Masaaki Iwatsuki, Hiroyuki Yamamoto, Hiroaki Miyata, Yoshihiro Kakeji, Kazuhiro Yoshida, Hiroyuki Konno, Yasuyuki Seto, Hideo Baba,
Despite interest in surgeon and hospital volume effects on total gastrectomy (TG), clinical significance has not been confirmed in a large-scale population. This study aimed at clarifying the association of surgeon and hospital volume on postoperative mortality after TG for gastric cancer among Japanese patients in National Clinical Database (NCD).Between 2011 and 2015, we retrospectively extracted data on TG for gastric cancer from the NCD. The primary outcome was operative mortality. We divided ...
Tópico(s): Esophageal Cancer Research and Treatment
2020 - Springer Science+Business Media | Gastric Cancer
Michitaka Honda, Hiraku Kumamaru, Tsuyoshi Etoh, Hiroaki Miyata, Yuichi Yamashita, Kazuhiro Yoshida, Yasuhiro Kodera, Yoshihiro Kakeji, Masafumi Inomata, Hiroyuki Konno, Yasuyuki Seto, Seigo Kitano, Masahiko Watanabe, Naoki Hiki,
Laparoscopic gastrectomy (LG) might have greater clinical benefits for elderly patients as less invasive surgery; however, there is still little evidence to support its benefit. We evaluated the surgical outcomes of elderly patients in a nationwide prospective cohort study. One hundred and sixty-nine participating institutions were identified by stratified random sampling, and were adjusted for hospital volume, type and location. During 1 year from 2014 to 2015, consecutive patients who underwent ...
Tópico(s): Colorectal Cancer Surgical Treatments
2018 - Springer Science+Business Media | Gastric Cancer
Masaaki Iwatsuki, Hiroyuki Yamamoto, Hiroaki Miyata, Yoshihiro Kakeji, Kazuhiro Yoshida, Hiroyuki Konno, Yasuyuki Seto, Hideo Baba,
Despite interest in surgeon and hospital volume effects on distal gastrectomy, clinical significance has not been confirmed in a large-scale population. We studied to clarify the effects of surgeon and hospital volume on postoperative mortality after distal gastrectomy for gastric cancer among Japanese patients in a nationwide web-based data entry system.We extracted data on distal gastrectomy for gastric cancer from the National Clinical Database between 2011 and 2015. The primary outcome was operative ...
Tópico(s): Esophageal Cancer Research and Treatment
2018 - Springer Science+Business Media | Gastric Cancer
Tsuyoshi Etoh, Michitaka Honda, Hiraku Kumamaru, Hiroaki Miyata, Kazuhiro Yoshida, Yasuhiro Kodera, Yoshihiro Kakeji, Masafumi Inomata, Hiroyuki Konno, Yasuyuki Seto, Seigo Kitano, Naoki Hiki,
Tópico(s): Esophageal and GI Pathology
2017 - Springer Science+Business Media | Surgical Endoscopy
Naoki Hiki, Michitaka Honda, Tsuyoshi Etoh, Kazuhiro Yoshida, Yasuhiro Kodera, Yoshihiro Kakeji, Hiraku Kumamaru, Hiroaki Miyata, Yuichi Yamashita, Masafumi Inomata, Hiroyuki Konno, Yasuyuki Seto, Seigo Kitano,
Laparoscopic distal gastrectomy (LDG) is becoming the standard procedure for gastric cancer. However, supporting evidence thus far has been derived primarily from randomized control trials conducted by centers of excellence. In the present study we used the National Clinical Database (NCD) in Japan to prospectively accumulate data from diverse types of hospitals and examine whether LDG is a safe and valid standard procedure.From the NCD, 169 institutions were selected to form a cohort that was considered ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2017 - Springer Science+Business Media | Gastric Cancer
Hiroya Takeuchi, Hiroaki Miyata, Soji Ozawa, Harushi Udagawa, Harushi Osugi, Hisahiro Matsubara, Hiroyuki Konno, Yasuyuki Seto, Yuko Kitagawa,
Tópico(s): Lung Cancer Diagnosis and Treatment
2017 - Springer Science+Business Media | Annals of Surgical Oncology
Tatsuto Nishigori, Hiroaki Miyata, Hiroshi Okabe, Yasushi Toh, Hisahiro Matsubara, Hiroyuki Konno, Yasuyuki Seto, Yoshiharu Sakai,
Abstract Background Previous studies have reported that patients undergoing oesophagectomy in high-volume hospitals experience lower mortality rates. However, there has been ongoing discussion regarding the validity of evidence for this association. The purpose of this study was to investigate the relationship between hospital volume and risk-adjusted mortality following oesophagectomy in Japan, using a nationwide web-based database. Methods The study included patients registered in the database ...
Tópico(s): Gastric Cancer Management and Outcomes
2016 - Oxford University Press | British journal of surgery
Masahiko Shigemura, Satoshi Konno, Yasuyuki Nasuhara, Chikara Shimizu, Kazuhiko Matsuno, Masaharu Nishimura,
Abstract Ovarian cancer is the leading cause of death among gynecologic malignancies and despite advances in treatment, more than 50% of all patients will experience recurrence, resulting in worse overall prognosis. Therefore, identification of novel biomarkers for ovarian cancer is of significant interest. microRNA (miRNA) constitute a class of small gene regulatory RNA molecules (18–24 nt) and by sequence complementarity, they negatively regulate messenger RNA (mRNA) translation of target genes. ...
Tópico(s): Cancer-related molecular mechanisms research
2012 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
Satoru Kobayashi, Kazuhisa Sato, Eiki Hayashi, Toshihiro Osaka, Toyohiko J. Konno, Yasuyuki Kaneno, Takayuki Takasugi,
The effects of alloying elements (Ti, Nb, Ta, Cr, W, Re, Co and Si) on the phase equilibria among Ni (A1), Ni3Al (L12) and Ni3V (D022) phases were studied by means of microstructure observation and energy dispersive spectroscopy analysis on thin foils. It was found that the alloying elements can be classified into four categories: (a) Ti stabilizing the phases in the order: L12 > D022 > A1, (b) Nb and Ta stabilizing the phases: D022 > L12 > A1, (c) Cr, W, Re and Co stabilizing the phases: A1 > D022 > L12, (d) Si stabilizing ...
Tópico(s): High Temperature Alloys and Creep
2012 - Elsevier BV | Intermetallics
Masaharu Nishimura, Hironi Makita, Katsura Nagai, Satoshi Konno, Yasuyuki Nasuhara, Masaru Hasegawa, Kaoruko Shimizu, Tomoko Betsuyaku, Yoichi M. Ito, Satoshi Fuke, Takeshi Igarashi, Yasushi Akiyama, Shigeaki Ogura,
Rationale: Although the rate of annual decline in FEV1 is one of the most important outcome measures in chronic obstructive pulmonary disease (COPD), little is known about intersubject variability based on clinical phenotypes.Objectives: To examine the intersubject variability in a 5-year observational cohort study, particularly focusing on emphysema severity.Methods: A total of 279 eligible patients with COPD (stages I–IV: 26, 45, 24, and 5%) participated. We conducted a detailed assessment of pulmonary ...
Tópico(s): Asthma and respiratory diseases
2011 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Kiminori Ohta, Shunsuke Konno, Yasuyuki Endo,
Although the complexation of carborane derivatives with β-cyclodextrin (β-CD) is well-known, we present here the first observation of the complexation of carborane derivatives with α-CD in aqueous solution. The stoichiometry and association constant (Ka) of the complexes were estimated from Job's plots and NMR titration studies, respectively. The carborane : α-CD stoichiometry was 1 : 1 in all cases. The complexation ability and selectivity of the carborane derivatives for α-CD are markedly decreased ...
Tópico(s): Radioactive element chemistry and processing
2009 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Kenichiro Shimada, Toru Yoshihara, Masahiko Yamamoto, Katsuhiko Konno, Yasuyuki Momoi, Koji Nishifuji, Toshiroh Iwasaki,
The correlation between skin barrier function and transepidermal water loss (TEWL) was evaluated in dogs. Stratum corneum (SC) of 10 healthy dogs was removed by tape stripping (TS), which decreased the corneal layer to allow for permeation of fluorescent dye into skin. TEWL of damaged skin was measured with the closed-chamber-type TEWL analyzer, CC-01. The frequency of TS was directly related to the decrease of SC and the increased permeation of fluorescent dye, and TEWL increased with increasing impairment ...
Tópico(s): Ocular Surface and Contact Lens
2008 - Japanese Society of Veterinary Science | Journal of Veterinary Medical Science
Kiminori Ohta, Shunsuke Konno, Yasuyuki Endo,
β-Cyclodextrin formed the most robust complexes with o-carboranols 1b and 1c in aqueous solution, and the association constants estimated from NMR titration studies indicated Ka >1 × 106 M−1 and Ka = 6 × 105 M−1, respectively.
Tópico(s): Radiopharmaceutical Chemistry and Applications
2008 - Elsevier BV | Tetrahedron Letters
M Kimura, Yasuhiro Matsumura, T Konno, Yasuyuki Miyauchi, Hiroshi Maeda,
The toxic effects of the degradation products of bilirubin that were formed by reaction with bilirubin oxidase were investigated with the C 1300 mouse neuroblastoma cell line by examining the following parameters: growth inhibition, morphologic characteristics, membrane transport, DNA synthesis, and protein synthesis. The addition of bilirubin to the cells resulted in definite cytotoxic effects on all of these parameters in a dose-dependent fashion; the addition of bilirubin oxidase reversed the ...
Tópico(s): Methemoglobinemia and Tumor Lysis Syndrome
1990 - SAGE Publishing | Experimental Biology and Medicine
Hiroto Yamasaki, Motoaki Goto, Toyohiko Yoshihara, Maiko Sekiguchi, Katsuhiko Konno, Yasuyuki Momoi, Toshiroh Iwasaki,
Flexor tendonitis in racehorses which is caused by racing or training diminishes their running ability. In the present study, the involvement of hyperthermia in the development of flexor tendonitis is investigated. When fibroblasts isolated from the superficial digital flexor tendon of a horse are cultured, their survival rate decreases after 1 hour of exposure to a temperature of 43°C. When a racehorse runs on a dirt track, the center of the tendon runs a fever of 43°C or more. This finding suggests ...
Tópico(s): Exercise and Physiological Responses
2001 - | Journal of Equine Science
Satoshi Takeda, Kouichi Shiosaki, Yasufumi Kaneda, Tetsuya Nakasatomi, Hitomi Yoshizaki, Kenji Someya, Yusuke Konno, Yasuyuki Eda, Youichirou Kino, Naoki Yamamoto, Mitsuo Honda,
By using the hepatitis B core (HBc) protein gene as a carrier, HIV-1 env V3 gene was inserted into the carrier gene, and the HIV gene was expressed inside a chimeric HIV-HBc particle (HIV-HBc), which was a unique candidate for induction of HIV-specific CTL activity. This was seen significantly in mice without the need of an adjuvant, because other responses specific for the HIV peptide such as T-cell proliferation and antibody production were not induced. However, when hemagglutinating virus of Japan ( ...
Tópico(s): Herpesvirus Infections and Treatments
2004 - Elsevier BV | Clinical Immunology
Hironi Makita, Masaru Suzuki, Satoshi Konno, Kaoruko Shimizu, Yasuyuki Nasuhara, Katsura Nagai, Yasushi Akiyama, Satoshi Fuke, Hiroshi Saito, Takeshi Igarashi, Kimihiro Takeyabu, Masaharu Nishimura,
Purpose: Causes of death may be unique and different in Japanese patients with COPD because they are generally older, thinner, experience fewer exacerbations, and live longer than those in other countries. We investigated the detailed mortality profile in the Hokkaido COPD cohort study, which completed a 10-year follow-up with a very low dropout rate. Patients and Methods: We prospectively examined the 10-year natural history in 279 Japanese patients with COPD (GOLD 1, 26%; GOLD 2, 45%; GOLD 3, 24%; ...
Tópico(s): Health Promotion and Cardiovascular Prevention
2020 - Dove Medical Press | International Journal of COPD
Shingo Kanaji, Arata Takahashi, Hiroaki Miyata, Shigeru Marubashi, Yoshihiro Kakeji, Hiroyuki Konno, Mitsukazu Gotoh, Yasuyuki Seto,
Tópico(s): Pancreatic and Hepatic Oncology Research
2018 - Springer Science+Business Media | Surgery Today
Yoshihiro Kakeji, Arata Takahashi, Harushi Udagawa, Michiaki Unno, Itaru Endo, Chikara Kunisaki, Akinobu Taketomi, Akira Tangoku, Tadahiko Masaki, Shigeru Marubashi, Kazuhiro Yoshida, Mitsukazu Gotoh, Hiroyuki Konno, Hiroaki Miyata, Yasuyuki Seto,
Abstract The National Clinical Database ( NCD ) of Japan started its registration in 2011 and over 9 000 000 cases from more than 5000 facilities were registered over a 6‐year period. This is the report of NCD based upon gastrointestinal surgery information in excess of 3 200 000 cases from 2011 to 2016 adding data of complications. About 70% of all gastrointestinal surgeries were carried out at certified institutions, and the percentage of surgeries done at certified institutions was particularly high ...
Tópico(s): Gastric Cancer Management and Outcomes
2017 - Wiley | Annals of Gastroenterological Surgery
Katsura Nagai, Tomoko Betsuyaku, Satoshi Konno, Yoko Ito, Yasuyuki Nasuhara, Nobuyuki Hizawa, Takahito Kondo, Masaharu Nishimura,
Oxidative stress is involved in asthma. This study assessed the carbonylation of sputum proteins in 23 uncontrolled adult asthmatic patients and 23 healthy controls. Carbonylated proteins (68 kDa and 53 kDa) were elevated in asthmatics when compared to controls and the 68-kDa carbonylated protein was significantly correlated with sputum eosinophilia. The kinetics of protein carbonylation in bronchoalveolar lavage fluid (BALF) were then examined in a mouse ovalbumin-induced allergic inflammation model. ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2008 - Taylor & Francis | Free Radical Research
Kiyohiko Omichi, Kiyoshi Hasegawa, Hiraku Kumamaru, Hiroaki Miyata, Hiroyuki Konno, Yasuyuki Seto, Masaki Mori, Norihiro Kokudo,
Tópico(s): Esophageal Cancer Research and Treatment
2021 - Springer Science+Business Media | Langenbeck s Archives of Surgery
Takeshi Ohki, Masakazu Yamamoto, Hiroaki Miyata, Yasuto Sato, Yoshihisa Saida, Tsuyoshi Morimoto, Hiroyuki Konno, Yasuyuki Seto, Koichi Hirata,
Colorectal perforation has a high rate of mortality. We compared the incidence and fatality rates of colorectal perforation among different hospitals in Japan using data from the nationwide surgical database. Patients were registered in the National Clinical Database (NCD) between January 1st, 2011 and December 31st, 2013. Patients with colorectal perforation were identified from surgery records by examining if acute diffuse peritonitis (ADP) and diseases associated with a high probability of colorectal ...
Tópico(s): Diverticular Disease and Complications
2017 - Wolters Kluwer | Medicine
Masahiko Shigemura, Satoshi Konno, Yasuyuki Nasuhara, Noriharu Shijubo, Chikara Shimizu, Masaharu Nishimura,
Serum KL-6, a sialylated sugar chain on human MUC1, is used as a marker of interstitial lung diseases. We recently reported that efflux behavior of KL-6/MUC1 from the alveoli into the bloodstream assessed by molecular analysis differed according to genetically determined molecular sizes and influenced serum KL-6 concentrations in sarcoidosis. This study was designed to investigate associations between molecular size and efflux behavior of KL-6/MUC1, and factors contributing to serum KL-6 concentrations ...
Tópico(s): Sarcoidosis and Beryllium Toxicity Research
2013 - Elsevier BV | Clinica Chimica Acta
Kazuhiro Haraguchi, K Konno, Kaori Yamada, Yasuyuki Kitagawa, Kazuo Nakamura, Hiromichi Tanaka,
Tópico(s): Synthetic Organic Chemistry Methods
2010 - Elsevier BV | Tetrahedron
Shunsuke Suzuki, Goutham Kukkadapu, Yudai Ishii, Takuma Katsumic, Koichi Kinoshita, Yoshinaka Takeda, Satoshi Sakaida, Mitsuru KONNO, Yasuyuki Sakai, Kotaro Tanaka, Mitsuharu Oguma, William J. Pitz,
Methanol has been considered as a potential renewable liquid fuel and blending it with gasoline and diesel is an effective way to reduce greenhouse gas emissions from the transport sector. To understand the mixing effect of methanol on the formation of polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs), the fuel-rich oxidation of toluene with and without methanol was studied using a flow reactor at atmospheric pressure, temperatures from 1050 to 1350 K, equivalence ratio of 9.0, and ...
Tópico(s): Catalysis and Oxidation Reactions
2022 - Elsevier BV | Proceedings of the Combustion Institute
Yoshio Haga, Hiroaki Miyata, Akira Tsuburaya, Mitsukazu Gotoh, Kazuhiro Yoshida, Hiroyuki Konno, Yasuyuki Seto, Yoshiyuki Fujiwara, Hideo Baba,
Gastric cancer is the second leading cause of cancer death worldwide. Surgery is the mainstay treatment for gastric cancer. There are no prediction models that examine the severity of postoperative morbidity. Herein, we constructed prediction models that analyze the risk for postoperative morbidity based on severity.Perioperative data were retrieved from the National Clinical Database in patients who underwent elective gastric cancer resection between 2011 and 2012 in Japan. Severity of postoperative ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2019 - Wiley | Annals of Gastroenterological Surgery
Masae I. Ishihara, Yasuo Konno, Kiyoshi Umeki, Yasuyuki Ohno, Kihachiro Kikuzawa,
Tree growth, especially diameter growth of tree stems, is an important issue for understanding the productivity and dynamics of forest stands. Metabolic scaling theory predicted that the 2/3 power of stem diameter at a certain time is a linear function of the 2/3 power of the initial diameter and that the diameter growth rate scales to the 1/3 power of the initial diameter. We tested these predictions of the metabolic scaling theory for 11 Japanese secondary forests at various growth stages. The ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2016 - Public Library of Science | PLoS ONE
Yoshiki Kajiwara, Arata Takahashi, Hideki Ueno, Yoshihiro Kakeji, Hiroshi Hasegawa, Susumu Eguchi, Takanori Goi, Akio Saiura, Akira Sasaki, Shuji Takiguchi, Hiroya Takeuchi, Chie Tanaka, Masaji Hashimoto, Naoki Hiki, Akihiko Horiguchi, Satoru Matsuda, Tsunekazu Mizushima, Shigeru Marubashi, Mitsukazu Gotoh, Hiroyuki Konno, Hiroyuki Yamamoto, Hiroaki Miyata, Yasuyuki Seto, Yuko Kitagawa,
The National Clinical Database (NCD) of Japan is a nationwide data entry system for surgery, and it marked its 10th anniversary in 2020. The aim was to present the 2020 annual report of gastroenterological surgery of the NCD.
Tópico(s): Pancreatic and Hepatic Oncology Research
2023 - Wiley | Annals of Gastroenterological Surgery
Sho Nakakubo, Naoki Kishida, Kenichi Okuda, Keisuke Kamada, Masami Iwama, Masaru Suzuki, Isao Yokota, Yoichi M. Ito, Yasuyuki Nasuhara, Richard C. Boucher, Satoshi Konno,
BackgroundPrevious SARS-CoV-2 infection and vaccination, coupled with the rapid evolution of SARS-CoV-2 variants, have modified COVID-19 clinical manifestations. We aimed to characterise the clinical symptoms of COVID-19 individuals in omicron BA.2 and BA.5 Japanese pandemic periods to identify omicron and subvariant associations between symptoms, immune status, and clinical outcomes.MethodsIn this registry-based observational study, individuals registered in Sapporo's web-based COVID-19 information ...
Tópico(s): SARS-CoV-2 detection and testing
2023 - Elsevier BV | The Lancet Infectious Diseases
Shigeru Marubashi, Arata Takahashi, Yoshihiro Kakeji, Hiroshi Hasegawa, Hideki Ueno, Susumu Eguchi, Itaru Endo, Takanori Goi, Akio Saiura, Akira Sasaki, Shuji Takiguchi, Hiroya Takeuchi, Chie Tanaka, Masaji Hashimoto, Naoki Hiki, Akihiko Horiguchi, Tadahiko Masaki, Kazuhiro Yoshida, Mitsukazu Gotoh, Hiroyuki Konno, Hiroyuki Yamamoto, Hiroaki Miyata, Yasuyuki Seto, Yuko Kitagawa,
Abstract Background We aimed to present the 2019 annual report of the gastroenterological section of the National Clinical Database (NCD). Methods We reviewed 609,589 cases recorded in 2019 and 5,029,764 cases registered from 2011 to 2019 for the 115 selected gastroenterological surgical procedures. Results The main features of gastroenterological surgery in Japan were similar to those described in the 2018 annual report, namely, that 1) operative numbers gradually increased in all procedures, except ...
Tópico(s): Esophageal and GI Pathology
2021 - Wiley | Annals of Gastroenterological Surgery