Min Soo Byun, Sung Wook Park, Jun Ho Lee, Dahyun Yi, So Yeon Jeon, Hyo Jung Choi, Haejung Joung, Un Hyung Ghim, Un Chul Park, Yoon‐Keun Kim, Seong A. Shin, Hyeong Gon Yu, Dong Young Lee,
Retinal biomarkers reflecting in vivo brain Alzheimer disease (AD) pathologic abnormalities could be a useful tool for screening cognitively normal (CN) individuals at the preclinical stage of AD.To investigate the association of both functional and structural alterations of the retina with in vivo AD pathologic abnormalities in CN older adults and model a screening tool for detection of preclinical AD.This cross-sectional study included a total of 49 CN individuals, and all assessment was done at ...
Tópico(s): Retinal Diseases and Treatments
2021 - American Medical Association | JAMA Ophthalmology
Soonjae Hwang, Chang-Gun Lee, Minjeong Jo, Chan Oh Park, Sun-Yeong Gwon, Samnoh Hwang, Hye Chin Yi, So Yeon Lee, Yong‐Bin Eom, Baktiar Karim, Ki‐Jong Rhee,
The azoxymethane (AOM)/dextran sulfate sodium (DSS) murine model is commonly used to study colitis-associated cancer. The human commensal bacterium, enterotoxigenic Bacteroides fragilis (ETBF) secretes the Bacteroides fragilis toxin (BFT) which is necessary and sufficient to cause colitis. We report that BALB/c mice infected with WT-ETBF and administered three cycles of AOM/DSS developed numerous, large-sized polyps predominantly in the colorectal region. In addition, AOM/DSS-treated BALB/c mice orally ...
Tópico(s): Gut microbiota and health
2020 - Ivyspring International Publisher | International Journal of Medical Sciences
Joon Hyung Jung, Ga‐Won Lee, Jun Ho Lee, Min Soo Byun, Dahyun Yi, So Yeon Jeon, Gijung Jung, Haejung Joung, Seong A. Shin, Yu Kyeong Kim, Koung Mi Kang, Chul‐Ho Sohn, Dong Young Lee,
Multiparity - grand multiparity (i.e., five or more childbirths) in particular - has been reported to have an association with increased risk of Alzheimer's disease (AD) dementia or related cognitive decline in women. However, the pathological links underlying this relationship are still unknown. This study was conducted to examine the relationships of multiparity with cerebral amyloid-beta (Aβ) deposition, brain atrophy, and white matter hyperintensities (WMHs).In this study, total of 237 older women with ...
Tópico(s): Maternal Mental Health During Pregnancy and Postpartum
2020 - Frontiers Media | Frontiers in Aging Neuroscience
Hyon‐Seung Yi, So Yeon Kim, Jung Tae Kim∥, Young‐Sun Lee, Ji Sun Moon, Mingyo Kim, Yea Eun Kang, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Kwangsik Chun, Minho Shong, Bon Jeong Ku,
Abstract Chronic inflammation is a driving force for the development of metabolic disease including diabetes and obesity. However, the functional characteristics of T-cell senescence in the abnormal glucose homeostasis are not fully understood. We studied the patients visiting a hospital for routine health check-ups, who were divided into two groups: normal controls and people with prediabetes. Gene expression profiling of peripheral blood mononuclear cells from normal controls and patients with ...
Tópico(s): Immune Cell Function and Interaction
2019 - Springer Nature | Cell Death and Disease
Jee Wook Kim, Min Soo Byun, Jun Ho Lee, Dahyun Yi, So Yeon Jeon, Bo Kyung Sohn, Jun‐Young Lee, Seong A. Shin, Yu Kyeong Kim, Koung Mi Kang, Chul‐Ho Sohn, Dong Young Lee,
To investigate the relationships of serum albumin with in vivo Alzheimer disease (AD) pathologies, including cerebral β-amyloid (Aβ) protein deposition, neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMH), in the human brain.A total of 396 older adults without dementia underwent comprehensive clinical assessments, measurement of serum albumin level, and multimodal brain imaging, including [11C] Pittsburgh compound B-PET, 18F-fluorodeoxyglucose-PET, and MRI. Serum ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2020 - Lippincott Williams & Wilkins | Neurology
Young‐Sun Lee, Myung Ho Kim, Hyon‐Seung Yi, So Yeon Kim, Hee-Hoon Kim, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun, Jin-Seok Byun, Won‐Il Jeong,
The expression of chemokine receptor CX3CR1 is related to migration and signaling in cells of the monocyte-macrophage lineage. The precise roles of CX3CR1 in the liver have been investigated but not clearly elucidated. Here, we investigated the roles of CX3CR1 in hepatic macrophages and liver injury. Hepatic and splenic CX3CR1lowF4/80low monocytes and CX3CR1lowCD16- monocytes were differentiated into CX3CR1highF4/80high or CX3CR1highCD16+ macrophages by co-culture with endothelial cells. Moreover, ...
Tópico(s): Phagocytosis and Immune Regulation
2018 - Nature Portfolio | Scientific Reports
Sang‐Wook Yi, So Yeon Ryu, Heechoul Ohrr, Jae‐Seok Hong,
Background: Agent Orange (AO) was a mixture of phenoxy herbicides, containing several dioxin impurities including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Various military herbicides, including AO, were sprayed by the US military and allied forces for military purposes during the Vietnam War. This study was performed to identify the associations between the AO exposure and mortality in Korean Vietnam veterans. Methods: From 1 January 1992 to 31 December 2005, 180 639 Korean Vietnam veterans were ...
Tópico(s): Health, Environment, Cognitive Aging
2014 - Oxford University Press | International Journal of Epidemiology
Huhn Kim, Seungyoun Yi, So–Yeon Yoon,
When typing on smartphones or palm tablets, users generally make an effort to type correctly while simultaneously checking the small keyboard and the text display. Unlike physical keyboards that allow users to perform typing based on long-term muscle memory, virtual keyboards typically require more frequent eye movements between the keyboard and the text display areas. This study proposes a new way of designing a virtual keyboard display to reduce the effort associated with frequent eye-movements. ...
Tópico(s): Interactive and Immersive Displays
2018 - Elsevier BV | Displays
Rui Zhou, Yi Yang, So‐Yeon Park, Young‐Woo Seo, Sang‐Chul Jung, Kyung Keun Kim, Kwonseop Kim, Hangun Kim,
Abstract δ-Catenin shares common binding partners with β-catenin. As acetylation and deacetylation regulate β-catenin stability, we searched for histone acetyltransferases (HATs) or histone deacetylases (HDACs) affecting δ-catenin acetylation status and protein levels. We showed that p300/CBP-associated factor (PCAF) directly bound to and acetylated δ-catenin, whereas several class I and class II HDACs reversed this effect. Unlike β-catenin, δ-catenin was downregulated by PCAF-mediated acetylation ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2019 - Nature Portfolio | Scientific Reports
Rui Zhou, Yi Yang, So‐Yeon Park, Thanh Thi Nguyen, Young‐Woo Seo, Kyung Hwa Lee, Jae Hyuk Lee, Kyung Keun Kim, Jae‐Seoun Hur, Hangun Kim,
Abstract Lichens are symbiotic organisms that produce various secondary metabolites. Here, different lichen extracts were examined to identify secondary metabolites with anti-migratory activity against human lung cancer cells. Everniastrum vexans had the most potent inhibitory activity, and atranorin was identified as an active subcomponent of this extract. Atranorin suppressed β-catenin-mediated TOPFLASH activity by inhibiting the nuclear import of β-catenin and downregulating β-catenin/LEF and ...
Tópico(s): Medicinal plant effects and applications
2017 - Nature Portfolio | Scientific Reports
Bom‐Yi Lee, So‐Yeon Park, Hyun Mee Ryu, Chan‐Young Shin, K Ko, Jung‐Yeol Han, Gideon Koren, Youl‐Hee Cho,
Background Alcohol exposure has been shown to cause devastating effects on neurobehavioral development in numerous animal and human studies. The alteration of DNA methylation levels in gene‐specific promoter regions has been investigated in some studies of human alcoholics. This study was aimed to investigate whether social alcohol consumption during periconceptional period is associated with epigenetic alteration and its generational transmission in the blood cells. Methods We investigated patterns ...
Tópico(s): Birth, Development, and Health
2015 - Wiley | Alcoholism Clinical and Experimental Research
Yi Yang, So‐Yeon Park, Thanh Thi Nguyen, Young Hyun Yu, Tru Van Nguyen, Eun Gene Sun, Jayalal Udeni, Min‐Hye Jeong, Íris Susana Pires Pereira, Cheol Moon, Hyung‐Ho Ha, Kyung Keun Kim, Jae‐Seoun Hur, Hangun Kim,
Lichens produce various unique chemicals that can be used for pharmaceutical purposes. To screen for novel lichen secondary metabolites showing inhibitory activity against lung cancer cell motility, we tested acetone extracts of 13 lichen samples collected in Chile. Physciosporin, isolated from Pseudocyphellaria coriacea (Hook f. & Taylor) D.J. Galloway & P. James, was identified as an effective compound and showed significant inhibitory activity in migration and invasion assays against human lung cancer ...
Tópico(s): Botany and Plant Ecology Studies
2015 - Public Library of Science | PLoS ONE
Kyu‐Hyoung Lim, Sun‐Young Kim, Yoon-Su Lee, Ki Hwan Kim, Jinwon Kim, Jiyoung Rhee, Hye Jin Kim, Hyeon Gyu Yi, So Yeon Oh, Joo Han Lim, Sae‐Won Han, Sang Yoon Lee, Inho Kim, Sung‐Soo Yoon, Seonyang Park, Byoung Kook Kim,
We describe a 37-yr-old man who developed central pontine myelinolysis (CPM) after allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia. After HSCT, desquamation developed on the whole body accompanied by hyperbilirubinemia. The liver biopsy of the patient indicated graft-versus-host disease- related liver disease, and the dose of methylprednisolone was increased. Then, the patient developed altered mentality with eye ball deviation to the left, for which electroencephalogram ...
Tópico(s): Neurological Complications and Syndromes
2008 - Korean Academy of Medical Sciences | Journal of Korean Medical Science
Hyunjung Lee, So Yeon Yi, Jung Sun Kwon, Jong Min Choi, Dong Su Lee, Sang Hyun Lee, Yong‐Beom Shin,
Fast detection of pathogens is important for protecting our health and society. Herein, we present a high-performance nanogap impedimetric sensor for monitoring nucleic acid amplification in real time using isothermal recombinase polymerase amplification (RPA) for rapid pathogen detection. The nanogap electrode chip has two pairs of opposing gold electrodes with a 100 nm gap and was fixed to a PCB. Then, the nanogap impedimetric sensor was immersed in RPA reaction solution for the detection of E. ...
Tópico(s): Advanced Biosensing Techniques and Applications
2021 - Elsevier BV | Biosensors and Bioelectronics
Wang Sik Lee, Taejoon Kang, Kyung Jin Kwak, Kyoungsook Park, So Yeon Yi, Ui Jin Lee, Yong‐Beom Shin, Jinyoung Jeong,
This work reports on a rapid diagnostic platform for the detection of Plasmodium falciparum lactate dehydrogenase (PfLDH), a representative malaria biomarker, using a microfluidic microplate-based immunoassay. In this study, the microfluidic microplate made it possible to diagnose PfLDH with a small volume of sample (only 5 μL) and short time (< 90 min) compared to conventional immunoassays such as enzyme-linked immunosorbent assay (ELISA). Moreover, the diagnostic performance of PfLDH showed high sensitivity, ...
Tópico(s): Complement system in diseases
2020 - Springer Nature | Nano Convergence
Kyoungsook Park, Lan Hee Lee, Yong‐Beom Shin, So Yeon Yi, Yong-Won Kang, Dai‐Eun Sok, Jin Woong Chung, Bong Hyun Chung, Moonil Kim,
The principal objective of this study was to explore protein conformational changes using fluorescence resonance energy transfer (FRET) technology. Maltose binding protein (MBP) was adopted as a target model, due to its well-characterized structure and ligand specificity. To the best of our knowledge, this is the first report to provide information regarding the biological distance between the two lobes of MBP upon maltose binding. For the FRET pair, ECFP and EYFP were used as the donor and the acceptor, ...
Tópico(s): DNA and Nucleic Acid Chemistry
2009 - Elsevier BV | Biochemical and Biophysical Research Communications
Mi Yeon Lee, Hye‐Ran Kim, Eungwang Kim, So Yeon Yi, Seul Gee Hwang, Siyeong Yang, Eun‐Kyung Lim, Bongsoo Kim, Juyeon Jung, Taejoon Kang,
Multivalent immunoprobes can improve the sensitivity of biosensors because increased valency can strengthen the binding affinity between the receptor and target biomolecules. Here, we report surface-enhanced Raman scattering (SERS)-based immunoassays using multivalent antibody-conjugated nanoparticles (NPs) for the first time. Multivalent antibodies were generated through the ligation of Fab fragments fused with Fc-binding peptides to immunoglobulin G. This fabrication method is easy and fast because ...
Tópico(s): Biosensors and Analytical Detection
2018 - American Chemical Society | ACS Applied Materials & Interfaces
Hoang Hiep Nguyen, So Yeon Yi, Woubit Abdela, Moonil Kim,
Here, the rapid detection of Salmonella typhimurium by a portable surface plasmon resonance (SPR) biosensor in which the beam from a diode laser is modulated by a rotating mirror is reported. Using this system, immunoassay based on lipopolysaccharides (LPS)-specific monoclonal anti-Salmonella antibody was performed. For the purpose of orientation-controlled immobilization of antibodies on the SPR chip surface, the cysteine-mediated immobilization method, which is based on interaction between a gold ...
Tópico(s): Advanced Biosensing Techniques and Applications
2016 - Korean Vacuum Society | Applied Science and Convergence Technology
Jeong Hee Moon, So Yeon Yi, Ahreum Hwang, Gayoung Eom, Jieun Sim, Jinyoung Jeong, Eun‐Kyung Lim, Bong Hyun Chung, Bongsoo Kim, Juyeon Jung, Taejoon Kang,
We report facile and sensitive influenza virus detection method using surface-enhanced Raman scattering antibody probes.
Tópico(s): Advanced biosensing and bioanalysis techniques
2016 - Royal Society of Chemistry | RSC Advances
Young Eun Kim, So Yeon Yi, Chang‐Soo Lee, Yongwon Jung, Bong Hyun Chung,
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis of immuno-captured target protein efficiently complements conventional immunoassays by offering rich molecular information such as protein isoforms or modifications. Direct immobilization of antibodies on MALDI solid support enables both target enrichment and MS analysis on the same plate, allowing simplified and potentially multiplexing protein MS analysis. Reliable on-chip immuno-MALDI-TOF MS for ...
Tópico(s): Advanced Proteomics Techniques and Applications
2011 - Royal Society of Chemistry | The Analyst
Eun-Ju Jeong, Yoo Seok Jeong, Kyoungsook Park, So Yeon Yi, Junhyoung Ahn, Sang J. Chung, Moonil Kim, Bong Hyun Chung,
Here we describe a useful method for the site-directed immobilization of proteins with a DNA-binding domain (DNA-BD) on the cognate DNA-coated gold surface for surface plasmon resonance (SPR) imaging analyses. In order to assess the performance of this procedure, we utilized two DNA-BDs, yeast GAL4 DNA-BD, and bacterial LexA DNA-BD. After the immobilization of the cognate double-stranded DNAs (dsDNAs) to a gold chip surface with a monolayer of poly(l-lysine) for sequence-specific DNA–protein interaction, ...
Tópico(s): Gene expression and cancer classification
2008 - Elsevier BV | Journal of Biotechnology
Kyoungsook Park, Junhyoung Ahn, So Yeon Yi, Moonil Kim, Bong Hyun Chung,
The activation of caspase-3 plays an important role in the apoptotic process. In this study, we describe a novel method by which caspase-3-dependent proteolytic cleavage can be monitored, using a surface plasmon resonance (SPR) imaging protein chip system. To the best of our knowledge, this is the first report regarding the SPR imaging-based monitoring of caspase-3 activation. In order to evaluate the performance of this protocol, we constructed a chimeric caspase-3 substrate (GST:DEVD:EGFP) comprised ...
Tópico(s): RNA Interference and Gene Delivery
2008 - Elsevier BV | Biochemical and Biophysical Research Communications
Sang Hee Han, Sang Kyu Kim, Kyoungsook Park, So Yeon Yi, Hye Jung Park, Hong‐Kun Lyu, Moonil Kim, Bong Hyun Chung,
Tópico(s): Advanced Biosensing Techniques and Applications
2010 - Elsevier BV | Analytica Chimica Acta
Kyoungsook Park, So Yeon Yi, Chang‐Soo Lee, Kyoon Eon Kim, Hyun‐Sook Pai, Dai-Wu Seol, Bong Hyun Chung, Moonil Kim,
Tópico(s): Gene Regulatory Network Analysis
2007 - Springer Science+Business Media | The Protein Journal
Ji Hyae Lim, Da Eun Lee, Kyeong Sun Kim, Hyun Jin Kim, Bom Yi Lee, So Yeon Park, Hyun Kyong Ahn, Si Won Lee, Moon Young Kim, Hyun Mee Ryu,
Non-invasive prenatal test of trisomy 21 (T21) is being researched using fetal specific epigenetic biomarkers present in maternal plasma. We applied a methyl-CpG binding domain-based protein (MBD) method based on epigenetic characteristics of fetal specific-methylated regions with a high CpG density in HLCS on chromosome 21 and RASSF1A on chromosome 3 for the non-invasive detection of fetal T21 and estimated the diagnostic accuracy of the method.A nested case-control study was conducted with maternal ...
Tópico(s): Epigenetics and DNA Methylation
2013 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
Jeong Hoon Lee, Pan Kee Bae, Hyunho Kim, Yoon Ji Song, So Yeon Yi, Jungsun Kwon, Joon-Seok Seo, Jeong-min Lee, Han-Sang Jo, Seon Mee Park, Hee Sue Park, Kyeong Seob Shin, Seok Chung, Yong‐Beom Shin,
On-site severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) serological assays allow for timely in-field decisions to be made regarding patient status, also enabling population-wide screening to assist in controlling the coronavirus disease 2019 (COVID-19) pandemic. Here we propose a rapid microfluidic serological assay with two unique functions of nanointerstice filling and digitized flow control, which enable the fast/robust filling of the sample fluid as well as precise regulation of duration ...
Tópico(s): Biosensors and Analytical Detection
2021 - Elsevier BV | Biosensors and Bioelectronics
Kyoungsook Park, Jinyoung Jeong, So Yeon Yi, Wang Sik Lee, Yong‐Beom Shin,
This study demonstrates a novel and rapid antibacterial susceptibility testing (AST) method, called fluorescence resonance energy transfer (FRET) probe-based AST (F-AST), which relies on a nuclease-activated FRET probe that detects bacterial nucleases released by antibiotic-induced bacterial lysis. Three quality control (QC) strains and two additional clinically important strains were tested, and the minimum inhibitory concentration (MIC) values from both gold standard AST method (broth microdilution ( ...
Tópico(s): Biosensors and Analytical Detection
2019 - Elsevier BV | Biosensors and Bioelectronics
Jun‐Ho Lee, Min Soo Byun, Dahyun Yi, Kang Ko, So Yeon Jeon, Bo Kyung Sohn, Jun‐Young Lee, Younghwa Lee, Haejung Joung, Dong Young Lee,
Background: Previous studies indicated an association between Alzheimer’s disease (AD) dementia and air particulate matter (PM) with aerodynamic diameter <10μm (PM10), as well as smaller PM. Limited information, however, is available for the neuropathological links underlying such association. Objective: This study aimed to investigate the relationship between long-term PM10 exposure and in vivo pathologies of AD using multimodal neuroimaging. Methods: The study population consisted of 309 older adults ...
Tópico(s): Air Quality Monitoring and Forecasting
2020 - IOS Press | Journal of Alzheimer s Disease
Bo Kyung Sohn, Min Soo Byun, Dahyun Yi, So Yeon Jeon, Jun Ho Lee, Young Min Choe, Dong Woo Lee, Jun‐Young Lee, Yu Kyeong Kim, Chul‐Ho Sohn, Dong Young Lee,
Background: Physical activities (PA) have been suggested to reduce the risk of Alzheimer‘s disease (AD) dementia. However, information on the neuropathological links underlying the relationship is limited. Objective: We investigated the role of midlife and late-life PA with in vivo AD neuropathologies in old adults without dementia. Methods: This study included participants from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s disease (KBASE). The participants underwent ...
Tópico(s): Nutritional Studies and Diet
2022 - IOS Press | Journal of Alzheimer s Disease
So Yeon Yi, Jinyoung Jeong, Kyoon Eon Kim, Kyoungsook Park, Yong‐Beom Shin,
In this study, we describe a simple and rapid antibacterial susceptibility testing (AST) method for Staphylococcus aureus called S. aureus specific fluorescence resonance energy transfer (FRET) probe-based AST (SF-AST), which is based on an S. aureus specific FRET probe (SF probe) that detects micrococcal nuclease (MNase) activity secreted from S. aureus. The SF-AST was tested with an S. aureus quality control (QC) strain against six relevant antibiotics, and the minimum inhibitory concentration (MIC) ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2019 - American Chemical Society | ACS Infectious Diseases