Qiuping Xie, Jianguo Song Yan Huang, Ke Zhu, Qing Chen,
Abstract Previous meta‐analyses showed that coronary artery bypass grafting (CABG) has lower all‐cause mortality than percutaneous coronary intervention (PCI) for the management of coronary heart disease (CHD), but the long‐term outcomes were not analyzed thoroughly in patients with type 2 diabetes mellitus (T2DM). To perform a meta‐analysis of randomized controlled trials (RCTs) to explore the long‐term effectiveness between CABG and PCI in patients with T2DM and study the temporal trends using a cumulative ...
Tópico(s): Cardiac Imaging and Diagnostics
2021 - Wiley | Clinical Cardiology
Teng-Yun Wei, Yuanjie Wu, Qiuping Xie, Jia‐Wei Tang, Zhituo Yu, Songbai Yang, Shaoxin Chen,
Glarea lozoyensis is an important industrial fungus that produces the pneumocandin B0, which is used for the synthesis of antifungal drug caspofungin. However, because of the limitations and complications of traditional genetic tools, G. lozoyensis strain engineering has been hindered. In this study, we established an efficient CRISPR/Cas9-based gene editing tool in G. lozoyensis SIPI1208. With this method, gene mutagenesis efficiency in the target locus can be up to 80%, which enables the rapid ...
Tópico(s): Fungal and yeast genetics research
2020 - American Chemical Society | ACS Synthetic Biology
Tiantian Wang, Yanping Wu, Qiuping Xie, Haichen Yan, Xiaoming Zhou, Xing Yu, Yufei Chen, Cheng Xiang, Haichao Yan, Qunzi Zhao, Maolin Zhang, Ming Qi, Ping Wang, Yong Wang,
Abstract Background Remote access and endoscopic thyroid surgery has been gaining popularity because it allows patients to avoid a visible scar in the neck. There is limited data on transoral endoscopic thyroidectomy when it relates to patients with papillary thyroid carcinoma. We aim to evaluate the safety of ipsilateral central compartment dissection for patients who undergo transoral thyroidectomy (thyroidectomy vestibular approach–compartment lymph node dissection). Patients and Methods A total ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2019 - Oxford University Press | Japanese Journal of Clinical Oncology
Qiuping Xie, Cheng Xiang, Yong Wang, Haichao Yan, Qunzi Zhao, Xing Yu, Maolin Zhang, Ping Wang,
Tópico(s): Airway Management and Intubation Techniques
2019 - Springer Science+Business Media | Endocrine
Ectogenic pancreatic islet transplantation has long been discussed as having the potential to reverse diabetes. The aim of the present study was to evaluate the therapeutic efficacy of co‑transplantation with hypoxia pretreated mesenchymal stem cells (MSCs) and islets in a diabetic mouse model. MSCs were isolated from femoral and tibial bone marrow aspirates from female BALB/c donor mice. MSC proliferation rates and the expression levels of vascular endothelial growth factor A (VEGFA), interleukin ( ...
Tópico(s): Metabolism, Diabetes, and Cancer
2018 - Spandidos Publishing | Molecular Medicine Reports
Yong Wang, Ziyi Zhang, Qunzi Zhao, Qiuping Xie, Haichao Yan, Xing Yu, Cheng Xiang, Maolin Zhang, Ping Wang,
Abstract Background Transoral endoscopic thyroid surgery has been introduced in a few institutions. The purpose of this study was to present an innovative hybrid space‐maintaining method for the tri‐vestibular approach. Methods Eighteen consecutive patients underwent transoral endoscopic thyroidectomy. Three incisions were made in the vestibule. The surgical space was maintained with CO 2 insufflation along with a suspension device. Thyroidectomy and central neck dissection (CND) were performed safely ...
Tópico(s): Head and Neck Anomalies
2018 - Wiley | Head & Neck
Cheng Xiang, Maolin Zhang, Qunzi Zhao, Qiuping Xie, Haichao Yan, Xing Yu, Ping Wang, Yong Wang,
// Cheng Xiang 1 , Mao-lin Zhang 1 , Qun-zi Zhao 1 , Qiu-ping Xie 1 , Hai-chao Yan 1 , Xing Yu 1 , Ping Wang 1 , Yong Wang 1 1 Department of Thyroid Surgery, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang Province, China Correspondence to: Yong Wang, email: surgwy@yeah.net Keywords: thyroid cancer, lncRNA, 131 I, PARP-1, SLC6A9-5:2 Received: September 16, 2016 Accepted: December 28, 2016 Published: January 10, 2017 ABSTRACT Recent studies have indicated that long non-coding RNAs ...
Tópico(s): RNA Research and Splicing
2017 - Impact Journals LLC | Oncotarget
Qiuping Xie, Cheng Xiang, Gang Wang, Kefeng Lei, Y. Wang,
In various studies, metastasis associated with colon cancer 1 (MACC1) has been frequently reported to be abnormally highly expressed in human lung cancer, colon cancer, and hepatocellular carcinoma. Our study focuses on the association of MACC1 expression with gastric cancer (GC). During our experiment, the MACC1 expression was tested in 105 GC samples using an immunohistochemical (IHC) method. The clinical characteristics and prognosis of these patients were summarized. During analysis, MACC1 distribution ...
Tópico(s): Gastric Cancer Management and Outcomes
2016 - Springer Science+Business Media | Journal of Zhejiang University SCIENCE B
Yong Wang, Xing Yu, Ping Wang, Chundi Miao, Qiuping Xie, Haichao Yan, Qunzi Zhao, Maolin Zhang, Cheng Xiang,
Transoral endoscopic approach is the natural orifice surgery applied in thyroidectomy to achieve an excellent cosmetic result. Recurrent laryngeal nerve (RLN) injury is the most common complication and little advancement was achieved in the previous clinical studies of transoral thyroid surgery. Herein, we introduced the method of intraoperative neuromonitoring (IONM) for transoral endoscopic thyroid surgery.Patients with thyroid carcinoma received transoral endoscopic thyroid surgery through vestibular ...
Tópico(s): Airway Management and Intubation Techniques
2016 - Mary Ann Liebert, Inc. | Journal of Laparoendoscopic & Advanced Surgical Techniques
Qiuping Xie, Ping Wang, Haichao Yan, Yong Wang,
To demonstrate the feasibility of intraoperative nerve monitoring (IONM) in total endoscopic thyroidectomy (TET) for high-risk thyroid cancer and to confirm its additional benefit on reducing surgery duration and protecting the recurrent laryngeal nerve (RLN).One hundred twenty-three patients with or without autoimmune thyroiditis (AT) underwent TET using IONM or not were included in the study. The primary outcome measures were the time used on related surgery procedures and the prevalence of RLN injury. ...
Tópico(s): Airway Management and Intubation Techniques
2015 - Mary Ann Liebert, Inc. | Journal of Laparoendoscopic & Advanced Surgical Techniques
Haichao Yan, Yong Wang, Ping Wang, Qiuping Xie, Qunzi Zhao,
Tópico(s): Head and Neck Anomalies
2014 - Springer Science+Business Media | Surgical Endoscopy
Gang Shu, Naisheng Lu, Xiaotong Zhu, Yong Xu, Min-qing DU, Qiuping Xie, Canjun Zhu, Qi Xu, Songbo Wang, Lina Wang, Ping Gao, Qianyun Xi, Yongliang Zhang, Qingyan Jiang,
Adipocyte dysfunction is associated with many metabolic diseases such as obesity, insulin resistance and diabetes. Previous studies found that phloretin promotes 3T3-L1 cells differentiation, but the underlying mechanisms for phloretin's effects on adipogenesis remain unclear. In this study, we demonstrated that phloretin enhanced the lipid accumulation in porcine primary adipocytes in a time-dependent manner. Furthermore, phloretin increased the utilization of glucose and nonesterified fatty acid, ...
Tópico(s): Bioactive natural compounds
2014 - Elsevier BV | The Journal of Nutritional Biochemistry
Bo Zhang, Miranbieke Buya, Wenjie Qin, Chongde Sun, Haolei Cai, Qiuping Xie, Bing Xu, Yulian Wu,
Islet replacement is a promising cure for insulin-dependent diabetes but is limited by a massive early cell death following transplantation. Overburden oxidative stress is one of the major factors causing cell damage. We have shown previously that anthocyanins in Chinese bayberry extract protected β cells (INS-1) from hydrogen peroxide (H2O2)-induced apoptosis and decreased grafts' apoptosis after transplantation partially through heme oxygenase-1 (HO-1) up-regulation. In the present study, we observed ...
Tópico(s): Pancreatic function and diabetes
2013 - American Chemical Society | Journal of Agricultural and Food Chemistry
Zhiyu Li, Bin Li, Yulian Wu, Qiuping Xie,
Left-sided portal hypertension (LSPH) followed by acute pancreatitis is a rare condition with most patients being asymptomatic. In cases where gastrointestinal (GI) bleeding is present, however, the condition is more complicated and the mortality is very high because of the difficulty in diagnosing and selecting optimal treatment. A successfully treated case with severe GI bleeding by transcatheter splenic artery embolization is reported in this article. The patient exhibited severe uncontrollable ...
Tópico(s): Liver Disease Diagnosis and Treatment
2013 - Springer Science+Business Media | Journal of Zhejiang University SCIENCE B
Muxing Kang, Biao Jiang, Bin Xu, Wenjie Lu, Qingqu Guo, Qiuping Xie, Bo Zhang, Xin Dong, Daniel Chen, Yulian Wu,
The stubborn chemoresistance of pancreatic ductal adenocarcinoma (PDA) is simultaneously influenced by tumor parenchymal and stromal factors, and the ctritical role of Notch ligand Delta-like 4 (DLL4) in the regulation of tumor malignancies has been observed. DLL4 positive expression ratio between duct cells from clinical tumor and adjacent tissues was statistically significant, and the overactivation of DLL4/Notch pathway enhanced the phenotype of EMT and cancer stem cell, even can induce multi-chemoresistance ...
Tópico(s): Epigenetics and DNA Methylation
2012 - Elsevier BV | Cancer Letters
Ying Chen, Muxing Kang, Wenjie Lu, Qingqu Guo, Bingbo Zhang, Qiuping Xie, Yulian Wu,
Tópico(s): Nuclear Receptors and Signaling
2012 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
Ying Chen, Qingqu Guo, Bingbo Zhang, Muxing Kang, Qiuping Xie, Yulian Wu,
Bufalin, an active component of the Chinese medicine chan'su, has been reported to have an inhibitory effect on the growth of various types of cancer cells. In the present study, we investigated whether gemcitabine combined with bufalin enhanced the antitumor efficacy in pancreatic cancer. Three pancreatic cancer cell lines (Bxpc-3, Mia PaCa-2 and Panc-1) were treated with gemcitabine and/or bufalin in vitro. The combination treatment demonstrated greater inhibition of cellular growth and apoptosis. ...
Tópico(s): Peptidase Inhibition and Analysis
2012 - Spandidos Publishing | Oncology Letters
Bo Zhang, Biao Jiang, Ying Chen, Hai Huang, Qiuping Xie, Muxing Kang, Hui Zhang, Chuanxin Zhai, Yulian Wu,
Islets can be visualized on MRI by labeling with superparamagnetic contrast agent during the transplantation procedure. However, whether the signal intensity reflects the cell number and cellular viability has not been determined. We used a self‐synthesized novel superparamagnetic contrast agent –polyvinylpyrrolidone‐coated superparamagnetic iron oxide nanoparticles (PVP‐SPIO) – to label β ‐TC‐6 cells (a mouse insulinoma cell line) or primary islets with commercial Feridex as a control. The labeling efficiency ...
Tópico(s): Neonatal Health and Biochemistry
2012 - Hindawi Publishing Corporation | Contrast Media & Molecular Imaging
Bingdi Chen, Hui Zhang, Chuanxin Zhai, Ning Du, Chen Sun, Jingwen Xue, Deren Yang, Hai Huang, Bingbo Zhang, Qiuping Xie, Yulian Wu,
We developed a simple and novel layer-by-layer (LBL) assembly in combination with covalent connection strategy for the synthesis of multifunctional carbon nanotubes (CNTs)-based magnetic-fluorescent nanohybrids as multimodal cellular imaging agents for detecting human embryonic kidney (HEK) 293T cells via magnetic resonance (MRI) and confocal fluorescence imaging. Superparamagnetic iron oxide nanoparticles (SPIO) and near-infrared fluorescent CdTe quantum dots (QDs) were covalently coupled on the surface ...
Tópico(s): Nanocluster Synthesis and Applications
2010 - Royal Society of Chemistry | Journal of Materials Chemistry
Bo Zhang, Muxing Kang, Qiuping Xie, Bing Xu, Chongde Sun, Kunsong Chen, Yulian Wu,
Oxidative stress plays a pivotal role during the islet transplantation procedure, and antioxidant supplementation may protect grafts against oxidative injury. Chinese bayberry is one of six Myrica species native to China, and we demonstrated here that anthocyanins from Chinese bayberry extract (CBE) protect pancreatic β cells (INS-1) against hydrogen peroxide (H2O2)-induced necrosis and apoptosis. Anthocyanins time- and dose-dependently upregulated heme oxygenase-1 (HO-1) gene expression in β cells ...
Tópico(s): Cannabis and Cannabinoid Research
2010 - American Chemical Society | Journal of Agricultural and Food Chemistry
Hai Huang, Qiuping Xie, Muxing Kang, Bo Zhang, Hui Zhang, Jin Chen, Chuanxin Zhai, Deren Yang, Biao Jiang, Yulian Wu,
Superparamagnetic iron oxide nanoparticles (SPIO) are emerging as a novel probe for noninvasive cell tracking with magnetic resonance imaging (MRI) and have potential wide usage in medical research. In this study, we have developed a method using high-temperature hydrolysis of chelate metal alkoxide complexes to synthesize polyvinylpyrrolidone coated iron oxide nanoparticles (PVP-SPIO), as a biocompatible magnetic agent that can efficiently label mice islet β-cells. The size, crystal structure and ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2009 - IOP Publishing | Nanotechnology
Qiuping Xie, Hai Huang, Bin Xu, Xin Dong, Shunliang Gao, Bo Zhang, Yulian Wu,
It was recently reported that pluripotent mesenchymal stem cells (MSCs) in rodent bone marrow (BM) have the capacity to generate insulin-producing cells (IPCs) in vitro. However, little is known about this capacity in human BM-MSCs. We developed a nongenetic method to induce human BM-MSCs to transdifferentiate into IPCs both phenotypically and functionally. BM-MSCs from 12 human donors were sequentially cultured in specially defined conditions. Their differentiation extent toward β-cell phenotype was ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2009 - Elsevier BV | Differentiation
Qingqu Guo, Bingbo Zhang, Xin Dong, Qiuping Xie, Enqi Guo, Hai Huang, Yulian Wu,
Objectives: Although changes of plasma fibrinogen have been documented in limited pancreatic malignant tumors, a relationship between plasma fibrinogen and pancreatic cancer in a large-scale clinical study has not been shown. Methods: Preoperative plasma levels of fibrinogen were retrospectively analyzed in 133 pancreatic cancer and 38 pancreatic benign tumor patients. Results: Plasma fibrinogen in pancreatic cancer patients were significantly higher than those with benign pancreatic tumor (3.99 ± ...
Tópico(s): Pancreatitis Pathology and Treatment
2009 - Lippincott Williams & Wilkins | Pancreas
Qingqu Guo, Ying Chen, Bingbo Zhang, Muxing Kang, Qiuping Xie, Yulian Wu,
Pancreatic cancer is one human malignancy which has chemoresistant behavior to gemcitabine treatment. In this study, we revealed that emodin, an active component from Chinese medicinal herbs, could enhance pancreatic cancer cells apoptosis induced by gemcitabine. Survivin, a member of the inhibitor of apoptosis gene family, is involved in control of cell division and inhibition of apoptosis and described as a β-catenin/Tcf/Lef target gene. Western blot and PCR analysis showed that emodin suppressed ...
Tópico(s): Neuroblastoma Research and Treatments
2009 - Elsevier BV | Biochemical Pharmacology
Yulian Wu, Enqi Guo, Junxiu Yu, Qiuping Xie,
A soluble decoy receptor 3 (DcR3), also known as TR6 or M68, is a member of the TNF receptor family. It has been reported that high DcR3 expression occurs in many tumors.This prospective study evaluated the DcR3 tissue status by RT-PCR and its correlation with the lymph node (N) stages in 62 primary gastric cancers.DcR3 expression levels in patients with pN2-3 disease were much higher than those in patients with pN0-1 disease (median values 1.31 vs. 0, P < 0.01). Using ROC analysis, a cutoff level of ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2008 - Lippincott Williams & Wilkins | American Journal of Clinical Oncology
Enqi Guo, Lirong Chen, Qiuping Xie, Jian Chen, Zhiyu Tang, Yulian Wu,
Tópico(s): Colorectal Cancer Treatments and Studies
2007 - Springer Science+Business Media | Annals of Surgical Oncology
Yunxiang He, Yang Tang, Yifan Zhang, Liam R. MacFarlane, Jiaojiao Shang, Heping Shi, Qiuping Xie, Hui Zhao, Ian Manners, Junling Guo,
One-dimensional (1D) nanoscale objects abundant in nature commonly possess hierarchical structures and are generally constructed via bottom-up self-assembly strategies. The unique high aspect ratio morphology of the assembled nanofibrillar materials, such as collagen, cellulose, and silk, together with highly ordered architectures, endows a range of remarkable functionalities in nature. Inspired by this hierarchical building principle, block copolymers (BCPs) have been developed and employed to engineer ...
Tópico(s): biodegradable polymer synthesis and properties
2022 - American Institute of Physics | Applied Physics Reviews
Ping Wang, Yong Wang, Chundi Miao, Xing Yu, Haichao Yan, Qiuping Xie, Sanjay Jaiswal, Qunzi Zhao,
Tópico(s): Radiopharmaceutical Chemistry and Applications
2017 - Springer Science+Business Media | Annals of Surgical Oncology
Qiuping Xie, Shuai Tang, Yining Li,
Some studies have speculated that patients on angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) are more susceptible to adverse outcomes of coronavirus disease 2019 (COVID-19). Here, we performed a systematic review and meta-analysis to evaluate the safety and efficacy of administering ACEIs and ARBs to patients with COVID-19.Studies of COVID-19 were collected from the PubMed, Embase, medRxiv and BioRxiv databases. The pooled relative risk odds ratio (OR) and 95% ...
Tópico(s): Diverse Scientific Research Studies
2021 - AME Publishing Company | Annals of Palliative Medicine
Siyu Pan, Delong Hou, Gaofu Yang, Qiuping Xie, Sunxian Yan, Qi Zeng, Zhonghui Wang, Yi Chen, Haojun Fan,
Abstract Processing polyvinyl chloride (PVC) artificial material requires plasticizer that softens the PVC coating. Currently, utilizing unsaturated fatty acid methyl esters to obtain epoxidized fatty acid methyl ester (EFAME) bio-plasticizers constitutes an environmentally responsible solution to substitute conventional ortho-phthalates that are endocrine disruptors or probable carcinogens. However, commercial EFAMEs, even with the highest epoxy value (ca. 5.5–5.8%) so far, still suffer from fast ...
Tópico(s): Advanced Polymer Synthesis and Characterization
2019 - Springer Nature | Journal of Leather Science and Engineering