Martin Kessel, Ivo Wildhaber, Simone Cohen, Wolfgang Baumeister,
... Search for more papers by this author Wolfgang Baumeister Wolfgang Baumeister Max-Planck Institut für Biochemie, D-8033 ... Search for more papers by this author Wolfgang Baumeister Wolfgang Baumeister Max-Planck Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Author Information Martin Kessel1, Ivo Wildhaber2, Simone Cohen1 and Wolfgang Baumeister2 1Department of Membrane and Ultrastructure Research, Hadassah ...
Tópico(s): Bacteriophages and microbial interactions
1988 - Springer Nature | The EMBO Journal
Henrick Riemenschneider, Qiang Guo, Jakob M. Bader, Frédéric Frottin, Daniel Farny, Gernot Kleinberger, Christian Haass, Matthias Mann, F. Ulrich Hartl, Wolfgang Baumeister, Mark S. Hipp, Felix Meissner, Rubén Fernández‐Busnadiego, Dieter Edbauer,
... Search for more papers by this author Wolfgang Baumeister Wolfgang Baumeister Department of Molecular Structural Biology, Max Planck ... Search for more papers by this author Wolfgang Baumeister Wolfgang Baumeister Department of Molecular Structural Biology, Max Planck Institute ...
Tópico(s): Protein Degradation and Inhibitors
2022 - Springer Nature | EMBO Reports
Wolfgang Baumeister, R. Guckenberger, Harald Engelhardt, Christopher L. Woodcock,
... Decoration in Electron Microscopy of Biological Macromolecules WOLFGANG BAUMEISTER, WOLFGANG BAUMEISTER Max-Planck-Institut für Biochemie, D-8033 ... Search for more papers by this author WOLFGANG BAUMEISTER, WOLFGANG BAUMEISTER Max-Planck-Institut für Biochemie, D-8033 Martinsried, ...
Tópico(s): Ion-surface interactions and analysis
1986 - Wiley | Annals of the New York Academy of Sciences
Rubén Fernández‐Busnadiego, Nikolas Schrod, Zdravko Kochovski, Shoh Asano, Dimitri Vanhecke, W. Baumeister, Vladan Lučić,
... author on: Oxford Academic PubMed Google Scholar Wolfgang Baumeister, Wolfgang Baumeister * Max Planck Institute of Biochemistry, Am Klopferspitz 18, ...
Tópico(s): Photosynthetic Processes and Mechanisms
2011 - Oxford University Press | Microscopy
Itika Saha, Patricia Yuste‐Checa, Miguel da Silva Padilha, Qiang Guo, Roman Körner, Hauke Holthusen, Victoria A. Trinkaus, Irina Dudanova, Rubén Fernández‐Busnadiego, Wolfgang Baumeister, David W. Sanders, Saurabh Gautam, Marc I. Diamond, F. Ulrich Hartl, Mark S. Hipp,
Abstract Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The existence of cellular machinery for the removal of such aggregates has remained unclear, as specialized disaggregase chaperones are thought to be absent in mammalian cells. Here we show in cell culture and in neurons that the hexameric ATPase valosin-containing protein (VCP) is recruited to ubiquitylated Tau fibrils, resulting in their ...
Tópico(s): Heat shock proteins research
2023 - Nature Portfolio | Nature Communications
Beate Rockel, Jürgen Peters, Brigitte Kühlmorgen, Robert M. Glaeser, Wolfgang Baumeister,
... Search for more papers by this author Wolfgang Baumeister Corresponding Author Wolfgang Baumeister Department of Molecular Structural Biology, Max-Planck- ... Search for more papers by this author Wolfgang Baumeister Corresponding Author Wolfgang Baumeister Department of Molecular Structural Biology, Max-Planck-Institute ... Jürgen Peters2, Brigitte Kühlmorgen2, Robert M. Glaeser1 and Wolfgang Baumeister 2 1Life Sciences Division, Lawrence Berkeley National Laboratory, ...
Tópico(s): Biochemical and Molecular Research
2002 - Springer Nature | The EMBO Journal
Hideyuki Yoshimura, T. Scheybani, Wolfgang Baumeister, Kuniaki Nagayama,
... Protein Solution on Aqueous SubphasesHideyuki Yoshimura, Tschangiz Scheybani, Wolfgang Baumeister, and Kuniaki NagayamaCite this: Langmuir 1994, 10, 9, ...
Tópico(s): Protein purification and stability
1994 - American Chemical Society | Langmuir
Birgitta Kütting, Wobbeke Weistenhöfer, Thomas Baumeister, Wolfgang Uter, Hans Drexler,
The effectiveness of a skin care programme is based mainly on the effectiveness of the products used and the frequency and diligence of the application of skin care products.The present cross-sectional study was aimed at evaluating the implementation and acceptance of generally recommended skin protective means at the workplace.We included in our study 1355 metalworkers, employed in 19 factories, mainly of small or medium-size. The majority of participants were male (96.7%, n = 1310). The investigation ...
Tópico(s): Dermatology and Skin Diseases
2009 - Oxford University Press | British Journal of Dermatology
Eva Beiner, Victoria S. Lucas, Julian Reichert, Diana-Victoria Buhai, Meike Jesinghaus, Stephanie Vock, Armin Drusko, David Baumeister, Wolfgang Eich, Hans‐Christoph Friederich, Jonas Tesarz,
Evidence suggests an involvement of hypothalamic-pituitary-adrenal (HPA) axis dysregulation in the development and maintenance of fibromyalgia syndrome (FMS). However, studies on the stress response via the HPA-axis in individuals with FMS show conflicting results. To better understand the relationship between FMS and HPA-axis dysregulation, we (1) systematically summarized the current level of evidence on HPA biomarkers in individuals with FMS compared with individuals without and (2) evaluated whether ...
Tópico(s): Musculoskeletal pain and rehabilitation
2023 - Lippincott Williams & Wilkins | Pain
David Baumeister, Wolfgang Eich, Silvia Saft, Olga Geisel, Rainer Hellweg, Anja Finn, Camilla I. Svensson, Jonas Tesarz,
Abstract There has been a surging interest in the putative role of peripheral growth factors in the pathophysiology of fibromyalgia, specifically in the peripheral sensitization that occurs in chronic pain disorders. This cross-sectional study set out to assess and compare brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in plasma samples from fibromyalgia patients and healthy controls. Plasma BDNF and NGF were measured in 89 fibromyalgia patients and 36 pain-free controls, and ...
Tópico(s): Nerve injury and regeneration
2019 - Nature Portfolio | Scientific Reports
Katharina Lau, Sebastian‐Edgar Baumeister, Wolfgang Lieb, Peter J. Meffert, Markus M. Lerch, Julia Mayerle, Henry Völzke,
Summary Background Research on the association between alcohol consumption and hepatic steatosis revealed conflictive results. Aim To investigate the associations between average daily alcohol consumption and binge drinking with hepatic steatosis, and to analyse combined effects of average daily alcohol consumption and binge drinking with body mass index ( BMI ) on hepatic steatosis. Methods Data from the population‐based Study of Health in Pomerania ( SHIP ) conducted in north‐east Germany comprising 4009 ...
Tópico(s): Alcohol Consumption and Health Effects
2015 - Wiley | Alimentary Pharmacology & Therapeutics
Marcello Ricardo Paulista Markus, Peter J. Meffert, Sebastian E. Baumeister, Wolfgang Lieb, Ulrike Siewert, Sabine Schipf, Manja Koch, Jan A. Kors, Stephan B. Felix, Marcus Dörr, Giovanni Targher, Henry Völzke,
Background Hepatic steatosis (HS) affects up to 35% of adults in the general population. Atrial fibrillation (AF) is the most prevalent sustained arrhythmia and has a substantial impact on healthcare costs. We analyzed cross-sectional associations of HS and serum liver enzyme levels with prevalent AF in a general population sample. Methods We analyzed data from 3090 women and men, aged 20–81 years, from the population-based Study of Health in Pomerania. HS was determined by ultrasonography. Serum ...
Tópico(s): Liver Disease and Transplantation
2015 - Elsevier BV | Atherosclerosis
Robin Haring, Sebastian E. Baumeister, Wolfgang Lieb, Bettina von Sarnowski, Henry Völzke, Stephan B. Felix, Matthias Nauck, Henri Wallaschofski,
Background Elevated glycated hemoglobin (HbA1c) is associated with increased risk of cardiovascular disease (CVD) and mortality but little is known about potential mechanisms underlying the reported associations. Methods We used data from 1798 non-diabetic participants from the population-based cohort Study of Health in Pomerania (SHIP) to investigate cross-sectional and longitudinal associations of HbA1c with subclinical atherosclerosis (common carotid artery intima-media thickness [CCA-IMT]), cardiac ...
Tópico(s): Diabetes Management and Research
2014 - Elsevier BV | Diabetes Research and Clinical Practice
Neeltje van den Berg, Claudia Meinke-Franze, Thomas Fiß, Sebastian E. Baumeister, Wolfgang Hoffmann,
Data of the German population-based cohort SHIP (Study of Health in Pomerania) were analysed to examine treatment rates, antihypertensive substances prescribed, and the proportion of hypertensive study participants reaching target values for blood pressure as well as determinants. The study population was defined using baseline data of the cohort (collected between 1997 and 2001). Participants with blood pressure values ≥140/90 mmHg and/or antihypertensive medication with known hypertension and participants ...
Tópico(s): Sodium Intake and Health
2013 - BioMed Central | BMC Public Health
Henry Völzke, K.M. Kloker, Axel Krämer, Lutz Güertler, Martina Dören, Sebastian‐Edgar Baumeister, Wolfgang Hoffmann, Ulrich John,
Recent outbreaks of diphtheria have drawn attention to the re-emergence of this disease. This study investigated susceptibility to diphtheria in north-east Germany and its relationship to gender and social factors. A study population of 4275 individuals recruited for the population-based Study of Health in Pomerania (SHIP) was available for analysis. IgG antibodies against diphtheria toxin were determined by ELISA and were used to define susceptibility to diphtheria (i.e., IgG titres < 0.1 IU/mL). The ...
Tópico(s): Intramuscular injections and effects
2006 - Elsevier BV | Clinical Microbiology and Infection
Stefan Buziol, Imtiaz Bashir, Anja Baumeister, Wolfgang Claaßen, Naruemol Noisommit‐Rizzi, Werner Mailinger, Matthias Reuß,
Abstract Knowledge of concentrations of intracellular metabolites is important for quantitative analysis of metabolic networks. As far as the very fast response of intracellular metabolites in the millisecond range is concerned, the frequently used pulse technique shows an inherent limitation. The time span between the disturbance and the first sample is constrained by the time necessary to obtain a homogeneous distribution of the pertubation within the bioreactor. For determination of rapid changes, ...
Tópico(s): Mass Spectrometry Techniques and Applications
2002 - Wiley | Biotechnology and Bioengineering
Hans Baumeister, Wolfgang Meyerhof,
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2000 - Elsevier BV | Journal of Physiology-Paris
Hans-Jürgen Kreienkamp, Ercan Akgün, Hans Baumeister, Wolfgang Meyerhof, Dietmar Richter,
Somatostatin (SST) inhibits the secretion of many peptide hormones including growth hormone (GH). The various functions of SST are mediated through at least five different receptor subtypes (SSTR1–5), their precise physiological roles have not been solved yet. Here we report on studies concerning the functional role of SSTR1 in the modulation of GH release from somatotrophs. Primary cell cultures from pituitaries of wild‐type SSTR1 mice exposed to the SSTR1 selective somatostatin analog CH‐275 show ...
Tópico(s): Neuroendocrine Tumor Research Advances
1999 - Wiley | FEBS Letters
Johann Baumeister, Wolfgang Scondo, Michael A. Demetriou, I. G. Rosen,
The on-line or adaptive identification of parameters in abstract linear and nonlinear infinite-dimensional dynamical systems is considered. An estimator in the form of an infinite-dimensional linear evolution system having the state and parameter estimates as its states is defined. Convergence of the state estimator is established via a Lyapunov estimate. The finite-dimensional notion of a plant being sufficiently rich or persistently excited is extended to infinite dimensions. Convergence of the ...
Tópico(s): Nonlinear Dynamics and Pattern Formation
1997 - Society for Industrial and Applied Mathematics | SIAM Journal on Control and Optimization
Ute Baumeister, Wolfgang Brandt, H. Hartung, Mariusz Jaskólski,
On the Conformational Behaviour of Substituted Phenylbenzoates ‐ Molecular and Crystal Structure of the Nematogenic Compound 4′‐(ß‐Cyanoethyl)‐phenyl‐4‐n‐pentoxybenzoate The title compound crystallizes in the monoclinic space group P2 1 /n with a = 1567.6(2) pm, b = 915.5(1) pm, c = 1459.1(1) pm, β = 115.30(1)°, and four molecules per unit cell. The structure has been solved by direct methods and refined to R = 0.104. The molecules adopt a markedly stretched form and show a parallel arrangement of their long ...
Tópico(s): Polyoxometalates: Synthesis and Applications
1983 - Wiley | Journal für praktische Chemie
Melissa Hoyer, Cristina Capitanio, Ian R. Smith, Julia C. Paoli, Anna Bieber, Yizhi Jiang, João A. Paulo, Miguel A. Gonzalez‐Lozano, Wolfgang Baumeister, Florian Wilfling, Brenda A. Schulman, J. Wade Harper,
The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate many cellular functions, ranging from protein and lipid synthesis to calcium ion flux and inter-organelle communication. A case in point concerns the process of neurogenesis, where a refined tubular ER network is assembled via ER shaping proteins into the newly formed neuronal projections to create highly polarized dendrites and axons. Previous studies have suggested a role for autophagy in ER remodelling, as autophagy- ...
Tópico(s): Protein Degradation and Inhibitors
2024 - Nature Portfolio | Nature Cell Biology
Marco Schärfke, Hans Baumeister, Wolfgang Meyerhof,
... Silver-Stained Proteins on Nitrocellulose MembranesMarco Schärfke, Hans Baumeister & Wolfgang MeyerhofMarco SchärfkeDeutsches Institut für Ernährungsforschung und Universität Potsdam, ...
Tópico(s): Advanced Proteomics Techniques and Applications
2001 - Future Science Ltd | BioTechniques
Sophie Reimann, Ute Baumeister, Wolfgang H. Binder,
The synthesis and thermal properties of a new type of precision polyethylene containing perfectly placed conformationally constraining elements after every 16 methylene units are presented. The precise placement of a 2,6‐diaminopyridine moiety (DAP) is accomplished via acyclic diene metathesis (ADMET) polymerization of specially designed monomers, where the DAP serves as the conformational constraint. Polymerization of the diene‐monomer ( N,N′ ‐pyridin‐2,6‐diyl‐bis‐dec‐9‐enamide) displaying free‐amide ...
Tópico(s): Organometallic Complex Synthesis and Catalysis
2014 - Wiley | Macromolecular Chemistry and Physics
Dorothy Yanling Zhao, Felix J.B. Bäuerlein, Itika Saha, F. Ulrich Hartl, Wolfgang Baumeister, Florian Wilfling,
Aggregation of proteins containing expanded polyglutamine (polyQ) repeats is the cytopathologic hallmark of a group of dominantly inherited neurodegenerative diseases, including Huntington's disease (HD). Huntingtin (Htt), the disease protein of HD, forms amyloid-like fibrils by liquid-to-solid phase transition. Macroautophagy has been proposed to clear polyQ aggregates, but the efficiency of aggrephagy is limited. Here, we used cryo-electron tomography to visualize the interactions of autophagosomes ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2024 - Elsevier BV | Molecular Cell
Maryam Khoshouei, Günther Gerisch, Maria Ecke, Julio Ortiz, Jiirgen M. Plitzko, Radostin Danev, Wolfgang Baumeister,
... this author on: Oxford Academic Google Scholar Wolfgang Baumeister Wolfgang Baumeister Department of Molecular Structural Biology, Max-Planck Institute ...
Tópico(s): Surface Chemistry and Catalysis
2015 - Oxford University Press | Microscopy and Microanalysis
Ute Baumeister, Wolfgang Brandt, H. Hartung, W. Wedler, H.-J. Deutscher, R. Frach, Mariusz Jaskólski,
Abstract The title compound, with the formula C4H9—C6H10—CH2—C6H10—COO—C6H4CN (CBMC), crystallizes in the monoclinic space group P21/n with a = 6.4075(7) Å, b = 18.345(2) Å c = 19.423(2) Å, β = 98.614(9) Å and four molecules per unit cell. The structure was solved by direct methods and refined to R = 0.052. The CBMC molecules adopt an elongated banana-shaped form enabling the formation of a monotropic nematic phase 2 degrees below the melting point. The X-ray experiments were complemented by a conformational ...
Tópico(s): Plant and animal studies
1985 - | Molecular crystals and liquid crystals
Meijing Li, Ishita Tripathi‐Giesgen, Brenda A. Schulman, Wolfgang Baumeister, Florian Wilfling,
Selective macroautophagy (hereafter referred to as autophagy) describes a process in which cytosolic material is engulfed in a double membrane organelle called an autophagosome. Autophagosomes are carriers responsible for delivering their content to a lytic compartment for destruction. The cargo can be of diverse origin, ranging from macromolecular complexes to protein aggregates, organelles, and even invading pathogens. Each cargo is unique in composition and size, presenting different challenges ...
Tópico(s): RNA Interference and Gene Delivery
2023 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Christos Papantoniou, Ulrike Laugks, Julia Betzin, Cristina Capitanio, José Javier Ferrero, José Sánchez‐Prieto, Susanne Schoch, Nils Brose, Wolfgang Baumeister, Benjamin H. Cooper, Cordelia Imig, Vladan Lučić,
Synaptic vesicle tethering, priming, and neurotransmitter release require a coordinated action of multiple protein complexes. While physiological experiments, interaction data, and structural studies of purified systems were essential for our understanding of the function of the individual complexes involved, they cannot resolve how the actions of individual complexes integrate. We used cryo-electron tomography to simultaneously image multiple presynaptic protein complexes and lipids at molecular ...
Tópico(s): Neuroscience and Neuropharmacology Research
2023 - American Association for the Advancement of Science | Science Advances
Hugo van den Hoek, Nikolai Klena, Mareike A. Jordan, Gonzalo Alvarez Viar, Ricardo D. Righetto, Miroslava Schaffer, Philipp S. Erdmann, William Wan, Stefan Geimer, Jürgen M. Plitzko, Wolfgang Baumeister, Gaia Pigino, Virginie Hamel, Paul Guichard, Benjamin D. Engel,
The cilium is an antenna-like organelle that performs numerous cellular functions, including motility, sensing, and signaling. The base of the cilium contains a selective barrier that regulates the entry of large intraflagellar transport (IFT) trains, which carry cargo proteins required for ciliary assembly and maintenance. However, the native architecture of the ciliary base and the process of IFT train assembly remain unresolved. In this work, we used in situ cryo-electron tomography to reveal ...
Tópico(s): Protist diversity and phylogeny
2022 - American Association for the Advancement of Science | Science
Cryogenic electron tomography (cryo-ET) is the application of tomographic principles of data acquisition and reconstruction to frozen-hydrated biological specimens. It combines a close-to-life preservation of cellular structures with the power of high-resolution three-dimensional imaging, which allows us to study the molecular architecture of cells, or their molecular sociology, in unprecedented detail. Cryogenic electron tomography (cryo-ET) is the application of tomographic principles of data acquisition ...
Tópico(s): Advanced X-ray Imaging Techniques
2022 - Cell Press | Cell