Xiao Chen, Dongdong Wang, Hong Xu, Zhiping Li,
... weight, the CYP3A5 genotype and combined treatment with Wuzhi capsule can affect tacrolimus clearance in children with ... were CYP3A5*3/*3 and did not take Wuzhi capsule, people who had the CYP3A5*1 allele and did not take Wuzhi capsule, people who were CYP3A5*3/*3 and took Wuzhi capsule, and people who had the CYP3A5*1 allele and took Wuzhi capsule, respectively. In addition, we found that 0. ... were CYP3A5*3/*3 and did not take Wuzhi capsule, who were CYP3A5*3/*3 and took Wuzhi capsule, and who had the CYP3A5*1 allele ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2019 - Wiley | Journal of Clinical Pharmacy and Therapeutics
Lin Yan, Zhiqiang Yang, Yunying Shi, Jing Ren, Cuili Yang, Zhengli Wan, Yangjuan Bai, Limei Luo, Lanlan Wang, Yi Li,
... was demonstrated in rats and healthy volunteers that Wuzhi capsules could inhibit metabolism and maintain blood concentration ... tacrolimus. However, there are no clinical studies of Wuzhi capsules in renal transplant recipients. This research aimed to assess the effect of Wuzhi capsules on the blood concentration of tacrolimus in ... renal transplant recipients receiving tacrolimus with or without Wuzhi capsules were included in this retrospective study. The ... study included 126 recipients, with 86 recipients receiving Wuzhi capsules (WZCs) and the other 40 recipients not ...
Tópico(s): Drug Transport and Resistance Mechanisms
2019 - International Scientific Information Inc. | Annals of Transplantation
Xiao Chen, Dongdong Wang, Hong Xu, Zhiping Li,
... the polymorphisms of CYP3A5, and concomitant medication of wuzhi-capsule were included into the covariates affecting tacrolimus ... carry CYP3A5*3/*3 and no coadministration of wuzhi-capsule, patients who carry CYP3A5*1 allele and no coadministration of wuzhi-capsule, patients who carry CYP3A5*3/*3 and coadministration of wuzhi-capsule, patients who carry CYP3A5*1 allele and coadministration of wuzhi-capsule, and their clearance ratios were 1:1. ... patients based on CYP3A5 genotype and coadministration with wuzhi-capsule.
Tópico(s): Pharmacogenetics and Drug Metabolism
2019 - Taylor & Francis | Xenobiotica
C. Liu, Songmei Hu, Luhuan Fei, Zongguang Huang,
... 64III0604, adult male; type locality : Xin-min Ziang, Wuzhi Shan,Hainan, altitude 750m; May 20, 1964; collected ... collected with the holotype.Paratypes: 21 , 3 from Wuzhi Shan and Dali of Diaulo Shan, Hainan; altitude ... Wang I-sheng.Allotype: No. 64III0673, adult 'female; Wuzhi Shan, Hainan, altitude 800 m; May 4, 1964. ... stages including metamor-phosized individuals, from Jingko Ling, Wuzhi Shan, Dali of Diaulo Shan, Gianfen Ling and ... 4)Holotype: No. 64III1371, adult male; type locality: Wuzhi Shan, Hainan, altitude 700 m; May 14, 1964; ...
Tópico(s): Wildlife Ecology and Conservation
1973 - | Dongwu xuebao
Lizhi Chen, Yunyun Yang, Xuebin Wang, Chenyu Wang, Wei-Wei Lin, Zheng Jiao, Zhuo Wang,
... and better understand the drug-drug interaction between Wuzhi capsule and tacrolimus in Chinese renal transplant recipients. ... linear mixed-effects model to determine the suitable Wuzhi capsule dose in combination with tacrolimus. Data on ... Our final model identified creatinine clearance rate, hematocrit, Wuzhi capsule dose, CYP3A5*3 genetic polymorphisms, and tacrolimus ... between-subject variability (BSV) was 25.4%. The Wuzhi capsule showed a dose-dependent effect on tacrolimus ... of tacrolimus when combined with different doses of Wuzhi capsule. Additionally, this model can be used for ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2021 - Dove Medical Press | Pharmacogenomics and Personalized Medicine
Huizhen Zhang, Yiming Jiang, Jingjing Wu, Chuanqi Zheng, Xiaorong Ran, Dongshun Li, Min Huang, Huichang Bi,
... a restorative, tonic and nutrition in many countries. Wuzhi tablet, an ethanol extract preparation of Schisandra sphenanthera , ... used in China. Our previous studies show that Wuzhi tablet and its active lignans significantly protect liver ... was employed to decipher the metabolic map of Wuzhi tablet and its active lignans. Serum (2 h) ... a 700 mg/kg single oral dose of Wuzhi tablet, and mice liver microsome samples after incubation ... in vivo studies revealed the metabolic profile of Wuzhi tablet and its active lignans and demethylation and ...
Tópico(s): Biochemical Acid Research Studies
2016 - Wiley | Journal of Separation Science
Jiali Li, Siyang Chen, Xiaoling Qin, Qian Fu, Huichang Bi, Yu Zhang, Xueding Wang, Longshan Liu, Changxi Wang, Min Huang,
... of an ethanolic extraction preparation of Schisandra sphenanthera (Wuzhi tablet) as a tacrolimus-sparing agent in renal ... the Part I study. After co-administration of Wuzhi tablet, the average individual increment (%) in dose-adjusted ... assigned to receive tacrolimus by CYP3A5 genotype plus Wuzhi tablet co-administration guided dosing (study group) or ... groups. Our results show that CYP3A5 genotype plus Wuzhi tablet co-administration guided tacrolimus dosing is a ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2017 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Hua Wei, Xu Wen, Fei Cai, Gang Zhao, Jin Feng, Lianna Sun, Wansheng Chen,
... simultaneous determination of multiple bioactive lignan constituents of Wuzhi capsule in rat plasma. The extraction, separation, and analytical conditions were optimized. Five constituents of the Wuzhi capsule (schisandrin, schisandrol B, schisantherin A, schisanhenol, and ... pharmacokinetic study of the five components in the Wuzhi capsule.
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2010 - Elsevier BV | Journal of Pharmaceutical and Biomedical Analysis
Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai‐Shu Lin, Jae‐Gook Shin, Xiaoqiang Xiang,
... schisandrin A, the most abundant active ingredients of Wuzhi capsule, are known to inhibit tacrolimus metabolism by ... schisandrin A to drug-drug interaction (DDI) between Wuzhi capsule and tacrolimus using physiologically-based pharmacokinetic (PBPK) ... and schisandrin A to DDI between tacrolimus and Wuzhi capsule. This may provide more insights for the ...
Tópico(s): Cancer therapeutics and mechanisms
2017 - Wiley | Basic & Clinical Pharmacology & Toxicology
Xiao Chen, Dongdong Wang, Hong Xu, Zhiping Li,
... Carlo method. Body weight and co-administration of wuzhi capsule were indicated to influence tacrolimus clearance in ... in patients without vs. with co-administration of wuzhi capsule was 1:0.71. In addition, in patients who were not administered wuzhi capsule, an initial dosage regimen of 0.15 ... 23-60 kg; in patients who were administered wuzhi capsule, an initial dosage regimen of 0.10 ...
Tópico(s): Liver Disease and Transplantation
2020 - Spandidos Publishing | Experimental and Therapeutic Medicine
Wanyi Chen, Lu Chen, Ning Ji, Min Zhang,
... kidney and liver toxicity. In the clinic, the Wuzhi capsule is approved to attenuate cyclophosphamide toxicity in ... investigate the effects of the principal ingredients of Wuzhi capsule, schisandrin A (SIA) and schisantherin A (STA), ... were increased when cyclophosphamide was combined with the Wuzhi capsule, compared to cyclophosphamide alone. Our study shows ... to be considered when co-administered with the Wuzhi capsule.
Tópico(s): Chronic Myeloid Leukemia Treatments
2021 - Bentham Science Publishers | Recent Patents on Anti-Cancer Drug Discovery
Dongdong Wang, Xiao Chen, Zhiping Li,
... where WT, WZ, HGB and POD were weight, Wuzhi capsule (extracted from schisandra sphenanthera, whose primary efficient ... Chinese paediatric kidney transplantation patients was developed, and Wuzhi capsule and haemoglobin influence tacrolimus elimination in paediatric ...
Tópico(s): Liver Disease and Transplantation
2019 - Wiley | Journal of Clinical Pharmacy and Therapeutics
Zhu Zhang, Xiaobei Lu, Leipeng Dong, Ji-Wei Ma, Xiaoguang Fan,
... to investigate the correlation between the effect of Wuzhi soft capsule (WZC) on FK506 concentration and CYP3A5 ... which was relieved after the reduction of tacrolimus. Wuzhi soft capsule can significantly increase the blood concentration ...
Tópico(s): Hormonal Regulation and Hypertension
2019 - Wolters Kluwer | Medicine
Fang Cheng, Qiang Li, Jinglin Wang, Fang Zeng, Yu Zhang,
... is the cornerstone of immunosuppression after kidney transplantation. Wuzhi capsule (WZC), a prescribed ethanol extract of Nan- ... and adverse reactions were observed between the groups.Wuzhi capsule can increase tacrolimus concentration without negative effects ...
Tópico(s): Neurological Complications and Syndromes
2021 - Wiley | Journal of Clinical Pharmacy and Therapeutics
Jing Yan, Ying Kong, Xiongjun Hou, Hong Liu, Qun Fu, Zheng Jiao, Hongwei Peng, Xiaohua Wei,
... to different rates of metabolism in different subjects. Wuzhi Capsule (WZC) is a commonly used TAC-sparing ... of TAC q12h when co-administered with WZC.Wuzhi Capsule co-administration and CYP3A5 variants affect the ...
Tópico(s): Pharmacological Effects of Natural Compounds
2021 - Wiley | Journal of Clinical Pharmacy and Therapeutics
Yuyao Peng, Fei Jiang, Ran Zhou, Wanlin Jin, Yi Li, Weiwei Duan, Liqun Xu, Huan Yang,
... and narrow therapeutic window restrict its clinical application. Wuzhi capsule (WZC) could improve tacrolimus blood concentration by ... outcome after tacrolimus therapy. Keywords: myasthenia gravis, tacrolimus, Wuzhi capsule, clinical efficacy
Tópico(s): Cancer Treatment and Pharmacology
2021 - Dove Medical Press | Neuropsychiatric Disease and Treatment
Yao Du, Wei Song, Xiaofu Xiong, Weihong Ge, Huaijun Zhu,
... a population pharmacokinetic model of tacrolimus coadministration with Wuzhi capsule and optimise the dosage regimen in adult ... to optimise the recommended dose of tacrolimus and Wuzhi capsules.The estimated apparent clearance and volume of ... and 1210 L, respectively. The tacrolimus daily dose, Wuzhi capsule daily dose, postoperative time, alanine transaminase, haemoglobin, ... guidance for dosage optimisation of tacrolimus coadministered with Wuzhi capsules in adult liver transplantation patients.
Tópico(s): HIV/AIDS drug development and treatment
2022 - Taylor & Francis | Xenobiotica
Xiaoling Qin, Huichang Bi, Changxi Wang, Jiali Li, Xue‐ding Wang, Longshan Liu, Xiao Chen, Min Huang,
... distribution study with or without a dose of Wuzhi (WZ) tablet. Most of the FK506 tissue concentrations ...
Tópico(s): HIV/AIDS drug development and treatment
2009 - Wiley | Biomedical Chromatography
Hua Wei, Lianna Sun, Zongguang Tai, Shouhong Gao, Wenping Xu, Wansheng Chen,
... Schisandra sphenanthera and its traditional Chinese herbal preparations Wuzhi-capsule by optimizing the extraction, separation and analytical ... simultaneous determination of components in 13 batches of Wuzhi-capsule. The results indicate that this multi-component ...
Tópico(s): Phytochemistry and Biological Activities
2010 - Elsevier BV | Analytica Chimica Acta
Xiao Ling Qin, Hui Bi, Xue Ding Wang, Jia Li Li, Ying Wang, Xue Xin, Xiao Chen, Chang Xi Wang, Le Jia Xu, Yi Tao Wang, Min Huang,
... following the intake of a Chinese herbal preparation, Wuzhi Tablet (WZ, Schisandra sphenanthera extract). In order to ...
Tópico(s): Drug Transport and Resistance Mechanisms
2010 - Elsevier BV | International Journal of Pharmaceutics
Jing Jin, Huichang Bi, Jinqing Hu, Hang Zeng, Guoping Zhong, Lizi Zhao, Zhiying Huang, Min Huang,
Wuzhi tablet (WZ, registration no. in China: Z20025766) is a preparation of an ethanol herb extract of ...
Tópico(s): Plant-derived Lignans Synthesis and Bioactivity
2011 - Wiley | Phytotherapy Research
Xin‐ping Xue, Xiaoling Qin, Chenshu Xu, Guoping Zhong, Ying Wang, Min Huang, Huichang Bi,
In our previous reports, Wuzhi tablet (an herbal preparation of ethanol extract of Wuweizi ( Schisandra sphenanthera )) can significantly increase the blood concentration of tacrolimus and ...
Tópico(s): Drug Transport and Resistance Mechanisms
2012 - Wiley | Phytotherapy Research
Xiaoling Qin, Tao Yu, Ling-jue Li, Ying Wang, Hao-Min Gu, Yongtao Wang, Min Huang, Huichang Bi,
... PRED) to prevent acute rejection after organ transplantation. Wuzhi tablet (WZ, Schisandra sphenanthera extract) is often prescribed ...
Tópico(s): Drug Transport and Resistance Mechanisms
2012 - Elsevier BV | Phytomedicine
Xiaomei Fan, Pan Chen, Yiming Jiang, Ying Wang, Huasen Tan, Hang Zeng, Yongtao Wang, Aijuan Qu, Frank J. Gonzalez, Min Huang, Huichang Bi,
... NAC) is the primary antidote of APAP poisoning. Wuzhi tablet (WZ), the active constituents well identified and ...
Tópico(s): Liver physiology and pathology
2014 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Xiaoling Qin, Xiao Chen, Guoping Zhong, Xiaomei Fan, Ying Wang, Xin‐ping Xue, Ying Wang, Min Huang, Huichang Bi,
We recently reported that Wuzhi tablet (WZ), a preparation of the ethanol extract of Wuweizi (Schisandra sphenanthera), had significant effects on blood concentrations of Tacrolimus ( ...
Tópico(s): Plant-derived Lignans Synthesis and Bioactivity
2014 - Elsevier BV | Phytomedicine
Xiaomei Fan, Yiming Jiang, Ying Wang, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen, Aijuan Qu, Frank J. Gonzalez, Min Huang, Huichang Bi,
... enhance the function of liver and other organs. Wuzhi tablet (WZ) is a preparation of an ethanol ...
Tópico(s): Plant-derived Lignans Synthesis and Bioactivity
2014 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Hua Wei, Haijun Miao, Yunlei Yun, Jingxian Li, Xiaofeng Qian, Wu Rong, Wansheng Chen,
Background: Wuzhi capsule (WZC) is an ethanol extract from the ripe fruit of Schisandra sphenanthera in traditional Chinese medicine ...
Tópico(s): Tryptophan and brain disorders
2014 - Lippincott Williams & Wilkins | Therapeutic Drug Monitoring
Hua Wei, Xia Tao, Peng Di, Yingbo Yang, Jingxian Li, Xiaofeng Qian, Jin Feng, Wansheng Chen,
Wuzhi capsule (WZC) is a preparation of an ethanol herbal extract of Schisandra sphenanthera (Nan-Wuweizi), with ...
Tópico(s): Neurological Complications and Syndromes
2013 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Xiao Ling Qin, Chen Xiao, Ying Wang, Xin Xue, Ying Wang, Jia Li Li, Xue Ding Wang, Guo ping Zhong, Chang Xi Wang, Hui Yang, Min Huang, Hui Bi,
We recently reported that Wuzhi tablet (WZ; Schisandra sphenanthera extract) can inhibit P-glycoprotein (P-gp)–mediated efflux and CYP3A-mediated metabolism of tacrolimus (FK506) ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2013 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Huichang Bi, Fei Li, Kristopher W. Krausz, Aijuan Qu, Caroline H. Johnson, Frank J. Gonzalez,
... acetaminophen (APAP) hepatotoxicity would be of great value. Wuzhi tablet (WZ, extract of Schisandrae sphenanthera) possesses hepatoprotective ...
Tópico(s): Tryptophan and brain disorders
2013 - Hindawi Publishing Corporation | Evidence-based Complementary and Alternative Medicine