Nawaf Alkhayat, Yasser Elborai, Omer Al Sharif, Mohammad Al Shahrani, Omar Alsuhaibani, Mohammed Awad, Hatem Elghezal, Inesse ben-abdallah Bouhajar, Mona Alfaraj, Eman Al Mussaed, Fahad Alabbas, Ghaleb Elyamany,
Childhood acute lymphoblastic leukemia (ALL) is characterized by recurrent genetic aberrations. The identification of those abnormalities is clinically important because they are considered significant risk-stratifying markers.There are insufficient data of cytogenetic profiles in Saudi Arabian patients with childhood ALL leukemia. We have examined a cohort of 110 cases of ALL to determine the cytogenetic profiles and prevalence of FLT3 mutations and analysis of the more frequently observed abnormalities ...
Tópico(s): Acute Myeloid Leukemia Research
2017 - SAGE Publishing | Clinical Medicine Insights Oncology
Ayed A. Dera, Irfan Ahmad, Prasanna Rajagopalan, Mesfer Al Shahrani, Ahmed Saif, Mohammad Y. Alshahrani, Yasser Alraey, Ahmad M. Alamri, Sultan Alasmari, Mohammed Makkawi, Ali G. Alkhathami, Gaffar Sarwar Zaman, Abdulrahim R. Hakami, Razan Alhefzi, Mohammad A. Alfhili,
Objectives: To explore the antibacterial activity of thymoquinone (TQ), a quinone extracted from Nigella sativa . Methods: This study was conducted from May 2019 to March 2020 at the Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. The antimicrobial activity, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of TQ were determined using an agar well diffusion method and broth microdilution assays, and the ...
Tópico(s): Essential Oils and Antimicrobial Activity
2021 - Ministry of Defence and Aviation | Saudi Medical Journal
A. Al-Shahrani, Eisha Abrar, Ahmed Maawadh, Rana S Al‐Hamdan, Thamer Almohareb, Yasser F. AlFawaz, Mustafa Naseem, Fahim Vohra, Tariq Abduljabbar,
To evaluate Shear bond strength (SBS) of resin modified glass ionomer cement (RMGIC) on caries affected dentin after using different cavity disinfectants i.e., chlorhexidine gluconate (CHX), Er,Cr:YSGG laser (ECYL) and photodynamic therapy (PDT). Total 50 freshly extracted mandibular molars were obtained through non-traumatic extraction. All the samples were rooted vertically within self-cure acrylic resin blocks up to cervical level so that only coronal portion remain visible. Silicon carbide grinding ...
Tópico(s): Dental Erosion and Treatment
2020 - Elsevier BV | Photodiagnosis and Photodynamic Therapy
Abdulrahim R. Hakami, Abdullah Alshamrani, Mohamad Alqahtani, Yasser Alraey, Razan A. Alhefzi, Sultan Alasmari, Mohamed Makkawi, Gasim Dobie, Mushtaq Ahmad Mir, Mohamed Alshahrani, Ayed A. Dera, Mohammed Alfaifi, Mesfer Al Shahrani, Ahmad Matari, Ali Asiry,
Abstract Background and aim Despite the fact that the chikungunya viral infection is a neglected disease, complications such as hemorrhagic fever, arthritis, and lymphopenia remain a health concern. The aim of this study was to determine the prevalence of the chikungunya virus in the Southern Region, Saudi Arabia. Enzyme immunoassay and polymerase chain reaction have been compared between samples. Materials and methods Forty samples from two southern hospitals in Saudi Arabia were collected between ...
Tópico(s): Viral Infections and Outbreaks Research
2021 - BioMed Central | Virology Journal
Ghaleb Elyamany, Ariz Akhter, Hamza Kamran, Hassan Rizwan, Meer‐Taher Shabani‐Rad, Nawaf Alkhayat, Omar Sharif, Yasser Elborai, Mohammad Al Shahrani, Adnan Mansoor,
Genetic aberrations in the epigenome are rare in pediatric AML, hence expression data in epigenetic regulation and its downstream effect is lacking in childhood AML. Our pilot study screened epigenetic modifiers and its related oncogenic signal transduction pathways concerning clinical outcomes in a small cohort of pediatric AML in KSA. RNA from diagnostic BM biopsies (n = 35) was subjected to expression analysis employing the nCounter Pan-Cancer pathway panel. The patients were dichotomized into low ...
Tópico(s): Histone Deacetylase Inhibitors Research
2021 - Taylor & Francis | Pediatric Hematology and Oncology
Ghaleb Elyamany, Nawaf ALKHAYAT, Omar AL SHARIF, Yasser ELBORAI, Mohammad AL SHAHRANI, Omar ALSUHAIBANI,
NOTCH1 is now established to play a key role in the prognosis of several hematological malignancies. Notch proteins are multifaceted and involved in several key cellular functions with extensive crosstalk with other critical pathways; therefore, it is important to investigate NOTCH1 expression and its influence on other oncogenic pathways molecules in AML. In this pilot study, we correlated NOTCH1 and associated pathway expression patterns among childhood AML patients and correlated it with hematological ...
Tópico(s): Acute Myeloid Leukemia Research
2022 - Elsevier BV | Hematology Transfusion and Cell Therapy
Mesfer Al Shahrani, Prasanna Rajagopalan, Mohammad Abohassan, Mohammad Y. Alshahrani, Yasser Alraey, Reem M. Gahtani, Suresh Radhakrishnan, KHLOOD DAGREERY,
Estrogen receptor (ER) α is expressed in a subset of patient-derived acute myeloid leukemia (AML) cells, whereas Akt is predominantly expressed in most types of AML. Targeting AML with dual inhibitors is a novel approach to combat the disease. Herein, we examined a novel small molecule, 3-(4-isopropyl) benzylidene-8-ethoxy,6- methyl, chroman-4-one (SBL-060), capable of targeting AML cells by inhibiting ERα and Akt kinase. The chemical properties of SBL-060 were identified by proton nuclear magnetic ...
Tópico(s): Acute Myeloid Leukemia Research
2021 - Cognizant Communication Corporation | Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
Mesfer Al Shahrani, Prasanna Rajagopalan, Mohammad Abohassan, Mohammad Y. Alshahrani, Yasser Alraey,
Predicting novel dual inhibitors to combat adverse effects such as the development of resistance to vemurafenib in melanoma treatment due to the reactivation of MAPK and PI3K/AKT signaling pathways is studied to help in reversal of cancer symptoms.Reversal of cancer symptoms in melanoma associated with vemurafenib resistance is driven by reactivation of MAPK and PI3K/Akt signaling pathways. Novel dual inhibitors targeting these proteins would be beneficial to combat resistance.High-throughput virtual ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2022 - Elsevier BV | Saudi Journal of Biological Sciences
Mesfer Al Shahrani, Reem M. Gahtani, Mohammad Abohassan, Mohammad Y. Alshahrani, Yasser Alraey, Ayed A. Dera, Mohammed Asiri, Prasanna Rajagopalan,
Gastric cancers are caused primarily due to the activation and amplification of the EGFR or HER2 kinases resulting in cell proliferation, adhesion, angiogenesis, and metastasis. Conventional therapies are ineffective due to the intra-tumoral heterogeneity and concomitant genetic mutations. Hence, dual inhibition strategies are recommended to increase potency and reduce cytotoxicity. In this study, we have conducted computational high-throughput screening of the ChemBridge library followed by
Tópico(s): Synthesis and pharmacology of benzodiazepine derivatives
2023 - Cognizant Communication Corporation | Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
Hanan H. Balkhy, Abdullah M. Assiri, Haifa Al Mousa, Seif Al-Abri, Huda Al‐Katheeri, Huda Alansari, Najiba M. Abdulrazzaq, Awa Aïdara‐Kane, Didier Pittet, Didier Pittet, Awa Aïdara‐Kane, Elisabeth Erlacher-Vindel, Hail Mater Al Abdely, Adel Othman, Sameera M. Al Johani, Abubaker Fadlelmula, Aiman El‐Saed, Gregory Poff, Abdulrahman Al Habrawy, Yousuf Al Omi, Alaa Mutlaq, Ahmed Hakawi, Mohammed Zahrani, Sami Al Hajjar, Sahar Al Thawadi, Ali M. Somily, Hosam M. Zowawi, Saeed Al Shahrani, Mohamed Al Quwaizini, Ali Al Sahaaf, Mohammed Fayez Ahmed Salim, Kamal Zidan, Safaa Khawajah, Jameela Alsalman, Nermin Kamal Saeed, Noura Al Qalloushi, Abeer Aly Omar, Najiba M. Abdulrazzaq, Zaina Al Maskari, Faryal Ali Khamis Al Lawati, Hilal Al Hashami, Mubarak Al Yaqoubi, Khalifa Al Shaqsi, Huda Al Harthi, Khalid Elawad, Wael Ezzeldin Said Hussein, Yasser Mohamed Abdelkader Morsy, Salah Ahmed Abdalkarim Taha, Eman Abdulrahman Al Maslamani, Maryam Al Sulaiti,
The Gulf Cooperation Council Center for Infection Control (GCC-IC) has placed the emergence of antimicrobial resistance (AMR) on the top of its agenda for the past four years. The board members have developed the initial draft for the GCC strategic plan for combating AMR in 2014. The strategic plan stems from the WHO mandate to combat AMR at all levels. The need for engaging a large number of stakeholders has prompted the GCC-IC to engage a wider core of professionals in finalizing the plan. A multi- ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2016 - Elsevier BV | Journal of Infection and Public Health
Mohammed.H. Faizo, Hussain Al‐Qahtani, Falah S. AL-harbi, Faisal A . AL-shoeal, Abdulrahman S. AL-shahrani, Abdullah M. AL-mutairi, Yasser M. AL-qarni, Nasse A . AL-dossari, Ahmed M. AL-asmari, Omar.S. Althobaiti, Mustafa. I Maes,
the aim of the current study is, the importance of the role of the medical secretary in society, the impact of the medical secretary in terms of coordinating appointments between patients and doctors, what are the health services provided by the medical secretary. The questionnaire was created electronically via the Google Drive program, and then it was distributed via mobile phone on the social networking program (WhatsApp). Using e-mail for all participants to respond to the questionnaire. 600 ...
Tópico(s): Healthcare Quality and Satisfaction
2023 - Green Wave Publishing of Canada | Journal of Survey in Fisheries Sciences