By Stewart Tendler, Anthony Bevins, By Anthony Bevins, Political Correspondent, By Geraldine Norman Sale Room Correspondent, By Barrie Clement, Labour Reporter, , By Richard Evans Lobby Reporter, From Michael Binyon, From Colin Hughes, , From David Watts, , From David Felton Labour Correspondent, By Lucy Hodges, Education Correspondent, By Richard Dowden, By Philip Webster, Political Reporter, By David Smith, Economics Correspondent, By Pearce Wright Science Editor, From Julian Haviland, , By Rupert Morris, By Nicholas Timmins, Social services Correspondent, By John Young, Agriculture Correspondent, By David Young, Energy Correspondent, By Patricia Clough, By Peter Evans, By Richard Thomson, By Peter Davenport, By Charles Knevitt, Architecture Correspondent, By Bill Johnstone, Technology Correspondent, From Christopher Thomas, , From Frank Johnson, , From Robert Fisk, , From Richard Wigg, From Michael Hamlyn, , By Michael Baily Transport Editor, From David Watts, From Keith Dalton, From Alan McGregor, By Edward Mortimer, From Alice Brinton, , From Our Correspondent, , From a Correspondent, , From Mohsin Ali, From Roger Boyes, , From Our Correspondent, From Mario Modiano, , From a Bridge Correspondent, , From Mary Lee, By Our Foreign Staff, John Percival, Stephen Pettitt, Diane Keaton, , David Robinson, Hilary Finch, Noël Goodwin, William Kay, Christopher Hird, Shona Crawford Poole, PHS, Michael Binyon, David West, Jack Straw, Miles Kington, S. T. FAHM., N. J. ROBSON, , JOHN ENGLEHEART, , BRIAN GANT, , JOHN-MACKIE, , PHILIP GOODHART, , L. R. TEMPLE, , GRAHAM S. BRADY., DAVID GILES, , K. B. PARKINSON, , IAN MACLAY, , D. J. LEECH, , ANTHONY SMALLHORN, By Andrew Wiseman, Executive Editor Kenneth Fleet, From Maxwell Newton, By William Kay City Editor, By Alison Eadie, By Derek Harris, By Patience Wheatcroft, By Cliff Feltham, By Derek Pain, Pam Spooner, John Lawless, By David Young Energy Correspondent, By Rex Bellamy Tennis Correspondent, By Geoffrey Green, By David Powell, By Tim Glover, By Pat Butcher, David Miller, By John Watson, By Marcus Williams, By Ivo Tennant, By Kichard Streeton, By Peter Ball, By John Nicholls, By Mandarin (Michael Phillips), By Christopher Warman Property Correspondent, CW, Peter Dear, Peter Davalle, PH,
... tightened in resorts as police seek suspects, Mrs Yoko Nakamura join, Linda Christmas in the Commons Delights of ...
1985 - Gale Group | TDA
Masao Fujiwara, Yoko Nakamura, Hidekazu Fukamizu,
... andSearch for more papers by this authorYoko NAKAMURA, Yoko NAKAMURA Department of Plastic and Reconstructive Surgery, Kyoto University ... andSearch for more papers by this authorYoko NAKAMURA, Yoko NAKAMURA Department of Plastic and Reconstructive Surgery, Kyoto University ...
Tópico(s): Skin and Cellular Biology Research
2008 - Wiley | The Journal of Dermatology
... this author on: Oxford Academic PubMed Google Scholar Yoko Nakamura, Yoko Nakamura Search for other works by this author on: ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2005 - Oxford University Press | The Journal of Biochemistry
Chigusa Sonoda, Asako Tagami, Daizo Nagatomo, Satoko Yamada, Rieko Fuchiwaki, Masaru Haruyama, Yoko Nakamura, Kimiko Kawano, Mika Okada, Yoko Shioyama, Kazunori Iryoda, Hideo Wakamatu, Yoshio Hidaka,
Tópico(s): Vibrio bacteria research studies
2008 - National Institute of Infectious Diseases | Japanese Journal of Infectious Diseases
Motohiro Senda, Akihiro Ito, Akiko Tsuchida, Tomoko Hagiwara, Tsuguhiro Kaneda, Yoko Nakamura, Kenji Kasama, Makoto Kiso, Kazuhiro Yoshikawa, Yoko Katagiri, Yoshinari Ono, Manabu Ogiso, Takeshi Urano, Keiko Furukawa, Shinichi Oshima, Koichi Furukawa,
Although disialyl glycosphingolipids such as GD3 and GD2 have been considered to be associated with malignant tumours, whether branched-type disialyl glycosphingolipids show such an association is not well understood. We investigated the sialyltransferases responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside). Among six GalNAc:α2,6-sialyltransferases cloned to date, we focused on ST6GalNAc III, V and VI, which utilize sialylglycolipids as ...
Tópico(s): Ubiquitin and proteasome pathways
2007 - Portland Press | Biochemical Journal
Kiyoshi Migita, Atsumasa Komori, Hideko Kozuru, Yuka Jiuchi, Minoru Nakamura, Michio Yasunami, Hiroshi Furukawa, Seigo Abiru, Kazumi Yamasaki, Shinya Nagaoka, Satoru Hashimoto, Shigemune Bekki, Hiroshi Kamitsukasa, Yoko Nakamura, Hajime Ohta, Masaaki Shimada, Hironao Takahashi, Eiji Mita, Taizo Hijioka, Haruhiro Yamashita, Hiroshi Kouno, Makoto Nakamuta, Keisuke Ario, Toyokichi Muro, Hironori Sakai, Kazuhiro Sugi, Hideo Nishimura, Kaname Yoshizawa, Takeaki Sato, Atsushi Naganuma, Tatsuji Komatsu, Yukio Oohara, Fujio Makita, M. Tomizawa, Hiroshi Yatsuhashi,
Recent studies have demonstrated that micro (mi)RNA molecules can be detected in the circulation and can serve as potential biomarkers of various diseases. This study used microarray analysis to identify aberrantly expressed circulating miRNAs in patients with type 1 autoimmune hepatitis (AIH) compared with healthy controls. Patients with well-documented and untreated AIH were selected from the National Hospital Organization (NHO)-AIH-liver-network database. They underwent blood sampling and liver ...
Tópico(s): Liver Disease Diagnosis and Treatment
2015 - Public Library of Science | PLoS ONE
Minoru Nakamura, Yuki Shimizu‐Yoshida, Yasushi Takii, Atsumasa Komori, Terufumi Yokoyama, Toshihito Ueki, Manabu Daikoku, Koji Yano, Takehiro Matsumoto, Kiyoshi Migita, Hiroshi Yatsuhashi, Masahiro Ito, Naohiko Masaki, Hiroshi Adachi, Yukio Watanabe, Yoko Nakamura, Takeo Saoshiro, Takeshi Sodeyama, Michiaki Koga, Shinji Shimoda, Hiromi Ishibashi,
Background/Aims The presence of antibodies to the 210-kDa glycoprotein of the nuclear pore complex (gp210) is highly indicative of primary biliary cirrhosis (PBC). However, the significance of anti-gp210 antibody titers for monitoring PBC remains unresolved. Methods We used an ELISA with a gp210 C-terminal peptide as an antigen to assess serum antibody titers in 71 patients with PBC. Results Patients were classified into three groups: Group A in whom anti-gp210 titers were sustained at a high level, ...
Tópico(s): Hepatitis B Virus Studies
2004 - Elsevier BV | Journal of Hepatology
Yoshihiro Aiba, Minoru Nakamura, Satoru Joshita, Tatsuo Inamine, Atsumasa Komori, Kaname Yoshizawa, Takeji Umemura, Hitomi Horie, Kiyoshi Migita, Hiroshi Yatsuhashi, Makoto Nakamuta, Nobuyoshi Fukushima, Takeo Saoshiro, Shigeki Hayashi, Hiroshi Kouno, Hajime Ota, Toyokichi Muro, Yukio Watanabe, Yoko Nakamura, Toshiki Komeda, Masaaki Shimada, Naohiko Masaki, Tatsuji Komatsu, Michiyasu Yagura, Kazuhiro Sugi, Michiaki Koga, Kazuhiro Tsukamoto, Eiji Tanaka, Hiromi Ishibashi,
Tópico(s): Liver Disease Diagnosis and Treatment
2011 - Springer Science+Business Media | Journal of Gastroenterology
Kiyoshi Migita, Minoru Nakamura, Seigo Abiru, Yuka Jiuchi, Shinya Nagaoka, Atsumasa Komori, Satoru Hashimoto, Shigemune Bekki, Kazumi Yamasaki, Tatsuji Komatsu, Masaaki Shimada, Hiroshi Kouno, Taizo Hijioka, Motoyuki Kohjima, Makoto Nakamuta, Michio Kato, Kaname Yoshizawa, Hajime Ohta, Yoko Nakamura, Eiichi Takezaki, Hideo Nishimura, Takeaki Sato, Keisuke Ario, Noboru Hirashima, Yukio Oohara, Atsushi Naganuma, Toyokichi Muro, Hironori Sakai, Eiji Mita, Kazuhiro Sugi, Haruhiro Yamashita, Fujio Makita, Hiroshi Yatsuhashi, Hiromi Ishibashi, Michio Yasunami,
Background/Aims Recent studies demonstrated an association of STAT4 polymorphisms with autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, indicating multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 polymorphisms on the susceptibility and phenotype of type-1 autoimmune hepatitis in a Japanese National Hospital Organization (NHO) AIH multicenter cohort study. Methodology/Principal Findings Genomic DNA ...
Tópico(s): Liver Disease Diagnosis and Treatment
2013 - Public Library of Science | PLoS ONE
Minoru Nakamura, Hisayoshi Kondo, Tsuyoshi Mori, Atsumasa Komori, Mutsumi Matsuyama, Masahiro Ito, Yasushi Takii, Makiko Koyabu, Terufumi Yokoyama, Kiyoshi Migita, Manabu Daikoku, Seigo Abiru, Hiroshi Yatsuhashi, Eiichi Takezaki, Naohiko Masaki, Kazuhiro Sugi, Koichi Honda, Hiroshi Adachi, Hidehiro Nishi, Yukio Watanabe, Yoko Nakamura, Masaaki Shimada, Tatsuji Komatsu, Akira Saito, Takeo Saoshiro, Hideharu Harada, Takeshi Sodeyama, Shigeki Hayashi, Akihide Masumoto, Takehiro Sando, Tetsuo Yamamoto, Hironori Sakai, Masakazu Kobayashi, Toyokichi Muro, Michiaki Koga, Zakera Shums, Gary L. Norman, Hiromi Ishibashi,
The predictive role of antinuclear antibodies (ANAs) remains elusive in the long-term outcome of primary biliary cirrhosis (PBC). The progression of PBC was evaluated in association with ANAs using stepwise Cox proportional hazard regression and an unconditional stepwise logistic regression model based on the data of 276 biopsy-proven, definite PBC patients who have been registered to the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ). When death of hepatic failure/liver ...
Tópico(s): Systemic Lupus Erythematosus Research
2006 - Lippincott Williams & Wilkins | Hepatology
Minae Kawashima, Yuki Hitomi, Yoshihiro Aiba, Nao Nishida, Kaname Kojima, Yosuke Kawai, Hitomi Nakamura, Atsushi Tanaka, Mikio Zeniya, Etsuko Hashimoto, Hiromasa Ohira, Kazuhide Yamamoto, Masanori Abe, Kazuhiko Nakao, Satoshi Yamagiwa, Shuichi Kaneko, Masao Honda, Takeji Umemura, Takafumi Ichida, Masataka Seike, Shotaro Sakisaka, Masaru Harada, Osamu Yokosuka, Yoshiyuki Ueno, Michio Senju, Tatsuo Kanda, Hidetaka Shibata, Takashi Himoto, Kazumoto Murata, Yasuhiro Miyake, Hirotoshi Ebinuma, Makiko Taniai, Satoru Joshita, Toshiki Nikami, Hajime Ota, Hiroshi Kouno, Hirotaka Kouno, Makoto Nakamuta, Nobuyoshi Fukushima, Motoyuki Kohjima, Tatsuji Komatsu, Toshiki Komeda, Yukio Ohara, Toyokichi Muro, Tsutomu Yamashita, Kaname Yoshizawa, Yoko Nakamura, Masaaki Shimada, Noboru Hirashima, Kazuhiro Sugi, Keisuke Ario, Eiichi Takesaki, Atsushi Naganuma, Hiroshi Mano, Haruhiro Yamashita, Kouki Matsushita, Kazuhiko Yamauchi, Fujio Makita, Hideo Nishimura, Kiyoshi Furuta, Naohiro Takahashi, Masahiro Kikuchi, Naohiko Masaki, Tomohiro Tanaka, Sumito Tamura, Akira Mori, Shintaro Yagi, Ken Shirabe, Atsumasa Komori, Kiyoshi Migita, Masahiro Ito, Shinya Nagaoka, Seigo Abiru, Hiroshi Yatsuhashi, Michio Yasunami, Shinji Shimoda, Kenichi Harada, Hiroto Egawa, Yoshihiko Maehara, Shinji Üemoto, Norihiro Kokudo, Hajime Takikawa, Hiromi Ishibashi, Kazuaki Chayama, Masashi Mizokami, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura,
A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) and POU2AF1 (rs4938534) as strong susceptibility loci for PBC. In this study, we performed GWAS in additional 1,923 Japanese individuals (894 PBC cases and 1,029 healthy controls), and combined the results with the previous data. This GWAS, together with a subsequent replication study in an independent set of 7,024 Japanese ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2016 - Oxford University Press | Human Molecular Genetics
Li Zhang, Jian Yao, John Withers, Xiu‐Fang Xin, R. Banerjee, Qazi Fariduddin, Yoko Nakamura, Kinya Nomura, Gregg A. Howe, Wilhelm Boland, Honggao Yan, Sheng Yang He,
Significance Pathogen infections can cause significant crop losses worldwide and major disturbances in natural ecosystems. Understanding the molecular basis of plant disease susceptibility is important for the development of new strategies to prevent disease outbreaks. Recent studies have identified the plant jasmonate (JA) hormone receptor as one of the common targets of pathogen virulence factors. In this study, we modified the JA receptor and showed that transgenic Arabidopsis plants with the ...
Tópico(s): Plant and animal studies
2015 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Akihiro Ishii, Yoko Nakamura, Itaru Oikawa, Atsunori Kamegawa, Hitoshi Takamura,
Single-phase rutile-type TiO2 thin films with a high refractive index (n) and a low extinction coefficient (k) prepared on glass are expected to improve the performance of anti-reflection coatings. In this study, TiO2 thin films were prepared by the pulsed laser deposition (PLD) method at temperatures ranging from room temperature to 600 °C under an oxygen partial pressure of 1–9 Pa or a 10−5 Pa vacuum, and their crystal structure, microstructure and optical properties were investigated. A single-phase ...
Tópico(s): ZnO doping and properties
2015 - Elsevier BV | Applied Surface Science
Naomi Tsurikisawa, Chiyako Oshikata, Takahiro Tsuburai, Satoshi Sugano, Yoko Nakamura, Takuya Shimoda, Shunpei Tamama, Ken Adachi, Ayako Horita, Ikuo Saito, Hiroshi Saito,
Chronic eosinophilic pneumonia (CEP) or eosinophilic gastroenteritis (EG), or both, with asthma precede the onset of eosinophilic granulomatosis with polyangiitis (EGPA) in half of all EGPA patients. It is not known what determines whether patients with CEP or with EG following asthma will develop EGPA.We studied 17 EGPA patients and 12 patients with CEP but without EGPA. We assayed serum ICAM-1, VCAM-1, and VEGF, and the percentage of peripheral blood CD4(+) T cells producing IL-17 (Th17 cells), at ...
Tópico(s): Vasculitis and related conditions
2015 - BioMed Central | BMC Immunology
Yoshihiro Joshua Ono, Akiko Tanabe, Yoko Nakamura, Hikaru Yamamoto, Atsushi Hayashi, Tomohito Tanaka, Hiroshi Sasaki, Masami Hayashi, Yoshito Terai, Masahide Ohmichi,
Although endometriosis is suspected to be a cause of premature ovarian insufficiency (POI), the mechanism(s) underlying this process have not been elucidated. Recently, androgens were shown to promote oocyte maturation and to play a role in folliculogenesis. In addition, several reports have documented low testosterone levels in the follicular fluid obtained from endometriosis patients. We therefore examined whether the low levels of serum testosterone are associated with the apoptosis of granulosa ...
Tópico(s): Ovarian function and disorders
2014 - Public Library of Science | PLoS ONE
Tina Keller‐Costa, Peter C. Hubbard, Christian Paetz, Yoko Nakamura, José P. Da Silva, Ana Rato, Eduardo N. Barata, Bernd Schneider, Adelino V. M. Canário,
Knowledge of the chemical identity and role of urinary pheromones in fish is scarce, yet it is necessary in order to understand the integration of multiple senses in adaptive responses and the evolution of chemical communication [1Stacey N. Hormonally derived sex pheromones in fishes.in: Norris D.O. Lopez K.H. Hormones and Reproduction of Vertebrates. Academic Press, London2011: 169-192Google Scholar]. In nature, Mozambique tilapia (Oreochromis mossambicus) males form hierarchies, and females mate ...
Tópico(s): Insect Pheromone Research and Control
2014 - Elsevier BV | Current Biology
Yoko Nakamura, Mohamud Daya, Eileen M. Bulger, Martin Schreiber, Robert C. Mackersie, Renee Y. Hsia, N. Clay Mann, James F. Holmes, Kristan Staudenmayer, Zachary Sturges, Michael M. Liao, Jason S. Haukoos, Nathan Kuppermann, Erik D. Barton, Craig D. Newgard,
Study objective We evaluate trauma undertriage by age group, the association between age and serious injury after accounting for other field triage criteria and confounders, and the potential effect of a mandatory age triage criterion for field triage. Methods This was a retrospective cohort study of injured children and adults transported by 48 emergency medical services (EMS) agencies to 105 hospitals in 6 regions of the western United States from 2006 through 2008. We used probabilistic linkage to ...
Tópico(s): Injury Epidemiology and Prevention
2012 - Elsevier BV | Annals of Emergency Medicine
Minoru Nakamura, Nao Nishida, Minae Kawashima, Yoshihiro Aiba, Atsushi Tanaka, Michio Yasunami, Hitomi Nakamura, Atsumasai Komori, Makoto Nakamuta, Mikio Zeniya, Etsuko Hashimoto, Hiromasa Ohira, Kazuhide Yamamoto, Morikazu Onji, Shuichi Kaneko, Masao Honda, Satoshi Yamagiwa, Kazuhiko Nakao, Takafumi Ichida, Hajime Takikawa, Masataka Seike, Takeji Umemura, Yoshiyuki Ueno, Shotaro Sakisaka, Kentaro Kikuchi, Hirotoshi Ebinuma, Noriyo Yamashiki, Sumito Tamura, Yasuhiko Sugawara, Akira Mori, Shintaro Yagi, Ken Shirabe, Akinobu Taketomi, Kuniaki Arai, Kyoko Monoe, Tatsuki Ichikawa, Makiko Taniai, Yasuhiro Miyake, Teru Kumagi, Masanori Abe, Kaname Yoshizawa, Satoru Joshita, Shinji Shimoda, Koichi Honda, Hiroki Takahashi, Katsuji Hirano, Yasuaki Takeyama, Kenichi Harada, Kiyoshi Migita, Masahiro Ito, Hiroshi Yatsuhashi, Nobuyoshi Fukushima, Hajime Ota, Tatsuji Komatsu, Takeo Saoshiro, Jinya Ishida, Hirotsugu Kouno, Hirotaka Kouno, Michiyasu Yagura, Masakazu Kobayashi, Toyokichi Muro, Naohiko Masaki, Keiichi Hirata, Yukio Watanabe, Yoko Nakamura, Masaaki Shimada, Noboru Hirashima, Toshiki Komeda, Kazuhiro Sugi, Michiaki Koga, Keisuke Ario, Eiichi Takesaki, Yoshihiko Maehara, Shinji Üemoto, Norihiro Kokudo, Hirohito Tsubouchi, Masashi Mizokami, Yasuni Nakanuma, Katsushi Tokunaga, Hiromi Ishibashi,
For the identification of susceptibility loci for primary biliary cirrhosis (PBC), a genome-wide association study (GWAS) was performed in 963 Japanese individuals (487 PBC cases and 476 healthy controls) and in a subsequent replication study that included 1,402 other Japanese individuals (787 cases and 615 controls). In addition to the most significant susceptibility region, human leukocyte antigen (HLA), we identified two significant susceptibility loci, TNFSF15 (rs4979462) and POU2AF1 (rs4938534) (combined ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2012 - Elsevier BV | The American Journal of Human Genetics
Norikazu Kanda, Naoki Morimoto, Artem A. Ayvazyan, Satoru Takemoto, Katsuya Kawai, Yoko Nakamura, Yuki Sakamoto, Tsuguyoshi Taira, Shigehiko Suzuki,
The objective of this study was to evaluate the ability of a scaffold, collagen–gelatin sponge (CGS), to release basic fibroblast growth factor (bFGF) in a sustained manner, using a pressure-induced decubitus ulcer model involving genetically diabetic mice. We confirmed that CGSs impregnated with a bFGF concentration of up to 50 µg/cm2 were able to sustain the release of bFGF throughout their biodegradation. We prepared decubitus ulcers on diabetic mice. After debriding the ulcers, we implanted CGSs ( ...
Tópico(s): Tendon Structure and Treatment
2012 - Wiley | Journal of Tissue Engineering and Regenerative Medicine
Naoki Morimoto, Tatsuya Ito, Satoru Takemoto, Mikiko Katakami, Norikazu Kanda, Harue Tada, Shiro Tanaka, Satoshi Teramukai, Katsuya Kawai, Yoko Nakamura, Yasunari Kasai, Masayuki Yokode, Taira Maekawa, Akira Shimizu, Shigehiko Suzuki,
Cultured dermal substitutes have been used for the treatment of chronic skin ulcers; however, the biological risks of animal‐derived materials in the culture process such as foetal bovine serum (FBS) have been reported. In this study, we prepared an autologous fibroblast‐seeded artificial dermis (AFD) using animal‐product‐free medium supplemented with 2% patient autologous serum and without any animal‐derived materials such as trypsin in the culturing process. We applied the AFD in five patients with ...
Tópico(s): Pressure Ulcer Prevention and Management
2012 - Wiley | International Wound Journal
Hidefumi Ishikawa, Yoko Nakamura, Jun‐ichiro Jo, Yasuhiko Tabata,
The objective of this study is to develop a sustained release system of small interfering RNA (siRNA) inside cells aiming at a prolonged time period of gene suppression. Gelatin aqueous solution containing luciferase siRNA was coacelvated by acetone addition, followed by the glutaraldehyde (GA) crosslinking of gelatin to prepare gelatin nanospheres incorporating siRNA. The nanospheres were degraded with time in phosphate-buffered saline solution containing collagenase to release siRNA incorporated. ...
Tópico(s): Nanoparticle-Based Drug Delivery
2012 - Elsevier BV | Biomaterials
Yoko Nakamura, Axel Mithöfer, Erich Kombrink, Wilhelm Boland, Shin Hamamoto, Nobuyuki Uozumi, Kentaro Tohma, Minoru Ueda,
Abstract Jasmonates are ubiquitously occurring plant growth regulators with high structural diversity that mediate numerous developmental processes and stress responses. We have recently identified 12-O-β-d-glucopyranosyljasmonic acid as the bioactive metabolite, leaf-closing factor (LCF), which induced nyctinastic leaf closure of Samanea saman. We demonstrate that leaf closure of isolated Samanea pinnae is induced upon stereospecific recognition of (−)-LCF, but not by its enantiomer, (+)-ent-LCF, and that ...
Tópico(s): Plant and Biological Electrophysiology Studies
2011 - Oxford University Press | PLANT PHYSIOLOGY
Yoko Nakamura, Kazuhiko Tagawa, Tsutomu Oka, Toshikazu Sasabe, Hikaru Ito, Hiroki Shiwaku, Albert R. La Spada, Hitoshi Okazawa,
The spinocerebellar ataxia type 7 (SCA7) gene product, Ataxin-7 (ATXN7), localizes to the nucleus and has been shown to function as a component of the TATA-binding protein-free TAF-containing-SPT3-TAF9-GCN5-acetyltransferase transcription complex, although cytoplasmic localization of ATXN7 in affected neurons of human SCA7 patients has also been detected. Here, we define a physiological function for cytoplasmic ATXN7. Live imaging reveals that the intracellular distribution of ATXN7 dynamically changes ...
Tópico(s): Mitochondrial Function and Pathology
2011 - Oxford University Press | Human Molecular Genetics
Kiyoshi Migita, Yukio Watanabe, Yuka Jiuchi, Yoko Nakamura, Akira Saito, Michiyasu Yagura, Hajime Ohta, Masaaki Shimada, Eiji Mita, Taizo Hijioka, Haruhiro Yamashita, Eiichi Takezaki, Toyokichi Muro, Hironori Sakai, Makoto Nakamuta, Seigo Abiru, Atsumasa Komori, Masahiro Ito, Hiroshi Yatsuhashi, Minoru Nakamura, Hiromi Ishibashi,
Although the outcome of autoimmune hepatitis (AIH) is generally good, the natural course and likelihood of progression to cirrhosis or hepatocellular carcinoma (HCC) remain undefined, and may vary by region and population structure. Our aims were to evaluate risk factors that contribute to poor outcome and particularly development of HCC in a prospective multicentric cohort study of AIH.The study group comprised 193 Japanese patients with AIH who were prospectively followed up at annual intervals ...
Tópico(s): Liver Disease and Transplantation
2011 - Wiley | Liver International
Hirokazu Hara, Yoko Nakamura, Masayuki Ninomiya, Ryosuke Mochizuki, Tetsuro Kamiya, Elias Aizenman, Mamoru Koketsu, Tetsuo Adachi,
Activation of microglia induces the production of various inflammatory mediators including nitric oxide (NO), leading to neurodegeneration in many central nervous system diseases. In this study, we examined the effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' on lipopolysaccharide (LPS)-induced NO production using rat immortalized microglia HAPI cells. 4′-O-β-d-Glucopyranosyl-3′,4-dimethoxychalcone (A2) inhibited LPS-induced inducible NO synthase (iNOS) expression and NO production. ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2011 - Elsevier BV | Bioorganic & Medicinal Chemistry
Yoko Nakamura, Sho Inomata, Makoto Ebine, Yoshiyuki Manabe, Izumi Iwakura, Minoru Ueda,
We report on the design, synthesis and assessment of a novel biaryl-linked (BArL) molecular probe for the exploration of low-abundant target proteins for bioactive compounds based on the activity based protein profiling (ABPP) approach. Surprisingly, the performance of the BArL probe was better than that of the stepwise tagging approach that is considered to be the most effective method used in ABPP study.
Tópico(s): Protein Degradation and Inhibitors
2010 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
Kiyoshi Migita, Yukio Watanabe, Yuka Jiuchi, Yoko Nakamura, Akira Saito, Michiyasu Yagura, Hideo Morimoto, Masaaki Shimada, Eiji Mita, Taizo Hijioka, Haruhiro Yamashita, Eiichi Takezaki, Toyokichi Muro, Hironori Sakai, Makoto Nakamuta, Seigo Abiru, Koji Yano, Atsumasa Komori, Hiroshi Yatsuhashi, Minoru Nakamura, Hiromi Ishibashi,
Tópico(s): Liver Disease and Transplantation
2010 - Springer Science+Business Media | Journal of Gastroenterology
Dineshkumar Kandasamy, Rashaduz Zaman, Yoko Nakamura, Tao Zhao, Henrik Hartmann, Martin N. Andersson, Almuth Hammerbacher, Jonathan Gershenzon,
Outbreaks of the Eurasian spruce bark beetle ( Ips typographus ) have decimated millions of hectares of conifer forests in Europe in recent years. The ability of these 4.0 to 5.5 mm long insects to kill mature trees over a short period has been sometimes ascribed to two main factors: (1) mass attacks on the host tree to overcome tree defenses and (2) the presence of fungal symbionts that support successful beetle development in the tree. While the role of pheromones in coordinating mass attacks has been ...
Tópico(s): Insect-Plant Interactions and Control
2023 - Public Library of Science | PLoS Biology
Samuel A. Bradley, Beata Joanna Lehka, Frederik G. Hansson, Khem B. Adhikari, Daniela Rago, Paulina Rubaszka, Ahmad K. Haidar, Ling Chen, Lea G. Hansen, Olga Gudich, Konstantina Giannakou, Bettina Lengger, Ryan T. Gill, Yoko Nakamura, Thomas Dugé de Bernonville, Κωνσταντίνος Κουδούνας, David Romero-Suárez, Ling Ding, Yi‐Jun Qiao, Thomas M. Frimurer, Anja A. Petersen, Sébastien Besseau, Sandeep Kumar, Nicolas Gautron, C. Mélin, Jillian Marc, Remi Jeanneau, Sarah E. O’Connor, Vincent Courdavault, Jay D. Keasling, Jie Zhang, Michael K. Jensen,
Abstract Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with marketed pharmaceutical activities against a wide range of indications, including cancer, malaria and hypertension. Halogenated MIAs have shown improved pharmaceutical properties; however, synthesis of new-to-nature halogenated MIAs remains a challenge. Here we demonstrate a platform for de novo biosynthesis of two MIAs, serpentine and alstonine, in baker’s yeast Saccharomyces cerevisiae and deploy ...
Tópico(s): Phytochemical Studies and Bioactivities
2023 - Nature Portfolio | Nature Chemical Biology
Harley O. W. Gordon, Christin Fellenberg, Nathalie D. Lackus, Finn Archinuk, Amanda Sproule, Yoko Nakamura, Tobias G K�llner, Jonathan Gershenzon, David P. Overy, C. Peter Constabel,
Salicinoids are salicyl alcohol-containing phenolic glycosides with strong antiherbivore effects found only in poplars and willows. Their biosynthesis is poorly understood, but recently a UDP-dependent glycosyltransferase, UGT71L1, was shown to be required for salicinoid biosynthesis in poplar tissue cultures. UGT71L1 specifically glycosylates salicyl benzoate, a proposed salicinoid intermediate. Here, we analyzed transgenic CRISPR/Cas9-generated UGT71L1 knockout plants. Metabolomic analyses revealed ...
Tópico(s): CRISPR and Genetic Engineering
2022 - Oxford University Press | The Plant Cell