin, Nick Szczepanik and George Caulkin, Rob Wright, Rodney Bewes, Thomas Schwarz, Lode Willems, David Powell Athletics Correspondent, Adam Sage, Bernard Aspinwall, David Robinson, Clive Mathieson, John Russell Taylor, Matt Dickinson, Andrew Roberts, Simon Saradzhyan, Lucy Pinney, Paul Wilkinson, James Allcock, James Doran and Sally Patten, Jeannette Hyde, Francis Gilbert, Min Cooper, Tom Baldwin, Arthur Leathley and Roland Watson, Carl Mortished, International Business Editor, Deborah Brett, Cathy Harris, Michael Arditti, Richard Owen, Damian Whitworth, David Kettle, Roger Boyes, Lesley Doyle, Chloë Bryan-Brown, Robert Cole Edited, Stephanie Billen, Alison Kervin, Rugby Editor, Nick Szczepanik, Paula Hawkins and Sally Patten, Linda Farmer, Peter Thompson, James Doran, James Pringle, Valerie Elliott, Countryside Editor, Jane Shilling, John Kelly, Paul McCann Media Correspondent, Deborah King, Matthew Parris, Julian Brazier, David Morkill, Andre Camara, Mrs H. E. Atkinson, Tim Wapshott, Jennie Vartan, Alan Lee, Jane Owen, Ben MacIntyre, Roy Hattersley, Diana Moore, Ian Brodie, Josa Young, Robert De Niro, Monica M. Ludlam, F. P. L. Manson, Graham Searjeant, Jackie Morgan, Fraser Nelson, Anne Ashworth Personal Finance Editor, William Cash, Annabelle Thorpe, Martin Waller, Tom Tickell, Michael Horsnell, Gillian Harris, Chris Ayres, Danny Baker, Fran Littlewood, Laura Peek, Jo Hansford, Benedict Nightingale, Dr Thomas Stuttaford, Jill Crawshaw, R. D. Bridgewater, Alyson Rudd, Paul Connolly, Sam Kiley, Tom Chesshyre, Alice Miles, Valerie Grove, Adam Sherwin, Jason Conway, Michael Evans, Allan Hall, Tony Kelly, Sally Patten, Cath Urquhart Travel Editor, Fraser Nelson Retail Correspondent, David Hands, Rugby Correspondent, Lea Paterson, Economics Correspondent, Christopher Irvine, Jeffrey Dudgeon, Susan Emmett,
... steps down Sidestepping the Matthews myth 'That he wan the greatest footballer of his age should be ... Mahoney, 1903-1968 Painting Exhibition 20/20 Vision: Marc Buffery Christ Church Picture Gallery, Feb 26 and ...
2000 - Gale Group | TDA
J. Law-Wan, Marc-Antoine Sparfel, Sophie Derolez, Nicolas Azzopardi, Philippe Goupille, J. Detert, Denis Mulleman, Théodora Bejan‐Angoulvant,
Objective To identify patient characteristics associated with responsiveness to tumour necrosis factor inhibitors (TNFi) in rheumatoid arthritis (RA). Materials and methods Individual patient data from 29 randomised controlled trials (RCTs) evaluating the efficacy of a TNFi versus placebo or conventional therapy were obtained. Response to treatment was assessed in subgroups according to the following baseline characteristics: smoking status, physical activity, sex, age, body mass index, autoantibody ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2021 - BMJ | RMD Open
Mark P. Abrams, Elaine Y. Wan, Marc Waase, John Morrow, José Dizon, Hirad Yarmohammadi, Jeremy Berman, Geoffrey Rubin, Alexander Kushnir, Timothy J. Poterucha, Pierre Elias, David A. Rubin, Frederick Ehlert, Angelo Biviano, Nir Uriel, Hasan Garan, Deepak Saluja,
Electrocardiographic characteristics in COVID-19-related mortality have not yet been reported, particularly in racial/ethnic minorities.We reviewed demographics, laboratory and cardiac tests, medications, and cardiac rhythm proximate to death or initiation of comfort care for patients hospitalized with a positive SARS-CoV-2 reverse-transcriptase polymerase chain reaction in three New York City hospitals between March 1 and April 3, 2020 who died. We described clinical characteristics and compared ...
Tópico(s): Long-Term Effects of COVID-19
2020 - Wiley | Journal of Cardiovascular Electrophysiology
Justine Bacchetta, Claus Peter Schmitt, Gema Ariceta, Sevcan A. Bakkaloğlu, Jaap W. Groothoff, Mandy Wan, Marc Vervloet, Rukshana Shroff, Dieter Haffner,
Abstract Secondary hyperparathyroidism (SHPT) is an important complication of advanced chronic kidney disease (CKD) in children, which is often difficult to treat with conventional therapy. The calcimimetic cinacalcet is an allosteric modulator of the calcium-sensing receptor. It has proven to be effective and safe in adults to suppress parathyroid hormone (PTH), but data on its use in children are limited. To date, studies in children only consist of two randomized controlled trials, nine uncontrolled ...
Tópico(s): Potassium and Related Disorders
2019 - Oxford University Press | Nephrology Dialysis Transplantation
Nabin Aryal, Lulu Wan, Marc H. Overgaard, Adam Carsten Stoot, Yiming Chen, Pier‐Luc Tremblay, Tian Zhang,
Microbial electrosynthesis is a bioprocess where microbes reduce CO2 into multicarbon chemicals with electrons derived from the cathode of a bioelectrochemical reactor. Developing a highly productive microbial electrosynthesis reactor requires excellent electrical connection between the electrochemical setup, the cathode, and the microbes. Copper is a highly conductive cathode material widely employed in electrochemical apparatuses. However, the antimicrobial properties of copper limit its usage ...
Tópico(s): Supercapacitor Materials and Fabrication
2019 - Elsevier BV | Bioelectrochemistry
Tony Wan, Marc Rodger, Wanzhen Zeng, Philippe Robin, Marc Righini, Michael J. Kovacs, Melanie Tan, Marc Carrier, Susan R. Kahn, Philip S. Wells, David R. Anderson, Isabelle Chagnon, Susan Solymoss, Mark Crowther, Richard H. White, Linda M. Vickars, Sadri Bazarjani, Grégoire Le Gal,
Tópico(s): Central Venous Catheters and Hemodialysis
2017 - Elsevier BV | Thrombosis Research
Joshua A. Sommers, Taraswi Banerjee, Twila Hinds, Bingbing Wan, Marc S. Wold, Ming Lei, Robert Brosh,
Understanding how cellular machinery deals with chromosomal genome complexity is an important question because protein bound to DNA may affect various cellular processes of nucleic acid metabolism. DNA helicases are at the forefront of such processes, yet there is only limited knowledge how they remodel protein-DNA complexes and how these mechanisms are regulated. We have determined that representative human RecQ and Fe-S cluster DNA helicases are potently blocked by a protein-DNA interaction. The ...
Tópico(s): CRISPR and Genetic Engineering
2014 - Elsevier BV | Journal of Biological Chemistry
Arash Joushaghani, Rajiv Iyer, Joyce K. S. Poon, J. Stewart Aitchison, C. Martijn de Sterke, Jun Wan, Marc M. Dignam,
We observed exact dynamic localization in its general case in strongly coupled curved waveguide arrays with periodic, nonsquare-wave curvatures. We achieved a six times change in the dynamic localization bandwidth by changing a design parameter in our deviated-square-wave curvature. By analyzing the relation between the bandwidth and curvature profile, we offer a general method to control the localization bandwidth.
Tópico(s): Advanced Fiber Optic Sensors
2012 - American Physical Society | Physical Review Letters
Rajiv Iyer, J. Stewart Aitchison, Jun Wan, Marc M. Dignam, C. Martijn de Sterke,
We present experimental observations of exact dynamic localization of an optical beam in a periodically curved AlGaAs waveguide array. The dynamic localization of the beam is "exact" in that it is observed even when the photonic band of the array is not well described in the nearest-neighbor tight-binding approximation. We present the spatial evolution of the beam around the two-period plane in the structure, explicitly demonstrating the delocalization and subsequent relocalization of the beam. We ...
Tópico(s): Advanced Fiber Laser Technologies
2007 - Optica Publishing Group | Optics Express
Xuecheng Zhang, Xiaolei Wu, Seth D. Findley, Jinrong Wan, Marc Libault, Henry T. Nguyen, Steven B. Cannon, Gary Stacey,
The lysin motif (LysM) domain is an ancient and ubiquitous protein module that binds peptidoglycan and structurally related molecules. A genomic survey in a large number of species spanning all kingdoms reveals that the combination of LysM and receptor kinase domains is present exclusively in plants. However, the particular biological functions and molecular evolution of this gene family remain largely unknown. We show that LysM domains in plant LysM proteins are highly diversified and that a minimum ...
Tópico(s): Plant Pathogenic Bacteria Studies
2007 - Oxford University Press | PLANT PHYSIOLOGY
P. Domachuk, C. Martijn de Sterke, Jun Wan, Marc M. Dignam,
We present a detailed examination of the properties of ac electric fields that result in the dynamic localization of electrons in periodic potentials. Although exact dynamic localization can only occur if the ac electric fields are discontinuous at all changes in sign, we show that it is surprisingly tolerant to smoothing these discontinuities. We also show that within the nearest-neighbor tight-binding limit, all symmetric ac electric fields are guaranteed to exhibit dynamic localization for some ...
Tópico(s): Nonlinear Photonic Systems
2002 - American Physical Society | Physical review. B, Condensed matter
CDC20/CDH1 activates the anaphase-promoting complex (APC) and targets various substrates for degradation, thereby allowing the ordered progression through mitosis and G 1 . We have found multiple functional CDH1 homologues in the chick. The transcripts of these novel genes are differentially localized to proliferating, differentiated, and postmitotic tissues. All four proteins bind and form a complex with APC in vitro and in cultural cells and have quantitatively different activities in mediating ubiquitination ...
Tópico(s): RNA Research and Splicing
2001 - National Academy of Sciences | Proceedings of the National Academy of Sciences
António Guia, Xiaodong Wan, Marc Courtemanche, Normand Leblanc,
Abstract —Large-conductance Ca 2+ -dependent K + channels (K Ca ), which are abundant on the sarcolemma of vascular myocytes, provide negative feedback via membrane hyperpolarization that limits Ca 2+ entry through L-type Ca 2+ channels ( I CaL ). We hypothesize that local accumulation of subsarcolemmal Ca 2+ during I CaL openings amplifies this feedback. Our goal was to demonstrate that Ca 2+ entry through voltage-gated I CaL channels can stimulate adjacent K Ca channels by a localized interaction in enzymatically ...
Tópico(s): Neuroscience and Neuropharmacology Research
1999 - Lippincott Williams & Wilkins | Circulation Research
Ying Yan, Yukino Kobayashi, Cong Huang, Bo Liu, Wanqiang Qian, Fanghao Wan, Marc F. Schetelig,
The spotted-wing Drosophila (Drosophila suzukii Matsumura) is native to eastern Asia, but has become a global threat to fruit production. In recent years, CRISPR/Cas9 targeting was established in this species allowing for functional genomic and genetic control studies. Here, we report the generation and characterization of Cas9-expressing strains of D. suzukii. Five independent transgenic lines were generated using a piggyBac construct containing the EGFP fluorescent marker gene and the Cas9 gene ...
Tópico(s): Insect symbiosis and bacterial influences
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Fanchao Ye, Xiaoxing Zhang, Yi Li, Qianqian Wan, Jean‐Marc Bauchire, Dunpin Hong, Song Xiao, Ju Tang,
At present, reports on the arc interruption and decomposition behaviour of a C4F7N/air gas mixture especially the biosafety of its by-products are limited. Herein, a 57% C4F7N/43% air gas mixture was employed as an arc-quenching medium to conduct 200 breaking tests on a load switch (630 A/24 kV). The arc interruption and decomposition behaviour of the gas mixture were evaluated, and the biosafety of the decomposition products was assessed based on an acute inhalation toxicity test. It was found that ...
Tópico(s): Electrical Fault Detection and Protection
2022 - Institution of Engineering and Technology | High Voltage
Wan Yang, Marc Lipsitch, Jeffrey Shaman,
Significance Infectious disease surveillance systems are powerful tools for monitoring and understanding infectious disease dynamics; however, underreporting (due to both unreported and asymptomatic infections) and observation errors in these systems create challenges for delineating a complete picture of infectious disease epidemiology. This issue is true for influenza, an infectious disease of pandemic potential. Here we develop and present influenza inference systems capable of compensating for ...
Tópico(s): Data-Driven Disease Surveillance
2015 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Jessica Donington, Chi Wan Koo, Marc Ballas,
Lung cancer is the leading cause of cancer-related death in the United States. Emerging technologies for the treatment of early-stage non-small cell lung cancer are currently focused on less invasive approaches to obtaining local tumor control, including minimally invasive and less radical resections, as well as image-guided ablative therapies. Targeted chemotherapeutic agents represent the newest area of treatment for advanced non-small cell lung cancer. These novel agents capitalize on our increased ...
Tópico(s): Lung Cancer Research Studies
2011 - Lippincott Williams & Wilkins | Journal of Thoracic Imaging
Thiosulfate is an alternative lixiviant for the leaching of precious metals. Research and development of thiosulfate leach technology has been prompted by environmental concerns with the use of cyanide and problems associated with the processing of difficult-to-treat ores. The Newmont Mining, Nevada, operation has successfully developed a combined biooxidation–thiosulfate heap-leaching process for carbonaceous/high sulfide ores and a direct thiosulfate heap-leaching process for carbonaceous/low ...
Tópico(s): Mineral Processing and Grinding
2003 - Elsevier BV | International Journal of Mineral Processing
K Wan, Jean‐Marc Chovelon, Nicole Jaffrézic‐Renault,
Langmuir–Blodgett (LB) films containing butyrylcholinesterase (BuChE) are fabricated to realise an enzymatic field effect transistor (ENFET) for the detection of organophosphorus pesticides in water. Trichlorfon as a common pesticide is examined in our work. The BuChE-immobilised LB films are formed by adsorbing the enzyme molecules onto a stearylamine monolayer using the electrostatic force. Enzyme/stearylamine mixed LB films are immobilized onto a pH-ISFET surface and treated by glutaraldehyde vapour ...
Tópico(s): Electrochemical Analysis and Applications
2000 - Elsevier BV | Talanta
Nicole Jaffrézic‐Renault, Anne Senillou, C. Martelet, K Wan, Jean‐Marc Chovelon,
Different types of polymeric matrices were tested in order to optimize the characteristics of the specific ISFETs developed for the detection of an ionic pollutant, the ammonium ion and of a molecular pollutant, the trichlorfon which is a common organophosphorus pesticide. A miniaturized sensor for ammonium detection, based on the integration of both ammonium and reference FETs in a single chip, was fabricated. A differential measurement mode between both FETs was used, this mode of measurement ...
Tópico(s): Electrochemical Analysis and Applications
1999 - Elsevier BV | Sensors and Actuators B Chemical
K Wan, Jean‐Marc Chovelon, Nicole Jaffrézic‐Renault, А. П. Солдаткин,
Trichlorfon as a common pesticide is detected using a BuChE-FET sensor which is prepared either with cross-linked BSA–glutaraldehyde membrane or photocross-linkable PVA/SbQ (poly(vinyl alcohol) containing styrylpyridinium) membrane. On the basis of these BuChE-FET sensors, a biochemical test for trichlorfon in liquid was developed by enzyme inhibition. PVA/SbQ membrane shows better characteristics compared to BSA membrane: larger linear dynamic range in kinetic mode, better reproducibility, and above ...
Tópico(s): Electrochemical Analysis and Applications
1999 - Elsevier BV | Sensors and Actuators B Chemical
Ming Yuan, Mickael Coupé, Yanqiang Bai, Guillemette Gauquelin‐Koch, Shizhong Jiang, P Aubry, Yumin Wan, Marc‐Antoine Custaud, Yinghui Li, Philippe Arbeille,
We quantified the impact of 60-day head-down bed rest (HDBR) with countermeasures on arterial and venous response to tilt. Methods: Twenty-one males: 7 control (Con), 7 resistive vibration exercise (RVE) and 7 Chinese herb (Herb) were assessed. Subjects were identified as finisher (F) or non-finishers (NF) at the post-HDBR 20-min tilt test. The cerebral (MCA), femoral (FEM) arterial flow velocity and leg vascular resistance (FRI), the portal vein section (PV), the flow redistribution ratios (MCA/FEM; MCA/PV), ...
Tópico(s): Thermoregulation and physiological responses
2012 - Public Library of Science | PLoS ONE
Wan C. Tsai, Marc B. Hershenson, Ying Zhou, Umadevi Sajjan,
Azithromycin (AZM) has been used as an anti-inflammatory agent in the treatment of cystic fibrosis (CF), particularly those with chronic infection with P. aeruginosa (PA). To investigate mechanisms associated with the beneficial effects of AZM in CF, we examined bacterial load, cytokine levels, and clearance of inflammatory cells in CF mice infected with mucoid PA and treated with AZM. Gut-corrected Cftr tm1Unc -TgN(FABPCFTR)#Jaw CF mice infected with an alginate-overproducing PA CF-isolate were treated ...
Tópico(s): Nosocomial Infections in ICU
2009 - Springer Science+Business Media | Inflammation Research
Aymeric Silvin, Stefan Uderhardt, Cécile Piot, Sandro Dá Mesquita, Katharine Yang, Laufey Geirsdóttir, Kevin Mulder, Eyal David, Zhaoyuan Liu, Cécile Bridlance, Morgane Sonia Thion, Xiao Meng Zhang, Wan Ting Kong, Marc Deloger, Vasco F. Fontes, Assaf Weiner, Pui Lai Rachel Ee, Regine J. Dress, Jing Hang, Akhila Balachander, Svetoslav Chakarov, Benoît Malleret, Garett Dunsmore, Olivier Cexus, Jinmiao Chen, Sonia Garel, Charles‐Antoine Dutertre, Ido Amit, Jonathan Kipnis, Florent Ginhoux,
Brain macrophage populations include parenchymal microglia, border-associated macrophages, and recruited monocyte-derived cells; together, they control brain development and homeostasis but are also implicated in aging pathogenesis and neurodegeneration. The phenotypes, localization, and functions of each population in different contexts have yet to be resolved. We generated a murine brain myeloid scRNA-seq integration to systematically delineate brain macrophage populations. We show that the previously ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2022 - Cell Press | Immunity