Shigeru Miyake, Yasuo Sumi, Lily Yan, Seiichi Takekida, Tsuyoshi Fukuyama, Yoshiki Ishida, Shun Yamaguchi, Kazuhiro Yagita, Hitoshi Okamura,
Single brief and discrete light treatments are sufficient to reset the overt mammalian rhythms of nocturnal rodents. In the present study, we examined the phase-dependent response of the mammalian clock genes, Per1 and Per2, to a brief strong light-stimulus (1000 lux) in the circadian oscillator center, the suprachiasmatic nucleus (SCN) of rats. Light-induced elevation of Per1 mRNA was observed through the subjective night (CT16, CT20 and CT0 (=CT24)) with a marked peak at the subjective dawn (CT0). However, ...
Tópico(s): Spaceflight effects on biology
2000 - Elsevier BV | Neuroscience Letters
Yoshimitsu Fukuyama, Yoshiki Moriwaki, Yukari Matsuo,
We report the observation of laser-induced fluorescence spectra of ${\text{Ba}}^{+*}\text{\ensuremath{-}}\text{He}$ exciplexes. The experiment is carried out in an environment of cold gaseous helium at a temperature range of $3--30\phantom{\rule{0.3em}{0ex}}\mathrm{K}$. We have observed the emission spectra of exciplexes by means of excitation of the $6p\phantom{\rule{0.3em}{0ex}}^{2}P_{3∕2}\ensuremath{\leftarrow}6s\phantom{\rule{0.3em}{0ex}}^{2}S_{1∕2}$ transition of ${\text{Ba}}^{+}$ ions. It is found ...
Tópico(s): Atomic and Subatomic Physics Research
2004 - American Physical Society | Physical Review A
Yasuhiro Shimizu, Yoshiki Fukuyama, Tomoki Narikiyo, Hiromichi Arai, Tetsuro Seiyama,
Abstract Among the perovskite-type oxides examined, SrTiO3 showed a high sensitivity to oxygen in the “lean-burn” region. The resistivity characteristics of the specimen were also investigated in the exhaust gas of propane-oxygen combustion. SrSnO3 is promising for a combustion monitoring sensor.
Tópico(s): Electrical and Bioimpedance Tomography
1985 - Oxford University Press | Chemistry Letters
Yoshimitsu Fukuyama, Yoshiki Moriwaki, Yukari Matsuo,
We report the formation rate constants and the dissociation cross sections of ${\mathrm{Ba}}^{+*}\text{\ensuremath{-}}\mathrm{He}$ exciplexes in an environment of cold gaseous helium at temperatures of $3--25\phantom{\rule{0.3em}{0ex}}\mathrm{K}$. We have observed laser-induced fluorescence spectra of ${\mathrm{Ba}}^{+}$ and ${\mathrm{Ba}}^{+*}\text{\ensuremath{-}}\mathrm{He}$ exciplexes by means of $D2$ excitation of ${\mathrm{Ba}}^{+}$ ions. Using the rate equation analyses of fluorescence intensities of ${\mathrm{ ...
Tópico(s): Atomic and Subatomic Physics Research
2007 - American Physical Society | Physical Review A
TADASHI HIRAHARA, Hisao Yasuhara, Osamu Matsui, Morimasa YAMANAKA, Masayuki Tanaka, Shin-ichi FUKUYAMA, AKIHIRO IZUMIDA, KENICHI YOSHIKI, Kazuo Kodama, Masahisa NAKAI, Norimasa SASAKI,
[in Japanese]
Tópico(s): Animal Virus Infections Studies
1990 - Japanese Society of Veterinary Science | The Japanese Journal of Veterinary Science
Yasuhiro Shimizu, Yoshiki Fukuyama, Chunying Yu, Hiromichi Arai,
The oxygen sensitivity of SrTiO3 doped with Al2O3 was sufficiently high in the lean-burn region. However, the usefulness of these specimens as oxygen sensors was limited by the fact that a transition into n-type semiconductivity appeared in the vicinity of the stoichiometric point of air-fuel combustion, due to the small value of the solubility limit of Al2O3 in SrTiO3. On the other hand, Cr2O3 retained p-type semiconductivity even in the richburn region. Thus the properties of a dual-disc semiconductor ...
Tópico(s): Gas Sensing Nanomaterials and Sensors
1988 - Elsevier BV | Sensors and Actuators
Shunichiro Ito, Misuzu Fukuyama, Kazuo Tanaka, Yoshiki Chujo,
Abstract π ‐Conjugated polymers composed of a boron β ‐diketiminate complex with different regioregularity are synthesized by using Suzuki–Miyaura and Yamamoto couplings. The films formed with the polymers show luminescence chromism upon exposure to solvent vapors. Most importantly, the chromic behavior depends on the regioregularity of the polymers. Wide‐angle X‐ray diffraction, thermal analysis, and density functional theory calculations suggest that the chromism can originate from the morphological ...
Tópico(s): Conducting polymers and applications
2022 - Wiley | Macromolecular Chemistry and Physics
Shuzo Yamamoto, Yasufumi Shigeyoshi, Yoshiki Ishida, Tsuyoshi Fukuyama, Shun Yamaguchi, Kazuhiro Yagita, Takahiro Moriya, Shigenobu Shibata, Naoyuki Takashima, Hitoshi Okamura,
... JapanSearch for more papers by this authorYoshiki Ishida, Yoshiki Ishida Department of Anatomy and Brain Science, Kobe University School of Medicine, Chuo-ku, Kobe 650-0017, JapanSearch for more papers by this authorTsuyoshi Fukuyama, Tsuyoshi Fukuyama Department of Anatomy and Brain Science, ... JapanSearch for more papers by this authorYoshiki Ishida, Yoshiki Ishida Department of Anatomy and Brain Science, Kobe University School of Medicine, Chuo-ku, Kobe 650-0017, JapanSearch for more papers by this authorTsuyoshi Fukuyama, Tsuyoshi Fukuyama Department of Anatomy and Brain Science, ...
Tópico(s): Psychological and Temporal Perspectives Research
2001 - Wiley | The Journal of Comparative Neurology
Takashi Fukuyama, Yoshinobu Ichiki, Sousuke Yamada, Yoshiki Shigematsu, Tetsuro Baba, Yoshika Nagata, Makiko Mizukami, Masakazu Sugaya, Mitsuhiro Takenoyama, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto,
Cytokines produced by tumor cells may have various effects on antitumor immune responses and tumor growth. In the present study, the cytokine production of 31 lung cancer cell lines was evaluated, while any correlation with the histological type, the induction of tumor‐specific cytotoxic T lymphocytes (CTL) in vitro , and angiogenesis and the infiltration of inflammatory cells in tumor tissues were also examined. Production of interleukin (IL)‐1α, IL‐1β, IL‐4, IL‐6, IL‐8, IL‐10, tumor necrosis factor ( ...
Tópico(s): Cancer Cells and Metastasis
2007 - Wiley | Cancer Science
Yoshitaka Hayashi, Yoshiki Sawa, Naoto Fukuyama, Yuji Miyamoto, Toshiki Takahashi, Hiroe Nakazawa, Hikaru Matsuda,
ObjectivesThis study was designed to examine the myocardial protective effect of leukocyte-depleted terminal blood cardioplegia in association with nitric oxide and peroxynitrite production, especially for patients undergoing prolonged aortic crossclamping.MethodsFifty-four patients (34 men, 20 women, mean age 56.7 ± 12.7 years) undergoing aortic valve replacement were randomly allocated to one of two groups; group LDTC (n = 27) received 10 minutes of leukocyte-depleted terminal blood cardioplegic solution, ...
Tópico(s): Cardiac Arrest and Resuscitation
2003 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Yoshitaka Hayashi, Yoshiki Sawa, Naoto Fukuyama, Hiroe Nakazawa, Hikaru Matsuda,
Heat-shock protein 70 (HSP70) plays a major role in the pathophysiology of inflammation, and the induction of HSP70 before the onset of inflammation can reduce organ damage through a self-protective system. Glutamine is known to be an inducer of HSP70, and its preoperative administration seems useful in attenuating cardiopulmonary bypass (CPB)-induced inflammatory response.Adult male Sprague-Dawley rats (group G, received 100 mg/kg of glutamine via the right jugular vein 3 times per day for 1 week ...
Tópico(s): Thermal Regulation in Medicine
2002 - Lippincott Williams & Wilkins | Circulation
Y Hayashi, Yoshiki Sawa, Naoto Fukuyama, Hiroe Nakazawa, Hikaru Matsuda,
Cardiopulmonary bypass (CPB) increases nitric oxide (NO) production by the activation of NO synthases (NOS). However, the role of NO from inducible NOS (iNOS) in CPB-induced inflammatory response remains unclear. We examined the effect of a selective iNOS inhibitor, aminoguanidine, on CPB-induced inflammatory response in a rat-CPB model.Adult Sprague-Dawley rats underwent 60 minutes of CPB (100 mL x kg(-1) x min(-1), 34 degrees C). Group A (n = 10) received 100 mg/kg of aminoguanidine intraperitoneally ...
Tópico(s): Neuropeptides and Animal Physiology
2001 - Elsevier BV | The Annals of Thoracic Surgery
Yasuhiro Shimizu, Yoshiki Fukuyama, Hiromichi Arai, Tetsuro Seiyama,
The perovskite-type oxides (ABO3) were studied from the viewpoints of application for oxygen sensors. Among the perovskite-type oxides examined, SrTiO3 showed a high sensitivity to oxygen in the temperature range from 550 to 800 °C in the "lean-burn" region (102 Pa < PO2 102 Pa and showed a p-type semiconductive nature. As for SrSnO3, no significant changes in the conductivity were observed in the "lean-burn" region, since the change of the conduction mechanism from p-type to n-type occurred in this region. ...
Tópico(s): Advanced Sensor Technologies Research
1986 - American Chemical Society | ACS symposium series
Yukari Matsuo, Yoshimitsu Fukuyama, Yoshiki Moriwaki,
... Icon Cite Search Site Citation Yukari Matsuo, Yoshimitsu Fukuyama, Yoshiki Moriwaki; Temperature and Pressure Control of Cold Helium ...
Tópico(s): Cold Atom Physics and Bose-Einstein Condensates
2006 - American Institute of Physics | AIP conference proceedings
Ryosuke Kato, Misuzu Fukuyama, Yasuhiro Morisaki, Yoshiki Chujo,
Abstract Optically active macrocycles consisting of two P‐stereogenic bisphosphine units and two π‐conjugated linkers were synthesized via [2 + 2] cyclization. A clear Cotton effect was observed in the π–π* transition region of the π‐conjugated units, indicating that the chirality is induced by the P‐stereogenic bisphosphine moieties onto the π‐conjugated linkers. Compared with model compounds, the orientation of the two π‐conjugated units was essential to the induced circular dichroism. Macrocycles ...
Tópico(s): Organoboron and organosilicon chemistry
2016 - Wiley | Heteroatom Chemistry
Kenichi Harada, Katsuyoshi Zaha, Rina Bando, Ryo Irimaziri, Miwa Kubo, Yoshiki Koriyama, Yoshiyasu Fukuyama,
(-)-Talaumidin (1), a 2,5-biaryl-3,4-dimethyltetrahydrofuran lignan, shows potent neurotrophic activities such as neurite-outgrowth promotion and neuroprotection. Previously, we found that (-)-(1S,2R,3S,4R)-stereoisomer 2 exhibited more significant activity than did the natural product talaumidin (1). However, the preparation of optically active (-)-2 requires a complicated synthetic route. To explore new neurotrophic compounds that can be obtained on a large scale, we established a short step synthetic route ...
Tópico(s): Pharmacological Effects of Natural Compounds
2018 - Elsevier BV | European Journal of Medicinal Chemistry
Makiko Mizukami, Takeshi Hanagiri, Manabu Yasuda, Koji Kuroda, Yoshiki Shigematsu, Tetsuro Baba, Takashi Fukuyama, Yoshika Nagata, Tetsuya So, Yoshinobu Ichiki, Masakazu Sugaya, Tomoko So, Mitsuhiro Takenoyama, Kenji Sugio, Kosei Yasumoto,
Abstract We previously reported the humoral immune response of tumor-infiltrating B lymphocytes in a lung cancer patient and 22 genes coding tumor-associated antigens identified using the serological identification of antigens by recombinant expression cloning method. In this study, we investigated one of these genes, designated University of Occupational and Environmental Health—Lung cancer antigen-1 (UOEH-LC-1), which has an extracellular domain. Quantitative reverse transcription-PCR revealed ...
Tópico(s): Glycosylation and Glycoproteins Research
2007 - American Association for Cancer Research | Cancer Research
Masakazu Sugaya, Mitsuhiro Takenoyama, Yoshiki Shigematsu, Tetsuro Baba, Takashi Fukuyama, Yoshika Nagata, Makiko Mizukami, Tetsuya So, Yoshinobu Ichiki, Manabu Yasuda, Tomoko So, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto,
Abstract The aim of the present study was to elucidate the tumor‐specific cellular immunological responses occurring in a patient with large cell carcinoma of the lung who had no evidence of recurrence following surgical resections of both a primary lung lesion and a metastatic adrenal lesion. We analyzed an autologous tumor‐specific cytotoxic T lymphocytes (CTL clone F2b), which were HLA‐A*2402 restricted from regional lymph node lymphocytes. The F2b possessed T cell receptor (TCR) using the Vα5 ...
Tópico(s): T-cell and B-cell Immunology
2006 - Wiley | International Journal of Cancer
Makiko Mizukami, Takeshi Hanagiri, Yoshiki Shigematsu, Tetsuro Baba, Takashi Fukuyama, Yoshika Nagata, Tetsuya So, Yoshinobu Ichiki, Masakazu Sugaya, Manabu Yasuda, Tomoko So, Mitsuhiro Takenoyama, Kenji Sugio, Kosei Yasumoto,
Background: Tumor-infiltrating B lymphocytes (TIB) are often observed in lung cancer. The role of TIB in tumor growth has not been well investigated. Materials and Methods: Forty-four surgically-resected human lung cancer tissues were xenotransplanted into SCID mice. Their blood was collected and the volume of the transplanted tumors was measured regularly. The correlations between the IgG titer in the sera and the growth of the transplanted tumors according to the clinicopathological variables were ...
Tópico(s): Glycosylation and Glycoproteins Research
2006 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
Yoshitaka Hayashi, Yoshiki Sawa, Motonobu Nishimura, Naoto Fukuyama, Hajime Ichikawa, Shigeaki Ohtake, Hiroe Nakazawa, Hikaru Matsuda,
Objective: Cardiopulmonary bypass (CPB) is known to induce post-bypass systemic inflammatory response. Peroxynitrite (ONOO−) is a potent oxidant formed by a rapid reaction between nitric oxide (NO) and superoxide anion. We hypothesized that ONOO− plays a role in the development of post-bypass systemic inflammatory response and examined the efficacy of ONOO− scavenger in a rat-CPB model. Methods: Adult Sprague–Dawley rats underwent 60 min of CPB (100 ml/kg per min, 34 °C). Group-P (n=10) received 50 mg/ ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2004 - Oxford University Press | European Journal of Cardio-Thoracic Surgery
Yoshiki Ishida, Kazuhiro Yagita, Tsuyoshi Fukuyama, Masataka Nishimura, Mamoru Nagano, Yasufumi Shigeyoshi, Shun Yamaguchi, Takahide Komori, Hitoshi Okamura,
Abstract Casein kinase Iϵ (CKIϵ) and casein kinase Iδ (CKIδ) phosphorylate clock oscillating mPER proteins, and play a key role in the transcription (post)translation feedback loop that generates circadian rhythm. In the present study, the expression profiles of CKIϵ and CKIδ mRNAs were examined in the mice clock center, suprachiasmatic nucleus (SCN). Moderate levels of CKIϵ and CKIδ mRNAs were constantly expressed in the SCN in both light:dark and constant dark conditions. This finding supports the ...
Tópico(s): Spaceflight effects on biology
2001 - Wiley | Journal of Neuroscience Research
Y Hayashi, Yoshiki Sawa, Shigeaki Ohtake, Naoto Fukuyama, Hiroe Nakazawa, Hikaru Matsuda,
Tópico(s): Analytical Chemistry and Sensors
2001 - Elsevier BV | The Annals of Thoracic Surgery
Rika Inano, Naoya Oishi, Takeharu Kunieda, Yoshiki Arakawa, Takayuki Kikuchi, Hidenao Fukuyama, Susumu Miyamoto,
Abstract Preoperative glioma grading is important for therapeutic strategies and influences prognosis. Intratumoral heterogeneity can cause an underestimation of grading because of the sampling error in biopsies. We developed a voxel-based unsupervised clustering method with multiple magnetic resonance imaging (MRI)-derived features using a self-organizing map followed by K-means. This method produced novel magnetic resonance-based clustered images (MRcIs) that enabled the visualization of glioma ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2016 - Nature Portfolio | Scientific Reports
Yasuhiro Shimizu, Yoshiki Fukuyama, Hiromichi Arai,
Abstract A lean-burn oxygen sensor composed of two different sintered semiconductors was made by electrically contacting the discs of SrAl0.01Ti0.99O3 and Cr2O3 with Pt mesh by mechanical pressing. The resistance-λ′ characteristic of the connected device was investigated in the exhaust gas of oxygen-propane combustion, where λ′ stands for the oxygen excess ratio. It was found that the SrAl0.01Ti0.99O3Cr2O3 device had promising properties for a lean-burn oxygen sensor, because the device exhibited ...
Tópico(s): Acoustic Wave Resonator Technologies
1985 - Oxford University Press | Chemistry Letters
Yoshitaka Hayashi, Sawa Yoshiki, Motonobu Nishimura, Shinichiro J. Tojo, Naoto Fukuyama, Hiroe Nakazawa, Hikaru Matsuda,
P-selectin participates in the development of inflammatory disorders. Cardiopulmonary bypass is thought to induce inflammatory response and increase nitric oxide production. To evaluate the role of P-selectin in bypass-induced inflammatory response and its association with nitric oxide production, we examined the effect of P-selectin monoclonal antibody in a rat model of cardiopulmonary bypass.Twenty adult Sprague-Dawley rats undergoing cardiopulmonary bypass for 60 minutes were divided into 2 groups. ...
Tópico(s): Cardiac Ischemia and Reperfusion
2000 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Motonobu Hayano, Yoichi Imamura, Mitsuhiro Tsuruta, Junichi Inoue, Hiroshi Nakashima, Kuniaki FUKUYAMA, Yoshiki Eguchi, Shinsuke Tsuji, Shuzo Matsuo, Katsusuke Yano,
Electrophysiologic study of a 55-year-old patient with Lown-Ganong-Levine syndrome associated with apical hypertrophic cardiomyopathy is reported. The patient had a history of recurrent attacks of tachyarrhythmia and his electrocardiogram showed a short P-R interval (0.10 see) with narrow QRS complex and left ventricular hypertrophy with giant negative T waves. His cineangiogram showed severe apical hypertrophy. An electrophysiologic study was performed. The results of programmed atrial pacing show ...
Tópico(s): Cardiac Structural Anomalies and Repair
1988 - Japanese Heart Journal Assoc | Japanese Heart Journal
Yoshinobu Ichiki, Yoshiki Shigematsu, Tetsuro Baba, Hironobu Shiota, Takashi Fukuyama, Yoshika Nagata, Tetsuya So, Manabu Yasuda, Mitsuhiro Takenoyama, Kosei Yasumoto,
Abstract The present study analyzed the antitumor effect of γδT cells transduced with the TCR of cancer‐specific CTLs to establish forceful cancer‐specific adoptive immunotherapy. We cloned the TCRαβ genes from CTLs showing HLA‐B15 restricted recognition of Kita‐Kyushu lung cancer antigen‐1 (KK‐LC‐1), a cancer/germline gene antigen, identified in a lung adenocarcinoma case (F1121). The TCRαβ and CD8 genes were transduced into γδT cells induced from PBLs of healthy volunteers stimulated with zoledronate ...
Tópico(s): Immunotherapy and Immune Responses
2020 - Wiley | Cancer Science
Hiroyasu Komuro, Shuichi Shinohara, Yasunori Fukushima, Ayako Demachi‐Okamura, Daisuke Muraoka, Katsuhiro Masago, Takuya Matsui, Yusuke Sugita, Yusuke Takahashi, Reina Nishida, Chieko Takashima, Takashi Ohki, Yoshiki Shigematsu, Fumiaki Watanabe, Katsutoshi Adachi, Takashi Fukuyama, Hiroshi Hamana, Hiroyuki Kishi, Daiki Miura, Yuki Tanaka, Kousuke Onoue, Kazuhide Onoguchi, Yoshiko Yamashita, Richard Stratford, Trevor Clancy, Rui Yamaguchi, Hiroaki Kuroda, Kiyoshi Doi, Hisashi Iwata, Hirokazu Matsushita,
Background CD8 + tumor infiltrating lymphocytes (TILs) are often observed in non-small cell lung cancers (NSCLC). However, the characteristics of CD8 + TILs, especially T-cell populations specific for tumor antigens, remain poorly understood. Methods High throughput single-cell RNA sequencing and single-cell T-cell receptor (TCR) sequencing were performed on CD8 + TILs from three surgically-resected lung cancer specimens. Dimensional reduction for clustering was performed using Uniform Manifold Approximation ...
Tópico(s): CAR-T cell therapy research
2023 - BMJ | Journal for ImmunoTherapy of Cancer
Yukitaka Ueki, Hiroshi Nakamura, Shingo Matsumoto, Tetsuro Tominaga, Shozo Miyake, Yuichi Kita, Yoshiki Katayama, S. Fukuyama, Yoshimi Hirasawa, Kanako Yoshida, Kei Eguchi,
Nitric oxide (NO) is formed in small amounts in vivo and is rapidly oxidized by interacting with oxygen, making measurement of its level difficult. The chemiluminescence assay is the most widely used method for detecting NO and is extremely sensitive to very small amounts of NO. However, it is difficult to prepare small amounts of NO to be used as a standard for NO analysis. NOR-1, a derivative of NOR-3, is a newly discovered NO donor with rapid NO-releasing activity. We assessed the dynamics of ...
Tópico(s): Neuroscience of respiration and sleep
2002 - Lippincott Williams & Wilkins | Blood Coagulation & Fibrinolysis
Rika Inano, Naoya Oishi, Takeharu Kunieda, Yoshiki Arakawa, Yukihiro Yamao, Sumiya Shibata, Takayuki Kikuchi, Hidenao Fukuyama, Susumu Miyamoto,
Gliomas are the most common intra-axial primary brain tumour; therefore, predicting glioma grade would influence therapeutic strategies. Although several methods based on single or multiple parameters from diagnostic images exist, a definitive method for pre-operatively determining glioma grade remains unknown. We aimed to develop an unsupervised method using multiple parameters from pre-operative diffusion tensor images for obtaining a clustered image that could enable visual grading of gliomas. ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2014 - Elsevier BV | NeuroImage Clinical