Emily E. Bosco, R. James Christie, Rosa A. Carrasco, Darrin Sabol, Jiping Zha, Karma Dacosta, Lee R. Brown, Maureen Kennedy, John Meekin, Sandrina Phipps, Joanne Ayriss, Qun Du, Binyam Bezabeh, Partha S. Chowdhury, Shannon Breen, Cui Chen, Molly Reed, MaryJane Hinrichs, Haihong Zhong, Zhan Xiao, Rakesh Dixit, Ronald Herbst, David A. Tice,
... Reed 5 , MaryJane Hinrichs 5 , Haihong Zhong 1 , Zhan Xiao 1 , Rakesh Dixit 5 , Ronald Herbst 1 and ...
Tópico(s): Advanced Breast Cancer Therapies
2018 - Impact Journals LLC | Oncotarget
Baolei Wang, Yan Zhang, Xing‐Hai Liu, Liyuan Zhang, Yizhou Zhan, Xiǎo Zhang, Li‐Zhong Wang, Yonghong Li, Zhengming Li,
... Xing-Hai Liu, Li-Yuan Zhang, Yi-Zhou Zhan, Xiao Zhang, Li-Zhong Wang, Yong-Hong Li & Zheng- ...
Tópico(s): Click Chemistry and Applications
2016 - Taylor & Francis | Phosphorus, sulfur, and silicon and the related elements
Le Wang, Gerard M. Sullivan, Laura A. Hexamer, Lisa Hasvold, Reema K. Thalji, Magdalena Przytulinska, Zhi‐Fu Tao, Gaoquan Li, Zehan Chen, Zhan Xiao, Wen‐Zhen Gu, John Xue, Mai-Ha Bui, Philip J. Merta, Peter Kovar, Jennifer J. Bouska, Haiying Zhang, Chang Park, Kent D. Stewart, Hing L. Sham, Thomas J. Sowin, Saul H. Rosenberg, Nan‐Horng Lin,
A novel series of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones have been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via structure-based design. Aided by protein X-ray crystallography, medicinal chemistry efforts led to the identification of compound 46d, with potent enzymatic activity against Chk1 kinase. While maintaining a low cytotoxicity of its own, compound 46d exhibited a strong ability to abrogate G2 arrest and increased the cytotoxicity of camptothecin by ...
Tópico(s): Microtubule and mitosis dynamics
2007 - American Chemical Society | Journal of Medicinal Chemistry
Zehan Chen, Zhan Xiao, Wen‐Zhen Gu, John Xue, Mai H. Bui, Peter Kovar, Gaoquan Li, Gary Wang, Zhi‐Fu Tao, Yunsong Tong, Nan‐Horng Lin, Hing L. Sham, Jean Y. J. Wang, Thomas J. Sowin, Saul H. Rosenberg, Haiying Zhang,
The majority of cancer therapeutics induces DNA damage to kill cells. Normal proliferating cells undergo cell cycle arrest in response to DNA damage, thus allowing DNA repair to protect the genome. DNA damage induced cell cycle arrest depends on an evolutionarily conserved signal transduction network in which the Chk1 kinase plays a critical role. In mammalian cells, the p53 and RB pathways further augment the cell cycle arrest response to prevent catastrophic cell death. Given the fact that most ...
Tópico(s): Cancer therapeutics and mechanisms
2006 - Wiley | International Journal of Cancer
Zhan Xiao, John Xue, Thomas J. Sowin, Haiying Zhang,
Abstract Mammalian cells initiate cell cycle arrest at different phases of the cell cycle in response to various forms of genotoxic stress to allow time for DNA repair, and thus preserving their genomic integrity. The protein kinases checkpoint kinase 1 (Chk1), checkpoint kinase 2 (Chk2), and mitogen-activated protein kinase–activated protein kinase 2 (MK2) have all been shown to be involved in cell cycle checkpoint control. Recently, cell cycle checkpoint abrogation has been proposed as one way to ...
Tópico(s): Cancer therapeutics and mechanisms
2006 - American Association for Cancer Research | Molecular Cancer Therapeutics
Zhan Xiao-Gui, Hongmei Li, Zeng Hao-Sheng,
We propose a method to realize the teleportation of an unknown entangled state that consists of many qudits through a partially entangled-qudit quantum channel with the help of 2log2d-bit classical communication. The operations used in the teleportation process include a generalized Bell-state measurement and a series of single-qudit π-measurements performed by Alice, a series of generalized qudit-Pauli gates and two-level unitary gates, as well as a qubit measurement performed by Bob. For a maximally ...
Tópico(s): Quantum Mechanics and Applications
2006 - Institute of Physics | Chinese Physics Letters
Zhan Xiao, John Xue, Dimitri Semizarov, Thomas J. Sowin, Saul H. Rosenberg, Haiying Zhang,
Paclitaxel (Taxol) is the most-prescribed anti-mitotic agent for a variety of advanced metastatic cancers. It induces mitotic arrest leading to apoptosis through microtubule stabilization. Chk1 is the major cell-cycle checkpoint kinase mediating S- and G2-arrests in response to various DNA-damages. Chk1 inhibitor is anticipated and has been demonstrated to potentiate the cytotoxicity of DNA-damaging agents through abrogation of cell-cycle checkpoints. Paclitaxel does not, however, induce Chk1 activation, ...
Tópico(s): Cancer-related Molecular Pathways
2005 - Wiley | International Journal of Cancer
Gary T. Wang, Gaoquan Li, Robert A. Mantei, Zehan Chen, Peter Kovar, Wendy Gu, Zhan Xiao, Haiying Zhang, Hing L. Sham, Thomas J. Sowin, Saul H. Rosenberg, Nan‐Horng Lin,
The discovery of 1-(5-chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas as a new class of potent (IC50 values of 3−10 nM) and selective inhibitors of Chk1 kinase was described. One of these compounds (2e) potentiates HeLa cells by over 22-fold against doxorubicin in an antiproliferation assay, and SW620 cells against camptothecin by 20-fold in an antiproliferation assay and 14-fold in a soft agar assay. Flow cytometry (FACS) analysis confirmed that 2e abrogated G2 checkpoint arrest of H1299 cells ...
Tópico(s): Cell death mechanisms and regulation
2005 - American Chemical Society | Journal of Medicinal Chemistry
Zhan Xiao, John Xue, Thomas J. Sowin, Saul H. Rosenberg, Haiying Zhang,
Chk1 is the major mediator in the activation of cell-cycle checkpoints in response to a variety of genotoxic stresses. We have previously shown that inhibition of Chk1 sensitizes tumor cells to topoisomerase inhibitors such as camptothecin and doxorubicin through abrogation of cell-cycle arrest (S or G2/M checkpoints). However, it was not clear whether inhibition of Chk1 could potentiate antimetabolites, a mainstay of cancer therapy, which confer genotoxic stress through a different mechanism than ...
Tópico(s): Microtubule and mitosis dynamics
2004 - Springer Nature | Oncogene
Daohai Zhang, Xiao Zhan, Teng Zhou, Jingyu Du, Kaixiang Zou, Yingchun Luo,
N/B co-doped porous carbon materials (NBPCs) are regarded as an ideal cathode material for Zn-ion hybrid supercapacitors (ZHSCs). As a capacitive cathode material, the improvement of specific surface area (SSA) and pore structure can efficiently enhance the capacity and rate capability of NBPCs. However, the B atom doping progress will patch up the defect and pore of NBPCs, thereby impeding the further expansion of the SSA area and porous structure. This paper designs a new route for high-efficiency ...
Tópico(s): Advanced Battery Materials and Technologies
2024 - Elsevier BV | Journal of Material Science and Technology
Junjie Liu, Yiwei You, Ling Huang, Qizheng Zheng, Zhefei Sun, Kai Fang, Liyuan Sha, Miao Liu, Xiao Zhan, Jinbao Zhao, Ye‐Chuang Han, Qiaobao Zhang, Yanan Chen, Shunqing Wu, Li Zhang,
As the preferred anode material for sodium-ion batteries, hard carbon (HC) confronts significant obstacles in providing a long and dominant low-voltage plateau to boost the output energy density of full batteries. The critical challenge lies in precisely enhancing the local graphitization degree to minimize Na
Tópico(s): Supercapacitor Materials and Fabrication
2024 - | Advanced Materials
Xiao Zhan, Miao Li, Xiaolin Zhao, Yaning Wang, Sha Li, Weiwei Wang, Jiande Lin, Zi‐Ang Nan, Jiawei Yan, Zhefei Sun, Haodong Liu, Fei Wang, Jiayu Wan, Jianjun Liu, Qiaobao Zhang, Li Zhang,
Abstract As the core component of solid-state batteries, neither current inorganic solid-state electrolytes nor solid polymer electrolytes can simultaneously possess satisfactory ionic conductivity, electrode compatibility and processability. By incorporating efficient Li + diffusion channels found in inorganic solid-state electrolytes and polar functional groups present in solid polymer electrolytes, it is conceivable to design inorganic-organic hybrid solid-state electrolytes to achieve true fusion ...
Tópico(s): Advancements in Battery Materials
2024 - Nature Portfolio | Nature Communications
Weiming Xiong, Jiande Lin, Huiqun Wang, Sha Li, Junhao Wang, Yuxiang Mao, Xiao Zhan, De‐Yin Wu, Li Zhang,
The practical application of lithium-sulfur (Li-S) batteries is greatly hindered by soluble polysulfides shuttling and sluggish sulfur redox kinetics. Rational design of multifunctional hybrid materials with superior electronic conductivity and high electrocatalytic activity, e.g., heterostructures, is a promising strategy to solve the above obstacles. Herein, a binary metal sulfide MnS-MoS2 heterojunction electrocatalyst is first designed for the construction of high-sulfur-loaded and durable Li- ...
Tópico(s): Advanced battery technologies research
2023 - Elsevier BV | Journal of Energy Chemistry
Yansong Zhang, Wen‐Hua Li, Xin‐Gui Tang, Ke Meng, Siyuan Zhang, Xue-Zhan Xiao, Xiaobin Guo, Yanping Jiang, Zhenhua Tang,
Dielectric ceramic materials with high energy-storage density and excellent charge-discharge performance are desirable for use in dielectric capacitors. In this study, (Na0.5Bi0.5)0.75Sr0.25TiO3–xNb2O5 (denoted as NBSTNx) lead-free ceramics were prepared by a solid-state reaction method. Polarization-electric field hysteresis loops (P–E loops) reflected the energy storage characteristics of the NBSTNx ceramics. Introducing Nb into a pure NBST ceramic can reduce the large remnant polarization (Pr) and ...
Tópico(s): Microwave Dielectric Ceramics Synthesis
2022 - Elsevier BV | Journal of Alloys and Compounds
Qing Zhao, Hongzhen Fan, Yanli Li, Lei Liu, Yaxue Wu, Yanli Zhao, Zhan-Xiao Tian, Zhiren Wang, Yunlong Tan, Shuping Tan,
At present, there is no established biomarker for the diagnosis of depression. Meanwhile, studies show that acoustic features convey emotional information. Therefore, this study explored differences in acoustic characteristics between depressed patients and healthy individuals to investigate whether these characteristics can identify depression.Participants included 71 patients diagnosed with depression from a regional hospital in Beijing, China, and 62 normal controls from within the greater community. ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2022 - Frontiers Media | Frontiers in Psychiatry
Wei Hu, Lin Zhang, Ming Xing Li, Jing Shen, Xiaodong Liu, Zhan Xiao, Ding Wu, Idy H. T. Ho, Justin C. Y. Wu, Cynthia Cheung, Yu Chen Zhang, H. Y. A. Lau, Hassan Ashktorab, Duane T. Smoot, Evandro Fei Fang, Matthew T.V. Chan, Tony Gin, Wei Gong, William Ka Kei Wu, Chi Hin Cho,
Helicobacter pylori (H. pylori) is a common human pathogenic bacterium. Once infected, it is difficult for the host to clear this organism using the innate immune system. Increased antibiotic resistance further makes it challenging for effective eradication. However, the mechanisms of immune evasion still remain obscure, and novel strategies should be developed to efficiently eliminate H. pylori infection in stomachs. Here we uncovered desirable anti-H. pylori effect of vitamin D3 both in vitro and ...
Tópico(s): Ion Transport and Channel Regulation
2019 - Taylor & Francis | Autophagy
Wei Hu, Hung Chan, Lan Lu, K. T. Wong, Sunny H. Wong, Ming X Li, Zhan Xiao, Chi H. Cho, Tony Gin, Matthew T.V. Chan, William Ka Kei Wu, Lin Zhang,
Autophagy is a conserved intracellular degradation process enclosing the bulk of cytosolic components for lysosomal degradation to maintain cellular homeostasis. Accumulating evidences showed that a specialized form of autophagy, known as xenophagy, could serve as an innate immune response to defend against pathogens invading inside the host cells. Correspondingly, infectious pathogens have developed a variety of strategies to disarm xenophagy, leading to a prolonged and persistent intracellular ...
Tópico(s): Vibrio bacteria research studies
2019 - Elsevier BV | Seminars in Cell and Developmental Biology
Zhenyu Xu, Yuliang Wang, Zhan Xiao, Chang Zou, Xian Zhang, Zhu Wang, Dinglan Wu, Shan Yu, Franky Leung Chan,
The TMPRSS2:ERG (T:E) fusion gene is generally believed to be mainly regulated by the activated androgen receptor (AR) signaling in androgen-dependent prostate cancer. However, its persistent expression in castration-resistant and neuroendocrine prostate cancers implies that other transcription factors might also regulate its expression. Here, we showed that up-regulation of nuclear receptor estrogen-related receptor alpha (ERRα) was closely associated with the oncogenic transcription factor ERG expression ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2018 - Springer Nature | Oncogene
Haihong Zhong, April Davis, Maria Ouzounova, Rosa A. Carrasco, Cui Chen, Shannon Breen, Yong S. Chang, Jiaqi Huang, Zheng Liu, Yihong Yao, Elaine M. Hurt, Jacques Moisan, Michael Fung, David A. Tice, Shawn G. Clouthier, Zhan Xiao, Max S. Wicha, Hasan Körkaya, Robert E. Hollingsworth,
Abstract Elevated levels of the proinflammatory cytokine IL6 are associated with poor survival outcomes in many cancers. Antibodies targeting IL6 and its receptor have been developed for chronic inflammatory disease, but they have not yet been shown to clearly benefit cancer patients, possibly due to antibody potency or the settings in which they have been tested. In this study, we describe the development of a novel high-affinity anti-IL6 antibody, MEDI5117, which features an extended half-life ...
Tópico(s): Immunotherapy and Immune Responses
2016 - American Association for Cancer Research | Cancer Research
Jing Shen, Zhi Jie Li, Long Fei Li, Lan Lu, Zhan Xiao, William Ka Kei Wu, Lin Zhang, Ming Xing Li, Wei Hu, Kam Ming Chan, Chi Hin Cho,
Tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ) were originally identified to show potent anti-tumor activity and immunomodulatory capability. Unfortunately, several clinical studies of relevant cancer therapy did not observe significant response in maximum tolerated dose whether given alone or in combination. We have identified a tumor vasculature homing peptide (TCP-1 peptide) which targets only the vasculature of colorectal tumors but not normal blood vessels in animals and humans. ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2016 - BioMed Central | Journal of Translational Medicine
Zhan Xiao, Jing Shen, Lin Zhang, Long Fei Li, Ming Xing Li, Wei Hu, Zhi Jie Li, Chi Hin Cho,
Aberrant epigenetic reprogramming occurs frequently in the development of tumors. Histone H3 lysine 27 trimethylation (H3K27me3) exerts a repressive epigenetic mark on a large number of genes. UTX and JMJD3 are the only two histone demethylases which activate gene expression via demethylating H3K27me3 to H3K27me2 or H3K27me1. Current studies show that dysregulation of these two proteins are heavily linked to oncogenesis in various tissue types. Accumulating evidence suggested that there is remarkable ...
Tópico(s): Histone Deacetylase Inhibitors Research
2016 - Bentham Science Publishers | Current Medicinal Chemistry
Liyan Jiang, Jiaqi Huang, Brandon W. Higgs, Zhibin Hu, Zhan Xiao, Xin Yao, Sarah J. Conley, Haihong Zhong, Zheng Liu, Philip Z. Brohawn, Dong Shen, Song Wu, Xiaoxiao Ge, Yue Jiang, Yizhuo Zhao, Yuqing Lou, Chris Morehouse, Wei Zhu, Yinong Sebastian, Meggan Czapiga, Vaheh Oganesyan, Haihua Fu, Yanjie Niu, Wei Zhang, Katie Streicher, David A. Tice, Heng Zhao, Meng Zhu, Lin Xu, Ronald Herbst, Xinying Su, Yi Gu, Shyoung Li, Lihua Huang, Jianren Gu, Baohui Han, Bahija Jallal, Hongbing Shen, Yihong Yao,
Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly in the Asian patient population. Here we conducted whole exome sequencing (WES) and transcriptomic sequencing of primary tumors from 99 Chinese SCLC patients. Dysregulation of tumor suppressor genes TP53 and RB1 was observed in 82% and 62% of SCLC patients, ...
Tópico(s): Cancer Genomics and Diagnostics
2016 - Public Library of Science | PLoS Genetics
Zhan Xiao, Rosa A. Carrasco, Kevin Schifferli, Krista Kinneer, Ravinder Tammali, Hong Chen, Ray Rothstein, Leslie Wetzel, Chunning Yang, Partha S. Chowdhury, Ping Tsui, Philipp Steiner, Bahija Jallal, Ronald Herbst, Robert E. Hollingsworth, David A. Tice,
Abstract HER3/ERBB3 is a kinase-deficient member of the EGFR family receptor tyrosine kinases (RTK) that is broadly expressed and activated in human cancers. HER3 is a compelling cancer target due to its important role in activation of the oncogenic PI3K/AKT pathway. It has also been demonstrated to confer tumor resistance to a variety of cancer therapies, especially targeted drugs against EGFR and HER2. HER3 can be activated by its ligand (heregulin/HRG), which induces HER3 heterodimerization with ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2016 - American Association for Cancer Research | Molecular Cancer Therapeutics
Jiahua Li, Zhan Xiao-Gui, Chunling Ding, Duo Zhang, Ying Wu,
We present a perturbation technique to study the linear and nonlinear output characteristics of coherent photon transport in a parity-time ($\mathcal{PT}$)-symmetric double-microcavity system where one passive cavity contains a single quantum emitter. It is found that (i) for the linear transmission of a low-power input probe field, the output spectra of the proposed $\mathcal{PT}$-symmetric system exhibit a single transparent resonance dip and two symmetric, strongly amplifying sidebands, i.e., an inverted ...
Tópico(s): Nonlinear Photonic Systems
2015 - American Physical Society | Physical Review A
Feng Xue, Brandon W. Higgs, Jiaqi Huang, Chris Morehouse, Wei Zhu, Xin Yao, Philip Z. Brohawn, Zhan Xiao, Yinong Sebastian, Zheng Liu, Yun Xia, Dong Shen, Mike Kuziora, Zhengwei Dong, Hulin Han, Yi Gu, Jianren Gu, Qiang Xia, Yihong Yao,
Orthotopic liver transplantation (OLT) can be an effective treatment option for certain patients with early stage hepatocellular carcinoma (HCC) meeting Milan, UCSF, or Hangzhou criteria. However, HCC recurrence rates post-OLT range from 20 to 40 %, with limited follow-up options. Elucidating genetic drivers common to primary and post-OLT recurrent tumors may further our understanding and help identify predictive biomarkers of recurrence—both to ultimately help manage clinical decisions for patients ...
Tópico(s): Cancer-related molecular mechanisms research
2015 - BioMed Central | Journal of Translational Medicine
Zhan Xiao-Gui, Liu-Gang Si, Anshou Zheng, Xiaoxue Yang,
We theoretically investigate the slow light in a quadratically coupled optomechanical system. Different from the linear coupling case, the slow light via quadratic coupling derives from a two-phonon process, and the fluctuation in displacement plays a vital role in nonlinear coherence. The numerical results show that the slow light can be realized in an extensive range of parameters even at high temperature, e.g., 200 K. We also find that the environment temperature which provides almost all of ...
Tópico(s): Photonic and Optical Devices
2013 - IOP Publishing | Journal of Physics B Atomic Molecular and Optical Physics
J. S. Swers, Luba Grinberg, Lin Wang, Hui Feng, Kristen Lekstrom, Rosa A. Carrasco, Zhan Xiao, Ivan Inigo, Ching Ching Leow, Herren Wu, David A. Tice, Manuel Baca,
Activation of TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) can induce apoptosis in a variety of human cancer cell lines and xenografts, while lacking toxicity in normal cells. The natural ligand and agonistic antibodies show antitumor activity in preclinical models of cancer, and this had led to significant excitement in the clinical potential of these agents. Unfortunately, this optimism has been tempered by trial data that, thus far, are not showing clear signs of efficacy in cancer ...
Tópico(s): NF-κB Signaling Pathways
2013 - American Association for Cancer Research | Molecular Cancer Therapeutics
Zhan Xiao, Rosa A. Carrasco, Krista Kinneer, Darrin Sabol, Bahija Jallal, Steve Coats, David A. Tice,
EphB4 is a member of the Eph receptor tyrosine kinase family shown to act in neuronal guidance and mediate venal/arterial separation. In contrast to these more established roles, EphB4's function in cancer is much less clear. Here we illustrate both tumor promoting as well as suppressing roles of EphB4, by showing that its activation resulted in inhibition of the Ras/ERK pathway in endothelial cells but activation of the same pathway in MCF-7 breast cancer cells. This was true if EphB4 was stimulated ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2012 - Taylor & Francis | Cancer Biology & Therapy
Nai-Ying Yang, C. Fernández, Melanie Richter, Zhan Xiao, Fatima Valencia, David A. Tice, Elena B. Pasquale,
Receptor tyrosine kinases of the Eph family play multiple roles in the physiological regulation of tissue homeostasis and in the pathogenesis of various diseases, including cancer. The EphA2 receptor is highly expressed in most cancer cell types, where it has disparate activities that are not well understood. It has been reported that interplay of EphA2 with oncogenic signaling pathways promotes cancer cell malignancy independently of ephrin ligand binding and receptor kinase activity. In contrast, ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2010 - Elsevier BV | Cellular Signalling
Xin-Wen Wang, Deng-Yu Zhang, Shi-Qing Tang, Zhan Xiao-Gui, Kaiming You,
Tópico(s): Quantum Computing Algorithms and Architecture
2010 - Springer Science+Business Media | International Journal of Theoretical Physics