... Difficult Terrain of Oyashirazu in the Hokuriku Area. Yui Was Described as Having the Best Scenery on the Tokaido with a Clear View of Mt. Fuji. Color. width 259 mm x height 202 mm. Series: Kusakabe, Kinbei (Album 4). Photographer: Kusakabe, Kinbei.
0000 - Gale Group | NCCO Photography
This major history of Hong Kong tells the remarkable story of how a cluster of remote fishing villages grew into an icon of capitalism. The story began in 1842 with the founding of the Crown Colony after the First Anglo-Chinese war - the original 'Opium War'. As premier power in Europe and an expansionist empire, Britain first created in Hong Kong a major naval station and the principal base to open the Celestial Chinese Empire to trade. Working in parallel with the locals, the British built it up ...
Tópico(s): Hong Kong and Taiwan Politics
2004 - Association of College and Research Libraries | Choice Reviews Online
... This Photo Structure Is Very Similar to the "Yui No Zu" in the "53 Stations ... 209 mm. Series: Ogawa, Kazumasa (Album 2). Photographer: Ogawa, Kazumasa.
0000 - Gale Group | NCCO Photography
... widespread universal library classifications (Decimal Classification of D'yui (DKD), Universal Decimal Classification (UDK), Classification of Library of Congress (KBK), Library-Bibliographic Classification (BBK)) are analysed in the article. Histories of these ...
Tópico(s): Diverse Scientific Research in Ukraine
1970 - Institute for Digitalisation of Education of the NAES of Ukraine | Information Technologies and Learning Tools
Yui Okada, Kyoko Oh‐oka, Yuki Nakamura, Kayoko Ishimaru, Shuji Matsuoka, Ko Okumura, Hideoki Ogawa, Masashi Hisamoto, Tohru Okuda, Atsuhito Nakao,
Background Resveratrol is a bioactive polyphenol enriched in red wine that exhibits many beneficial health effects via multiple mechanisms. However, it is unclear whether resveratrol is beneficial for the prevention of food allergy. This study investigated whether resveratrol inhibited the development of food allergy by using a mouse model of the disease. Methodology/Principal Findings Mice fed standard diet or standard diet plus resveratrol were sensitized by intragastric administration of ovalbumin ( ...
Tópico(s): Coffee research and impacts
2012 - Public Library of Science | PLoS ONE
Yui Shikiya, Shunsuke Tomita, Tsutomu Arakawa, Kentaro Shiraki,
Nonspecific adsorption of protein on solid surfaces causes a reduction of concentration as well as enzyme inactivation during purification and storage. However, there are no versatile inhibitors of the adsorption between proteins and solid surfaces at low concentrations. Therefore, we examined additives for the prevention of protein adsorption on polystyrene particles (PS particles) as a commonly-used material for vessels such as disposable test tubes and microtubes. A protein solution was mixed ...
Tópico(s): Polymer Surface Interaction Studies
2013 - Public Library of Science | PLoS ONE
Yui Yamaoka, Nanako Tamiya, Yoko Moriyama, Felipe Alfonso Sandoval Garrido, Ryo Sumazaki, Haruko Noguchi,
The number of children with disability is increasing gradually in Japan. Previous researches in other countries have reported that parents as caregivers (CGs) of children with disability have mental health problems, but the actual situation has not been examined nationwide in Japan so far. The aim of this study was to evaluate the association between mental health of CGs who had children with disability and characteristics of children, CGs, and household based on the nation-wide survey. This study ...
Tópico(s): Family Support in Illness
2015 - Public Library of Science | PLoS ONE
Yui K. Matsumoto, Kazuo Okanoya,
Mice produce ultrasonic vocalizations featuring a variety of syllables. Vocalizations are observed during social interactions. In particular, males produce numerous syllables during courtship. Previous studies have shown that vocalizations change according to sexual behavior, suggesting that males vary their vocalizations depending on the phase of the courtship sequence. To examine this process, we recorded large sets of mouse vocalizations during male–female interactions and acoustically categorized ...
Tópico(s): Infant Health and Development
2016 - Public Library of Science | PLoS ONE
Yui K. Matsumoto, Masanori Kasai, Kazuya Tomihara,
Several studies have reported regulatory effects of estrogens on fear conditioning in female rodents. However, these studies used different doses, durations, and/or administration methods, and reported inconsistent results. To clarify the effect of estrogen on fear conditioning, we investigated the effects of different doses and durations of estradiol administration on freezing behavior during contextual fear conditioning in ovariectomized (OVX) mice. In Experiment 1, OVX ICR mice received a single ...
Tópico(s): Estrogen and related hormone effects
2018 - Public Library of Science | PLoS ONE
Yui Nemoto, Rie Saito, Hitoshi Oomachi,
To elucidate and reduce the risk of radionuclide contamination in wildlife caused by the Tokyo Electric Power Company Fukushima Dai-ichi Nuclear Power Station accident, it is important to understand radionuclide variations in the wild animal population. Here, we used environmental monitoring data and muscle samples collected from Asian black bear (Ursus thibetanus) and wild boar (Sus scrofa) from May 2011 to March 2016 to examine seasonal variation in radiocesium (137Cs) concentrations in muscle tissues ( ...
Tópico(s): Nuclear and radioactivity studies
2018 - Public Library of Science | PLoS ONE
... the Yahoo! homepage and a contributor to the YUI library. He is also a keynote speaker, and author ...
Tópico(s): Mobile and Web Applications
2013 - Association for Computing Machinery | Queue
Daishi Yui, Yoichiro Nishida, Tomoko Nishina, Kaoru Mogushi, Mio Tajiri, Satoru Ishibashi, Itsuki Ajioka, Kinya Ishikawa, Hidehiro Mizusawa, Shigeo Murayama, Takanori Yokota,
Oxidative stress has a ubiquitous role in neurodegenerative diseases and oxidative damage in specific regions of the brain is associated with selective neurodegeneration. We previously reported that Alzheimer disease (AD) model mice showed decreased insulin-degrading enzyme (IDE) levels in the cerebrum and accelerated phenotypic features of AD when crossbred with alpha-tocopherol transfer protein knockout (Ttpa-/-) mice. To further investigate the role of chronic oxidative stress in AD pathophysiology, ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Public Library of Science | PLoS ONE
Kuang-Yui Michael Chen, Jiaming Sun, Jason S. Salvo, David Baker, Patrick Barth,
Eukaryotic transmembrane helical (TMH) proteins perform a wide diversity of critical cellular functions, but remain structurally largely uncharacterized and their high-resolution structure prediction is currently hindered by the lack of close structural homologues. To address this problem, we present a novel and generic method for accurately modeling large TMH protein structures from distant homologues exhibiting distinct loop and TMH conformations. Models of the adenosine A2AR and chemokine CXCR4 ...
Tópico(s): Glycosylation and Glycoproteins Research
2014 - Public Library of Science | PLoS Computational Biology
Jun Kitano, Yui Kawagishi, Seiichi Mori, Catherine L. Peichel, Takashi Makino, Masakado Kawata, Makoto Kusakabe,
Sex steroids mediate the expression of sexually dimorphic or sex-specific traits that are important both for mate choice within species and for behavioral isolation between species. We investigated divergence in sex steroid signaling between two sympatric species of threespine stickleback (Gasterosteus aculeatus): the Japan Sea form and the Pacific Ocean form. These sympatric forms diverge in both male display traits and female mate choice behaviors, which together contribute to asymmetric behavioral ...
Tópico(s): Marine and fisheries research
2011 - Public Library of Science | PLoS ONE
Takeaki Wajima, Yui Anzai, Tetsuya Yamada, Hideaki Ikoshi, Norihisa Noguchi,
Oldenlandia diffusa has been empirically used as a therapeutic adjunct for the treatment of respiratory infections. To establish the basic evidence of its clinical usefulness, antimicrobial and biofilm inhibitory activities of an O. diffusa extract were examined against clinical isolates of Haemophilus influenzae, a major causative pathogen of respiratory and sensory organ infections. No significant growth inhibitory activity was observed during incubation for more than 6 h after the extract addition ...
Tópico(s): Plant Pathogens and Fungal Diseases
2016 - Public Library of Science | PLoS ONE
Akinori Yamasaki, Yui Jin, Yoshinori Ohsumi,
Autophagy is an intracellular degradation pathway targeting organelles and macromolecules, thereby regulating various cellular functions. Phosphorylation is a key posttranscriptional protein modification implicated in the regulation of biological function including autophagy. Under asynchronous conditions, autophagy activity is predominantly suppressed by mechanistic target of rapamycin (mTOR) kinase, but whether autophagy-related genes (ATG) proteins are phosphorylated differentially throughout the ...
Tópico(s): Ubiquitin and proteasome pathways
2020 - Public Library of Science | PLoS Biology
Akiko Hatori, Joji Yui, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Yuichiro Yoshida, Masanao Ogawa, Nobuki Nengaki, Kazunori Kawamura, Toshimitsu Fukumura, Ming‐Rong Zhang,
Purpose The translocator protein (18 kDa) (TSPO) is highly expressed on the bronchial and bronchiole epithelium, submucosal glands in intrapulmonary bronchi, pneumocytes and alveolar macrophages in human lung. This study aimed to perform positron emission tomography (PET) imaging of lung inflammation with [18F]FEDAC, a specific TSPO radioligand, and to determine cellular sources enriching TSPO expression in the lung. Methods An acute lung injury model was prepared by intratracheal administration of ...
Tópico(s): Orthopedic Infections and Treatments
2012 - Public Library of Science | PLoS ONE
Akiko Hatori, Joji Yui, Lin Xie, Tomoteru Yamasaki, Katsushi Kumata, Masayuki Fujinaga, Hidekatsu Wakizaka, Masanao Ogawa, Nobuki Nengaki, Kazunori Kawamura, Ming‐Rong Zhang,
Liver damage induced by drug toxicity is an important concern for both medical doctors and patients. The aim of this study was to noninvasively visualize acute liver damage using positron emission tomography (PET) with N-benzyl-N-methyl-2-[7,8-dihydro-7-(2-[(18)F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]acetamide ([(18)F]FEDAC), a radiotracer specific for translocator protein (18 kDa, TSPO) as a biomarker for inflammation, and to determine cellular sources enriching TSPO expression in the liver. A mild ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2014 - Public Library of Science | PLoS ONE
Erin A. Ronayne, Yui Chun S. Wan, Beth A. Boudreau, Robert Landick, Michael M. Cox,
Ref is an HNH superfamily endonuclease that only cleaves DNA to which RecA protein is bound. The enigmatic physiological function of this unusual enzyme is defined here. Lysogenization by bacteriophage P1 renders E. coli more sensitive to the DNA-damaging antibiotic ciprofloxacin, an example of a phenomenon termed phage-antibiotic synergy (PAS). The complementary effect of phage P1 is uniquely traced to the P1-encoded gene ref. Ref is a P1 function that amplifies the lytic cycle under conditions ...
Tópico(s): CRISPR and Genetic Engineering
2016 - Public Library of Science | PLoS Genetics
Nan‐Hua Chang, Yui-Ho Cheung, Christina Loh, Evelyn Pau, Valérie Roy, Yong-Chun Cai, Joan Wither,
The presence of autoantibodies in New Zealand Black (NZB) mice suggests a B cell tolerance defect however the nature of this defect is unknown. To determine whether defects in B cell anergy contribute to the autoimmune phenotype in NZB mice, soluble hen egg lysozyme (sHEL) and anti-HEL Ig transgenes were bred onto the NZB background to generate double transgenic (dTg) mice. NZB dTg mice had elevated levels of anti-HEL antibodies, despite apparently normal B cell functional anergy in-vitro. NZB dTg ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2010 - Public Library of Science | PLoS ONE
Chung Yi Tse, Charles Ka Yui Leung,
In development economics, growth in credit is generally associated with faster long‐run growth as financial intermediation improves the efficiency of channeling capital to productive investment. Yet, among developing countries high growth in credit almost always guarantees the outbreak of a financial crisis. The authors attempt to reconcile the two seemingly contradictory facts with an endogenous growth model in which entry to international borrowing entails some significant fixed cost. The poorest ...
Tópico(s): Fiscal Policy and Economic Growth
2002 - Wiley | Review of International Economics
Dana Wai Yi Tsui, Yui‐Ming Lam, Wing S. Lee, Tak Yeung Leung, Tze Kin Lau, Elizabeth T. Lau, M. H. Y. Tang, Ranjit Akolekar, K. H. Nicolaides, Rossa W. K. Chiu, Y. M. Dennis Lo, S Chim,
Background Noninvasive prenatal diagnosis of fetal aneuploidy by maternal plasma analysis is challenging owing to the low fractional and absolute concentrations of fetal DNA in maternal plasma. Previously, we demonstrated for the first time that fetal DNA in maternal plasma could be specifically targeted by epigenetic (DNA methylation) signatures in the placenta. By comparing one such methylated fetal epigenetic marker located on chromosome 21 with another fetal genetic marker located on a reference ...
Tópico(s): Epigenetics and DNA Methylation
2010 - Public Library of Science | PLoS ONE
Studies of tariffs have tended to ignore their impact on housing markets. This paper builds a simple dynamic general‐equilibrium model to bridge the gap. The model is consistent with empirical findings that housing prices in several small open economies, and the price of nontradeables relative to tradeables, have increased over time. The model also allows closed‐form solutions of the elasticity of the economic growth rate, the housing‐stock growth rate, and the housing‐price growth rate, with respect ...
Tópico(s): Housing Market and Economics
2001 - Wiley | Review of Development Economics
Why do some countries enjoy high economic growth rates while some suffer in “low‐growth traps”? Why are tax policies in different countries so different? Some suggest that it is exactly these differences in government policies which contribute to the difference in economic growth rates. This paper considers a small open economy which sustains its economic growth by adopting new technologies. When the value of initial wealth is “relatively small,” policies which promote growth most result in the highest ...
Tópico(s): Fiscal Policy and Economic Growth
1999 - Wiley | Review of International Economics
Shinichi Harada, Yui Yamazaki, Shuichi Koda, Shogo Tokuyama,
Orexin-A (a neuropeptide in the hypothalamus) plays an important role in many physiological functions, including the regulation of glucose metabolism. We have previously found that the development of post-ischemic glucose intolerance is one of the triggers of ischemic neuronal damage, which is suppressed by hypothalamic orexin-A. Other reports have shown that the communication system between brain and peripheral tissues through the autonomic nervous system (sympathetic, parasympathetic and vagus nerve) ...
Tópico(s): Sleep and related disorders
2014 - Public Library of Science | PLoS ONE
Kang Moo Huh, Yong Woo Cho, Hesson Chung, Ick Chan Kwon, Seo Young Jeong, Tooru Ooya, Won‐Kyu Lee, Shintaro Sasaki, Nobuhiko Yui,
Abstract Summary: Supramolecular hydrogels have been prepared on the basis of polymer inclusion complex (PIC) formation between poly(ethylene glycol) (PEG)‐modified chitosans and α‐cyclodextrin (α‐CD). A series of PEG‐modified chitosans were synthesized by coupling reactions between chitosan and monocarboxylated PEG using water‐soluble carbodiimide (EDC) as coupling agent. With simple mixing, the resultant supramolecular assembly of the polymers and α‐CD molecules led to hydrogel formation in aqueous ...
Tópico(s): Polymer Surface Interaction Studies
2004 - Wiley | Macromolecular Bioscience
Yoshiaki Maeda, Hironori Dobashi, Yui Sugiyama, Tatsuya Saeki, Tae-Kyu Lim, Manabu Harada, Tadashi Matsunaga, Tomoko Yoshino, Tsuyoshi Tanaka,
Detection and identification of microbial species are crucial in a wide range of industries, including production of beverages, foods, cosmetics, and pharmaceuticals. Traditionally, colony formation and its morphological analysis (e.g., size, shape, and color) with a naked eye have been employed for this purpose. However, such a conventional method is time consuming, labor intensive, and not very reproducible. To overcome these problems, we propose a novel method that detects microcolonies (diameter ...
Tópico(s): Image Processing Techniques and Applications
2017 - Public Library of Science | PLoS ONE
Rokusuke Yoshikawa, Haruka Abe, Yui Igasaki, Saeki Negishi, Hiroaki Goto, Jiro Yasuda,
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic novel coronavirus that has caused a worldwide outbreak. Here we describe a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay that uses a portable device for efficient detection of SARS-CoV-2. This RT-LAMP assay specifically detected SARS-CoV-2 without cross-reacting with the most closely related human coronavirus, SARS-CoV. Clinical evaluation of nasal swab samples from suspected SARS-CoV- ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2020 - Public Library of Science | PLoS neglected tropical diseases
Shigeki Moriguchi, Yasuharu Shinoda, Yui Yamamoto, Yuzuru Sasaki, Kosuke Miyajima, Hideaki Tagashira, Kohji Fukunaga,
Dehydroepiandrosterone (DHEA) is the most abundant neurosteroid synthesized de novo in the central nervous system. We previously reported that stimulation of the sigma-1 receptor by DHEA improves cognitive function by activating calcium/calmodulin-dependent protein kinase II (CaMKII), protein kinase C and extracellular signal-regulated kinase in the hippocampus in olfactory bulbectomized (OBX) mice. Here, we asked whether DHEA enhances neurogenesis in the subgranular zone of the hippocampal dentate ...
Tópico(s): Receptor Mechanisms and Signaling
2013 - Public Library of Science | PLoS ONE
Evelyn Pau, Yui-Ho Cheung, Christina Loh, Ginette Lajoie, Joan Wither,
Genetic loci on New Zealand Black (NZB) chromosomes 1 and 13 play a significant role in the development of lupus-like autoimmune disease. We have previously shown that C57BL/6 (B6) congenic mice with homozygous NZB chromosome 1 (B6.NZBc1) or 13 (B6.NZBc13) intervals develop anti-nuclear antibodies and mild glomerulonephritis (GN), together with increased T and B cell activation. Here, we produced B6.NZBc1c13 bicongenic mice with both intervals, and demonstrate several novel phenotypes including: marked ...
Tópico(s): Immunotherapy and Immune Responses
2012 - Public Library of Science | PLoS ONE