Yoshiaki Hikasa, Mizue Abe, Takahiro Satoh, Yoko Hisashi, Shigeo OGASAWARA, Hiroshi Matsuda,
Aggregatory and antiaggregatory effects of imidazol(in)e and non-imidazol(in)e α-adrenergic agents on canine platelets were examined turbidimetrically in citrated platelet-rich plasma or washed platelet solution. Each α-adrenoceptor agonist alone did not induce aggregation, but adrenaline and noradrenaline potentiated dose-dependently aggregation stimulated by ADP, collagen or thrombin. Small potentiation of ADP- or collagen-stimulated aggregation was also observed in response to oxymetazoline. ...
Tópico(s): Hormonal and reproductive studies
1999 - Karger Publishers | Pharmacology
Miki Nishio, Yoko To, Tomohiko Maehama, Yukari Aono, Junji Otani, Hiroki Hikasa, Akihiro Kitagawa, Koshi Mimori, Takehiko Sasaki, Hiroshi Nishina, Shinya Toyokuni, John P. Lydon, Kazuwa Nakao, Tak W. Mak, Tohru Kiyono, Hidetaka Katabuchi, Hironori Tashiro, Akira Suzuki,
Abstract Cervical cancer (CC) is usually initiated by infection with high‐risk types of human papillomavirus (HPV). The HPV E6 and E7 proteins target p53 and RB, respectively, but other cellular targets likely exist. We generated uterus‐specific MOB1A/B double KO (u Mob1 DKO) mice, which immediately developed cervical squamous cell carcinoma in situ. Mutant cervical epithelial cells showed YAP1‐dependent hyperproliferation, altered self‐renewal, impaired contact inhibition, and chromosomal instability. ...
Tópico(s): Fibroblast Growth Factor Research
2020 - Wiley | Cancer Science
Ayumi Sakuramoto, Yoko Hasegawa, Kazuma Sugahara, Yoshiyuki Komoda, Kana Hasegawa, Shinichi Hikasa, Mai Kurashita, Junya Sakai, Masahiro Arita, Kazuhiro Yasukawa, Hiromitsu Kishimoto,
The aim of the present study was to evaluate the physical properties of "admixture paste", which is a commercially available gel containing hinokitiol for use against severe stomatitis, and its characteristics as a moisturizing gel and denture adhesive.The admixture paste, which contained dexamethasone (Dexaltin®), gel for oral care (Refrecare H®) and petrolatum, and its 3 components, either alone or in different combinations, were subjected to viscosity, adhesiveness and elution testing to compare ...
Tópico(s): Head and Neck Surgical Oncology
2018 - BioMed Central | BMC Cancer
Masahiro Yamamoto, Xin Bing, Kenji Watanabe, Takako Ooshio, Kiyonaga Fujii, Xi Chen, Yôko Okada, Hiroaki Abe, Yoshimitsu Taguchi, Naoyuki Miyokawa, Hiroyuki Furukawa, Yuji Nishikawa,
... Wang J. Morikawa T. Miyachi Y. Takano Y. Hikasa H. Itoh T. Suzuki S.O. Kurihara H. ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2017 - Elsevier BV | American Journal Of Pathology
Miwako Hoshi, Yoko Kuriyama, Motoko Hasumi, Mako Hikasa,
A developmental scale for symbolic functions in early childhood is proposed. Based on the constituents of manipulative plays, developmental levels are hypothesized as follows: Level 0-no symbolization, where children use a thing according to its physica l property; Level 1-symbolization of action, where children use things in the conve ntional manner even in the play setting; Level 2-symbolization of object and action, where children use a thing or doll to stand for another thing or person which ...
Tópico(s): Values and Moral Education
1988 - Japanese Association of Educational Psychology | The Japanese Journal of Educational Psychology
Yoko Hasegawa, Ayumi Sakuramoto-Sadakane, Mitsuyoshi Yoshida, Mineka Yoshikawa, Sonoko Nozaki, Shinichi Hikasa, Nobuhide Horii, Hideyuki Sugita, Takahiro Ono, Ken Shinmura, Hiromitsu Kishimoto,
Abstract Objective This study aimed to assess the relationship between oral hygiene/stomatognathic function and residual intraoral medication in older adults and to identify the oral factors associated with residual oral medication. Methods The study included 309 older adults (77 men, 232 women, mean age: 74.1 ± 7.4 years) who were prescribed medications at regular intervals. The following survey items were assessed: overall physical condition, intraoral condition and oral function. Participants prescribed ...
Tópico(s): Salivary Gland Disorders and Functions
2019 - Wiley | Gerodontology
... autumn harvest strawberry on the bench system Yuji HIKASA*1,2, Tomo OOMIYA*1,3, Eiji FUKUKAWA* ...
Tópico(s): Plant Micronutrient Interactions and Effects
2010 - Taylor & Francis | Soil Science & Plant Nutrition