Signed: Agostinho Albano da Silveira Pinto, Augusto Xavier Palmeirim, Carlos Bento da Silva. Book.
0000 - Gale Group | The Making of Modern World
Philipp Wahle, Giovanna Brancati, Christoph Harmel, Zhisong He, Gabriele Gut, Jacobo Sarabia del Castillo, Aline Xavier da Silveira dos Santos, Qianhui Yu, Pascal Noser, Jonas Simon Fleck, Bruno Gjeta, Dinko Pavlinić, Simone Picelli, M. W. Hess, Gregor W. Schmidt, Tom T. A. Lummen, Yanyan Hou, Patricia Galliker, David Goldblum, Márton Balogh, Cameron S. Cowan, Hendrik P. N. Scholl, Botond Roska, Magdalena Renner, Lucas Pelkmans, Barbara Treutlein, J. Gray Camp,
Abstract Organoids generated from human pluripotent stem cells provide experimental systems to study development and disease, but quantitative measurements across different spatial scales and molecular modalities are lacking. In this study, we generated multiplexed protein maps over a retinal organoid time course and primary adult human retinal tissue. We developed a toolkit to visualize progenitor and neuron location, the spatial arrangements of extracellular and subcellular components and global ...
Tópico(s): Cell Image Analysis Techniques
2023 - Nature Portfolio | Nature Biotechnology
Produção Nacional
Revisado por pares
Thiago Marques Fidalgo, Evelyn D Silveira, Dartiu Xavier da Silveira,
Alcohol use is apparently related to high prevalences of psychiatric comorbidity, although scientific studies focusing the problem among adolescents are still lacking.To evaluate the performance of adolescents with different patterns of alcohol use on screening instruments for psychiatric disorders.Forty-one adolescents seeking assistance for alcohol-related problems were compared to a nonclinical sample of 43 adolescents. These 84 users were divided in three sub-groups according to pattern of recent ...
Tópico(s): Prenatal Substance Exposure Effects
2007 - Taylor & Francis | The American Journal of Drug and Alcohol Abuse
Produção Nacional
Revisado por pares
M.C. Di Pietro, Evelyn Doering-Silveira, Maria Paula T. Oliveira, Leonardo Quicoli Rosa-Oliveira, Dartiu Xavier da Silveira,
The use of alcohol and other drugs among medical students has been a theme of growing interest and concern on the part of researchers, teaching institutions and medical associations since the decade of the 1960's.Recent use of alcohol, tobacco, tranquillisers, amphetamines, cannabis, organic solvents, and cocaine among 456 medical students was surveyed.Assessment was done by means of a self-report questionnaire according to World Health Organisation guidelines.Among medical students, after alcohol ...
Tópico(s): Substance Abuse Treatment and Outcomes
2006 - Elsevier BV | Addictive Behaviors
Produção Nacional
Revisado por pares
Simone Meneghetti Zatta, Mariel Mendez, Juliana Doering Xavier da Silveira, Leonardo Maringolo, CONRADO TAZIMA NITTA, Dartiu Xavier da Silveira, Thiago Marques Fidalgo,
BACKGROUND: The Brown Attention-Deficit Disorder Scale (BADDS) was developed as a self-report assessment that was designed to screen for presence of symptoms of attention deficit hyperactivity disorder (ADHD). The objective here was to translate and validate the adult self-report BADDS for use in Brazil. DESIGN AND SETTING: Cross-cultural validation study conducted in an addiction unit at a public university hospital. METHODS: This study included a control group (n = 100) and a drug-user group (n = 100). ...
Tópico(s): Bipolar Disorder and Treatment
2018 - Medical Association of São Paulo | Sao Paulo Medical Journal
Produção Nacional
Revisado por pares
Evelyn Doering-Silveira, Charles S. Grob, Marlene Dobkin de Ríos, Enrique López, Luisa K. Alonso, Cristiane Tacla, Dartiu Xavier da Silveira,
Abstract Ritual use of ayahuasca within the context of the Brazilian ayahuasca churches often starts during late childhood or early adolescence. Premature access to psychoactive drugs may represent a risk factor for drug misuse. Conversely, religious affiliation seems to play a protective role in terms of substance abuse. The objective of this study was to describe patterns of drug use in a sample of adolescents using ayahuasca within a religious setting. Forty-one adolescents from a Brazilian ayahuasca ...
Tópico(s): Cannabis and Cannabinoid Research
2005 - Taylor & Francis | Journal of Psychoactive Drugs
Produção Nacional
Revisado por pares
Evelyn Doering-Silveira, Enrique López, Charles S. Grob, Marlene Dobkin de Ríos, Luisa K. Alonso, Cristiane Tacla, Itiro Shirakawa, Paulo Henrique Ferreira Bertolucci, Dartiu Xavier da Silveira,
Abstract The purpose of the study was to evaluate neuropsychologically adolescents who use ayahuasca in a religious context. A battery of neuropsychological tests was administered to adolescents who use ayahuasca. These subjects were compared to a matched control group of adolescents who did not use ayahuasca. The controls were matched with regards to sex, age, and education. The neuropsychological battery included tests of speeded attention, visual search, sequencing, psychomotor speed, verbal ...
Tópico(s): Neuroscience and Neuropharmacology Research
2005 - Taylor & Francis | Journal of Psychoactive Drugs
Produção Nacional
Revisado por pares
Juliana Doering-Silveira, Thiago Marques Fidalgo, Carolina Nascimento, Juliana Mariano Alves, Caroline Lumy Seito, Maria Grazia Saita, Lorenza Oliveira Belluzzi, Laila Paula Sousa Camilo Silva, Dartiu Xavier da Silveira, Leonardo Quicoli Rosa-Oliveira,
Alcohol misuse is generally not detected in hospital settings. The goal of this study was to estimate the prevalence of alcohol abuse and dependence in hospitalized patients in a university hospital in Sao Paulo (Brazil). Patients were randomly selected from all hospital admissions. The final sample consisted of 169 adult inpatients. Two screening tools were used: the Short Alcohol Dependence Data (SADD) and the CAGE questionnaires. In this sample, 25.4% of patients could be considered alcohol dependent ...
Tópico(s): Alcohol Consumption and Health Effects
2014 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Produção Nacional
Revisado por pares
Mauro Barbosa Terra, Dartiu Xavier da Silveira, Taís de Campos Moreira, Maristela Ferigolo, Cláudia Galvão Mazoni, Fernanda Xavier Arena, Helena Maria Tannhauser Barros,
OBJECTIVE: This work was designed to validate the Portuguese version of the Contemplation Ladder, whose purpose is to assess the motivational phase to quit smoking among tobacco users using a telephone service. METHOD: A cross-sectional study was conducted in a nationwide drug use information hotline. In order to assess the convergent validation, the correlation between the Contemplation Ladder and the URICA Scale was calculated, which was previously validated. RESULTS: The study included 271 tobacco ...
Tópico(s): Obesity, Physical Activity, Diet
2009 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Jornal Brasileiro de Psiquiatria
Aline Xavier da Silveira dos Santos, Prisca Liberali,
Self-organization is a process by which interacting cells organize and arrange themselves in higher order structures and patterns. To achieve this, cells must have molecular mechanisms to sense their complex local environment and interpret it to respond accordingly. A combination of cell-intrinsic and cell-extrinsic cues are decoded by the single cells dictating their behaviour, their differentiation and symmetry-breaking potential driving development, tissue remodeling and regenerative processes. ...
Tópico(s): Cell Image Analysis Techniques
2018 - Wiley | FEBS Journal
Produção Nacional
Revisado por pares
Fabiane Frota da Rocha Morgado, Erika Maria Kopp Xavier da Silveira, Anna Maria Sales, Lilian Pinheiro Rodrigues do Nascimento, Euzenir Nunes Sarno, José Augusto da Costa Nery, Aldair J. Oliveira, Ximena Illarramendi,
Describe the process of cross-cultural adaptation of the "Explanatory Model Interview Catalog - Stigma Scale" for people affected by leprosy in Brazil.After being authorized by the author of the scale to use it in the national context, we initiated the five steps process of cross-cultural adaptation: (1) translation, (2) synthesis meeting, (3) back-translation, (4) committee of experts and (5) pre-test. The internal consistency of the scale was evaluated using Cronbach's alpha coefficient.The 15 items of ...
Tópico(s): Health, Nursing, Elderly Care
2017 - UNIVERSIDADE DE SÃO PAULO | Revista de Saúde Pública
Produção Nacional
Revisado por pares
Marco Antonio Nocito Echevarria, Tassio Andrade Reis, Giulianno Ruffo Capatti, Victor Siciliano Soares, Dartiu Xavier da Silveira, Thiago Marques Fidalgo,
The aim of this paper is to extensively review the current literature available on N-acetylcysteine (NAC) treatment for cocaine dependence (clinical and experimental studies). We screened all articles published before February 2016 reporting on the use of NAC as a pharmacological intervention for cocaine dependence or discussed its potential as a therapeutic approach for cocaine dependence. We described our results qualitatively. 21 studies matched our search criteria: 6 clinical trials and 15 animal ...
Tópico(s): Ion channel regulation and function
2017 - Elsevier BV | Psychiatry Research
Produção Nacional
Revisado por pares
Eduardo Ekman Schenberg, Maria Angélica de Castro Comis, João Felipe Morel Alexandre, Luís Fernando Tófoli, Bruno Daniel Rasmussen Chaves, Dartiu Xavier da Silveira,
Objective This report documents the phenomenology of the subjective experiences of 22 patients with substance-related disorders who were involved in a treatment combining cognitive–behavioral therapy and hospital sessions with ibogaine in Brazil. Methods Participants underwent a one-to-one semi-structured interview exploring the subjective effects of ibogaine. We employed interpretative phenomenological analysis to identify relevant phenomenological categories, including physical sensations, perceptual ( ...
Tópico(s): Chemical synthesis and alkaloids
2017 - Akadémiai Kiadó | Journal of Psychedelic Studies
Produção Nacional
Revisado por pares
Renato Filev, Douglas Senna Engelke, Dartiu Xavier da Silveira, Luiz E. Mello, Jair Guilherme Santos-Junior,
The motivational circuit activated by ethanol leads to behavioral changes that recruit the endocannabinoid system (ECS). Case reports and observational studies suggest that the use of Cannabis sp. mitigates problematic ethanol consumption in humans. Here, we verified the effects of the two main phytocannabinoid compounds of Cannabis sp., cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), in the expression of ethanol-induced locomotor sensitization in mice. Male adult DBA/2 mice were exposed ...
Tópico(s): Neuroscience and Neuropharmacology Research
2017 - Elsevier BV | Alcohol
Produção Nacional
Revisado por pares
Eduardo Ekman Schenberg, Luís Fernando Tófoli, DANIEL REZINOVSKY, Dartiu Xavier da Silveira,
Background The States of Consciousness Questionnaire (SOCQ) was developed to assess the occurrence features of the change in consciousness induced by psilocybin, and includes the Mystical Experience Questionnaire (MEQ), developed to assess the ocurrence of mystical experiences in altered states of consciousness. Objective To translate the SOCQ to Brazilian Portuguese and validate the 30-item MEQ. Methods The SOCQ was translated to Brazilian Portuguese and backtranslated into English. The two English ...
Tópico(s): Paranormal Experiences and Beliefs
2017 - UNIVERSIDADE DE SÃO PAULO | Archives of Clinical Psychiatry (São Paulo)
Produção Nacional
Revisado por pares
Eduardo Ekman Schenberg, Maria Angélica de Castro Comis, João Felipe Morel Alexandre, Bruno Daniel Rasmussen Chaves, Luís Fernando Tófoli, Dartiu Xavier da Silveira,
Substance use disorders are important contributors to the global burden of disease, but current treatments are not associated with high rates of recovery. The lack of approved and effective treatments is acutely problematic for psychostimulants like cocaine and crack cocaine. One promising alternative in the treatment of drug dependence in general and psychostimulants in particular is the use of the psychedelic alkaloid ibogaine combined with psychotherapy. This was recently shown to induce prolonged ...
Tópico(s): Chemical synthesis and alkaloids
2017 - Akadémiai Kiadó | Journal of Psychedelic Studies
Georgios Savoglidis, Aline Xavier da Silveira dos Santos, Isabelle Riezman, Paolo Angelino, Howard Riezman, Vassily Hatzimanikatis,
We present a model-based method, designated Inverse Metabolic Control Analysis (IMCA), which can be used in conjunction with classical Metabolic Control Analysis for the analysis and design of cellular metabolism. We demonstrate the capabilities of the method by first developing a comprehensively curated kinetic model of sphingolipid biosynthesis in the yeast Saccharomyces cerevisiae. Next we apply IMCA using the model and integrating lipidomics data. The combinatorial complexity of the synthesis ...
Tópico(s): Lipid metabolism and biosynthesis
2016 - Elsevier BV | Metabolic Engineering
Produção Nacional
Revisado por pares
Paulo César Ribeiro Barbosa, Rick J. Strassman, Dartiu Xavier da Silveira, Kelsy Catherina Nema Areco, Robert Hoy, Jessica Pommy, Robert J. Thoma, Michael P. Bogenschutz,
Hoasca (also called ayahuasca) is a N,N-dimethyltryptamine (DMT) – containing psychedelic brew originally used for magico-religious purposes by Amerindian populations of the Amazon Basin. Recently, Brazilian syncretic churches have helped spread the ritual use of hoasca to Western societies. The aim of this study was to evaluate substance use, and neuropsychological and psychological functioning of regular hoasca users within a religious setting. Assessment of socio-economic status, mood, personality ...
Tópico(s): Death Anxiety and Social Exclusion
2016 - Elsevier BV | Comprehensive Psychiatry
Produção Nacional
Revisado por pares
Tânia Bitancourt, Maria Cristina Ribeiro Grilli Tissot, Thiago Marques Fidalgo, José Carlos Fernandes Galduróz, Dartiu Xavier da Silveira Filho,
Substance use among teenage students and factors associated were investigated through a survey using a questionnaire adapted from the WHO's Program on Research and Reporting on the Epidemiology of Drug Dependence, additional questions on family factors and personal risks, and the Coopersmith Self-Esteem Inventory, adapted to Brazil. The target population consisted of 3891 10–22-year-old students from the city of Embu das Artes, São Paulo, Brazil. The prevalence of lifetime substance use was 26.7%. ...
Tópico(s): Prenatal Substance Exposure Effects
2016 - Elsevier BV | Psychiatry Research
Produção Nacional
Revisado por pares
Vítor S. Tardelli, Mariana Pimentel Pádua do Lago, Dartiu Xavier da Silveira, Thiago Marques Fidalgo,
Tópico(s): Alcoholism and Thiamine Deficiency
2016 - Elsevier BV | Psychiatry Research
Harsha Garadi Suresh, Aline Xavier da Silveira dos Santos, Wanda Kukulski, Jens Tyedmers, Howard Riezman, Bernd Bukau, Axel Mogk,
Cells adapt to changing nutrient availability by modulating a variety of processes, including the spatial sequestration of enzymes, the physiological significance of which remains controversial. These enzyme deposits are claimed to represent aggregates of misfolded proteins, protein storage, or complexes with superior enzymatic activity. We monitored spatial distribution of lipid biosynthetic enzymes upon glucose depletion in Saccharomyces cerevisiae. Several different cytosolic-, endoplasmic reticulum–, ...
Tópico(s): Mitochondrial Function and Pathology
2015 - American Society for Cell Biology | Molecular Biology of the Cell
Produção Nacional
Revisado por pares
Benedikt Fischer, Peter Blanken, Dartiu Xavier da Silveira, Andréa Donatti Gallassi, Elliot M. Goldner, Jürgen Rehm, Mark Tyndall, Evan Wood,
There are an estimated several million crack-cocaine users globally; use is highest in the Americas. Most crack users are socio-economically marginalized (e.g., homeless), and feature elevated risks for morbidity (e.g., blood-borne viruses), mortality and crime/violence involvement, resulting in extensive burdens. No comprehensive reviews of evidence-based prevention and/or treatment interventions specifically for crack use exist. We conducted a comprehensive narrative overview of English-language ...
Tópico(s): Homelessness and Social Issues
2015 - Elsevier BV | International Journal of Drug Policy
Produção Nacional
Revisado por pares
Eduardo Ekman Schenberg, João Felipe Morel Alexandre, Renato Filev, André M. Cravo, João Ricardo Sato, Suresh Muthukumaraswamy, Maurı́cio Yonamine, Marian Waguespack, Izabela Lomnicka, Steven A. Barker, Dartiu Xavier da Silveira,
Ritual use of ayahuasca, an amazonian Amerindian medicine turned sacrament in syncretic religions in Brazil, is rapidly growing around the world. Because of this internationalization, a comprehensive understanding of the pharmacological mechanisms of action of the brew and the neural correlates of the modified states of consciousness it induces is important. Employing a combination of electroencephalogram (EEG) recordings and quantification of ayahuasca's compounds and their metabolites in the systemic ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2015 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Eduardo Ekman Schenberg, Maria Angélica de Castro Comis, Bruno Rasmussen Chaves, Dartiu Xavier da Silveira,
Ibogaine is an alkaloid purported to be an effective drug dependence treatment. However, its efficacy has been hard to evaluate, partly because it is illegal in some countries. In such places, treatments are conducted in underground settings where fatalities have occurred. In Brazil ibogaine is unregulated and a combined approach of psychotherapy and ibogaine is being practiced to treat addiction. To evaluate the safety and efficacy of ibogaine, we conducted a retrospective analysis of data from ...
Tópico(s): Forensic Toxicology and Drug Analysis
2014 - SAGE Publishing | Journal of Psychopharmacology
Caroline Wilson-Zbinden, Aline Xavier da Silveira dos Santos, Ingrid Stoffel-Studer, Aniek van der Vaart, Kay Hofmann, Fulvio Reggiori, Howard Riezman, Claudine Kraft, Matthias Peter,
Abstract Autophagy is a highly regulated pathway that selectively degrades cellular constituents such as protein aggregates and excessive or damaged organelles. This transport route is characterized by engulfment of the targeted cargo by autophagosomes. The formation of these double-membrane vesicles requires the covalent conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine (PE). However, the origin of PE and the regulation of lipid flux required for autophagy remain poorly ...
Tópico(s): Mosquito-borne diseases and control
2014 - Oxford University Press | Genetics
Aline Xavier da Silveira dos Santos, Isabelle Riezman, Auxiliadora Aguilera-Romero, Fabrice David, Manuele Piccolis, Robbie Loewith, Olivier Schaad, Howard Riezman,
The regulatory pathways required to maintain eukaryotic lipid homeostasis are largely unknown. We developed a systematic approach to uncover new players in the regulation of lipid homeostasis. Through an unbiased mass spectrometry-based lipidomic screening, we quantified hundreds of lipid species, including glycerophospholipids, sphingolipids, and sterols, from a collection of 129 mutants in protein kinase and phosphatase genes of Saccharomyces cerevisiae. Our approach successfully identified known ...
Tópico(s): Lipid metabolism and biosynthesis
2014 - American Society for Cell Biology | Molecular Biology of the Cell
Produção Nacional
Revisado por pares
Francisco Carlos Machado Rocha, Jair Guilherme Santos-Junior, Sérgio Carlos Stefano, Dartiu Xavier da Silveira,
Tópico(s): PARP inhibition in cancer therapy
2013 - Springer Science+Business Media | Journal of Neuro-Oncology
Produção Nacional
Revisado por pares
Cássia Canha Coelhoso, Douglas Senna Engelke, Renato Filev, Dartiu Xavier da Silveira, Luiz E. Mello, Jair Guilherme Santos-Junior,
Background There is a close relationship between the endocannabinoid system and alcoholism. This study investigated possible differential expression of cannabinoid receptors CB1 (CB1R) and CB2 (CB2R) in an outbred mice strain displaying behavioral variability to ethanol (EtOH)-induced locomotor sensitization. Methods Male adult Swiss mice treated chronically with EtOH (2 g/kg, i.p., daily for 21 days) were classified as "EtOH_High" or "EtOH_Low" according to their locomotor activity after the 21st EtOH ...
Tópico(s): Neuroscience and Neuropharmacology Research
2013 - Wiley | Alcoholism Clinical and Experimental Research
Produção Nacional
Eduardo Ferreira de Castro-Neto, Rafael Henrique da Cunha, Dartiu Xavier da Silveira, Maurı́cio Yonamine, Telma Luciana Furtado Gouveia, Ésper A. Cavalheiro, Débora Amado, Maria da Graça Naffah‐Mazzacoratti,
To evaluate changes in neurotransmission induced by a psychoactive beverage ayahuasca in the hippocampus and amygdala of naive rats.The level of monoamines, their main metabolites and amino acid neurotransmitters concentrations were quantified using high performance liquid chromatography (HPLC). Four groups of rats were employed: saline-treated and rats receiving 250, 500 and 800 mg/kg of ayahuasca infusion (gavage). Animals were killed 40 min after drug ingestion and the structures stored at -80 °C ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2013 - Baishideng Publishing Group | World Journal of Biological Chemistry
Produção Nacional
Revisado por pares
Ricardo Fontão de Pauli, Cássia Canha Coelhoso, Carolina Tesone-Coelho, Alessandra Linardi, Luiz E. Mello, Dartiu Xavier da Silveira, Jair Guilherme Santos-Junior,
Chronic drug exposure and drug withdrawal induce expressive neuronal plasticity which could be considered as both functional and pathological responses. It is well established that neuronal plasticity in the limbic system plays a pivotal role in relapse as well as in compulsive characteristics of drug addiction. Although increases in FosB/DeltaFosB expression constitute one of the most important forms of neuronal plasticity in drug addiction, it is unclear whether they represent functional or pathological ...
Tópico(s): Neuroscience and Neuropharmacology Research
2013 - Elsevier BV | Pharmacology Biochemistry and Behavior