Yoko Nagayama, N. Sakurai, K. Yamamoto, Arimasa Honda, Masahiro Makuta, Ritsuro Suzuki,
... with Lower-Respiratory-Tract Infections Get access Yoko Nagayama, Yoko Nagayama Department of Parasitology, Chiba University School of Medicine, ... Japan Please address requests for reprints to Dr. Yoko Nagayama, Department of Parasitology, Chiba University School of Medicine, ...
Tópico(s): Microbial infections and disease research
1988 - Oxford University Press | The Journal of Infectious Diseases
Toshiaki Iba, Koichiro Aihara, Atushi Yamada, Masataka Nagayama, Yoko Tabe, Akimichi Ohsaka,
Introduction Thrombosis is a major complication in diabetes mellitus. Since Factor Xa inhibitors are not only inhibit the coagulation system but also attenuate the leukocyte-endothelial interaction in acute inflammation models, the purpose of this study is to confirm the similar effects of rivaroxaban in a mouse model of type 2 diabetes mellitus. Materials and Methods In the treatment groups, either 5 or 10 mg/kg of rivaroxaban dissolved in DMSO was orally given to KK-Ay mice for 7 weeks (n = 6 in ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2013 - Elsevier BV | Thrombosis Research
Yoko Nagayama, Toshikazu Tsubaki, Shigeru NAKAYAMA, Jun Wada, Kazuko Taguchi, Tsuyosi Toba, Yoichi Kohno,
Lower respiratory tract infection in childhood often results in airway obstruction, characterized by wheezing. However, contribution of bacterial colonization to the wheezy state in children remains unclear. Wheezing and non-wheezing children requiring hospitalization were classified into three groups: (i) wheezing children having a past history of recurrent wheezing; (ii) wheezing children without such history; and (iii) non-wheezing children as control subjects. Respiratory secretions as sputum were ...
Tópico(s): Pediatric health and respiratory diseases
2007 - Wiley | Pediatric Allergy and Immunology
Yoko Nagayama, Toshikazu Tsubaki, Shigeru NAKAYAMA, Jun Wada, Kazuko Taguchi, Noriko Tateno, Tsuyoshi Toba,
It is reasonable to compare immune reactions between boys and girls because many infections in the early stages are predominant in males. A relationship between immunomodulatory effects of sex hormone surge in boys at early months and infectious diseases is still unclear. We compared clinical features between boys and girls who suffered from wheezing that was initially triggered by acute respiratory syncytial virus (RSV) bronchiolitis. For systemic immune response evaluation, white blood cell (WBC) ...
Tópico(s): Respiratory Support and Mechanisms
2005 - Wiley | Pediatric Allergy and Immunology
Yoko Nagayama, Toshikazu Tsubaki, Tsuyoshi Toba, Shigeru NAKAYAMA, Ookusu Kiyofumi,
Children who are destined to develop asthma are considered to be susceptible to a variety of respiratory pathogens. To elucidate respiratory inflammation among these children, we measured the levels of eosinophil cationic protein (ECP) and tryptase in sputum taken from three different groups of wheezy infants and young children: those with a first wheeze (n = 15); those with recurrent wheeze (n = 27); and those with recurrent wheeze with respiratory distress, namely asthma (n = 56). The numbers of eosinophils ...
Tópico(s): Respiratory viral infections research
2001 - Wiley | Pediatric Allergy and Immunology
Yoko Nagayama, Y. Odazima, S. Nakayama, Tsuyoshi Toba, Shigeru Funabashi,
To examine the increase in eosinophils and basophilic cells in the respiratory areas of infants and young children with asthma (n = 111), we analyzed the numbers of eosinophils and basophilic cells in sputum and nasal smears. The number of children with eosinophilia grades of 2+ or greater (> or = 11 cells/five fields in x1000 magnification) in sputum and nasal smears, respectively, in each age group was as follows: 33% and 21% under 1 year, 59% and 64% at 1 year, and 79-80% and 75-78% at 2-3 years. An ...
Tópico(s): Inhalation and Respiratory Drug Delivery
1995 - Wiley | Pediatric Allergy and Immunology
Yoko Nagayama, Nobukiyo Sakurai,
Abstract To examine if the occurrence of wheezing among children with lower respiratory tract infections is associated with atopic predisposition, serum levels of IgE were determined for groups of children with or without wheezing, during infection with Mycoplasma pneumoniae or respiratory syncytial virus (RSV). In M. pneumoniae infection, more than 60% of wheezy children over 2 years of age showed a high IgE level (200 IU/mL or more), while IgE levels were less than 200 IU/mL in 73% of non‐wheezy ...
Tópico(s): Respiratory and Cough-Related Research
1991 - Wiley | Pediatric Pulmonology
Yoko Nagayama, Nobukiyo Sakurai, Koshi YAMAMOTO,
Abstract A comparative study on the clinical presentation of Mycoplasma pneumoniae infection was performed in 56 patients with pleuropneumonia and those who had pneumonia without pleural effusion. The latter consisted of 773 cases; their age distribution reached a peak at 3–5 years of age in males and at 4–6 years in females. The 56 cases with pleuropneumonia were distributed among children of all ages. Pneumococcal infection was demonstrated by blood culture in one of 56 cases. Serological tests ...
Tópico(s): Respiratory viral infections research
1990 - Wiley | Pediatric Pulmonology
Nobukiyo Sakurai, Yoko Nagayama, Akihito Honda, Masahiro Makuta, Koshi YAMAMOTO, Somei Kojima,
The causes of lower respiratory tract infections in 1544 children attending a Japanese hospital over a period of 7 years were investigated. Both cultivation and two serological techniques were used to detect Mycoplasma pneumoniae whereas viral involvement was investigated only by serology. Pathogens were identified in 52 % of 1175 patients with pneumonia and 36% of 369 patients without pneumonia. Mycoplasma pneumoniae infection was specifically diagnosed in 414 (26·8 %) of the 1544 patients. Respiratory ...
Tópico(s): Microbial infections and disease research
1988 - Elsevier BV | Journal of Infection
Yoko Nagayama, Nobukiyo Sakurai, Kazuto Tamai, Atsuko Niwa, Koshi YAMAMOTO,
Mycoplasma pneumoniae was isolated from pleural exudates of 2 children with pleuropneumonia. The organism was also isolated from cerebrospinal fluid of a child with meningeal manifestations and from the cerebrospinal fluid as well as pleural exudate of another child who died 21 days after onset of disease. More extensive attempts to cultivate M. pneumoniae from nonpulmonary sites are recommended.
Tópico(s): Bacterial Infections and Vaccines
1987 - Informa | Scandinavian Journal of Infectious Diseases
Yoko Nagayama, Nobukiyo Sakurai, Toshiro Nakahara, Masahiro Makuta, Somei Kojima, Shigeru Funabashi, Akihito Honda,
Allergic predisposition among infants with bronchiolitis was examined. The number of infants with serum IgE exceeding mean +1 SD was 31/70 (44.3%). The rate of positive radioallergosorbent test (RAST) scores of 1 or more to mites, egg white, or milk was 31/71 (43.7%) and that of scores over 2 was 11/71 (15.5%). Eosinophils and/or mast cells were found in their nasal smears on several occasions. These results indicated that allergic predisposition may be observed among infants with bronchiolitis.
Tópico(s): Pediatric health and respiratory diseases
1987 - Taylor & Francis | Journal of Asthma
Kōtarō Murakami, HISATAKA EZIMA, Yoshihisa Takaishi, Yoshio Takeda, Tetsuro Fujita, AKIHIKO SATO, Yoko Nagayama, Toshihiro Nohara,
Two new steroidal alkaloid glycosides, tentatively named SL-c (1) and SL-d (2), were obtained from the stems of Solanum lyratum THUNB. The chemical structures of 1 and 2 were characterized respectively as β-lycotrioside and β-lycotetraoside, both having a mixture of (25ζ)-solanidan-3β, 23β-diol and (25ζ)-Δ5-solaniden-3β, 23β-diol as the aglycone moiety. These compounds markedly inhibited the growth of a human cervical cancer cell line, JTC-26.
Tópico(s): Potato Plant Research
1985 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Yoko Nagayama, Nobukiyo Sakurai, Somei Kojima, Shigeru Funabashi,
Total IgE and specific IgE antibodies to common allergens were determined by the enzyme-linked immunosorbent assay in children with Mycoplasma pneumoniae or respiratory syncytial virus (RSV) infections. The decrease of total IgE from the acute to convalescent phase was observed in 105 of 134 (78.4%) children with M. pneumoniae infection and in 40 of 49 (81.6%) of those with RSV infection. Similarly, many patients showed a decrease of the responses of specific IgE in the convalescent phase of the infections. ...
Tópico(s): Respiratory and Cough-Related Research
1987 - Taylor & Francis | Journal of Asthma
Yutaka Mori, Yasuyuki Ogawa, Akiyoshi Mochizuki, Y. Nakamura, Teppei Fujimoto, Chie Sugita, Shojiro Miyazaki, Kazuhiko Tamaki, Takahiro Nagayama, Yoko Nagai, Shinichi Inoue, Katsuyoshi Chiba, Takahide Nishi,
We report synthesis and optimization of a series of (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. Chemical modification of P1', P2' and P3 portions led to a promising 3,5-disubstituted piperidine 32o showing high renin inhibitory activity and favorable oral exposure in both rats and cynomolgus monkeys with acceptable CYP and hERG current inhibition. Compound 32o exhibited a significant blood pressure lowering effect by oral administration in two ...
Tópico(s): Synthesis and Biological Evaluation
2013 - Elsevier BV | Bioorganic & Medicinal Chemistry
Yutaka Mori, Yasuyuki Ogawa, Akiyoshi Mochizuki, Yuji Nakamura, Chie Sugita, Shojiro Miyazaki, Kazuhiko Tamaki, Yumi Matsui, Mizuki Takahashi, Takahiro Nagayama, Yoko Nagai, Shinichi Inoue, Takahide Nishi,
Utilizing X-ray crystal structure analysis, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides were designed and identified as renin inhibitors. The most potent compound 15 demonstrated favorable pharmacokinetic and pharmacodynamic profiles in rat.
Tópico(s): Nitric Oxide and Endothelin Effects
2012 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Yoko Nagayama, Toshikazu Tsubaki, Jun Wada, Kazuko Taguchi, Shigeru NAKAYAMA, Tsuyoshi Toba,
Although enhanced immune reaction caused by the respiratory syncytial virus (RSV) in allergen-sensitized animal model has been reported, RSV illnesses in children already sensitized or having recurrent wheezing episodes have not been completely studied. In addition, the reason for male dominances in RSV infection at young ages was also inconclusive. Therefore, gender analysis in recurrent wheezing children with RSV infection can shed light on asthma pathogenesis. We studied the clinical features ...
Tópico(s): Neonatal Respiratory Health Research
2006 - Wiley | Pediatric Allergy and Immunology
Satoshi Yamaguchi, Kuniki Eguchi, Yoshihiro Kiura, Masaaki Takeda, Tetsuya Nagayama, Hiroyuki Uchida, Yoko Ito, T Hotta, Kazunori Arita, Kaoru Kurisu,
Tópico(s): Spinal Fractures and Fixation Techniques
2007 - Springer Science+Business Media | Neurosurgical Review
Katsuyoshi Sakaguchi, Takakazu Yagi, Aya Maeda, Kunihiro Nagayama, Sawako Uehara, Yoko Saito‐Sakoguchi, K. Kanematsu, Shouichi Miyawaki,
Abstract Background There are few large‐scale epidemiologic studies examining the associations between sleep problems, gastroesophageal reflux disease ( GERD ) symptoms, lifestyle and food habits and problem behaviors (PB) in adolescents. The aim of this study was to evaluate the associations among these factors in Japanese adolescents. Methods A cross‐sectional survey of 1840 junior high school students was carried out using questionnaires. The subjects were classified into PB or normal behavior ( NB ) ...
Tópico(s): Pediatric health and respiratory diseases
2013 - Wiley | Pediatrics International
Yoko Nagayama, Toshikazu Tsubaki, Tsuyoshi Toba, Hiroshi Kawakami, Kiyofumi Okusu,
Quantitatively cultured bacteria in sputum sampled from asthmatic children aged 0–14 years was examined to determine whether there is a relationship between asthmatic states and bacterial species present in the respiratory tract. We used cytological examination to improve the specificity of pathogens cultured in sputum. Asthmatic children were divided into three groups: (i) group 1, acute asthma attack (n = 191); (ii) group 2, prolonged asthma attack (n = 68); and (iii) group 3, pneumonia without asthma ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
1999 - Elsevier BV | Allergology International
Hideki Watanabe, Kazuyoshi Nagayama, Nobuyuki Enomoto, Jun Itakura, Yoko Tanabe, Kosei Hamano, Namiki Izumi, Chifumi Sato, Mamoru Watanabe,
The correlation between hepatitis C virus (HCV) genomic sequences and circulating HCV RNA levels was assessed to investigate the genetic elements affecting viral load. The interferon sensitivity-determining region (ISDR) sequence and the serum viral load were strongly correlated in 226 patients examined. Analysis of the entire HCV genome from six patients (three with a high and the others with a low viral load) with similar ISDR sequences identified several candidate residues associated with viral ...
Tópico(s): Hepatitis B Virus Studies
2003 - Elsevier BV | Virology
Y. Nakamura, Chie Sugita, Masaki Meguro, Shojiro Miyazaki, Kazuhiko Tamaki, Mizuki Takahashi, Yoko Nagai, Takahiro Nagayama, Mikio Kato, Hiroshi Suemune, Takahide Nishi,
Introduction of the 2,2-dimethyl-4-phenylpiperazin-5-one scaffold into the P(3)-P(1) portion of the (2S,4S,5S)-5-amino-6-dialkylamino-4-hydroxy-2-isopropylhexanamide backbone dramatically increased the renin inhibitory activity without using the interaction to the S(3)(sp) pocket. Compound 31 exhibited >10,000-fold selectivity over other human proteases, and 18.5% oral bioavailability in monkey.
Tópico(s): Renin-Angiotensin System Studies
2012 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Toshiaki Iba, Mari Emmi, Makoto Hiki, Masataka Nagayama, Koichiro Aihara, Yoko Tabe, Maiko Yuri, Akimichi Ohsaka,
Tópico(s): Acute Myocardial Infarction Research
2016 - Springer Science+Business Media | International Journal of Hematology
Takumi Sannomiya, Juliane Junesch, Fumio Hosokawa, Kuniaki Nagayama, Yoshihiro Arai, Yoko Kayama,
A new fabrication method of carbon based phase plates for phase-contrast transmission electron microscopy is presented. This method utilizes colloidal masks to produce pores as well as disks on thin carbon membranes for phase modulation. Since no serial process is involved, carbon phase plate membranes containing hundreds of pores can be mass-produced on a large scale, which allows "disposal" of contaminated or degraded phase modulating objects after use. Due to the spherical shape of the mask colloid ...
Tópico(s): Digital Holography and Microscopy
2014 - Elsevier BV | Ultramicroscopy
Kunio Yoshizumi, Kyoko Harada, Yukiko Kobayashi, Miho Aita, Masuzo NAGAYAMA, Yoko Yamaguchi,
Water absorption of a cotton towel treated with two types of household softeners was examined by Larose method. The conventional and latest ones contain distearyl dimethyl ammonium chloride and dioleyl dimethyl ammonium chloride, respectively, as a softener base. The former caused the deteriorated water absorption of the towel according to the increase of its bath concentration. However, almost normal water absorption was found in the latter's case over all the concentration range examined here. ...
Tópico(s): Textile materials and evaluations
1993 - | Sen i Gakkaishi
Yoko Tanabe, K Nagayama, Naoya Enomoto, Namiki Izumi, Junichi Tazawa, Masayuki Kurosaki, Naoya Sakamoto, C Sato, Mamoru Watanabe,
Summary. In hepatitis C virus (HCV) genotype 2b infection, viral eradication (sustained viral response; sVR) is obtained in about 40% by interferon monotherapy, whereas a considerable proportion of non‐sVR patients exhibit sustained biochemical response (sBR) showing normal biochemical values despite persistent viraemia. However, the mechanism of sBR has not yet been established. In this study, we analysed serial changes in full‐length sequences of HCV genotype 2b before and after interferon (IFN) therapy ...
Tópico(s): Systemic Lupus Erythematosus Research
2005 - Wiley | Journal of Viral Hepatitis
Shin-ichi Kayano, Yoko Matsumura, Yoko Kitagawa, Mayumi Kobayashi, Asuka Nagayama, Nami Kawabata, Hiroe Kikuzaki, Yoshimi Kitada,
The chemical structures of six isoflavones (1–6) isolated from the kudzu root (Pueraria lobata) were elucidated on the basis of the NMR and MS analyses to be four isoflavone C-glycosides as 6″-O-α-d-glucopyranosylpuerarin (1), puerarin (2), 3′-methoxypuerarin (3), 6″-O-α-d-apiofranosylpuerarin (4), and two aglycons as biochanin A (5) and formononetin (6), respectively. The estrogenic activities of isolated compounds and related isoflavones were evaluated using a yeast two-hybrid assay. Genistein exhibited ...
Tópico(s): Phytochemicals and Antioxidant Activities
2012 - Elsevier BV | Food Chemistry
Kunihiro Suzuki, Yoko Tada, Yuji Kataoka, Tsutomu Nagayama,
Monte Carlo simulation is widely used for predicting ion implantation profiles in amorphous targets. Here, we compared Monte Carlo simulation results with a vast database of ion implantation secondary ion mass spectrometry (SIMS), and showed that the Monte Carlo data sometimes deviated from the experimental data. We modified the electron stopping power model, calibrated its parameters, and reproduced most of the database. We also demonstrated that Monte Carlo simulation can accurately predict profiles ...
Tópico(s): Silicon and Solar Cell Technologies
2009 - Institute of Electronics Engineers of Korea | JSTS Journal of Semiconductor Technology and Science
Yasunori Nagayama, Ayumi Iyama, Seitaro Oda, Narumi Taguchi, Takeshi Nakaura, Daisuke Utsunomiya, Yoko Kikuchi, Yasuyuki Yamashita,
Tópico(s): Medical Imaging Techniques and Applications
2018 - Springer Science+Business Media | European Radiology
Yuji Nakamura, Teppei Fujimoto, Yasuyuki Ogawa, Hidenori Namiki, Sayaka Suzuki, Masayoshi Asano, Chie Sugita, Akiyoshi Mochizuki, Shojiro Miyazaki, Kazuhiko Tamaki, Yoko Nagai, Shinichi Inoue, Takahiro Nagayama, Mikio Kato, Katsuyoshi Chiba, Kiyoshi Takasuna, Takahide Nishi,
With the aim to address an undesired cardiac issue observed with our related compound in the recently disclosed novel series of renin inhibitors, further chemical modifications of this series were performed. Extensive structure-activity relationships studies as well as in vivo cardiac studies using the electrophysiology rat model led to the discovery of clinical candidate trans-adamantan-1-ol analogue 56 (DS-8108b) as a potent renin inhibitor with reduced potential cardiac risk. Oral administration ...
Tópico(s): Nitric Oxide and Endothelin Effects
2013 - Elsevier BV | Bioorganic & Medicinal Chemistry
Yoko Nagayama, Toshikazu Tsubaki, Tsuyoshi Toba, Shigeru NAKAYAMA, Ookusu Kiyofumi,
Tópico(s): Respiratory and Cough-Related Research
2004 - Elsevier BV | Allergology International