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Revisão Acesso aberto Revisado por pares

Chayakrit Krittanawong, Muzamil Khawaja, Jacqueline E. Tamis‐Holland, Saket Girotra, Sunil V. Rao,

... the unique etiologies for myocardial infarction in these younger patients as nonatherosclerotic etiologies occur more frequently in ... older age,2 the incidence of AMI in younger patients (<45 years of age) has progressively increased ... and studies have shown that the proportion of younger patients with AMI has steadily grown over the ... rapidly diagnose, risk stratify, and manage AMI in younger patients. This review explores the various etiologies for ... mortality of AMI has been declining less among younger individuals as compared with older individuals.4 The ...

Tópico(s): Acute Myocardial Infarction Research

2023 - Wiley | Journal of the American Heart Association

Artigo Revisado por pares

Julia S. Wong, Hajime Uno, Angela C. Tramontano, Chiara Pellegrini, Jennifer R. Bellon, Matthew D. Cheney, Patricia H. Hardenbergh, Alice Y. Ho, Kathleen C. Horst, J.N. Kim, K.L. Leonard, Meena S. Moran, C.C. Park, A. Recht, R. Shiloh, Alphonse G. Taghian, Laura Warren, Jean L. Wright, Y Chun, Rinaa S. Punglia,

... 6 months with pre-specified stratification by age (younger than 45 vs. 45 years or older). QOL ... treatment arms (p=0.71) or separately in younger (p=0.15) and older cohorts (p=0.27). However, HF patients younger than 45 were less bothered by side-effects ... and nausea (p=0.02) vs. CF patients younger than 45. Among patients who took unpaid time ... better 6-month QOL in some domains among younger patients. Our early results support the use of ... 6 months with pre-specified stratification by age (younger than 45 vs. 45 years or older). QOL ...

Tópico(s): Breast Cancer Treatment Studies

2023 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics

Artigo Acesso aberto Revisado por pares

Emily H Gordon, Nancye M. Peel, Ruth E. Hubbard, Natasha Reid,

... relatively little is known about the frailty of younger adult inpatients.This study aimed to measure frailty ... and over and to examine how frailty in younger adult inpatients differs from middle-aged and older ... and domains was conducted across three age groups: younger (18-49 years), middle-aged (50-69 years) ... prolonged length of stay and unfavourable discharge destination.Younger adults (n = 214; 23.5%) had a mean ( ... 19 (0.10). Approximately 27% (n = 57) of younger adults were frail (FI > 0.25). Mood and ... pain were the most frequently affected domains in younger adults and 50% had ≥3 comorbidities. Frailty increased ...

Tópico(s): Health Systems, Economic Evaluations, Quality of Life

2023 - Oxford University Press | QJM

Artigo Acesso aberto

Muhammad Bilal Abid, Noel Estrada-Merly, Mei‐Jie Zhang, Karen Chen, Christopher Bredeson, David Allan, Mitchell Sabloff, David I. Marks, Mark R. Litzow, Christopher S. Hourigan, Partow Kebriaei, Wael Saber,

... are still the preferred donor choice compared to younger matched unrelated donors (MUDs) in the contemporary era ... alloHCT from older MSDs (age ≥ 50 years) or younger MUDs (age ≤ 35 years) between 2011 and 2018. ... 58 years) and 539 underwent alloHCT from a younger MUD (median donor age, 25 year). In multivariable analysis, younger MUDs conferred a significantly decreased risk of relapse ( ... relapse at 5 years was significantly lower with younger MUDs than with older MSDs (26% versus 37%; P = .001). Younger MUDs were associated with a greater risk of ...

Tópico(s): Chronic Myeloid Leukemia Treatments

2023 - Elsevier BV | Transplantation and Cellular Therapy

Artigo Acesso aberto Revisado por pares

Shufang Sun, Shicun Xu, Arryn A. Guy, John Guigayoma, Yi Zhang, Yuanyuan Wang, Don Operario, Runsen Chen,

Importance Younger adults in China who are transgender and gender nonconforming (TGNC) and lesbian, gay, and bisexual (LGB) experience ... regions are also needed. Objectives To examine whether younger adult students’ psychiatric symptoms and suicide risk vary ... gender identity and identify risk factors within LGB younger adults and TGNC younger adults. Design, Setting, and Participants This cross-sectional ... risk. Results The analytic sample included 89 342 younger adults (mean [SD] age, 19.60 [1.75] ... with their cisgender heterosexual peers, TGNC and LGB younger adults were more likely to experience increased psychiatric ...

Tópico(s): LGBTQ Health, Identity, and Policy

2023 - American Medical Association | JAMA Network Open

Artigo Acesso aberto Revisado por pares

Zhiyu Qian, Khalid Al Khatib, Xi Chen, Sanvi Belani, Muhieddine Labban, Stuart R. Lipsitz, Alexander P. Cole, Hari S. Iyer, Quoc‐Dien Trinh,

... We studied the trends in PSA screening in younger Black and White men with the implementation of the 2012 and 2018 guidelines.Younger Black and White men (aged 40-54 years) ... investigate the temporal trend of PSA screening in younger Black and White men.A total of 142 ... steadily decreasing odds of PSA screening among both younger Black and White men in 2014, 2016, 2018, and 2020 compared with 2012 (for younger Black men: odds ratio [OR]2014 = 0.77, ... CI = 0.18 to 0.32; and for younger White men: OR2014 = 0.81, 95% CI = 0. ...

Tópico(s): Global Cancer Incidence and Screening

2023 - Oxford University Press | JNCI Cancer Spectrum

Artigo Acesso aberto Revisado por pares

Francisco Villavicencio, Jamie Perin, Hallie Eilerts-Spinelli, Diana Yeung, David Prieto‐Merino, Lucia Hug, David Sharrow, Danzhen You, Kathleen Strong, Robert E. Black, Li Liu,

Almost 6·5 million children and adolescents younger than 20 years died globally in 2021, the vast majority from preventable causes.1United Nations Inter-agency Group for Child Mortality EstimationLevels & Trends ... on causes of death for children and adolescents younger than 20 years for the period 2000–21. ... first 28 days of life), 1–59 months, younger than 5 years (aggregation of the previous two ... 6 491 000 deaths in children and adolescents younger than 20 years in 2021, with 5 096 000 (78·5%) deaths in children younger than 5 years and 1 395 000 (21· ...

Tópico(s): Food Security and Health in Diverse Populations

2023 - Elsevier BV | The Lancet Global Health

Artigo Acesso aberto Revisado por pares

Penghui Niu, Huang Huang, Lulu Zhao, Tongbo Wang, Xiaojie Zhang, Wanqing Wang, Yawei Zhang, Chunguang Guo, Dongbing Zhao, Yingtai Chen,

The survival outcomes of younger patients with gastric cancer (GC) have remained controversial. This study explores the clinicopathological characteristics, survival outcomes, and genetic alterations of younger and older patients with GC.Patients with GC ... Cancer Center (MSKCC) databases.A total of 1146 younger (<40 years of age) and 16,988 older (≥ ... of age) cases were included in the study. Younger patients had more poorly differentiated lesions than older ... from the NCCGCDB increased from 1998 to 2018. Younger patients with pTNM stage III had a lower ...

Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies

2022 - Wiley | Cancer Medicine

Artigo Acesso aberto Revisado por pares

Sonia Fernández–Ananín, Eulàlia Ballester, Berta Gonzalo, Clàudia Codina, Inka Miñambres, Antonio Pérez, Ignasi Gich, Sandra González, Cristina Serrano, Carmen Balagué,

... group) and those of 60 years or under (younger group). Variables evaluated included demographics and anthropometrics data, ... in the older group and 195 in the younger group. Outcomes related to weight loss in the ... subjects were modest compared to those in the younger population (older group %EWL 41.6 vs younger group %EWL 51.1, p < 0.05, older group %TWL 24.9% vs younger group %TWL 25.2%, p < 0.05). During follow-up, both older and younger patients showed an improvement in all the comorbidities: hypertension (older 82.5% vs 38.1%, younger 52.6% vs 29.2%, p < 0.05), ...

Tópico(s): Body Contouring and Surgery

2022 - Springer Science+Business Media | Obesity Surgery

Artigo Acesso aberto Revisado por pares

Ingo Fietze, Claudio L. Bassetti, David Mayleben, Scott Pain, Dalma Seboek Kinter, W. Vaughn McCall,

... 65 ('older adults') to those aged < 65 years ('younger adults'). Analyses by age (≥ 65 years, n = 364; < ... 39] vs 92 [38] min) in older than younger adults, while LPS was comparable (~ 65 min). Mean ... 17.4 min (10.7, 24.0) in younger patients and decreased LPS by a least-squares ... 9.7 min (3.7, 15.7) in younger patients. Daridorexant 50 mg increased sTST from baseline ... 57.1 min (48.9, 65.3) in younger patients. Daridorexant 50 mg progressively improved IDSIQ total ... 25 mg improved IDSIQ scores, but only in younger adults. In both age groups, in comparison with ...

Tópico(s): Restless Legs Syndrome Research

2022 - Adis, Springer Healthcare | Drugs & Aging