Dana Ďuricová, Ariane Leroyer, Guillaume Savoye, Hélène Sarter, Benjamin Pariente, Djamila Aoucheta, Laura Armengol‐Debeir, Delphine Ley, Dominique Turck, Laurent Peyrin‐Biroulet, Corinne Gower–Rousseau, Mathurin Fumery, JM Andre, M Antonietti, A Aouakli, Anne‐Sophie Armand, I Aroichane, Francesca Assi, J P Aubet, É. Auxenfants, F Ayafi-Ramelot, D Bankovski, B Barbry, N Bardoux, P. Baron, A Baudet, B Bazin, A Bebahani, J P Becqwort, V Benet, Habib Benali, C Benguigui, E Ben Soussan, A Bental, I. Berkelmans, J. Bernet, K Bernou, C Bernou-Dron, P Bertot, Nathalie Bertiaux-Vandaële, V Bertrand, E Billoud, N Biron, Benjamin Bismuth, M Bleuet, F Blondel, Valérie Blondin, P Bohon, E Boniface, P Bonnière, E Bonvarlet, P Bonvarlet, Arnaud Boruchowicz, R Bostvironnois, M Boualit, B Bouche, C Boudaillez, C Bourgeaux, Marie Bourgeois, Aurélie Bourguet, A Bourienne, J Branche, George A. Bray, Franck Brazier, P Breban, Hélène Brihier, V Brung-Lefebvre, P Bulois, P Burgiere, J Butel, J Y Canva, V. Canva-Delcambre, JP Capron, F Cardot, P. Carpentier, E Cartier, J F Cassar, M Cassagnou, JF Castex, Pablo Catalá, S Cattan, S Catteau, B Caujolle, G Cayron, C Chandelier, M Chantre, J. Charles, T Charneau, M Chavance-Thelu, Dragoş Chiriţă, A Choteau, J F Claerbout, P Y Clergue, H Coevoet, G Cohen, Roger Collet, J F Colombel, Stéphanie Coopman, J Corvisart, Antoine Cortot, F. Couttenier, J F Crinquette, V Crombe, I Dadamessi, V Dapvril, T Davion, S Dautreme, J Debas, N Degrave, F Dehont, C Delatre, Richard Delcenserie, O Delette, T Delgrange, L Delhoustal, JS Delmotte, S Demmane, G Deregnaucourt, P Descombes, J P Desechalliers, P Desmet, Pierre Desreumaux, G Desseaux, Philippe Desurmont, A Devienne, E Devouge, M Devred, A Devroux, A Dewailly, Sébastien Dharancy, A. Di Fiore, D. Djeddi, R Djedir, M L Dreher-Duwat, Raymond Dubois, C Dubuque, P Ducatillon, Julien Duclay, Bérengère Ducrocq, F Ducrot, P Ducrotté, A Dufilho, C Duhamel, D Dujardin, C Dumant-Forest, Dupas Jl, Floriane Dupont, Y Duranton, A Duriez, K El Achkar, M El Farisi, C. Elie, MC Elie-Legrand, A Elkhaki, M Eoche, D Evrard, J P Evrard, A Fatome, B Filoche, L Finet, Marjorie Flahaut, Christian Flamme, D Foissey, P Fournier, M C Foutrein-Comes, P Foutrein, D Fremond, T Frere, Mathurin Fumery, P. Gallet, C Gamblin, S Ganga-Zandzou, R Gérard, Guillaume Geslin, Y Gheyssens, N Ghossini, S Ghrib, T Gilbert, Brigitte Gillet, D. Godard, P. Godard, J M Godchaux, R Godchaux, G Goegebeur, Odile Goria, F. Gottrand, P. E. Gower, B Grandmaison, M Groux, C Guédon, J F Guillard, L Guillem, F Guillemot, D Guimber, B Haddouche, S Hakim, D Hanon, Vincent Hautefeuille, P Heckestweiller, G Hecquet, Hedde Jp, H Hellal, P E Henneresse, Benjamin Heyman, M Héraud, S. Hervé, P Hochain, L Houssin-Bailly, Philippe Houcke, B Huguenin, Silviu Iobagiu, Aleksandar Ivanović, I Iwanicki-Caron, E Janicki, M Jarry, J Jeu, JP Joly, C. Jonas, F Katherin, A Kerleveo, A Khachfe, A Kiriakos, J Kiriakos, O Klein, Maciej Kohut, R Kornhauser, D Koutsomanis, J E Laberenne, G Laffineur, Mylène Lagarde, P Lannoy, J Lapchin, M Lapprand, Dominique Laude, Richard Leblanc, P Lecieux, N Leclerc, C Le Couteulx, Jacques Ledent, J Lefèbvre, P Lefiliatre, Céline Legrand, A Le Grix, Pierre Lelong, B Leluyer, C Lenaerts, L Lepileur, A Leplat, E Lepoutre-Dujardin, H Leroi, MY Leroy, J Lesage, Xavier Lesage, J Lesage, I Lescanne-Darchis, J Lescut, D. Lescut, Baptiste Leurent, Philip T. Levy, M Lhermie, A Lion, B Lisambert, F Loire, S Louf, Alexandre Louvet, M.G. Luciani, Damien Lucidarme, J Lugand, O Macaigne, D Maetz, Dominique Maillard, H Mancheron, O Manolache, AB Marks-Brunel, Ruth Martí‐Lluch, Francisco Martín‐Luján, Guy Martin, E Marzloff, Philippe Mathurin, Jacques Mauillon, V. Maunoury, JL Maupas, B Mesnard, P Métayer, L Methari, Bénédicte Meurisse, F Meurisse, L. Michaud, X Mirmaran, P Modaine, A Monthe, L Morel, PE Mortier, Estelle Moulin, O. Mouterde, J Mudry,
Data on extra-intestinal manifestations [EIM] and their impact on the disease course of ulcerative colitis [UC] in population-based cohorts are scarce, particularly in paediatric- and elderly-onset UC patients. The aims of this population-based study were to assess: 1] the occurrence of EIM in paediatric- and elderly-onset UC; 2] the factors associated with EIM; and 3] their impact on long-term disease outcome.Paediatric-onset [< 17 years at diagnosis] and elderly-onset UC patients [> 60 years at diagnosis] ...
Oxford University Press
Dana Ďuricová, Hélène Sarter, Guillaume Savoye, Ariane Leroyer, Benjamin Pariente, Laura Armengol‐Debeir, Guillaume Bouguen, Delphine Ley, Dominique Turck, C. Templier, S. Buche, Laurent Peyrin‐Biroulet, Corinne Gower‐Rousseau, Mathurin Fumery, J M Andre, M Antonietti, A Aouakli, Anne‐Sophie Armand, I Aroichane, Francesca Assi, J P Aubet, É. Auxenfants, F Ayafi-Ramelot, D Bankovski, B Barbry, N Bardoux, P. Baron, A Baudet, B Bazin, A Bebahani, J P Becqwort, V Benet, Habib Benali, C Benguigui, E Ben Soussan, A Bental, I. Berkelmans, J. Bernet, K Bernou, C Bernou-Dron, P Bertot, Nathalie Bertiaux-Vandaële, V Bertrand, E Billoud, N Biron, Benjamin Bismuth, M Bleuet, F Blondel, Valérie Blondin, P Bohon, E Boniface, P Bonnière, E Bonvarlet, P Bonvarlet, Arnaud Boruchowicz, R Bostvironnois, M Boualit, B Bouche, C Boudaillez, C Bourgeaux, Marie Bourgeois, Aurélie Bourguet, A Bourienne, Julien Branche, George A. Bray, Franck Brazier, P Breban, Hélène Brihier, V Brung-Lefebvre, P Bulois, P Burgiere, J Butel, J Y Canva, V. Canva-Delcambre, J P Capron, F Cardot, P. Carpentier, E Cartier, J F Cassar, M Cassagnou, Julie Castex, Pablo Catalá, S Cattan, S Catteau, B Caujolle, G Cayron, C Chandelier, M Chantre, J. Charles, T Charneau, M Chavance-Thelu, Dragoş Chiriţă, A Choteau, J F Claerbout, P Y Clergue, H Coevoet, G Cohen, Roger Collet, J F Colombel, Stéphanie Coopman, J Corvisart, Antoine Cortot, F. Couttenier, J F Crinquette, V Crombe, I Dadamessi, V Dapvril, T Davion, S Dautreme, J Debas, N Degrave, F Dehont, C Delatre, Richard Delcenserie, O Delette, T Delgrange, L Delhoustal, J. S. Delmotte, S Demmane, G Deregnaucourt, P Descombes, J P Desechalliers, P Desmet, Pierre Desreumaux, G Desseaux, Philippe Desurmont, A Devienne, E Devouge, M Devred, A Devroux, A Dewailly, Sébastien Dharancy, A. Di Fiore, D. Djeddi, R Djedir, M L Dreher-Duwat, Raymond Dubois, C Dubuque, P Ducatillon, Julien Duclay, Bérengère Ducrocq, F Ducrot, P Ducrotté, A Dufilho, C Duhamel, D Dujardin, C Dumant-Forest, J L Dupas, Floriane Dupont, Y Duranton, A Duriez, K El Achkar, M El Farisi, C. Elie, M C Elie-Legrand, A Elkhaki, M Eoche, D Evrard, J P Evrard, A Fatome, B Filoche, L Finet, Marjorie Flahaut, Christian Flamme, D Foissey, P Fournier, Marie-Christine Comes, P Foutrein, D Fremond, T Frere, Mathurin Fumery, P. Gallet, C Gamblin, S Ganga-Zandzou, R Gérard, Guillaume Geslin, Y Gheyssens, N Ghossini, S Ghrib, T Gilbert, Brigitte Gillet, D. Godard, P. Godard, J M Godchaux, R Godchaux, G Goegebeur, Odile Goria, F. Gottrand, P. E. Gower, B Grandmaison, M Groux, C Guédon, J F Guillard, L Guillem, F Guillemot, D Guimber, B Haddouche, S Hakim, D Hanon, Vincent Hautefeuille, P Heckestweiller, G Hecquet, J P Hedde, H Hellal, P E Henneresse, Benjamin Heyman, M Héraud, S. Hervé, P Hochain, L Houssin-Bailly, Philippe Houcke, B Huguenin, Silviu Iobagiu, Aleksandar Ivanović, I Iwanicki-Caron, E Janicki, M Jarry, J Jeu, J P Joly, C. Jonas, F Katherin, A Kerleveo, A Khachfe, A Kiriakos, J Kiriakos, O Klein, Maciej Kohut, R Kornhauser, D Koutsomanis, J E Laberenne, G Laffineur, Mylène Lagarde, P Lannoy, J Lapchin, M Lapprand, Dominique Laude, Richard Leblanc, P Lecieux, N Leclerc, C Le Couteulx, Jacques Ledent, J Lefèbvre, P Lefiliatre, Céline Legrand, A Le Grix, Pierre Lelong, B Leluyer, C Lenaerts, L Lepileur, A Leplat, E Lepoutre-Dujardin, H Leroi, Maxime Leroy, J Lesage, Xavier Lesage, J Lesage, I Lescanne-Darchis, J Lescut, D. Lescut, Baptiste Leurent, Philip T. Levy, M Lhermie, A Lion, B Lisambert, F Loire, S Louf, Alexandre Louvet, M.G. Luciani, Damien Lucidarme, J Lugand, O Macaigne, D Maetz, Dominique Maillard, H Mancheron, O Manolache, A B Marks-Brunel, Ruth Martí‐Lluch, Francisco Martín‐Luján, Guy Martin, E Marzloff, Philippe Mathurin, Jacques Mauillon, V. Maunoury, Jean Maupas, B Mesnard, P Métayer, L Methari, Bénédicte Meurisse, F Meurisse, L. Michaud, X Mirmaran, P Modaine, A Monthe, L Morel, Pierre-Eugène Mortier, Estelle Moulin,
Extraintestinal manifestations (EIM) have been associated with more severe course of inflammatory bowel disease. The aim was to study the frequency of EIM in pediatric- and elderly-onset Crohn′s disease (CD) and the factors associated with EIM and their impact on long-term disease outcome. Pediatric- (age at diagnosis younger than 17 years) and elderly-onset CD patients (age at diagnosis 60 years or older) from a prospective population-based registry (EPIMAD) were recruited. Data on EIM and clinical ...
Oxford University Press
Marie Danielou, Hélène Sarter, Benjamin Pariente, Mathurin Fuméry, Delphine Ley, Christel Mamona, Maël Barthoulot, Cloé Charpentier, Laurent Siproudhis, Guillaume Savoye, Corinne Gower‐Rousseau, J M Andre, M Antonietti, A Aouakli, Anne‐Sophie Armand, I Aroichane, Francesca Assi, J P Aubet, É. Auxenfants, F Ayafi-Ramelot, K Azzouzi, D Bankovski, B Barbry, N Bardoux, P. Baron, A Baudet, B Bazin, A Bebahani, J P Becqwort, V Benet, Habib Benali, C Benguigui, E Ben Soussan, A Bental, I. Berkelmans, J. Bernet, K Bernou, C Bernou-Dron, P Bertot, Nathalie Bertiaux-Vandaële, V Bertrand, E Billoud, N Biron, Benjamin Bismuth, M Bleuet, F Blondel, Valérie Blondin, P Bohon, E Boniface, P Bonnière, E Bonvarlet, P Bonvarlet, Arnaud Boruchowicz, R Bostvironnois, M Boualit, B Bouche, C Boudaillez, C Bourgeaux, Marie Bourgeois, Aurélie Bourguet, A Bourienne, J Branche, George A. Bray, Franck Brazier, P Breban, M Bridenne, Hélène Brihier, V Brung-Lefebvre, P Bulois, P Burgiere, J Butel, J Y Canva, V. Canva-Delcambre, J P Capron, F Cardot, P. Carpentier, E Cartier, J F Cassar, M Cassagnou, Julie Castex, Pablo Catalá, S Cattan, S Catteau, B Caujolle, G Cayron, C Chandelier, M Chantre, J. Charles, T Charneau, M Chavance-Thelu, Dragoş Chiriţă, A Choteau, J F Claerbout, P Y Clergue, H Coevoet, G Cohen, Roger Collet, Jean–Frédéric Colombel, Stéphanie Coopman, J Corvisart, Antoine Cortot, F. Couttenier, J F Crinquette, V Crombe, I Dadamessi, V Dapvril, T Davion, S Dautreme, J Debas, N Degrave, F Dehont, C Delatre, Richard Delcenserie, O Delette, T Delgrange, L Delhoustal, J. S. Delmotte, S Demmane, G Deregnaucourt, P Descombes, J P Desechalliers, P Desmet, Pierre Desreumaux, G Desseaux, Philippe Desurmont, A Devienne, E Devouge, M Devred, A Devroux, A Dewailly, Sébastien Dharancy, A. Di Fiore, D. Djeddi, R Djedir, M L Dreher-Duwat, Raymond Dubois, C Dubuque, P Ducatillon, Julien Duclay, Bérengère Ducrocq, F Ducrot, P Ducrotté, A Dufilho, C Duhamel, D Dujardin, C Dumant-Forest, J L Dupas, Floriane Dupont, Y Duranton, A Duriez, K El Achkar, M El Farisi, C. Elie, M C Elie-Legrand, A Elkhaki, M Eoche, D Evrard, J P Evrard, A Fatome, B Filoche, L Finet, Marjorie Flahaut, Christian Flamme, D Foissey, P Fournier, M C Foutrein-Comes, P Foutrein, D Fremond, T Frere, Mathurin Fumery, P. Gallet, C Gamblin, S. Ganga, R Gérard, Guillaume Geslin, Y Gheyssens, N Ghossini, S Ghrib, T Gilbert, Brigitte Gillet, D. Godard, P. Godard, J M Godchaux, R Godchaux, G Goegebeur, Odile Goria, F. Gottrand, P. E. Gower, B Grandmaison, M Groux, C Guédon, J F Guillard, L Guillem, F Guillemot, D Guimberd, B Haddouche, S Hakim, D Hanon, Vincent Hautefeuille, P Heckestweiller, G Hecquet, J P Hedde, H Hellal, P E Henneresse, Benjamin Heyman, M Héraud, S. Hervé, P Hochain, L Houssin-Bailly, Philippe Houcke, B Huguenin, Silviu Iobagiu, Aleksandar Ivanović, I Iwanicki-Caron, E Janicki, M Jarry, J Jeu, J P Joly, C. Jonas, F Katherin, A Kerleveo, A Khachfe, A Kiriakos, J Kiriakos, O Klein, Maciej Kohut, R Kornhauser, D Koutsomanis, J E Laberenne, G Laffineur, Mylène Lagarde, A Lalanne, P Lannoy, J Lapchin, M Laprand, Dominique Laude, Richard Leblanc, P Lecieux, N Leclerc, C Le Couteulx, Jacques Ledent, J Lefèbvre, P Lefiliatre, Céline Legrand, A Le Grix, Pierre Lelong, B Leluyer, C Lenaerts, L Lepileur, A Leplat, E Lepoutre-Dujardin, H Leroi, Maxime Leroy, J Lesage, Xavier Lesage, J Lesage, I Lescanne-Darchis, J Lescut, D. Lescut, Baptiste Leurent, Philip T. Levy, M Lhermie, A Lion, B Lisambert, F Loire, S Louf, Alexandre Louvet, M.G. Luciani, Damien Lucidarme, J Lugand, O Macaigne, D Maetz, Dominique Maillard, H Mancheron, O Manolache, A B Marks-Brunel, Ruth Martí‐Lluch, Francisco Martín‐Luján, Guy Martin, E Marzloff, Philippe Mathurin, Jacques Mauillon, V. Maunoury, Jean Maupas, B Mesnard, P Métayer, L Methari, Bénédicte Meurisse, F Meurisse, L. Michaud, X Mirmaran, P Modaine, A Monthe, L Morel, Pierre-Eugène Mortier, Estelle Moulin,
Abstract Introduction Most studies of elderly-onset Crohn’s disease [CD; diagnosed in patients aged 60 or over] have described a mild course. However, data on the natural history of perianal fistulising CD [pfCD] in this population are scarce. In a population-based cohort study, we described the prevalence, natural history, and treatment of pfCD in patients with elderly-onset CD vs patients with paediatric-onset CD. Method All patients diagnosed with CD at or after the age of 60 between 1988 and 2006, ...
Oxford University Press
Anne Drougard, Audren Fournel, Alysson Marlin, Étienne Meunier, Anne Abot, Tereza Bautzová, Thibaut Duparc, Katie Louche, Aurélie Batut, Alexandre Lucas, Sophie Le Gonidec, Jean Lésage, Xavier Fioramonti, Cédric Moro, Philippe Valet, Patrice D. Cani, Claude Knauf,
Abstract Apelin is a bioactive peptide involved in the control of energy metabolism. In the hypothalamus, chronic exposure to high levels of apelin is associated with an increase in hepatic glucose production, and then contributes to the onset of type 2 diabetes. However, the molecular mechanisms behind deleterious effects of chronic apelin in the brain and consequences on energy expenditure and thermogenesis are currently unknown. We aimed to evaluate the effects of chronic intracerebroventricular ( ...
Tópico(s): Lipid metabolism and disorders
2016 - Nature Portfolio | Scientific Reports
Vivek Venugopal, Jin Chen, Frédéric Lesage, Xavier Intes,
In this experimental investigation, we explore the feasibility of using wide-field illumination for time-resolved fluorescence molecular tomography. The performance of wide-field patterns with a time-resolved imaging platform is investigated in vitro and in a small animal model. A Monte Carlo-based forward model is employed to reconstruct fluorescence yield based on time-gated datasets. An improvement in resolution and quantification when using the time-gate data type compared to the commonly used ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2010 - Optica Publishing Group | Optics Letters
Jin Chen, Vivek Venugopal, Frédéric Lesage, Xavier Intes,
This investigation explores the feasibility of performing diffuse optical tomography based on time-domain wide-field illumination and detection strategies. Wide-field patterned excitation and detection schemes are investigated in transmittance geometry with time-gated detection channels. A Monte Carlo forward model is employed to compute the time-resolved Jacobians for rigorous light propagation modeling. We demonstrate both in silico and experimentally that reconstructions of absorption structures ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2010 - Optica Publishing Group | Optics Letters
Priscilla Avenier, Mostafa Taoufik, Anne Lesage, Xavier Solans‐Monfort, Anne Baudouin, Aimery de Mallmann, Laurent Veyre, Jean‐Marie Basset, Odile Eisenstein, Lyndon Emsley, Elsje Alessandra Quadrelli,
Both industrial and biochemical ammonia syntheses are thought to rely on the cooperation of multiple metals in breaking the strong triple bond of dinitrogen. Such multimetallic cooperation for dinitrogen cleavage is also the general rule for dinitrogen reductive cleavage with molecular systems and surfaces. We have observed cleavage of dinitrogen at 250 degrees C and atmospheric pressure by dihydrogen on isolated silica surface-supported tantalum(III) and tantalum(V) hydride centers [(identical with ...
Tópico(s): Catalytic Processes in Materials Science
2007 - American Association for the Advancement of Science | Science
SM Lam, Frédéric Lesage, Xavier Intes,
Light propagation in tissue is known to be favored in the Near Infrared spectral range. Capitalizing on this fact, new classes of molecular contrast agents are engineered to fluoresce in the Near Infrared. The potential of these new agents is vast as it allows tracking non-invasively and quantitatively specific molecular events in-vivo. However, to monitor the bio-distribution of such compounds in thick tissue proper physical models of light propagation are necessary. To recover 3D concentrations ...
Tópico(s): Hemodynamic Monitoring and Therapy
2005 - Optica Publishing Group | Optics Express
Denis Lesage, Xavier Troussard, Brigitte Sola,
Multiple myeloma (MM) reflects the proliferation of terminally differentiated plasma cells with low proliferative capacities, synthesizing monoclonal immunoglobulin (Ig). Tumoral cells are post-germinal centre cells that have been subjected to rearrangement of variable/diversity/joining (VDJ) sequences of Ig heavy chain (IgH) genes, isotype switching and somatic hypermutation.1, 2 As the result of illegitimate switch recombinations, reciprocal translocations involving the IgH locus located on chromosome ...
Tópico(s): Microtubule and mitosis dynamics
2005 - Wiley | International Journal of Cancer
Farid Ichou, Denis Lesage, Xavier Machuron‐Mandard, Christophe Junot, Richard B. Cole, Jean‐Claude Tabet,
Control of the ion internal energy in mass spectrometry is needed to establish a workable mass spectral library. The purpose of this study is to understand and to compare the pressure effects on the collision‐induced dissociation (CID) spectrum pattern recorded using triple quadrupole instruments. The monoprotonated Leucine enkephalin [YGGFL, H + ] was used as a thermometer molecule to calibrate the electrospray ionization (ESI) and the CID internal energies deposited on the molecular species and the time ...
Tópico(s): Advanced Chemical Sensor Technologies
2013 - Wiley | Journal of Mass Spectrometry
Perrine Royal, Alba Andrés‐Bilbé, Pablo Ávalos Prado, Clément Verkest, Brigitte Wdziekonski, Sébastien Schaub, Anne Baron, Florian Lesage, Xavier Gasull, Joshua Levitz, Guillaume Sandoz,
It is often unclear why some genetic mutations to a given gene contribute to neurological disorders and others do not. For instance, two mutations have previously been found to produce a dominant negative for TRESK, a two-pore-domain K+ channel implicated in migraine: TRESK-MT, a 2-bp frameshift mutation, and TRESK-C110R. Both mutants inhibit TRESK, but only TRESK-MT increases sensory neuron excitability and is linked to migraine. Here, we identify a new mechanism, termed frameshift mutation-induced ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2018 - Cell Press | Neuron
C. Lesage, Coralie Barbe, A. Le Clainche, François-Xavier Lesage, Philippe Bernard, Florent Grange,
Head and neck melanomas (HNMs) are frequent and have a poorer prognosis than melanomas at other sites. Photoprotection in these locations is difficult. In this population-based study of 279 HNMs diagnosed in a French region between 2004 and 2009, major differences were found between genders. A clearcut, sex-related distribution was found between a "peripheral" area (scalp, forehead, temples, ears, and neck) and a "central" one (other parts of the face), with 56.7% of HNMs being located in the peripheral ...
Tópico(s): Indoor Air Quality and Microbial Exposure
2013 - Elsevier BV | Journal of Investigative Dermatology
C. Lesage, Christine Longvert, S. Prey, Sarah Maanaoui, Brigitte Dréno, L. Machet, O. Zehou, N. Kramkimel, G. Jeudy, F. Skowron, F. Aubin, L. Visseaux, S. Mansard, O. Dereure, François‐Xavier Lesage, B. Guillot,
Immune checkpoint inhibitors (ICI) significantly improve overall survival (OS) in patients with advanced melanoma, but immune-related colitis may occur and warrant anti-tumor necrosis factor α (TNFα) treatment in severe forms. A nationwide, multicenter retrospective survey was conducted to assess both, the real-life incidence of grade 3/4 ICI-induced colitis treated with anti-TNFα, in patients with advanced melanoma, and the consequence of this therapeutic strategy on disease outcome. All patients ...
Tópico(s): Melanoma and MAPK Pathways
2019 - Lippincott Williams & Wilkins | Journal of Immunotherapy
M.C. Laxenaire, D.A. Moneret‐Vautrin, S. Widmer, C. Mouton, Jean‐Louis Guéant, Marion Bonnet, H. Bricard, A. Facon, François‐Xavier Lesage, J. Valfrey, F Leynadier, J Motin, G. Occelli,
Huit CHU français ayant créé depuis quelques années une consultation d'allergoanesthésie permettant de réaliser le bilan diagnostique d'un accident anaphylactoïde peranesthésique ont été interrogés. Le but de cette enquête était de regrouper un grand nombre de patients testés selon le même schéma afin de faire le point actuel, en France, sur la fréquence de l'anaphylaxie parmi les mécanismes des réactions anaphylactoïdes survenant en anesthésie et d'en montrer les substances responsables. Le bilan ...
Tópico(s): Allergic Rhinitis and Sensitization
1990 - Elsevier BV | Annales Françaises d Anesthésie et de Réanimation
François‐Xavier Lesage, N. Jovenin, Frédèric Deschamps, Stella B. Vincent,
Background There is a lack of data about police officers' hearing thresholds and the risk of noise-induced hearing loss (NIHL) associated with this occupation. In France, 129 000 national police officers, 96 000 state police force members and 16000 municipal police officers may be affected by occupational noise exposure.
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2009 - Oxford University Press | Occupational Medicine
François‐Xavier Lesage, A. Chamoux, Sophie Berjot,
L'échelle visuelle analogique (Eva) a été proposée depuis une dizaine d'années pour évaluer cliniquement le stress. Des éléments de validation ont déjà été rapportés, comme par exemple la corrélation avec le modèle de Karasek. Néanmoins, de nombreux paramètres restent à valider. Un point fondamental dans la validation d'une échelle est d'analyser le paradoxe entre sa reproductibilité et sa capacité à mettre en évidence un phénomène. Le but de cette étude est d'évaluer la stabilité à un an de l'Eva ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2009 - Elsevier BV | Archives des maladies professionnelles et de médecine du travail/Archives des maladies professionnelles et de l'environnement
François‐Xavier Lesage, Sonia Martens-Resende, Frédèric Deschamps, Sophie Berjot,
Introduction: The aim of this study is to test the factorial structure and the internal consistency of the 12-items General Health Questionnaire adapted to work-related psychological distress (GHQW). Methods: A validated French version of the GHQ-12 was used and transformed to remind of the occupational context. A sample of 1014 workers completed the GHQW. Internal consis- tency was assessed by Cronbach’s α coefficient. The factorial structure was extracted with an exploratory factorial analysis ( ...
Tópico(s): Healthcare professionals’ stress and burnout
2011 - Scientific Research Publishing | Open Journal of Preventive Medicine
François‐Xavier Lesage, Sophie Berjot,
Background The visual analogue scale (VAS) is empirically used by occupational physicians to assess stress but very few studies have been published about its quantitative validation.
Tópico(s): Healthcare professionals’ stress and burnout
2011 - Oxford University Press | Occupational Medicine
François‐Xavier Lesage, Sophie Berjot, Frédèric Deschamps,
Abstract
Tópico(s): Resilience and Mental Health
2012 - Nofer Institute of Occupational Medicine | International Journal of Occupational Medicine and Environmental Health
François‐Xavier Lesage, Sophie Berjot, Frédèric Deschamps,
Clinicians increasingly require short, efficient methods for assessing distress, both in applied research and clinical settings. Most of the available questionnaires are unsuitable for busy clinical settings. The visual analogue scale (VAS) is widely but empirically used to assess perceived stress. To provide evidence on two of the psychometric properties of the VAS: its discriminative sensitivity (capacity to highlight a difference between groups) and its interconcept validity (the relationship between ...
Tópico(s): Musculoskeletal pain and rehabilitation
2012 - Oxford University Press | Occupational Medicine
Laurent Siproudhis, Véronique Sébille, F. Pigot, P Hemery, F. Juguet, D. Soudan, Iradj Sobhani, Xavier Lesage, Roland Ganansia, Éric Bellissant,
Tópico(s): Pelvic floor disorders treatments
2000 - Elsevier BV | Gastroenterology
Frédèric Deschamps, Jérôme Langrand, François‐Xavier Lesage,
Health Assessment of Self‐employed Hairdressers in France: Frederic DESCHAMPS, et al . Occupational Disease Department University Hospital of Reims, France— Objective Hairdressers have a high incidence of occupational diseases, owing to excessive wet work and exposure to chemical substances. The objective of this study was to assess the prevalence of occupational diseases in a population of self‐employed hairdressers, matched for age and sex with a control group of wage‐earning hairdressers. Method ...
Tópico(s): Contact Dermatitis and Allergies
2014 - Wiley | Journal of Occupational Health
Sophie Berjot, Emin Altıntaş, François‐Xavier Lesage, E. Grebot,
This aim of this study was to explore which kinds of working situations are regarded by psychologists as being particularly detrimental to their identity (personal and professional), how these situations are appraised in terms of threat and/or challenge, and what their impact is on perceived stress, work satisfaction, and perceived threat to occupational status. In all, 842 French psychologists answered an open format question requesting them to report a situation that was particularly difficult ...
Tópico(s): Employment and Welfare Studies
2013 - SAGE Publishing | SAGE Open
François‐Xavier Lesage, Sophie Berjot, Emin Altıntaş, Benjamin Paty,
Burnout among occupational health physicians in France was measured in a nationwide cross-sectional survey. The relationships between each dimension of burnout (emotional exhaustion, depersonalization, and feelings of low personal accomplishment) and stress level, identity threat, and job characteristics were analysed. E-mails were sent out to all occupational physicians working in France by the French Ministry of Labour, inviting them to fill out an online questionnaire. This questionnaire included ...
Tópico(s): Stress and Burnout Research
2013 - Oxford University Press | The Annals of Occupational Hygiene
Jean‐Frédéric Colombel, Daniel Mathieu, Jean-Michel Bouault, Xavier Lesage, Patrick Zavadil, P Quandallé, Antoine Cortot,
PURPOSE: Perineal involvement in Crohn's disease is a common and distressing condition, often refractory to medical or surgical treatments. Recent reports suggest the efficacy of hyperbaric oxygenation (HBO) in the healing of perineal lesions. We evaluated HBO in severe patients with perineal Crohn's disease. METHODS: Ten consecutive patients (8 women, 2 men; mean age, 30 years) were studied. There were four superficial fissures, four cavitating ulcers, six low or superficial fistulas, two high fistulas, ...
Tópico(s): Hidradenitis Suppurativa and Treatments
1995 - Lippincott Williams & Wilkins | Diseases of the Colon & Rectum
Charlotte Lanhers, Bruno Pereira, Géraldine Naughton, Marion Trousselard, François‐Xavier Lesage, Frédéric Dutheil,
Tópico(s): Sports injuries and prevention
2015 - Springer Science+Business Media | Sports Medicine
Charlotte Lanhers, Bruno Pereira, Géraldine Naughton, Marion Trousselard, François‐Xavier Lesage, Frédéric Dutheil,
Tópico(s): Cardiovascular and exercise physiology
2016 - Springer Science+Business Media | Sports Medicine
Marie Kraïm-Leleu, François‐Xavier Lesage, Moustapha Dramé, François Lebargy, Frédèric Deschamps,
The aim of this research was to examine the occupational risk factors for Chronic Obstructive Pulmonary Diseases (COPD) in a range of occupations.Eleven occupations involving different types of exposure were observed in this multicenter case-control study. Controls and cases were matched for sex, age and smoking. Multiple logistic regression analyses were used to estimate odds ratios (ORs).A total of 1,519 participants were initially recruited between September 2004 and September 2012. After matching, ...
Tópico(s): Occupational and environmental lung diseases
2016 - Public Library of Science | PLoS ONE
Frédéric Dutheil, Géraldine Naughton, Patricia Sindyga, François‐Xavier Lesage,
The diagnoses of workers being unfit to work may be a relevant health indicator. Therefore, the aim of this study was to analyze the one-year incidence of an unfit to work diagnosis.This one-year prospective study included all workers undergoing annual work medical examination from occupational health services in Troyes, France.Twenty-one occupational physicians followed 54,026 employees. The all-cause incidence of being unfit to return to work was 0.772%. The two main causes of being unfit to work ...
Tópico(s): Musculoskeletal pain and rehabilitation
2016 - Lippincott Williams & Wilkins | Journal of Occupational and Environmental Medicine
Sophie Berjot, Emin Altıntaş, E. Grebot, François‐Xavier Lesage,
The aims of this study were 1) to show that the use of different cut-off scores available in the literature can lead to erroneous conclusions, adding to the emerging literature highlighting the problems associated with its use, and 2) to propose an alternative technique − Cluster Analysis − to assess the risk of burnout as well as to identify profiles at risk of burnout. Burnout was measured among 664 French psychologists using the French-Canadian version of the Maslach Burnout Inventory (Dion & Tessier, ...
Tópico(s): Musculoskeletal pain and rehabilitation
2017 - Elsevier BV | Burnout Research