Young Chul Yoo, Jae‐Kwang Shim, Jon-Chan Kim, Youn Yi Jo, Jong‐Hoon Lee, Young Lan Kwak,
Yoo, Young-Chul*; Shim, Jae-Kwang*; Kim, Jon-Chan*; Jo, Youn-Yi*; Lee, Jong-Hoon*; Kwak, Young-Lan*† Author ...
Tópico(s): Cardiac and Coronary Surgery Techniques
2012 - Lippincott Williams & Wilkins | Survey of Anesthesiology
Sun Mi Kim, Hye Ri Kim, Kyoung Joon Min, Seo-Koo Yoo, Young-Chul Shin, Eun Jin Kim, Sang Won Jeon,
This study aimed to investigate resilience as a protective factor for suicidality among Korean workers.Participants were workers from 26 organizations in Korea, aged 18 to 63 years, who completed a self-reported questionnaire comprising items on sociodemographic factors, job stress, resilience, and suicidality. Completed questionnaires were collected from 4,405 persons, with 4,389 valid responses. Hierarchical logistic regression analyses were performed using suicidality as the dependent variable. ...
Tópico(s): Suicide and Self-Harm Studies
2020 - Korean Neuropsychiatric Association | Psychiatry Investigation
Ik‐Bu Sohn, Hun-Kook Choi, Dongyoon Yoo, Young-Chul Noh, Jiwhan Noh, Md. Shamim Ahsan,
This article demonstrates three-dimensional (3D) hologram printing in polymethyl methacrylate (PMMA) and linthum niobate (LiNbO3) samples by means of single beam femtosecond laser direct writing technique. We have printed double-layer 3D hologram, having a background and foreground layer, inside PMMA substrate. Triple-layer 3D hologram, comprising a background, middle, and foreground layer, has been fabricated inside LiNbO3 sample. In both cases, each layer is superimposed over the bottom layers of ...
Tópico(s): Laser Material Processing Techniques
2017 - Elsevier BV | Applied Surface Science
Hyung Jun Park, Jee Eun Lee, Gyeong Seon Choi, Heasoo Koo, Soo Jeong Han, Jeong Hyun Yoo, Young‐Chul Choi, Kee Duk Park,
Tópico(s): Protein Tyrosine Phosphatases
2017 - | Journal of Clinical Neurology
Da Hye Yoo, Young‐Chul Choi, Da Eun Nam, Sun Seong Choi, Ji Won Kim, Byung‐Ok Choi, Ki Wha Chung,
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a condition that affects many parts of the body, particularly the brain and muscles. This study examined a Korean MELAS-like syndrome patient with seizure, stroke-like episode, and optic atrophy. Target sequencing of whole mtDNA and 73 nuclear genes identified compound heterozygous mutations p.R205X and p.L255P in the FASTKD2. Each of his unaffected parents has one of the two mutations, and both mutations ...
Tópico(s): Ubiquitin and proteasome pathways
2017 - Elsevier BV | Mitochondrion
Mina Lee, Chang-Hyun Park, H. K. Chung, Hyeon Jin Kim, Yunseo Choi, Jeong Hyun Yoo, Young Chul Yoon, Young Bin Hong, Ki Wha Chung, Byung‐Ok Choi, Hyang Woon Lee,
Here, we report the structural evidence of cerebral white matter abnormalities in Charcot‐Marie‐Tooth (CMT) patients and the relationship between these abnormalities and clinical disability. Brain diffusion tensor imaging (DTI) was performed in CMT patients with demyelinating (CMT1A/CMT1E), axonal (CMT2A/CMT2E), or intermediate (CMTX1/DI‐CMT) peripheral neuropathy. Although all patients had normal brain magnetic resonance imaging, all genetic subgroups except CMT1A had abnormal DTI findings indicative ...
Tópico(s): Genetic Neurodegenerative Diseases
2016 - Wiley | Annals of Neurology
Sun Woo Hong, Seong Min Hong, Jae Wook Yoo, Young Chul Lee, Soyoun Kim, John T. Lis, Dong-ki Lee,
Ser-5 phosphorylation of the RNA polymerase II (Pol II) C-terminal domain by TFIIH kinase has been implicated in critical steps in mRNA synthesis, such as Pol II promoter escape and mRNA 5'-capping. However, the general requirement and precise role of TFIIH kinase in Pol II transcription still remain elusive. Here we use a chemical genetics approach to show that, for a majority of budding-yeast genes, specific inhibition of the yeast TFIIH kinase results in a dramatic reduction in both mRNA level ...
Tópico(s): RNA and protein synthesis mechanisms
2009 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Ju Dong Song, Sang Kwon Lee, Kang Mi Kim, Jong‐Won Kim, Jong Min Kim, Young Hyun Yoo, Young Chul Park,
Redox-sensitive transcriptional regulator redox factor-1 (Ref-1) is induced by oxidative stress and protects cells against it. However, the function of Ref-1 in regulating nitric oxide (NO) synthesis in macrophages has not been defined. We investigated the role of Ref-1 related to the regulation of NO synthesis in lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells. LPS stimulates the up-regulation and nuclear translocation of Ref-1 in macrophages. Importantly, Ref-1-deficient macrophages ...
Tópico(s): Redox biology and oxidative stress
2007 - Wiley | Immunology
Do Young Kim, Jin‐Yong Chung, Seung Gee Lee, Yoon Jae Kim, Ji-Eun Park, Ki Soo Yoo, Young Hyun Yoo, Young Chul Park, Byeong Gee Kim, Jong‐Min Kim,
Tópico(s): Autophagy in Disease and Therapy
2006 - Elsevier BV | Biochemical and Biophysical Research Communications
Sang-Eun Park, Ju Dong Song, Kang Mi Kim, Yeong Min Park, Nam Deuk Kim, Young Hyun Yoo, Young Chul Park,
The diphenyleneiodonium (DPI) is widely used as an inhibitor of flavoenzymes, particularly NADPH oxidase. In this study, we investigated the effect of DPI on the apoptosis of human RPE cells. DPI treatment in ARPE‐19 cells evoked a dose‐ and time‐dependent growth inhibition, and also induced DNA fragmentation and protein content of the proapoptotic factor Bax. In addition, DPI significantly induced the expression and phosphorylation of p53, which induces proapoptotic genes in response to DNA damage ...
Tópico(s): Cancer Research and Treatments
2006 - Wiley | FEBS Letters
Ki-Hyun Park, Han-Jae Shin, Young-Bum Song, H. H. Hyun, Hyun‐Jeong Cho, Hye-Seon Ham, Young-Bin Yoo, Young-Chul Ko, Woong-Tak Jun, Hwa-Jin Park,
We have studied the effects of ginsenoside Rb1 (GRb1) on the change in lipid contents in rat liver. When GRb1 was administered intraperitoneally to rats, liver microsomal cytochrome P-450 content and NADPH-cytochrome P-450 reductase activity were lower than those in control rats. The contents of triglyceride (TG) and cholesterol were decreased, but those of total phospholipid, phosphatidylcholine, and phosphatidylethanolamine were increased in the GRb1-treated group compared with controls. These results ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2002 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Hyun Jeong Kwak, Chang-Duk Jun, Hyun-Ock Pae, Ji-Chang Yoo, Young-Chul Park, Byung Min Choi, Yong Gil Na, Raekil Park, Hun-Taeg Chung, Hee Yong Chung, Woong‐Yang Park, Jeong‐Sun Seo,
Several studies have suggested a role for heat shock proteins (hsps) during development and differentiation. However, relatively little is known about the role of hsp70 in controlling human hematopoietic cell differentiation and death. Here, we show that constitutive expression of human inducible 70-kDa heat shock protein (hsp70) promotes differentiation of HL-60 cells and prevents apoptosis that occurred after terminal differentiation or directly by apoptotic agents. After treatment with phorbol ...
Tópico(s): Bee Products Chemical Analysis
1998 - Elsevier BV | Cellular Immunology
Ik‐Bu Sohn, Dongyoon Yoo, Young-Chul Noh, Jae-Hee Sung, Seong-Ku Lee, Hun-Kook Choi, Md. Shamim Ahsan,
We report on fabricating high-fill-factor plano-convex spherical and square micro-lens arrays on fused silica glass surface using CO2 laser assisted reshaping technique. Initially, periodic micro-pillars have been encoded on the glass surface by means of a femtosecond laser beam. Afterwards, the micro-pillars are polished several times by irradiating a CO2 laser beam on top of the micro-pillars. Consequently, spherical micro-lens array with micro-lens size of 50 um x 50 um and square micro-lens ...
Tópico(s): Laser Material Processing Techniques
2016 - Springer Science+Business Media | Journal of the Korean Physical Society
Jin Sun Cho, Ki Eun Seon, Min-Yu Kim, Sang Wun Kim, Young Chul Yoo,
Dexmedetomidine has sympatholytic, anti-inflammatory, and analgesic effects and may exert anti-tumor effect by acting on α2A adrenoreceptor. We investigated whether perioperative dexmedetomidine preserves immune function in patients undergoing uterine cancer surgery.One hundred patients were randomly assigned to the control or dexmedetomidine groups (50 patients each). Dexmedetomidine was infused at rates of 0.4 μg/kg/h intraoperatively and 0.15 μg/kg/h during the first 24 h postoperatively. The ...
Tópico(s): Anesthesia and Pain Management
2021 - Frontiers Media | Frontiers in Oncology
Myoung Hwa Kim, Dong Wook Kim, Seho Park, Joo Heung Kim, Ki‐Young Lee, Jisung Hwang, Young Chul Yoo,
Dexamethasone is widely used in cancer patients despite the concern that perioperative glucocorticoids may potentially cause immunosuppression. However, studies on the influence of dexamethasone on cancer recurrence after curative surgery have produced conflicting results. The goal of our study was to compare postoperative recurrence-free survival and overall survival between patients with breast cancer who received perioperative dexamethasone and those who did not. The medical records of 2729 patients ...
Tópico(s): Estrogen and related hormone effects
2019 - BioMed Central | BMC Cancer
Myoung Hwa Kim, Ju Eun Oh, Seho Park, Joo H. Kim, Ki‐Young Lee, Sun Joon Bai, Hyunjik Song, Hye Jeong Hwang, Dong Wook Kim, Young Chul Yoo,
There is growing interest in the effect of postoperative analgesics on oncological outcomes after cancer surgery. We investigated the impact of tramadol after breast cancer surgery on recurrence and mortality and explored the mechanism by which tramadol affects cultured breast cancer cells in vitro.Electronic medical records of patients who underwent breast cancer surgery between November 2005 and December 2010 at Severance Hospital in Korea were reviewed. Cox regression analyses were used to identify ...
Tópico(s): Inflammatory mediators and NSAID effects
2019 - Elsevier BV | British Journal of Anaesthesia
Jin Sun Cho, Hyoung‐Il Kim, Ki‐Young Lee, Taeil Son, Sun Joon Bai, Haegi Choi, Young Chul Yoo,
Tópico(s): Nausea and vomiting management
2017 - Springer Science+Business Media | Surgical Endoscopy
Myoung Hwa Kim, Ki‐Young Lee, Seho Park, Seung Il Kim, Hyung Seok Park, Young Chul Yoo,
Introduction We aimed to compare the effects of intraoperative lidocaine and magnesium on postoperative functional recovery and chronic pain after mastectomy due to breast cancer. Systemic lidocaine and magnesium reduce pain hypersensitivity to surgical stimuli; however, their effects after mastectomy have not been evaluated clearly. Methods In this prospective, double-blind, clinical trial, 126 female patients undergoing mastectomy were randomly assigned to lidocaine (L), magnesium (M), and control ( ...
Tópico(s): Nausea and vomiting management
2017 - Public Library of Science | PLoS ONE
Myoung Hwa Kim, Dong Wook Kim, Joo Heung Kim, Ki‐Young Lee, Seho Park, Young Chul Yoo,
Although previous studies have suggested that propofol inhibits cancer recurrence and metastasis, the association between anesthetic agents and the recurrence of breast cancer has not been clearly investigated. We compared total intravenous anesthesia and balanced anesthesia with volatile agents to investigate the differences in their effects on recurrence-free survival and overall survival after breast cancer surgery.The electronic medical records of 2,729 patients who underwent breast cancer surgery ...
Tópico(s): Anesthesia and Neurotoxicity Research
2017 - Impact Journals LLC | Oncotarget
Hyun Joo Kim, Ki‐Young Lee, Sun Joon Bai, Myoung Hwa Kim, Ein Oh, Young Chul Yoo,
The influence of different head and neck positions on the effectiveness of ventilation with the air-Q® self-pressurizing airway remains unevaluated. This study aimed to evaluate the influence of different head and neck positions on ventilation with the air-Q® SP airway.In this prospective, randomized crossover study, we enrolled 51 female patients who were to undergo elective gynaecological or breast surgery under general anaesthesia. An air-Q® SP airway was placed in all patients, and mechanical ...
Tópico(s): Head and Neck Surgical Oncology
2016 - Elsevier BV | British Journal of Anaesthesia
Seokyung Shin, Chan Hyuk Park, Hyun Ju Kim, Sang Hun Park, Sang Kil Lee, Young Chul Yoo,
Tópico(s): Nausea and vomiting management
2016 - Springer Science+Business Media | Surgical Endoscopy
Myoung Hwa Kim, Ki‐Young Lee, Kang-Young Lee, Byung‐Soh Min, Young Chul Yoo,
Carbon dioxide (CO2) absorption and increased intra-abdominal pressure can adversely affect perioperative physiology and postoperative recovery. Deep muscle relaxation is known to improve the surgical conditions during laparoscopic surgery. We aimed to compare the effects of deep and moderate neuromuscular block in laparoscopic colorectal surgery, including intra-abdominal pressure. In this prospective, double-blind, parallel-group trial, 72 adult patients undergoing laparoscopic colorectal surgery ...
Tópico(s): Anesthesia and Pain Management
2016 - Wolters Kluwer | Medicine
Hyun Kang, Duk Kyung Kim, Yong Seon Choi, Young Chul Yoo, Hyun Sik Chung,
In South Korea, as in many other countries, propofol sedation is performed by practitioners across a broad range of specialties in our country. However, this has led to significant variation in propofol sedation practices, as shown in a series of reports by the Korean Society of Anesthesiologists (KSA). This has led the KSA to develop a set of evidence-based practical guidelines for propofol sedation by non-anesthesiologists. Here, we provide a set of recommendations for propofol sedation, with the ...
Tópico(s): Anesthesia and Neurotoxicity Research
2016 - Korean Society of Anesthesiologists | Korean journal of anesthesiology
Young Song, Dong Wook Kim, Young Lan Kwak, Beom Seok Kim, Hyung Min Joo, Jin Woo Ju, Young Chul Yoo,
Urine output is closely associated with renal function and has been used as a diagnostic criterion for acute kidney injury (AKI). However, urine output during cardiopulmonary bypass (CPB) has never been identified as a predictor of postoperative AKI. Considering altered renal homeostasis during CPB, we made a comprehensible approach to CPB urine output and evaluated its predictability for AKI. Patients undergoing cardiovascular surgery with the use of CPB, between January 2009 and December 2011, were ...
Tópico(s): Chronic Kidney Disease and Diabetes
2016 - Wolters Kluwer | Medicine
Chan Hyuk Park, Seokyung Shin, Sang Kil Lee, Hyuk Lee, Yong Chan Lee, Jun Chul Park, Young Chul Yoo,
Background Although endoscopic submucosal dissection (ESD) is routinely performed under sedation, the difference in ESD performance according to sedation method is not well known. This study attempted to prospectively assess and compare the satisfaction of the endoscopists and patient stability during ESD between two sedation methods. Methods One hundred and fifty-four adult patients scheduled for ESD were sedated by either the IMIE (intermittent midazolam/propofol injection by endoscopist) or CPIA ( ...
Tópico(s): Gastroesophageal reflux and treatments
2015 - Public Library of Science | PLoS ONE
Jin Sun Cho, Hyoung‐Il Kim, Ki‐Young Lee, Ji Yeong An, Sun Joon Bai, Ju Yeon Cho, Young Chul Yoo,
Sympathetic hyperactivation is one of the causes of postoperative ileus, which occurs frequently after abdominal surgery and adversely influences the patient's prognosis. We aimed to investigate whether dexmedetomidine (DEX) could attenuate postoperative ileus in patients undergoing laparoscopic gastrectomy. Ninety-two patients were randomized to the control (n = 46) or DEX group (n = 46). DEX was administered at a loading dose of 0.5 μg/kg for 10 minutes, followed by an infusion rate of 0.4 μg/kg/h from ...
Tópico(s): Anesthesia and Sedative Agents
2015 - Wolters Kluwer | Medicine
Young Chul Yoo, Na Young Kim, Seokyung Shin, Young Deuk Choi, Jung Hwa Hong, Chan Yun Kim, HeeJoon Park, Sun Joon Bai,
This study aimed to determine whether continuous deep neuromuscular blockade (NMB) improves the surgical conditions and facilitates robotic-assisted laparoscopic radical prostatectomy (RALRP) under low intra-abdominal pressure (IAP) to attenuate the increase in intraocular pressure (IOP) during CO2 pneumoperitoneum in the steep Trendelenburg (ST) position.Sixty-seven patients undergoing RALRP were randomly assigned to a moderate NMB group (Group M), including patients who received atracurium infusion ...
Tópico(s): Anesthesia and Sedative Agents
2015 - Public Library of Science | PLoS ONE
Chang Kyun Lee, Seok Ho Dong, Eun Sun Kim, Sung‐Hoon Moon, Hong Jun Park, Dong‐Hoon Yang, Young Chul Yoo, Tae Hoon Lee, Sang Kil Lee, Jong Jin Hyun,
This study sought to characterize the current sedation practices of Korean endoscopists in real-world settings.All active members of the Korean Society of Gastrointestinal Endoscopy were invited to complete an anonymous 35-item questionnaire.The overall response rate was 22.7% (1,332/5,860). Propofol-based sedation was the dominant method used in both elective esophagogastroduodenoscopy (55.6%) and colonoscopy (52.6%). The mean satisfaction score for propofol-based sedation was significantly higher ...
Tópico(s): Enhanced Recovery After Surgery
2015 - Korean Association for the Study of the Liver | Gut and Liver
Young Chul Yoo, C. H. Park, Seokyung Shin, Yehyun Park, Sang Kil Lee, K. T. Min,
BackgroundModerate to deep sedation has been recommended during endoscopic submucosal dissection (ESD). However, it is often accompanied by adverse events such as respiratory depression or aspiration pneumonia. This study investigated the respiratory complications and ESD outcomes of two sedation protocols: moderate sedation with analgesic supplementation (MSAS) and analgesia targeted light sedation (ATLS).MethodsThe clinical data of 293 patients who underwent ESD between May and December 2012 were ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2015 - Elsevier BV | British Journal of Anaesthesia
Seokyung Shin, Tak Geun Oh, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Jae Bok Chung, Si Young Song, Jooyoun Cho, Sang-Hun Park, Young Chul Yoo, Seungmin Bang,
Background The importance of providing effective analgesia during sedation for complex endoscopic procedures has been widely recognized. However, repeated administration of opioids in order to achieve sufficient analgesia may carry the risk of delayed recovery after propofol based sedation. This study was done to compare recovery profiles and the satisfaction of the endoscopists and patients between conventional balanced propofol sedation and analgesia-oriented combination sedation for patients ...
Tópico(s): Anesthesia and Pain Management
2015 - Public Library of Science | PLoS ONE