Juri Frorip, E. Kokin, Jaan Praks, V. Poikalainen, Aime Ruus, I. Veermäe, L. Lepasalu, Winfried Schäfer, Hannu Mikkola, Jukka Ahokas,
The objective of this study was to analyse the energy use by the dairy case-farm with un-insulated cowsheds in Estonia for the period of 2009-2010. The energy balance calculation includes the direct energy input of fuel, lubricants and electricity and the indirect input of forage, cereals, concentrates for young stock, dairy cattle and buildings. Energy outputs are milk, meat, and manure. The energy values were calculated multiplying the quantities of inputs and outputs by their energy conversion ...
Tópico(s): Environmental Impact and Sustainability
2012 - Estonian Agricultural University | Agronomy Research
Oskar Bauß, Winfried Schäfer, Reza Sadat-Khonsari, Michael Knösel,
Introduction The aim of this retrospective study was to examine the effect of orthodontic extrusion on the pulpal vitality of maxillary incisors with a history of trauma. Methods Pulpal condition was examined clinically (rating of crown color and sensitivity testing with a cryogenic spray) and radiologically (periapical and panoramic radiographs) after orthodontic extrusion of previously traumatized (Orthodontics/Trauma group, n = 77) and nontraumatized teeth (Orthodontics group, n = 400) and after previous ...
Tópico(s): Dental Radiography and Imaging
2009 - Elsevier BV | Journal of Endodontics
Sigrid Kusch-Brandt, Britt Schumacher, Hans Oechsner, Winfried Schäfer,
The biogas yield of solid manure from dairy cattle depends on its quality and the proportion of excreta and organic litter material contained within. The biogas yield of both faeces and straw is available in literature. Straw is a common litter material of mixed farms. However, straw is scarcely available on dairy farms. Oat husks are appropriate to replace or supplement straw for use as litter material. In this study, the actual methane yield and the total methane potential of oat husks were determined. ...
Tópico(s): Bioenergy crop production and management
2011 - Elsevier BV | Biomass and Bioenergy
Justus Lieber, Cristian Urla, Winfried Baden, Jürgen Schäfer, Hans‐Joachim Kirschner, Jörg Fuchs,
We report a single-center study of minimally invasive thoracoscopic lung surgery with pediatric patients.We performed a retrospective analysis of patients who underwent thoracoscopic lung surgery between 2004 and 2013. The procedures were divided into anatomic and non-anatomical lung resections.Seventy-six patients with a mean age of 6.5 years (range: 7 days-17 years) and a mean weight of 11 kg (range: 2.6-56.0 kg) received thoracoscopic lung surgery for tumor metastases (n = 20), sequestration/congenital ...
Tópico(s): Tracheal and airway disorders
2015 - Wolters Kluwer | International Journal of Surgery
Winfried Haase, A Schäfer, Heini Murer, R. Kinne,
Orientation of rat renal and intestinal brush-border membrane vesicles was studied with two independent methods: electron-microscopic freeze-fracture technique and immunological methods. With the freeze-fracture technique a distinct asymmetric distribution of particles on the two membrane fracture faces was demonstrated; this was used as a criterion for orientation of the isolated membrane vesicles. For the immunological approach the accessibility or inaccessibility of aminopeptidase M localized ...
Tópico(s): Infant Nutrition and Health
1978 - Portland Press | Biochemical Journal
Andreas Möri, W. Russell Alexander, Hörst Geckeis, Winfried Häuser, Thorsten Schäfer, J. Eikenberg, Th. Fierz, C. Degueldre, Tiziana Missana,
Tópico(s): Radioactivity and Radon Measurements
2003 - Elsevier BV | Colloids and Surfaces A Physicochemical and Engineering Aspects
Anke Hinney, Thuy Trang Nguyen, André Scherag, Susann Friedel, Günter Brönner, Timo D. Müller, Harald Grallert, Thomas Illig, H.-Erich Wichmann, Winfried Rief, H. Schäfer, Johannes Hebebrand,
Background Obesity is a major health problem. Although heritability is substantial, genetic mechanisms predisposing to obesity are not very well understood. We have performed a genome wide association study (GWA) for early onset (extreme) obesity. Methodology/Principal Findings a) GWA (Genome-Wide Human SNP Array 5.0 comprising 440,794 single nucleotide polymorphisms) for early onset extreme obesity based on 487 extremely obese young German individuals and 442 healthy lean German controls; b) confirmatory ...
Tópico(s): Nutrition, Genetics, and Disease
2007 - Public Library of Science | PLoS ONE
F. van Valen, Simone Fulda, Borna Truckenbrod, Vera Eckervogt, Jürgen Sonnemann, Axel Hillmann, Robert Rödl, Christiane Hoffmann, Winfried Winkelmann, Lutz Schäfer, Barbara Dockhorn‐Dworniczak, Torsten Wessel, Joachim Boos, Klaus‐Michael Debatin, H. Jürgens,
We investigated the cytotoxic responsiveness of 40 cell lines derived from representatives of the Ewing's sarcoma family of tumours (ESFT), i.e., Ewing's sarcoma (ES), peripheral primitive neuroectodermal tumour (pPNET) and Askin tumour (AT), to tumour necrosis factor–related apoptosis-inducing ligand (TRAIL). Incubation with TRAIL at 100 ng/ml induced cell death at 24 hr in 19 of 26 ES, 11 of 12 pPNET and 2 of 2 AT cell lines. Half-maximal cell death concentrations (IC50 values) varied from 0.1 to 20 ...
Tópico(s): interferon and immune responses
2000 - Wiley | International Journal of Cancer
Hannes M. Beyer, Samuel Juillot, Kathrin Herbst, Sophia L. Samodelov, Konrad Müller, Wolfgang W. Schamel, Winfried Römer, Eberhard Schäfer, Ferenc Nagy, Uwe Strähle, Wilfried Weber, Matías D. Zurbriggen,
Protein trafficking in and out of the nucleus represents a key step in controlling cell fate and function. Here we report the development of a red light-inducible and far-red light-reversible synthetic system for controlling nuclear localization of proteins in mammalian cells and zebrafish. First, we synthetically reconstructed and validated the red light-dependent Arabidopsis phytochrome B nuclear import mediated by phytochrome-interacting factor 3 in a nonplant environment and support current ...
Tópico(s): Plant Molecular Biology Research
2015 - American Chemical Society | ACS Synthetic Biology
Sascha Tafelski, Winfried Häuser, Michael Schäfer,
Tópico(s): Infant Health and Development
2016 - Springer Science+Business Media | Der Schmerz
Katharina Rump, Matthias Unterberg, Agnes Dahlke, Hartmuth Nowak, Björn Koos, Lars Bergmann, Winfried Siffert, Simon Schäfer, Jürgen Peters, Michael Adamzik, Tim Rahmel,
Abstract Altered aquaporin 5 ( AQP5 ) expression in immune cells impacts on key mechanisms of inflammation and is associated with sepsis survival. Since epigenetic regulation via DNA methylation might contribute to a differential AQP5 expression in sepsis, we tested the hypotheses that DNA methylation of the AQP5 promotor (1) influences AQP5 expression, (2) is associated with the 30-day survival of septic patients, and (3) alters the nuclear transcription factor NF-κB binding. AQP5 mRNA expression was ...
Tópico(s): Ion Transport and Channel Regulation
2019 - Nature Portfolio | Scientific Reports
Andrew R.J. Mitchell, B LUCKEBERGFELD, Sandra Bührmann, U. Rushentsova, John I. Nürnberger, Winfried Siffert, Rainhild Schäfers, T Philipp, R WENZEL,
Objective We used the orally available endothelin A (ETA) receptor antagonist darusentan to characterize interactions between the major blood pressure-regulating systems in healthy men. Mediators of the endothelin system, the sympathetic nervous system, and the renin-angiotensin system act via G protein-coupled receptors with a possible involvement of the G-protein β3 subunit (GNB3) C825T polymorphism. We studied the influence of this polymorphism on the responses to ETA antagonism in the presence ...
Tópico(s): Thermoregulation and physiological responses
2004 - Wiley | Clinical Pharmacology & Therapeutics
Jeanette Erdmann, Anika Großhennig, Peter S. Braund, Inke R. König, Christian Hengstenberg, Alistair S. Hall, Patrick Linsel‐Nitschke, Sekar Kathiresan, Ben Wright, David‐Alexandre Trégouët, François Cambien, Petra Bruse, Zouhair Aherrahrou, Arnika Kathleen Wagner, Klaus Stark, Stephen M. Schwartz, Veikko Salomaa, Roberto Elosúa, Olle Melander, Benjamin F. Voight, Christopher J. O’Donnell, Leena Peltonen, David S. Siscovick, David Altshuler, Piera Angelica Merlini, Flora Peyvandi, Luisa Bernardinelli, Diego Ardissino, Arne Schillert, Stefan Blankenberg, Tanja Zeller, Philipp S. Wild, Dániel Schwarz, Laurence Tiret, Claire Perret, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schäfer, Winfried März, Wilfried Renner, Peter Bugert, Harald Klüter, Jürgen Schrezenmeir, Deborah C. Rubin, Stephen G. Ball, Anthony J. Balmforth, H‐Erich Wichmann, Thomas Meitinger, Marcus Fischer, Christa Meisinger, Jens Baumert, Annette Peters, Willem H. Ouwehand, Panos Deloukas, John R. Thompson, Andreas Ziegler, Nilesh J. Samani, Heribert Schunkert,
Jeanette Erdmann and colleagues identify a locus on chromosome 3q22.3 associated with coronary artery disease. The SNP with the strongest association is in MRAS, which encodes a membrane-anchored GTP-binding protein. We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified ...
Tópico(s): Glycosylation and Glycoproteins Research
2009 - Nature Portfolio | Nature Genetics
Walter Raasch, Britta Jungbluth, Ulrich Schäfer, Winfried Häuser, Peter Dominiak,
It is known that moxonidine acts as an agonist at presynaptic alpha(2)-adrenoceptors of the postganglionic sympathetic nerve terminals and leads to a reduction in noradrenaline release. In addition, it is conceivable that I(1)-binding sites located in other regions of the pre- and postganglionic sympathetic neurons are involved in this effect. Our aim was to investigate whether and to what extent activation of the I(1)-binding sites contributes to the moxonidine-induced inhibition of noradrenaline ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2002 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Winfried Lotz-Rambaldi, Ines Schäfer, R. ten Doesschate, Fritz Hohagen,
Abstract According to the aim of the Treaty of Rome from 1957 which postulated the free movement of workers throughout the European Union, the European Board of Psychiatry in the UEMS (European Union of Medical Specialists) carried out a comprehensive survey of training in psychiatry, including all member countries in order to evaluate the present state of training in psychiatry in each. The survey should indicate whether the training requirements [UEMS Section Psychiatry. Charter on training of medical ...
Tópico(s): Mental Health Treatment and Access
2008 - Cambridge University Press | European Psychiatry
Christian Klammt, Frank Löhr, Birgit Schäfer, Winfried Haase, Volker Dötsch, Heinz Rüterjans, Clemens Glaubitz, Frank Bernhard,
We demonstrate the high level expression of integral membrane proteins (IMPs) in a cell‐free coupled transcription/translation system using a modified Escherichia coli S30 extract preparation and an optimized protocol. The expression of the E. coli small multidrug transporters EmrE and SugE containing four transmembrane segments (TMS), the multidrug transporter TehA with 10 putative TMS, and the cysteine transporter YfiK with six putative TMS, were analysed. All IMPs were produced at high levels yielding ...
Tópico(s): Bacterial Genetics and Biotechnology
2004 - Wiley | European Journal of Biochemistry
Hörst Geckeis, Thorsten Schäfer, Winfried Häuser, Thomas Rabung, Tiziana Missana, C. Degueldre, Andreas Möri, J. Eikenberg, Th. Fierz, W. Russell Alexander,
Summary The influence of smectite colloids on the migration behaviour of U(VI), Th(IV), Pu(IV), Am(III), Np(V), Sr(II) and Cs(I) is investigated within the Colloid and Radionuclide Retardation experiment (CRR). Two in situ experiments in a well-characterized granitic fracture zone are carried out in presence and absence of bentonite colloids. Radionuclide retardation observed in the field studies increases in the sequence Np(V)∼U(VI)<Sr(II)<Cs(I), where a small fraction of colloid borne breakthrough ...
Tópico(s): Groundwater flow and contamination studies
2004 - R. Oldenbourg Verlag | Radiochimica Acta
Frank Euteneuer, Philipp Süssenbach, Sarina J. Schäfer, Winfried Rief,
Die deutschsprachigen Versionen der MacArthur-Skala zum subjektiven sozialen Status (SSS) im sozialen Umfeld (SSS-U) und in Deutschland (SSS-D) erfassen den wahrgenommen sozialen Status im Vergleich zu Personen des sozialen Umfelds (proximale Referenzgruppe) und der deutschen Bevölkerung (distale Referenzgruppe). Der SSS ist von großer Bedeutung für die psychische Gesundheit [Scott et al., 2014] und ist potenziell von besserem prädiktivem Wert für verschiedenste Gesundheitsmaße als traditionelle objektive ...
Tópico(s): Mental Health Treatment and Access
2014 - Karger Publishers | Verhaltenstherapie
Katharina Rump, Peter Brendt, Ulrich H. Frey, Simon Schäfer, Winfried Siffert, Jürgen Peters, Michael Adamzik,
Aquaporin 1 (AQP1) and AQP5 expression may impact on key mechanisms in sepsis. However, it is unclear whether these AQPs are expressed to an equal extent or regulated differentially. Accordingly, we investigated the time-dependent expression of AQP1 and AQP5 following stimulation with lipopolysaccharide (LPS) in cultured human THP-1 cells and in the lungs of mice injected with LPS. Furthermore, we tested the hypothesis that the β2 adrenoreceptor agonist terbutaline or its downstream effector cyclic ...
Tópico(s): Heart Failure Treatment and Management
2013 - Lippincott Williams & Wilkins | Shock
Jacob N. Ablin, Peter A. Ste‐Marie, Michael Schäfer, Winfried Häuser, Mary‐Ann Fitzcharles,
Tópico(s): Cannabis and Cannabinoid Research
2016 - Springer Science+Business Media | Der Schmerz
Thomas D. Szucs, Georg Guggenberger, Karin Berger, Winfried März, Jürgen R. Schäfer,
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
1998 - Springer Science+Business Media | Herz
Ulrich Hasse, Gottfried J. Palm, Winfried Hinrichs, Jan Schäfer, Fritz Scholz,
Single crystal silver wires can be grown at the nitrobenzene|water interface when silver ions dissolved in the aqueous phase are reduced by decamethyl ferrocene dissolved in the nitrobenzene phase. The successful growth of these wires depends on a number of experimental conditions, most prominently on the concentration ratio of reactants, nucleation rates, shape of formed nuclei, and wettability of nuclei. The size–time dependence can be modeled on the basis of microelectrode behavior of the silver ...
Tópico(s): Gold and Silver Nanoparticles Synthesis and Applications
2011 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Oskar Bauß, Winfried Schäfer, Reza Sadat-Khonsari, Michael Knösel,
Restricted accessAbstractFirst published online April 1, 2010Influence of orthodontic extrusion on pulpal vitality of traumatized maxillary incisorsO Bauss, W Schafer, […], R Sadat-Khonsari, and M Knosel+1-1View all authors and affiliationsVolume os17, Issue 2https://doi.org/10.1308/135576110791013848
Tópico(s): Dental Radiography and Imaging
2010 - SAGE Publishing | Primary Dental Care
Christoph Siethoff, Winfried Wagner‐Redeker, Mathias Schäfer, Michael Linscheid,
Ion traps have become an important and powerful tool in many fields of analytical chemistry. The immanent sensitivity of the device and the ability to perform MSn opens a wide variety of experimental setups even at very low sample concentration levels. Modern and intelligent instrument control is of particular importance. The spread of ion trap mass spectrometry will greatly enhance the amount of data generated by LC-MS laboratories. The ability to handle and screen the flood of information puts ...
Tópico(s): Analytical chemistry methods development
1999 - Swiss Chemical Society | CHIMIA International Journal for Chemistry
K. Levsen, Winfried Wagner‐Redeker, Karl-Heinz Schäfer, P. Dobberstein,
Tópico(s): Mass Spectrometry Techniques and Applications
1985 - Elsevier BV | Journal of Chromatography A
Jukka Ahokas, Hannu Mikkola, Tapani Jokiniemi, Mari Rajaniemi, Winfried Schäfer, Helis Rossner, V. Poikalainen, Jaan Praks, I. Veermäe, Juri Frorip, E. Kokin,
In ENPOS (Energy Positive Farm) project possibilities to save energy on Estoni an and Finnish farms was studied. Energy can be saved easily and without large financial costs 10 -30%. The most important thing is to increase the energy knowledge of the farmers. This means advisory work and energy education. Energy bookkeeping and energy analysis are important things in energy consumption follow- up. The farm energy consumption should be followed and with this acquired knowledge farmers can notice where ...
Tópico(s): Greenhouse Technology and Climate Control
2013 - Estonian Agricultural University | Agronomy Research
Andrew R.J. Mitchell, Margaret C. Pace, John I. Nürnberger, R WENZEL, Winfried Siffert, T Philipp, Rainhild Schäfers,
Objective A C825T polymorphism has been identified for the gene encoding the G-protein β3 subunit (GNB3). The 825T allele is associated with hypertension and obesity, which in turn are closely linked with resistance to the metabolic and vascular effects of insulin. We hypothesized that venodilation in response to insulin would be impaired in GNB3 825T-allele carriers. Because vasodilatory properties of insulin are mainly mediated by nitric oxide, we also investigated the influence of the T−786C polymorphism ...
Tópico(s): Hormonal Regulation and Hypertension
2005 - Wiley | Clinical Pharmacology & Therapeutics
Jens Nürnberger, Anabelle Opazo Saez, Anna Mitchell, Sandra Bührmann, René R. Wenzel, Winfried Siffert, T Philipp, Rainhild Schäfers,
Arterial stiffening is the major cause of increasing systolic blood pressure in arterial hypertension. Increased arterial stiffness is one major mechanism responsible for morbidity and mortality in hypertension. A C825T polymorphism was identified in the gene encoding the G-protein β3 subunit (GNB3), and an association of the T-allele with hypertension was demonstrated in several studies. In order to identify a pathogenetic link between hypertension and arterial stiffness, we compared two indices ...
Tópico(s): Sodium Intake and Health
2004 - Springer Nature | Journal of Human Hypertension
Roland Härtel-Petri, Anne Krampe-Scheidler, Wolf‐Dietrich Braunwarth, Ursula Havemann‐Reinecke, Peter Jeschke, Winfried Looser, Stephan Mühlig, Ingo Schäfer, Norbert Scherbaum, Lydia Bothe, Corinna Schaefer, Willem Hamdorf,
Abstract The increasing abuse of the street drug crystal meth (methamphetamine) in many countries worldwide has resulted in a growing demand to treat patients who have acquired a methamphetamine-related disorder. The results of a systematic literature search which led to the consensus-based recommendations by the Working Group of the German Agency for Quality in Medicine (Ärztliches Zentrum für Qualität in der Medizin - ÄZQ) are presented. Pharmacological treatments were reviewed in 58 out of the 103 ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2017 - Thieme Medical Publishers (Germany) | Pharmacopsychiatry
Anna Mitchell, Sandra Bührmann, Anne Seifert, Jens Nürnberger, René R. Wenzel, Winfried Siffert, Thomas Philipp, Rafael F. Schäfers,
The ultimate mode of action by which nitroglycerin elicits vasodilation remains elusive. Animal studies point to an involvement of pertussis toxin-sensitive G proteins. The 825T allele of the GNB3 C825T polymorphism in the gene encoding the G protein beta3 subunit is associated with enhanced signal transduction via pertussis toxin-sensitive pathways in vitro. We hypothesized that G proteins have a role in nitroglycerin-mediated vasodilation and that carriers of the 825T allele would exhibit a stronger ...
Tópico(s): Ion channel regulation and function
2003 - Wiley | Clinical Pharmacology & Therapeutics