Yi Shan, J. Zhang, Zehong Liu, Ming-Dao Wang, Yan Dong,
Tubulin protein is one of several members of a small family of globular proteins. It offers a potential target for anticancer drug design and development. Combretastatin A-4 (CA-4) is a potent anticancer and antiangiogenesis natural substance isolated from Combretum caffrum. Modifications on the CA-4 structure have led to a great number of novel CA-4 derivatives as potent tubulin inhibitors and high cytotoxic anticancer agents is becoming an interesting field, leading to a breakthrough in the treatment ...
Tópico(s): Click Chemistry and Applications
2011 - Bentham Science Publishers | Current Medicinal Chemistry
Hong Ge Chen, Yan Xin, Xin Yu Liu, Ming Dao Wang, Hui Huang, Xin Cheng Jia, J.A. Wang,
Three types of xylanases (EC 3.2.1.8) were detected in the strain Aspergillus niger A-25, one of which, designated as XynIII, also displayed β-(1,3-l,4)-glucanase (EC 3.2.1.73) activity, as determined by a zymogram analysis. XynIII was purified by ultrafiltration and ion-exchange chromatography methods. Its apparent molecular weight was about 27.9 kDa, as estimated by SDS-PAGE. The purified XynIII could hydrolyze birchwood xylan, oat spelt xylan, lichenin, and barley β-glucan, but not CMC, avicel ...
Tópico(s): Studies on Chitinases and Chitosanases
2006 - Springer Science+Business Media | Journal of Microbiology and Biotechnology
Ming‐Dao Zhang, Gang Wang, Dan-Xia Zhao, Cheng-Yan Huang, Hui Cao, Mindong Chen,
Over the past five years, perovskite solar cells (PSCs) have gained intense worldwide attention in the photovoltaic community due to their low cost and high power conversion efficiencies (PCEs). One of the most significant issues in achieving high PCEs of PSCs is the development of suitable low-cost hole-transporting materials (HTMs). Here, we put forward a new concept of HTMs for PSCs: a 3D structure with a core of coplanar quinolizino acridine, derived from the conventional concept of 2D triphenylamine ...
Tópico(s): Organic Electronics and Photovoltaics
2017 - Royal Society of Chemistry | Chemical Science
Ming‐Dao Zhang, Gang Wang, Baohui Zheng, Longyan Li, Boning Lv, Hui Cao, Mindong Chen,
Hydrogen peroxide has been widely studied in cell biology and liquid fuel cells as an oxidant or fuel, and highly efficient and durable electrocatalysts for H2O2 reduction and detection are in high demand. Here, a simple strategy to fabricate conductive 2D single/several-layer [Co3(HHTP)2]n MOF nanosheets, based on 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) and Co2+ ions, was developed by the Langmuir-Blodgett (LB) method combined with layer-by-layer (LbL) growth technology. The [Co3(HHTP)2]n MOF nanosheets ...
Tópico(s): Gas Sensing Nanomaterials and Sensors
2019 - Royal Society of Chemistry | Nanoscale
Yachao Jin, Yue Liu, Li Song, Jianghua Yu, Kuiran Li, Ming‐Dao Zhang, Jiali Wang,
Lowering the charge barrier is of central importance to develop the advanced lithium-carbon dioxide (Li-CO2) battery with high energy efficiency, yet great challenges remain owing to the sluggish decomposition kinetics of lithium carbonate (Li2CO3) discharge products. Herein, we demonstrate a latent cathode catalyst by strategically constructing the heterointerfaces in hollow NiS2/FeS2 nanostructures dispersed on N, S co-doped graphene aerogel (NiS2/FeS2-NSGA), which displays an exceptional capability ...
Tópico(s): Supercapacitor Materials and Fabrication
2021 - Elsevier BV | Chemical Engineering Journal
Jinliang Liu, Xiaoyan Zhou, Jin‐Long An, Yanqing Wang, Ming‐Dao Zhang, Ling Qin,
Urea solution electrolysis can treat wastewater that involves urea by anodic oxidation reaction of urea (UOR) and can also produce clean hydrogen by cathodic hydrogen evolution reaction (HER) with lower voltage. Therefore, it is of great importance to devise and synthesize new bifunctional electrocatalysts for both UOR and HER. Herein, a novel nickel metal–organic framework (Ni-bza, Hbza = 4-(1H-1,2,4-triazol-1-yl) benzoic acid) was constructed by a solvothermal method, followed by the study of the Ni- ...
Tópico(s): Advanced battery technologies research
2022 - American Chemical Society | Energy & Fuels
Tingting Cheng, Jin‐Song Hu, Chunhui Zhou, Yueming Wang, Ming‐Dao Zhang,
Tópico(s): Molecular Sensors and Ion Detection
2016 - Springer Science+Business Media | Science China Chemistry
Ling Qin, Si-Ying Zeng, Wei-Juan Zuo, Qing-He Liu, Jin Li, Gang Ni, Yan-Qing Wang, Ming‐Dao Zhang,
Tópico(s): Dendrimers and Hyperbranched Polymers
2016 - Elsevier BV | Polyhedron
Kuaibing Wang, Qingqing Li, Zhujuan Ren, Chao Li, Yang Chu, Zikai Wang, Ming‐Dao Zhang, Hua Wu, Qichun Zhang,
Two identical layered metal-organic frameworks (MOFs) (CoFRS and NiFRS) are constructed by using flexible 1,10-bis(1,2,4-triazol-1-yl)decane as pillars and 1,4-benzenedicarboxylic acid as rigid linkers. The single-crystal structure analysis indicates that the as-synthesized MOFs possess fluctuant 2D networks with large interlayer lattices. Serving as active electrode elements in supercapacitors, both MOFs deliver excellent rate capabilities, high capacities, and longstanding endurances. Moreover, ...
Tópico(s): Advancements in Battery Materials
2020 - Wiley | Small
Chunhui Zhang, Xiaohui Wang, Ming-Dao Sun, Zhonghua Kuang, Xian‐Ming Zhang, Ning Ren, S. Wu, Ziru Sang, Tao Sun, Zhanli Hu, Yongfeng Yang, Zheng Liu,
Both monolithic and semi-monolithic scintillator positron emission tomography (PET) detectors can measure the depth of interaction with single-ended readout. Usually scintillators with a thickness of 10 mm or less are used since the position resolutions of the detectors degrade as the scintillator thickness increases. In this work, the performance of a 20 mm thick long rectangular semi-monolithic scintillator PET detector was measured by using both single-ended and dual-ended readouts with silicon ...
Tópico(s): Atomic and Subatomic Physics Research
2021 - IOP Publishing | Physics in Medicine and Biology
Qing Hu, Qi-Ming Zheng, Jinliang Liu, Ling Qin, Huan-Jun Zhu, Xi Yang, Yan-Qing Wang, Ming‐Dao Zhang,
Hydrogen energy has been considering as an ideal renewable energy source and playing a very important role in daily life. Noble metal catalysts have shown excellent catalytic performance in electrolysis of water for hydrogen evolution, but their scarcity and high cost limit their large-scale use. Therefore, the design of non-noble metal catalysts with high catalytic activity and stability and low cost is an urgent problem to be solved. Two zinc-based coordination polymers have been synthesized by ...
Tópico(s): Fuel Cells and Related Materials
2021 - Elsevier BV | Chemical Engineering Journal
Libin Zhou, Xiao Wang, Ying Yang, Ling Wu, Fengying Li, Rong Zhang, Guoyue Yuan, Ning Wang, Ming‐Dao Chen, Guang Ning,
Berberine, a hypoglycemic agent, has been shown to decrease plasma free fatty acids (FFAs) level in insulin-resistant rats. In the present study, we explored the mechanism responsible for the antilipolytic effect of berberine in 3T3-L1 adipocytes. It was shown that berberine attenuated lipolysis induced by catecholamines, cAMP-raising agents, and a hydrolyzable cAMP analog, but not by tumor necrosis factor α and a nonhydrolyzable cAMP analog. Unlike insulin, the inhibitory effect of berberine on ...
Tópico(s): Diet, Metabolism, and Disease
2010 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Fengqi Zhang, Hanlin Chen, Shufeng Yang, Zhiqiang Feng, Heyong Wu, Geoffrey Batt, Xueqin Zhao, Ming-Dao Sun, A Min-Na, Shihui Wang, Yang Jianguo,
This study uses new seismic reflection profiles and exploratory well data to analyze the structural characteristics and evolution of the Sanjiang Basin in eastern Heilongjiang, NE China. The basin sequence was divided into six stratigraphic units, representing discrete Middle-Upper Jurassic, Lower Cretaceous, Upper Cretaceous, Eocene–Oligocene, Miocene and Quaternary phases of development. The Sanjiang Basin initiated as a passive marginal rift flank to the southern Mongol–Okhotsk Ocean during the ...
Tópico(s): High-pressure geophysics and materials
2012 - Elsevier BV | Journal of Asian Earth Sciences
Qingxiang Yang, Xing‐Qiu Chen, Jiehu Cui, Jin‐Song Hu, Ming‐Dao Zhang, Ling Qin, Gao-Feng Wang, Qingyi Lu, He‐Gen Zheng,
Solvothermal reactions of 4,4′-dicarboxydiphenylamine (H2L) with 4,4′-bis(imidazol-1-yl)phenyl (BIP) and 4,4′-bis(imidazol-1-yl)diphenyl (BIBP) in the presence of cobalt(II), cadmium(II), zinc(II) salts in H2O/CH3CN or H2O/DMF produced five new complexes, namely, [Co2(L)2(BIP)2·3H2O]n (1), [Co(L)(BIP)·2CH3CN]n (2), [Co(L)(BIBP)·H2O]n (3), [Cd(L)(BIBP)]n (4), [Zn(L)(BIBP)]n (5). Compound 1 has binuclear Co(II) clusters, which are linked by L2– and BIP to generate a rare three-dimensional (3D) non-interpenetrated ...
Tópico(s): Lanthanide and Transition Metal Complexes
2012 - American Chemical Society | Crystal Growth & Design
Cai Qi, Shuhan Wang, Xukun Zhu, Tong Zhang, Yanju Gou, Zexin Xie, Yachao Jin, Yao Wang, Li Song, Ming‐Dao Zhang,
The green and low-cost recycling of spent LiFePO4 (LFP) cathode materials has become an urgent problem to be solved. In this work, a completely green and easy scale-up recycling process is developed to recycle the cathode powders from spent LFP batteries. The optimal regeneration conditions are obtained by adjusting temperature, Li+ concentration and reductant dosage. Meanwhile, the mechanism of regeneration is investigated by microscopic characterization and electrochemical performance testing. ...
Tópico(s): Recycling and Waste Management Techniques
2022 - Elsevier BV | Journal of Alloys and Compounds
Yi‐Kai Lo, Po‐Min Wang, Genia Dubrovsky, Ming-Dao Wu, Michael Chan, James Dunn, Wentai Liu,
Implantable functional electrical stimulation (IFES) has demonstrated its effectiveness as an alternative treatment option for diseases incurable pharmaceutically (e.g., retinal prosthesis, cochlear implant, spinal cord implant for pain relief). However, the development of IFES for gastrointestinal (GI) tract modulation is still limited due to the poorly understood GI neural network (gut–brain axis) and the fundamental difference among activating/monitoring smooth muscles, skeletal muscles and neurons. ...
Tópico(s): Neurological disorders and treatments
2018 - Multidisciplinary Digital Publishing Institute | Micromachines
Yachao Jin, Tong Zhang, Na Pan, Shuhan Wang, Bo Zhang, Xukun Zhu, Yujia Hao, Xinyao Wang, Li Song, Ming‐Dao Zhang,
Oxygen evolution reaction (OER) plays an important role in electrochemical energy conversion and storage. However, the slow charge transport and high free energy of intermediates conversion greatly restrain the kinetics of OER. Herein, we strategically adopt the hexahydroxytriphenylene (HHTP) ligand to prepare an impressive Ni-Fe bimetallic conductive Metal-organic framework (MOF) in-situ grown on carbon cloth ([Ni2.87Fe0.13(HHTP)2]n/CC) via the conventional one-step hydrothermal method. The obtained [ ...
Tópico(s): Fuel Cells and Related Materials
2022 - Elsevier BV | Surfaces and Interfaces
Li Song, Haiyu Fan, Tao Wang, Tengfei Xiang, Ming‐Dao Zhang, Chuangang Hu, Wei Zhou, Jianping He,
The carbon-based electrocatalyst for rechargeable zinc-air battery not only needs bifunctional activities to oxygen reduction and evolution reactions, but also requires a high graphitization degree to maintain an excellent stability. Herein, a simple and scale-up strategy is developed to synthesize a highly active and stable electrocatalyst ([email protected]) through a solid-state thermal conversion process, derived from a single and easy-to-get precursor (cobaltic Prussian blue analogue). The Co ...
Tópico(s): Fuel Cells and Related Materials
2021 - Elsevier BV | Energy storage materials
Jian‐Liang Zhou, Yuanyuan Wang, Ling Qin, Ming‐Dao Zhang, Qingxiang Yang, He‐Gen Zheng,
Five new metal–organic frameworks have been synthesized under hydrothermal conditions, in CH3CN–H2O, DMF–CH3CH2OH–H2O and DMA–H2O, namely, [ZnL(bimx)0.5]n (1), {[CoL(4,4′-bipy)]·DMF}n (2), {[CdL(4,4′-bipy)]·DMF}n (3), {[ZnL(bibp)]·DMA·(H2O)2}n (4), {[CoL(bpyb)0.5]·(H2O)2}n (5) (bimx = 1,4-bis(imidazol-1-ylmethyl)benzene, 4,4′-biby = 4,4-pyridine, bibp = 4,4′-bis(imidazol-1-yl)biphenyl, bpyb = 1,4-bis(4-pyridyl)benzene, H2L = 4,4′-(phenylazanediyl)dibenzoic acid. These complexes were characterized by elemental analysis, ...
Tópico(s): Crystal structures of chemical compounds
2012 - Royal Society of Chemistry | CrystEngComm
Ming‐Dao Zhang, Ziyang Zhang, Zhongqiu Bao, Zemin Ju, Xingyong Wang, He‐Gen Zheng, Jing Ma, Xingfu Zhou,
This paper focuses on the structure modification of sensitizers for efficient porphyrin-sensitized solar cells (PSSCs).
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2014 - Royal Society of Chemistry | Journal of Materials Chemistry A
Zhuo-Zhi Lai, Xi Yang, Ling Qin, Jin‐Long An, Zi Wang, Xun Sun, Ming‐Dao Zhang,
One zinc-based coordination polymer was synthesized by a solvothermal method using zinc nitrate and 1,4-bis(1-imidazolyl)benzene (bib) ligand, {Zn(bib)·(SO4)·(H2O)}n (1). The fluorescence test results showed that compound 1 had a good fluorescence quenching effect on antibiotics and metal ions, especially norfloxacin and Fe3+. The limit of detection is calculated to be 7.04 μmol/L for norfloxacin. The results of the anti-interference experiment show that it selectively detect norfloxacin. Meanwhile, ...
Tópico(s): Advanced Nanomaterials in Catalysis
2021 - Elsevier BV | Journal of Solid State Chemistry
Ming Dao Wang, Hongge Chen, Xinyu Liu, Yuqian Gao, Kun Wu, Xincheng Jia,
Rehmannia glutinosa Libosch, a well known herb for Chinese traditional medicine, and sesame are two main crops in Northwestern Henan, China. It has been known however that, a rotation of these two crops, for example, cultivation of sesame preceeded with R. glutinosa Libosch, leads to decreased yield and poor quality of sesame. In order to identify the compound or allelochemicals which inhibit the growth of sesame, the effect of the crude tissue extractions of R. glutinosa on the germination rate, ...
Tópico(s): Plant Parasitism and Resistance
2010 - Academic Journals | AFRICAN JOURNAL OF BIOTECHNOLOGY
Ying Tong, Tao Wang, Bor‐ming Jahn, Ming-Dao Sun, Dawei Hong, Jingjing Gao,
The Altai orogen is an important constituent of the Central Asian Orogenic Belt (CAOB). The main orogenic processes occurred mainly in the early to middle Paleozoic and involved a series of northward subduction and terrane accretion. However, termination of the accretionary and post-accretionary processes remains poorly defined. The Chinese Altai is located in the southern part of this orogeny, which is widely intruded by Permian granitic plutons. These plutons are approximately circular in shape, ...
Tópico(s): Geochemistry and Geologic Mapping
2014 - Yale University | American Journal of Science
Chun‐Mao Lin, Chia-Lang Fang, You-Cheng Hseu, Chun‐Liang Chen, Jin-Wun Wang, Sheng-Lung Hsu, Ming-Dao Tu, Shih-Ting Hung, Chein Tai, Yih‐Huei Uen, Kai‐Yuan Lin,
Colon cancer is one of the most common malignant cancers worldwide but the current therapeutic approaches for advanced colon cancer are less efficient. This study investigated associations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised colon tissues from 263 patients with colon cancer. Paired t tests were used to analyze ...
Tópico(s): Colorectal Cancer Surgical Treatments
2013 - Public Library of Science | PLoS ONE
Ling Qin, Jinliang Liu, Xiaoyan Zhou, Yanqing Wang, Xun Sun, Ming‐Dao Zhang,
Due to the high price and rareness of precious metal electrocatalysts, the preparation of cheap, high-efficiency nonprecious metal electrocatalysts is urgently needed. In this paper, a Co-metal-organic framework (MOF) has been synthesized by the hydrothermal method. In view of the poor electrocatalytic performance of pristine Co-MOF, we used it as a template and obtained the Co-MOF-800 electrocatalyst by high-temperature calcination at 800 °C under a nitrogen atmosphere. To further improve the electrocatalytic ...
Tópico(s): MXene and MAX Phase Materials
2022 - American Chemical Society | Energy & Fuels
Z. G. Gan, Jian Jiang, Hua-Bin Yang, Zhiyuan Zhang, L. Ma, Lin Yu, Jianguo Wang, Yulin Tian, B. Ding, Huang Tian-Heng, Yongsheng Wang, S. Guo, Ming-Dao Sun, KaiLong WANG, Shan-Gui Zhou, Zhongzhou Ren, Xin‐Hui Zhou, X. Xu,
合成了两个缺中子新核素 216 U和 215 U. 目标核由熔合反 应产生后从薄靶中反冲出来, 在飞行中被兰州充气谱仪从大量的本底离子中分离并偏转到探测系统.探测系统 对目标核的注入以及随后将发生的衰变进行探测. 探测器上产生的信号经电子学处理后被数据获取系统转换 成一定格式的数据保存下来.实验采用能量-位置-时间关联的数据分析方法来寻找和鉴别目标核.在束流能量 为187.2MeV的情况下, 新核素 216 U的两个衰变态被观察到: 一是基态, 它的粒子能量为10.384(30)MeV, 半 衰期为 4.72 1.57 4.72 ms; 二是自旋宇称为8 + 的同核异能素态, 它的粒子能量为10.582(30)MeV和8.182(30)MeV, 半衰期为 1.80 0.48 1.31 ms.在束流能量为205.5MeV的情况下, 新核素 215 U被观测到, 它的粒子能量和半衰期被确 定为8.428(30)MeV和 1.33 0.29 0.73 ms.此外, 实验还观测到从 217 U的基态产生的两个新的跃迁, 它们的粒子能量 分别为8.210(30)MeV和8.098(30) ...
Tópico(s): Astronomical and nuclear sciences
2016 - Science China Press | Chinese Science Bulletin (Chinese Version)
Cheng-Cai Wang, Yunwei Mao, Zhiwei Shan, Ming Dao, Ju Li, Jun Sun, E. Ma, Subra Suresh,
Significance The formation of nanocrystals and cracks in metallic glasses subjected to cyclically varying strains in micro- and nanoscale systems is a topic of scientific and technological interest. However, no real-time studies of such phenomena in fatigued metallic glasses have thus far been reported. Here we present unique observations of nanocrystallization and the onset and progression of fatigue failure in a metallic glass through cyclic straining experiments conducted inside a high-resolution ...
Tópico(s): Microstructure and mechanical properties
2013 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Qiaodong Wei, Xiaolong Wang, Ce Zhang, Ming Dao, Xiaobo Gong,
Mechanical properties of red blood cells (RBCs) change during their senescence which supports numerous physiological or pathological processes in circulatory systems by providing crucial cellular mechanical environments of hemodynamics. However, quantitative studies on the aging and variations of RBC properties are largely lacking. Herein, we investigate morphological changes, softening or stiffening of single RBCs during aging using an in vitro mechanical fatigue model. Using a microfluidic system ...
Tópico(s): Blood properties and coagulation
2023 - Nature Portfolio | Scientific Reports
Sheng Yuan Leong, Wan Wei Lok, Kah Yee Goh, Hong Boon Ong, Hui Min Tay, Chengxun Su, Fang Kong, Megha Upadya, Wei Wang, Enkhtuya Radnaa, Ramkumar Menon, Ming Dao, Rinkoo Dalan, Subra Suresh, Wan‐Teck Lim, Han Wei Hou,
Cell-free RNAs and extracellular vesicles (EVs) are valuable biomarkers in liquid biopsies, but they are prone to preanalytical variabilities such as nonstandardized centrifugation or ex vivo blood degradation. Herein, we report a high-throughput and label-free inertial microfluidic device (ExoArc) for isolation of platelet-free plasma from blood for RNA and EV analysis. Unlike conventional inertial microfluidic devices widely used for cell sorting, a submicrometer size cutoff (500 nm) was achieved ...
Tópico(s): Nanopore and Nanochannel Transport Studies
2024 - American Chemical Society | ACS Nano
Ming‐Dao Zhang, Baohui Zheng, Qi-Fan Zhuang, Cheng-Yan Huang, Hui Cao, Mindong Chen, Bin Wang,
Perovskite solar cells (PSCs) are currently under both of intense academic and industrial investigations. Here, two dimethoxyphenylamine-substituted carbazole derivatives (SYN1 and PARA1), as hole-transporting materials (HTMs) for PSCs, have been synthesized via two-step synthesis with low cost and simple operation. PSCs devices based on SYN1 and PARA1 showed power conversion efficiencies (PCE) of 11.4% and 13.1%, respectively, outperforming that of Spiro-OMeTAD (12.0%), demonstrating the dimethoxyphenylamine- ...
Tópico(s): Organic Light-Emitting Diodes Research
2017 - Elsevier BV | Dyes and Pigments