Jiyeon Park, Joo Hee Choi, Sang‐Nam Lee, Hyung‐Ju Cho, Ji-Suk Ahn, Yong-Bum Kim, Do-Yong Park, Sang Chul Park, Soo In Kim, Min‐Jung Kang, Ah-Ra Jang, Jae-Hun Ahn, Tae-Sung Lee, Dong‐Yeon Kim, Sung Jae Shin, Joo‐Heon Yoon, Jong‐Hwan Park,
Arginine methylation is a posttranslational modification mediated by protein arginine methyltransferases (PRMTs). Although previous studies have shown that PRMT1 contributes to the severity of allergic airway inflammation or asthma, the underlying mechanism is poorly understood.
Tópico(s): Epigenetics and DNA Methylation
2021 - Elsevier BV | Journal of Allergy and Clinical Immunology
Dukyong Yoon, Jong-Hwan Jang, Byungjin Choi, Tae Young Kim, Changho Han,
Biosignals such as electrocardiogram or photoplethysmogram are widely used for determining and monitoring the medical condition of patients. It was recently discovered that more information could be gathered from biosignals by applying artificial intelligence (AI). At present, one of the most impactful advancements in AI is deep learning. Deep learning-based models can extract important features from raw data without feature engineering by humans, provided the amount of data is sufficient. This AI- ...
Tópico(s): EEG and Brain-Computer Interfaces
2020 - Korean Society of Anesthesiologists | Korean journal of anesthesiology
Sang Hyun Park, Chi Song, Yun Bae Kim, Young Sun Kim, Hwang Rae Chun, Jung Hyun Lee, Won Jong Seol, Hyung Sun Yoon, Myung Kwon Lee, Jong Hyup Lee, Choon Sang Bhang, Jae Hyung Park, Ji Young Park, Byung Hun, Young Dae Park, Sang Jeong Yoon, Chan Wook Park, Su Mi Yoon, Jong Hwan Choi, Ki Chul Shin, Dong Hoon Ko, Young Jin Kim, Dong Choon Seol,
Background/Aims The purpose of this study was to evaluate the clinicopathologic characteristics of colon cancers detected at the SOK Sokpeynhan Internal Medical Network, a nationwide system of primary health care institutions. Methods We analyzed 579 colon cancer patients diagnosed using colonoscopy at the SOK network from January 2011 through December 2012. Cancers from the rectum to the splenic flexure were classified as left colon cancer. Patients over 65 were classified as senior. Results The ...
Tópico(s): Genetic factors in colorectal cancer
2014 - Korean Association for the Study of Intestinal Diseases | Intestinal Research
Se-Ra Park, Dong‐Jae Kim, Seung Hyun Han, Min‐Jung Kang, Juneyoung Lee, Yu‐Jin Jeong, Sang-Jin Lee, Tae‐Hyoun Kim, Sang‐Gun Ahn, Jung‐Hoon Yoon, Jong‐Hwan Park,
Toll-like receptors (TLRs) orchestrate a repertoire of immune responses in macrophages against various pathogens. Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans are two important periodontal pathogens. In the present study, we investigated TLR signaling regulating cytokine production of macrophages in response to F. nucleatum and A. actinomycetemcomitans. TLR2 and TLR4 are redundant in the production of cytokines (interleukin-6 [IL-6] and tumor necrosis factor alpha [TNF-α]) in F. ...
Tópico(s): Immune cells in cancer
2014 - American Society for Microbiology | Infection and Immunity
Jeong Seon Yoon, Jong‐Hwan Lee, David Tweedie, Mohamed R. Mughal, Srinivasulu Chigurupati, Nigel H. Greig, Mark P. Mattson,
Tumor necrosis factor-α (TNF) plays a prominent role in the brain damage and functional deficits that result from ischemic stroke. It was recently reported that the thalidomide analog 3,6'-dithiothalidomide (3,6'-DT) can selectively inhibit the synthesis of TNF in cultured cells. We therefore tested the therapeutic potential of 3,6'-DT in a mouse model of focal ischemic stroke. Administration of 3,6'-DT immediately prior to a stroke or within 3 hr after the stroke reduced infarct volume, neuronal ...
Tópico(s): interferon and immune responses
2013 - Wiley | Journal of Neuroscience Research
Jeong Seon Yoon, Jong‐Hwan Lee, Tae Gen Son, Mohamed R. Mughal, Nigel H. Greig, Mark P. Mattson,
Pregabalin, a Ca2+ channel α2δ-subunit antagonist with analgesic and antiepileptic activity, reduced neuronal loss and improved functional outcome in a mouse model of focal ischemic stroke. Pregabalin administration (5–10 mg/kg, i.p.) 30–90 min after transient middle cerebral artery occlusion/reperfusion reduced infarct volume, neuronal death in the ischemic penumbra and neurological deficits at 24 h post-stroke. Pregabalin significantly decreased the amount of Ca2+/calpain-mediated α-spectrin proteolysis ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2010 - Elsevier BV | Neurobiology of Disease
Yoon-Jin Jung, Jong‐Hwan Yoon, R. G. Elliman, A.R. Wilkinson,
Si nanocrystals embedded in SiO2 films were exposed to an atomic H plasma at different temperatures. Photoluminescence intensity from the nanocrystals increases with increasing exposure time, followed by saturation that depends on the exposure temperature. The saturation level depends on the final exposure temperature and shows no dependence on the thermal history of exposure. This behavior is shown to be consistent with a model in which the steady-state passivation level is determined by a balance ...
Tópico(s): Thin-Film Transistor Technologies
2008 - American Institute of Physics | Journal of Applied Physics
Amanda Weyers, Bo Yang, Dae Sung Yoon, Jong‐Hwan Park, Fuming Zhang, Kyung‐Bok Lee, Robert J. Linhardt,
Cancer is one of the leading noncommunicable diseases that vastly impacts both developed and developing countries. Truly innovative diagnostics that inform disease susceptibility, prognosis, and/or response to treatment (theragnostics) are seriously needed for global public health and personalized medicine for patients with cancer. This study examined the structure and content of glycosaminoglycans (GAGs) in lethal and nonlethal breast cancer tissues from six patients. The glycosaminoglycan content ...
Tópico(s): Fibroblast Growth Factor Research
2012 - Mary Ann Liebert, Inc. | OMICS A Journal of Integrative Biology
Jong Hyun Yoon, Jong‐Hwan Shin, Tai Hyun Park,
The combined effect of superficial gas velocity, pH, initial phosphate concentration, and light intensity on cell growth was investigated for the mass production of cyanobacterial cells. The light intensity was manipulated to maintain a specific irradiation rate (qi) at a constant level for high cell density culture. The optimum condition for the batch culture was achieved at a superficial gas velocity of 2.0 cm/s, pH 7.0, and an initial phosphate concentration of 55 mg/l when the specific irradiation ...
Tópico(s): Calcium Carbonate Crystallization and Inhibition
2007 - Elsevier BV | Bioresource Technology
Jong‐Hoon Kim, Sunoh Kim, In‐Soo Yoon, Jong‐Hwan Lee, Byung-Jun Jang, Sang Min Jeong, Jun‐Ho Lee, Byung-Hwan Lee, Jin-Soo Han, Sekwan Oh, Hyung-Chun Kim, Tae Kyu Park, Hyewhon Rhim, Seung-Yeol Nah,
The precise cause of neuronal cell death in Huntington's disease (HD) is not known. Systemic administration of 3-nitropropionic acid (3-NP), an irreversible succinate dehydrogenase inhibitor, not only induces a cellular ATP depletions but also causes a selective striatal degeneration similar to that seen in HD. Recent accumulating reports have shown that ginseng saponins (GTS), the major active ingredients of Panax ginseng, have protective effects against neurotoxin insults. In the present study, we ...
Tópico(s): Natural product bioactivities and synthesis
2005 - Elsevier BV | Neuropharmacology
E.-R. Woo, Seung Hee Yoon, Jong Hwan Kwak, H.J. Kim, H. Park,
Various assay methods have been developed to evaluate the effectiveness of substances against human immunodeficiency virus (HIV). One of them is the Syncytia formation inhibition assay, which is based on the inhibition of the interaction between the HIV-1 envelope protein gp 120 and the cellular membrane protein CD4. A variation of this assay using recombinant virus vPE 16 and CD4(+) HeLa cell was developed to find anti-HIV compounds in natural products that inhibit gp 120-CD4 binding. VPE 16 expresses ...
Tópico(s): T-cell and Retrovirus Studies
1997 - Elsevier BV | Phytomedicine
Ying Li, Rujun Jin, Lan Li, Ji Suk Choi, Jong-Hwa Kim, Hyeon Jeong Yoon, Jong Hwan Park, Kyung Chul Yoon,
In this study, we investigated the effects of blue light exposure on nucleotide-binding oligomerization domain 2 (NOD2) expression on the mouse ocular surface and evaluated the role of NOD2 activation in light-induced cell death. Mice were divided into wild-type (WT), NOD2-knock out (KO), WT + blue light (WT + BL), and NOD2-KO + blue light (NOD2-KO + BL) groups, and the mice in the WT+BL and NOD2-KO + BL groups were exposed to blue light for 10 days. After 10 days of blue light exposure, increased reactive oxygen ...
Tópico(s): Connexins and lens biology
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Sang-Joon Park, Jong‐Hwan Yoon,
... Icon Cite Search Site Citation Sang-Joon Park, Jong-Hwan Yoon; Synthesis and memory properties of a self-assembled ...
Tópico(s): Advanced Memory and Neural Computing
2014 - American Institute of Physics | Applied Physics Letters
Sung‐Gang Jo, Eui-Jeong Noh, Jun-Young Lee, Green Kim, JooHee Choi, Mo-Eun Lee, Jung-Hee Song, Ji-Yoon Chang, Jong‐Hwan Park,
Tópico(s): Immune Response and Inflammation
2016 - Springer Science+Business Media | The Journal of Microbiology
Kyoung Ho Yoon, Jong‐Hwan Lee, Sang‐Gyun Kim, Jae‐Young Park, Hee-Sung Lee, Sang Jin Kim, Yoon-Seok Kim,
Recent biomechanical studies have reported that stress on the posterior cruciate ligament (PCL) graft increases as the posterior tibial slope (PTS) decreases (flattened) in knees with single-bundle (SB) and double-bundle PCL reconstruction. Clinical studies of SB PCL reconstruction have shown that a flattened PTS is associated with a lesser reduction in posterior tibial translation. There is no long-term study on the clinical outcomes and graft survival rates of SB PCL reconstruction based on the medial ...
Tópico(s): Sports injuries and prevention
2023 - SAGE Publishing | The American Journal of Sports Medicine
You Jin Won, Jong Yoon Yoo, Jong‐Hwan Lee, Seung Jun Hwang, Dong‐Hou Kim, Hea Nam Hong,
The aim of this study was to investigate whether erythropoietin (EPO) protect the spinal GABAergic neurons against kainic acid (KA)-excitotoxic damage in rat spinal cord cell cultures. We performed immunohistochemical staining and Western blotting of glutamate decarboxylase 67 (GAD67), one isoform of GABA-producing enzyme, which was considered to have involved in nonsynaptic functions, such as energy metabolism or trophic support. T exposure to KA significantly reduced the intensity of GAD67 expression ...
Tópico(s): Healthcare and Venom Research
2007 - Elsevier BV | Brain Research
Eun Jung Oh, Yoon Joo Chung, Jong‐Hwan Lee, Eun Jin Kwon, Eun Ah Choi, Young Keun On, Jeong Jin Min,
The emergence profiles in patients undergoing total intravenous anesthesia with either propofol or remimazolam with flumazenil reversal were compared. A prospective, double-blind, randomized trial. An operating room and a post-anesthesia care unit (PACU). Adult patients (n = 100) having American Society of Anesthesiologists (ASA) physical status of I-III undergoing general anesthesia were enrolled and randomly assigned to the propofol or the remimazolam group. The propofol group received target-controlled ...
Tópico(s): Anesthesia and Neurotoxicity Research
2023 - Elsevier BV | Journal of Clinical Anesthesia
Hong‐Ryeol Shin, Jihoon Lee, Cheol‐Ho Kim, Jong‐Hwan Yoon, Naoki Hirose, Tetsutaro Takikawa, Kwangwoo Cho,
ADCP current data and sea level data from tide gauges and satellite altimetry were used in order to analyze long-term variation of the Tsushima Warm Current (TWC) volume transport passing through the Korea/Tsushima Strait. The annual mean transport of the TWC estimated from ADCP current measurement for about 17 years (1997–2013) is 2.64 ± 0.41 Sv (Sv = 106 m3s−1) in the Korea/Tsushima Strait, 1.53 ± 0.36 Sv (about 58% of the total transport) in the western channel, and 1.11 ± 0.14 Sv (about 42%) in the eastern ...
Tópico(s): Marine and coastal ecosystems
2022 - Elsevier BV | Journal of Marine Systems
Jiyeon Park, Seung Yeon Yoo, Jae‐Hoon Ko, Sangmin Maria Lee, Yoon Joo Chung, Jong‐Hwan Lee, Kyong Ran Peck, Jeong Jin Min,
Abstract In 2015, we experienced the largest in-hospital Middle East respiratory syndrome (MERS) outbreak outside the Arabian Peninsula. We share the infection prevention measures for surgical procedures during the unexpected outbreak at our hospital. We reviewed all forms of related documents and collected information through interviews with healthcare workers of our hospital. After the onset of outbreak, a multidisciplinary team devised institutional MERS-control guidelines. Two standard operating ...
Tópico(s): COVID-19 and healthcare impacts
2020 - Nature Portfolio | Scientific Reports
Jong‐Hwan Yoon, Ichiro Yasuda,
Abstract A simple two-layered in/outflow model is studied to explain the peculiarity of the Kuroshio path. The geometry south of Japan with a length scale L and the characteristic velocity U of the Kuroshio give an important parameter γ = 2πU/β/L. The Kuroshio can take two kinds of paths for a given value of γ (multiple equilibria). One is straight path and the other a meandering path. The selection of a path. The selection of a path in a multiple equilibrium state depends upon the history of the parameter ...
Tópico(s): Ocean Waves and Remote Sensing
1987 - American Meteorological Society | Journal of Physical Oceanography
Ichiro Yasuda, Jong Hwan Yoon, Nobuo Suginohara,
The bimodality of the Kuroshio path is studied numerically with a barotropic inflow-outflow model. The dynamics that determines the path depends on the Rossby number,Ro (proportional to inlet velocity) and the Reynolds number (representing effects of viscosity). At lowRo (<Ro 1) only a meander path occurs, while at highRo(Ro 2) only a straight path is developed. Between these critical values (Ro 1≦Ro≦Ro2) either of the two paths can occur (multiple states), and the choice of path is determined by its ...
Tópico(s): Climate variability and models
1985 - Springer Science+Business Media | Journal of Engineering Physics and Thermophysics
Jin Jang, Tae Man Kim, Jaekyung Hyun, Jong Hwan Yoon, Choochon Lee,
Temperature dependent light induced dark- and photoconductivity changes and annealing of the changes have been investigated. The dark- and photoconductivity changes are accelerated as the temperature during the illumination is elevated. The activation energies of thermal relaxation time for undoped and phosphorus doped a-Si:H films showing conductivity decrease after illumination are the range 1.32–1.53 eV, those for the films showing conductivity increase 0.79–1.00 eV. The activation energy is ...
Tópico(s): CCD and CMOS Imaging Sensors
1983 - Elsevier BV | Journal of Non-Crystalline Solids
Tópico(s): Climate variability and models
1982 - Springer Science+Business Media | Journal of Engineering Physics and Thermophysics
Tópico(s): Climate variability and models
1982 - Springer Science+Business Media | Journal of Engineering Physics and Thermophysics
Tópico(s): Oceanographic and Atmospheric Processes
1982 - Springer Science+Business Media | Journal of Engineering Physics and Thermophysics
The effects of islands on equatorially trapped waves induced by the sudden onset of zonal wind are investigated by solving the shallow water equations numerically. The energy propagation associated with an equatorial Kelvin wave is almost unaffected by an island on the equator. The energy transmission ratio is over 0.8 even when the north‐south extent of the island is the same as the Rossby deformation radius. It is also shown that the Maldive Islands in the Indian Ocean and the Gilbert Islands ...
Tópico(s): Climate variability and models
1981 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Jong‐Hwan Yoon, Nobuo Suginohara,
Tópico(s): Tropical and Extratropical Cyclones Research
1977 - Springer Science+Business Media | Journal of Oceanography
Chanhyung Jeon, Jae‐Hun Park, Sergey M. Varlamov, Jong‐Hwan Yoon, Young Ho Kim, Seongbong Seo, Young‐Gyu Park, Hong Sik Min, Jae‐Hak Lee, Cheol‐Ho Kim,
The seasonal variation of semidiurnal internal tides in the East/Japan Sea was investigated using 25 month long output from a real-time ocean forecasting system. The z coordinate eddy-resolving high-resolution numerical model, called the RIAM ocean model, incorporates data assimilation that nudges temperature and salinity fields together with volume transport through the Korea Strait to produce realistic oceanic currents and stratification. In addition to atmospheric forcing, it includes tidal forcing ...
Tópico(s): Marine and coastal ecosystems
2014 - Wiley | Journal of Geophysical Research Oceans
Jong Hwan Yoon, Youngjin Cho, Hyun Ho Park,
The TNF receptor-associated factor (TRAF) proteins are structurally similar scaffold proteins that mediate between members of the TNF receptor (TNFR) family and downstream effector molecules such as kinases in the immune signalling pathway. Seven TRAFs have been identified, including TRAF4, which is a unique member that participates in many ontogenic processes, including nerve-system development. TRAFs commonly contain the TRAF domain, which mediates interaction with target receptors and effectors. ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2013 - Wiley | Acta Crystallographica Section D Biological Crystallography
Jae‐Hong Moon, Naoki Hirose, Jong-Hwan Yoon, Ig-Chan Pang,
Abstract A patchlike structure of low-salinity water detached from the Chanjiang “Diluted Water” (CDW) is frequently observed in the East China Sea (ECS). In this study, the offshore detachment process of CDW into the ECS is examined using a three-dimensional numerical model. The model results show that low-salinity water is detached from the CDW plume by the intense tide-induced vertical mixing during the spring tide period when the tidal current becomes stronger. During the spring tide, thickness ...
Tópico(s): Arctic and Antarctic ice dynamics
2010 - American Meteorological Society | Journal of Physical Oceanography