J. B. Griffin, Phil Yates, Liz Dolan, Widget Finn, Edward Owen, Alasdair Palmer, Peter Talbot Willcox, Andrew Pierce, Anatol Lieven, Jeremy Laurance, Rachel Cusk, Elizabeth Symons, Andrew Longmore, Tim Judah, Neil Bennett, Janet Bush, Economics Correspondent, Harvey Elliott, Ross Tieman, Industrial Correspondent, Philip Howard, Hilary Finch, Barry Watson (Secretary), Alexandra Frean Media Correspondent, James Bone, Roy Turner, Christopher Martin, Headmaster, Damian Whitworth and Katherine Bergen, Carl Mortished, Colin Narbrough, Michael Dynes and David Walker, Geoff Brown, Robert Sheehan, Bridge Correspondent, L. J. Manley, Giles Coren, Robert Miller, Joe Joseph, Martin Fletcher, Stuart Jones, John Adamson, Steve Keenan, Jonathan Prynn, Political Reporter, Stewart Tendler Crime Correspondent, Alan Lorimer, Norman Hammond, Archaeology Correspondent, Peter Ball, Alice Thomson Political Reporter, Jim McCue, Ewan Harper, Peter Ball and Louise Taylor, Raymond Keene Chess Correspondent, Rodney Sweetnam, Rachel Kelly, Ruth Gledhill Religion Correspondent, Nick Nuttall Technology Correspondent, Peter Waymark, Richard Ford Home Correspondent, Robin Young, Alice Thomson and Jonathan Prynn, Rodney Milnes, Eileen Fursland, Robert Bruce, Peter Smithers, Michael Clark, John Young, Anatole Kaletsky, David Hands, Charles Bremner, Michael Hughes, Ian McIntyre, Philip Bassett, Industrial Editor, Charles Elly, President, Aileen Ballantyne, Derwent May, Simon Tait, Elizabeth Weir, Russell Kempson, James Weir, John Woodcock, Janet Daley, Lucy Berrington, M. A. Jackson-Roberts, David Miller, Andrew Pierce and Ben Preston, Terry Eccles, Arthur Leathley, Political Correspondent, Wolfgang Münchau, Graham King, Dalya Alberge, Arts Correspondent, Piers Pottinger, Tim Jones, Transport Correspondent, Raymond Keene, David Robinson, Peter Davalle, Alan Clark, Frances Gibb, Legal Correspondent, Paul Wilkinson, P. H. S, Roger Smith, Director, Rodney Brooke, George Sivell, Assistant Business Editor, N. H. White, Barry Pickthall, Nigel Hawkes, Science Editor, Tim Heald, Kate Alderson, Janet M. Kapp, Julian Muscat, Neil Bennett, Deputy Business Editor, Martin Waller, Deputy City Editor, Ian Murray, Community Correspondent, Christopher Thomas, Ronnie Fox and Ian Hunter, David Churchill, kris Anderson, Agence France-Presse, Giles Whittell, Philip Webster Political Editor, Christopher Walker, Chris Parker, Kathryn Knight, Richard Evans Racing Correspondent, David Park, Alan Lee, Peter Riddell, Richard Beeston, Marianne Curphey and David Churchill, Allen Robertson, Ronald Teeman, Nadine Meisner, David Walker, Tim Jones, L. W. Docker, Robert Vint (Administrator), Tom Rhodes, Alan Hamilton and Marianne Darch, Philip Webster, Arthur Leathley and Jill Sherman, Jill Sherman, Political Correspondent, Marianne Curphey, Dr Thomas Stuttaford, John Howell, Michael Henderson, John Phillips, Alan Jackson, Stuart Henderson, Ross Tieman, Matthew Bond, John Dege, Stephen Tumim, Christopher Irvine, C. Langley,
Tories begin to woo back Euro-rebels Blair lambasts his 'foolish' MEPs Japan barred from VJ-Day £700,000 bill for forged painting Appointments Index Markets ...
1995 - Gale Group | TDA
Gabriele Zeck‐Kapp, Wolfgang Czech, Alexander Kapp,
Abstract Human dermal mast cells are capable of releasing cytokines, particularly preformed TNFα, upon appropriate stimulation. Masl cell activation in vivo was shown to be associated with an influx and activation of inflammatory cells, initially PMN “polymorphonuclear neutrophilic granulocytes” then eosinophils. In order to learn more about the mechanisms by which TNFα is capable of activating eosinophils, in the present study the effect of TNFα on morphology and function of highly purified normal ...
Tópico(s): Asthma and respiratory diseases
1994 - Wiley | Experimental Dermatology
Alexander Kapp, Gabriele Zeck‐Kapp, Wolfgang Czech, Erwin Schöpf,
Tópico(s): Eosinophilic Disorders and Syndromes
1994 - Elsevier BV | Journal of Investigative Dermatology
Alexander Kapp, Wolfgang Czech, Jean Krutmann, Erwin Schöpf,
Patients with atopic dermatitis frequently show elevated blood eosinophil counts, and eosinophil-derived major basic protein has been demonstrated in the eczematous skin from patients with atopic dermatitis. To evaluate further the role of eosinophils in the pathogenesis of atopic dermatitis, the concentration of eosinophil cationic protein was measured in serum samples of 42 patients with moderate to severe disease. The results were compared with those obtained in 32 patients with psoriasis with ( ...
Tópico(s): Allergic Rhinitis and Sensitization
1991 - Elsevier BV | Journal of the American Academy of Dermatology
Christoph Schubart, Robert Stöhr, Lars Tögel, Florian Fuchs, Horia Sı̂rbu, Gerhard Seitz, Ruth Seggewiß-Bernhardt, Rumo Leistner, William Sterlacci, Michael Vieth, Christoph Seidl, Michael Mugler, Markus Kapp, Wolfgang Hohenforst‐Schmidt, Arndt Hartmann, Florian Haller, Ramona Erber,
In non-small cell lung cancer (NSCLC), approximately 1-3% of cases harbor an increased gene copy number (GCN) of the MET gene. This alteration can be due to de novo amplification of the MET gene or can represent a secondary resistance mechanism in response to targeted therapies. To date, the gold standard method to evaluate the GCN of MET is fluorescence in situ hybridization (FISH). However, next-generation sequencing (NGS) is becoming more relevant to optimize therapy by revealing the mutational profile ...
Tópico(s): Cancer Genomics and Diagnostics
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Nadine Kapp, Wolfgang G. Kreyling, Holger Schulz, Vinzenz Im Hof, Peter Gehr, Manuela Semmler, Marianne Geiser,
Abstract Epidemiologic studies have associated cardiovascular morbidity and mortality with ambient particulate air pollution. Particles smaller than 100 nm in diameter (ultrafine particles) are present in the urban atmosphere in very high numbers yet at very low mass concentration. Organs beyond the lungs are considered as targets for inhaled ultrafine particles, whereby the route of particle translocation deeper into the lungs is unclear. Five rats were exposed to aerosols of ultrafine titanium ...
Tópico(s): Energy and Environment Impacts
2004 - Wiley | Microscopy Research and Technique
... and ingloriusly ended with the resignation of Dr. Wolfgang Kapp on March 17, has already been the subject of significant study. The details of the putsch ...
Tópico(s): European history and politics
1971 - Cambridge University Press | Central European History
Manfred Kapps, Wolfgang Kirmse,
Angewandte Chemie International Edition in EnglishVolume 8, Issue 1 p. 75-75 Communication Catalyzed Reactions of Diazomethane with Vinyloxirane Dr. M. Kapps, Dr. M. Kapps Institut für Organische Chemie der Universität, 355 Marburg, Bahnhofstr. 7 (Germany)Search for more papers by this authorProf. Dr. W. Kirmse, Corresponding Author Prof. Dr. W. Kirmse Institut für Organische Chemie der Universität, 355 Marburg, Bahnhofstr. 7 (Germany)Institut für Organische Chemie der Universität, 355 Marburg, Bahnhofstr. ...
Tópico(s): Advanced Chemical Physics Studies
1969 - Wiley | Angewandte Chemie International Edition
Marianne Geiser, Barbara Rothen‐Rutishauser, Nadine Kapp, Samuel Schürch, Wolfgang G. Kreyling, Holger Schulz, Manuela Semmler, Vinzenz Im Hof, J. Heyder, Peter Gehr,
High concentrations of airborne particles have been associated with increased pulmonary and cardiovascular mortality, with indications of a specific toxicologic role for ultrafine particles (UFPs; particles < 0.1 microm). Within hours after the respiratory system is exposed to UFPs, the UFPs may appear in many compartments of the body, including the liver, heart, and nervous system. To date, the mechanisms by which UFPs penetrate boundary membranes and the distribution of UFPs within tissue compartments ...
Tópico(s): Air Quality Monitoring and Forecasting
2005 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
WOLFGANG A. KAPP, DONALD G. LEMKE,
Tópico(s): Electromagnetic Launch and Propulsion Technology
1965 - American Institute of Aeronautics and Astronautics | AIAA Journal
Manfred Kapps, Wolfgang Kirmse,
Angewandte ChemieVolume 81, Issue 2 p. 86-86 Zuschriften Katalysierte Reaktionen des Diazomethans mit Vinyloxiran Dr. M. Kapps, Dr. M. Kapps Institut für Organische Chemie der Universität 355 Marburg, Bahnhofstraße 7Search for more papers by this authorProf. Dr. W. Kirmse, Prof. Dr. W. Kirmse Institut für Organische Chemie der Universität 355 Marburg, Bahnhofstraße 7Search for more papers by this author Dr. M. Kapps, Dr. M. Kapps Institut für Organische Chemie der Universität 355 Marburg, Bahnhofstraße ...
Tópico(s): Asymmetric Synthesis and Catalysis
1969 - Wiley | Angewandte Chemie
Dietmar Öfner, Alexander DeVries, Renate Schaberl-Moser, Richard Greil, Hans Rabl, Jörg Tschmelitsch, Matthias Zitt, Karin S. Kapp, Gerd Fastner, Felix Keil, Wolfgang Eisterer, Robert Jäger, Felix Offner, Michael Gnant, Josef Thaler,
Tópico(s): Colorectal Cancer Treatments and Studies
2011 - Springer Science+Business Media | Strahlentherapie und Onkologie
Jörn Elsner, Martin Oppermann, Wolfgang Czech, Alexander Kapp,
In contrast to C5a, which represents a well-established potent activator of the respiratory burst in polymorphonuclear neutrophilic granulocytes (PMN), the functional role of C3a in the activation of PMN is, so far, poorly understood. Herein, the potential role of human C3a in the activation of the respiratory burst in human PMN was investigated. The release of reactive oxygen species (ROS) of PMN from healthy donors was measured by lucigenin-dependent chemiluminescence. C3a dose-dependently induced ...
Tópico(s): Blood disorders and treatments
1994 - Elsevier BV | Blood
Jean Krutmann, Thomas L. Diepgen, Thomas A. Luger, Stephan Grabbe, H Meffert, N Sönnichsen, Wolfgang Czech, Alexander Kapp, H. Stege, Markus Grewe, Erwin Schöpf,
Abstract Background: The results of an open, single-center study suggested that phototherapy with high doses of UVA1 radiation (UVA1R; 340-400 nm) is effective for acute, severe exacerbations of atopic dermatitis (AD). Objective: The purpose of this study was to assess the effectiveness of high-dose UVA1 phototherapy for acute, severe AD in a randomized multicenter trial in direct comparison with topical glucocorticoid therapy. Methods: Patients were treated with high-dose UVA1R (10 days, 130 J/cm 2 /day; n = ...
Tópico(s): Asthma and respiratory diseases
1998 - Elsevier BV | Journal of the American Academy of Dermatology
Jörn Elsner, Martin Oppermann, Wolfgang Czech, Alexander Kapp,
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1994 - Elsevier BV | Blood
Wolfgang Kirmse, Manfred Kapps,
Abstract Einwirkung von Alkali auf Alkyl‐diallyl‐sulfonium‐Salze ( 3 bzw. 5 ) führt zu Alkyl‐[1‐vinyl‐buten‐(3)‐yl]‐sulfiden ( 4 bzw. 6 ). Die Wanderung eines Allylrestes in die zweite Allylstellung verläuft unter vollständiger Allylumlagerung, wie mit Hilfe deuterierter Verbindungen gezeigt wird.
Tópico(s): Chemical Synthesis and Reactions
1968 - Wiley | Chemische Berichte
Wolfgang Kirmse, Manfred Kapps,
Abstract Diazomethan reagiert mit Diallylsulfid und Allyläthern in Gegenwart von Kupfersalzen unter Cyclopropanbildung und Kettenverlängerung zu Butenyl‐Derivaten. Letztere entstehen unter Allylumlagerung. Die Reaktion wird als elektrophiler Angriff des modifizierten Methylens auf das Heteroatom mit anschließender Stevens‐Umlagerung gedeutet.
Tópico(s): Cyclopropane Reaction Mechanisms
1968 - Wiley | Chemische Berichte
Wolfgang Kirmse, Manfred Kapps, Robert B. Hager,
Abstract Einwirkung von Diazomethan auf Allylhalogenide in Gegenwart von Kupfersalzen liefert neben Halogenmethyl‐cyclopropanen auch 4‐Halogen‐olefine. Die Produktverteilung ist von der Art des Halogens, von den Substituenten an der Doppelbindung, vom Katalysator und vom Lösungsmittel abhängig. Die Cyclopropanbildung verläuft stereospezifisch. Die 4‐Halogen‐olefine entstehen unter Allylumlagerung, wie an methylsubstituierten und deuterierten Verbindungen gezeigt wird. Als Reaktionsmechanismus wird ...
Tópico(s): Synthetic Organic Chemistry Methods
1966 - Wiley | Chemische Berichte
İ. Çelik, Martin Hoppe, W. Lorenz, H. Sitter, N. Ishaque, Wolfgang Jungraithmayr, Bruce S. Kapp, E Schmiedel, K. J. Klose -RID -- -,
Tópico(s): Lanthanide and Transition Metal Complexes
1999 - Springer Science+Business Media | Inflammation Research
Franziska Veit, Dieter Graf, Saskia Momberger, Brigitte Helmich-Kapp, I Ruschenburg, Anja Peters, J. Kußmann, Wolfgang Saeger, Kurt Schmidt, Martin Toetsch, Kai Nestler, Klaus Mann,
Histological findings often display an association between papillary thyroid carcinomas (PTC) and autoimmune thyroiditis (AIT) and so differ significantly from follicular thyroid carcinomas (FTC). The aim of this interdisciplinary, retrospective study was to evaluate the association of AIT in patients with PTC and FTC and a control group of benign nodular goiters. One hundred thyroidectomies with histologically confirmed differentiated thyroid carcinomas, 67 with PTC and 33 with FTC, were submitted ...
Tópico(s): Genetic factors in colorectal cancer
2017 - Thieme Medical Publishers (Germany) | Hormone and Metabolic Research
Richard Pötter, Michael Gnant, W. Kwasny, Christoph Tausch, L. Handl-Zeller, B. Pakisch, Susanne Taucher, J. Hammer, G. Luschin-Ebengreuth, Marianne Schmid, Felix Sedlmayer, M. Stierer, G. Reiner, Karin S. Kapp, F Hofbauer, Andrea Rottenfusser, Sabine Pöstlberger, K. Haider, Wolfgang Draxler, R. Jakesz,
Purpose: In women with favorable early breast cancer treated by lumpectomy plus tamoxifen or anastrazole, it remains unclear whether whole breast radiotherapy is beneficial. Methods and Material: Between January 1996 and June 2004, the Austrian Breast and Colorectal Cancer Study Group (ABCSG) randomly assigned 869 women to receive breast radiotherapy ± boost (n = 414) or not (n = 417) after breast-conserving surgery (ABCSG Study 8A). Favorable early breast cancer was specified as tumor size <3 cm, Grading ...
Tópico(s): Breast Lesions and Carcinomas
2007 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Jonas S. Heitmann, Daniela Dörfel, Sabine Käyser, Michael Heuser, Felicitas Thol, Silke Kapp‐Schwoerer, Wolfgang Bethge, Ludger Große‐Hovest, Martin Steiner, Melanie Märklin, Juliane S. Walz, Richard F. Schlenk, Gundram Jung, Helmut R. Salih,
Even when achieving morphological complete remission (CR) after induction therapy, roughly half of acute myeloid leukemia (AML) patients display measurable residual disease (MRD) and eventually relapse. The surface receptor FLT3/CD135 is expressed on AML cells in almost all patients and constitutes a highly selective target antigen for immunotherapy, as expression on healthy tissues is limited to low levels on dendritic cells, monocytes and hematopoietic progenitor cells. FLYSYN is a chimeric Fc-optimized ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2020 - Elsevier BV | Blood
Marcus König, Wolfgang Vanscheidt, Matthias Augustin, H. Kapp,
Objective: A randomised clinical trial (n=42) compared the effectiveness of two approaches to debriding chronic leg ulcers: TenderWet 24, which is designed to support the autolytic degradation process, and Iruxol N (Santyl), an enzymatic treatment claimed to enhance the degradation process. Method: Patients were randomly assigned to one of the two treatment groups for three weeks. Wounds were evaluated weekly for the amount of eschar/slough, the area of healthy granulation and the re-epithelialised ...
Tópico(s): Date Palm Research Studies
2005 - Mark Allen Group | Journal of Wound Care
Wolfgang Czech, E. SCHÖPE, Alexander Kapp,
Tópico(s): Cell Adhesion Molecules Research
1996 - Oxford University Press | British Journal of Dermatology
Wolfgang Czech, E. SCHÖPE, Alexander Kapp,
E-selectin endothelial leucocyte adhesion molecule-1 is expressed on endothelial cells in distinct inflammatory skin diseases. E-selectin mediates the adhesion between activated endothelium and different inflammatory cells. To evaluate soluble E-selectin as a marker of disease activity in patients with atopic dermatitis and psoriasis, the concentration of soluble E-selectin, determined by ELISA, was studied in sera of patients before and after treatment and compared with normal non-atopic controls. ...
Tópico(s): Immune Response and Inflammation
1996 - Oxford University Press | British Journal of Dermatology
Wolfgang Czech, Erwin Schöpf, Alexander Kapp,
Tópico(s): Drug-Induced Adverse Reactions
1995 - Springer Science+Business Media | Inflammation Research
Johannes Ring, Knut Brockow, D. Duda, Thomas Eschenhagen, Thomas Fuchs, Isidor Huttegger, Alexander Kapp, Ludger Klimek, Ulrich Müller, B. Niggemann, Oliver Pfaar, Bernhard Przybilla, Wolfgang Rebien, E. Rietschel, Franziska Ruëff, Sabine Schnadt, M. Tryba, Margitta Worm, H. Sitter, G. Schultze‐Werninghaus,
Tópico(s): Asthma and respiratory diseases
2007 - Dustri-Verlag | Allergologie
Johannes Ring, Knut Brockow, D. Duda, Thomas Eschenhagen, Thomas Fuchs, Isidor Huttegger, Alexander Kapp, Ludger Klimek, Ulrich Müller, B. Niggemann, Oliver Pfaar, Bernhard Przybilla, Wolfgang Rebien, Ernst Rietschel, Franziska Ruëff, Sabine Schnadt, M. Tryba, Margitta Worm, H. Sitter, G. Schultze‐Werninghaus,
Tópico(s): Contact Dermatitis and Allergies
2007 - Springer Nature | Allergo Journal
Bettina Wedi, J. Elsner, Wolfgang Czech, J. H. Butterfield, Alexander Kapp,
The effect of inflammatory mediators on the expression of several surface adhesion molecules on the human mast-cell line (HMC)-1 was studied. By flow cytometry, it could be shown that among several surface adhesion molecules (ICAM-1/CD54, VLA-4/CD49d, Mac-1/CD11b, LFA-1/CD11a, LFA-2/CD2, LFA-3/CD58, VCAM-1), only the constitutively expressed immunoglobulin family member intercellular adhesion molecule-1 (ICAM-1) is modulated by proinflammatory cytokines on HMC-1 mast cells. Stimulation with tumor necrosis ...
Tópico(s): Asthma and respiratory diseases
1996 - Wiley | Allergy
Luisa F. Jiménez‐Soto, Stefan Kutter, Xaver Sewald, Claudia Ertl, Evelyn Weiss, U. Kapp, Manfred Rohde, Torsten Pirch, Kirsten Jung, Saverio Francesco Retta, Laurent Terradot, Wolfgang Fischer, Rainer Haas,
Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector protein via the cag-Type IV Secretion System (T4SS) into host cells is a major risk factor for severe gastric diseases, including gastric cancer. However, the mechanism of translocation and the requirements from the host cell for that event are not well understood. The T4SS consists of inner- and outer membrane-spanning Cag protein complexes and a surface-located pilus. Previously an arginine-glycine-aspartate ( ...
Tópico(s): Cell Adhesion Molecules Research
2009 - Public Library of Science | PLoS Pathogens