Kentaro Sakashita, Kengo Murata, Yukiko Takahashi, Miake Yamamoto, Kana Oohashi, Yu Sato, Miyako Kitazono, Akihiko Wada, Mikio Takamori,
Objective The standard anti-tuberculosis (TB) regimen occasionally causes acute kidney injury (AKI). The major etiology is rifampicin-induced acute interstitial nephritis. However, the standard management of AKI induced by anti-TB drugs has yet to be established. Methods We retrospectively reviewed patients with TB who developed AKI after starting standard anti-TB treatment between 2006 and 2016 at a single TB center. The clinical characteristics and the management are described. Results Among 1,430 ...
Tópico(s): Acute Kidney Injury Research
2018 - The Japanese Society of Internal Medicine | Internal Medicine
Masanori Kobayashi, Shigeru Oshima, Chiaki Maeyashiki, Yoichi Nibe, Kana Otsubo, Yu Matsuzawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe,
Ubiquitination is a crucial post-translational modification; however, the functions of ubiquitin-coding genes remain unclear. UBA52 encodes a fusion protein comprising ubiquitin at the N-terminus and ribosomal protein L40 (RPL40) at the C-terminus. Here we showed that Uba52-deficient mice die during embryogenesis. UBA52-deficient cells exhibited normal levels of total ubiquitin. However, UBA52-deficient cells displayed decreased protein synthesis and cell-cycle arrest. The overexpression of UBA52 ...
Tópico(s): Cancer-related Molecular Pathways
2016 - Nature Portfolio | Scientific Reports
Kana Shimada, Yu Mikami, Toshinori Murayama, Masayuki Yokode, Masatoshi Fujita, Toru Kita, Chiharu Kishimoto,
Background We assessed the hypothesis whether behavioral stress may affect the development of atherosclerosis and whether regular exercise training may influence the composition of atherosclerotic plaques in apolipoprotein (apo) E-deficient mice. Methods Atherosclerosis was induced in apo E-deficient mice fed a high fat diet. Exercise training (45 min swimming, 3 times/week) was conducted, and behavioral stress was provoked by glass marble-burying procedure. Mice were treated with marble-burying, ...
Tópico(s): Heart Rate Variability and Autonomic Control
2010 - Elsevier BV | International Journal of Cardiology
Sen Yagi, Shinya Furukawa, Kana Shiraishi, Yu Hashimoto, Kazuhiro Tange, Kenichirou Mori, Tomoyuki Ninomiya, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Aki Hasebe, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa,
Objective Serum albumin is used as a marker of acute inflammation. Several studies have addressed the association between serum albumin and clinical outcome in patients with ulcerative colitis (UC). While mucosal healing (MH) has been indicated as the therapeutic goal for UC, the association between serum albumin and MH remains unclear. We evaluated this issue in patients with UC overall and explored whether duration of UC affected this association. Design This cross-sectional study recruited consecutive ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2021 - BMJ | BMJ Open Gastroenterology
Jian Zhang, Shao-Ping Yang, Kana Wang, Yu Huang, Nian Yang, Zhongmei Yang, Zhenrong Zheng, Yujue Wang,
Cervical cancer is a prevalent tumor mainly induced by Human Papilloma Virus (HPV). Autophagy was inactivated with HPV to promote cancer progression. Here we explored the effects of crocin on cervical cancer cells, mainly on autophagy and apoptosis.SiHa cells were treated with crocin, and proliferation, metastases, apoptosis and autophagy were measured using a CCK-8 assay, transwell migration assay, flow cytometry and immunofluorescence. Protein levels were measured using western blotting. The antitumor ...
Tópico(s): Bioactive natural compounds
2020 - AME Publishing Company | Annals of Translational Medicine
Masayoshi Kukida, Masaki Mogi, Harumi Kan‐no, Kana Tsukuda, Hui‐Yu Bai, Bao‐Shuai Shan, Toshifumi Yamauchi, Akinori Higaki, Li‐Juan Min, Jun Iwanami, Takafumi Okura, Jitsuo Higaki, Masatsugu Horiuchi,
Vascular calcification is a common finding in atherosclerosis and in patients with chronic kidney disease. The renin-angiotensin system plays a role in the pathogenesis of cardiovascular remodeling. Here, we examined the hypothesis that angiotensin II type 2 receptor (AT2) stimulation has inhibitory effects on phosphate-induced vascular calcification. In vivo, calcification of the thoracic aorta induced by an adenine and high-phosphate diet was markedly attenuated in smooth muscle cell-specific AT2- ...
Tópico(s): Thyroid and Parathyroid Surgery
2018 - Elsevier BV | Kidney International
Misato Kikuchi, Yu Akahoshi, Hirofumi Nakano, Tomotaka Ugai, Hidenori Wada, Ryo Yamasaki, Kana Sakamoto, Koji Kawamura, Yu Ishihara, Miki Sato, Masahiro Ashizawa, Kiriko Terasako‐Saito, Shun‐ichi Kimura, Rie Yamazaki, Junya Kanda, Shinichi Kako, Junji Nishida, Yoshinobu Kanda,
Abstract Background Bloodstream infections ( BSI ) are frequently observed after allogeneic hematopoietic stem cell transplant ( HSCT ), and could cause morbidity and mortality. Methods We retrospectively evaluated the incidence, characteristics of, and risk factors for BSI at both pre‐ and post‐engraftment in 209 adult HSCT patients at our institute between June 2006 and December 2013. The median age at transplantation was 45 years (range, 15–65). A total of 122 patients received bone marrow, 68 received ...
Tópico(s): Infections and bacterial resistance
2015 - Wiley | Transplant Infectious Disease
Emi Sano, Chihiro Mori, Naoki Matsuoka, Yuka Ozaki, Keisuke Yagi, Aya Wada, Koichi Tashima, Shinsuke Yamasaki, Kana Tanabe, Kayo Yano, Yu‐suke Torisawa,
Organs-on-chips are microfluidic devices typically fabricated from polydimethylsiloxane (PDMS). Since PDMS has many attractive properties including high optical clarity and compliance, PDMS is very useful for cell culture applications; however, PDMS possesses a significant drawback in that small hydrophobic molecules are strongly absorbed. This drawback hinders widespread use of PDMS-based devices for drug discovery and development. Here, we describe a microfluidic cell culture system made of a tetrafluoroethylene- ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2019 - Multidisciplinary Digital Publishing Institute | Micromachines
Takuya Mori, Norikazu Maeda, Kana Inoue, Ryohei Sekimoto, Yu Tsushima, Keisuke Matsuda, Masaya Yamaoka, Takayoshi Suganami, Hitoshi Nishizawa, Yoshihiro Ogawa, Tohru Funahashi, Iichiro Shimomura,
AimsEphrin-B1 (EfnB1) was selected among genes of unknown function in adipocytes or adipose tissue and subjected to thorough analysis to understand its role in the development of obesity. Methods and ResultsEfnB1 mRNA and protein levels were significantly decreased in adipose tissues of obese mice and such reduction was mainly observed in mature adipocytes. Exposure of 3T3-L1 adipocytes to tumor necrosis factor-α (TNF-α) and their culture with RAW264.7 cells reduced EFNB1 levels. Knockdown of adipose ...
Tópico(s): Biomarkers in Disease Mechanisms
2013 - Public Library of Science | PLoS ONE
Tianhe Wang, Ziyan Zhu, Inoue Kana, Yuanzheng Yu, Hao He, Kunlin Wei,
Abstract Accumulating evidence indicates that the spatial error of human's hand localization appears subject-specific. However, whether the idiosyncratic pattern persists across time with good within-subject consistency has not been adequately examined. Here we measured the hand localization map by a Visual-matching task in multiple sessions over 2 days. Interestingly, we found that participants improved their hand localization accuracy when tested repetitively without performance feedback. Importantly, ...
Tópico(s): Action Observation and Synchronization
2020 - Nature Portfolio | Scientific Reports
Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hirofumi Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe,
Ubiquitin chains are formed with 8 structurally and functionally distinct polymers. However, the functions of each polyubiquitin remain poorly understood. We developed a polyubiquitin-mediated fluorescence complementation (PolyUb-FC) assay using Kusabira Green (KG) as a split fluorescent protein. The PolyUb-FC assay has the advantage that monoubiquitination is nonfluorescent and chain-specific polyubiquitination can be directly visualized in living cells without using antibodies. We applied the PolyUb- ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2017 - Taylor & Francis | Autophagy
Xiaoli Wang, Jun Iwanami, Li‐Juan Min, Kana Tsukuda, Hirotomo Nakaoka, Hui‐Yu Bai, Bao‐Shuai Shan, Harumi Kan‐no, Masayoshi Kukida, Toshiyuki Chisaka, Toshifumi Yamauchi, Akinori Higaki, Masaki Mogi, Masatsugu Horiuchi,
Abstract The classical renin–angiotensin system (RAS), known as the angiotensin (Ang)-converting enzyme (ACE)/Ang II/Ang II type 1 (AT1) receptor axis, induces various organ damages including cognitive decline. On the other hand, the ACE2/Ang-(1–7)/Mas receptor axis has been highlighted as exerting antagonistic actions against the classical RAS axis in the cardiovascular system. However, the roles of the ACE2/Ang-(1–7)/Mas axis in cognitive function largely remain to be elucidated, and we therefore ...
Tópico(s): Apelin-related biomedical research
2016 - Nature Portfolio | npj Aging and Mechanisms of Disease
Toshiyuki Chisaka, Masaki Mogi, Hirotomo Nakaoka, Harumi Kan‐no, Kana Tsukuda, Xiaoli Wang, Hui‐Yu Bai, Bao‐Shuai Shan, Masayoshi Kukida, Jun Iwanami, Takashi Higaki, Eiichi Ishii, Masatsugu Horiuchi,
We investigated the effects of fetal growth restriction (FGR) induced by maternal protein restriction on inflammatory vascular remodeling using a cuff-induced vascular injury mouse model. Dams (C57BL/6J strain mice) were fed an isocaloric diet containing 20% protein (normal protein; NP) or 8% protein (low protein; LP) from 10 weeks of age until delivery. On the day of delivery, all dams were returned to the NP diet. After weaning, offspring were fed the NP diet. When offspring were 10 weeks of age, ...
Tópico(s): Gestational Diabetes Research and Management
2015 - Oxford University Press | American Journal of Hypertension
Vendula Krynická, Martin Tichý, Jaroslav Krafl, Jianfeng Yu, Radek Kaňa, Marko Boehm, Peter J. Nixon, Josef Komenda,
The cyanobacterium Synechocystis sp. PCC 6803 expresses four different FtsH protease subunits (FtsH1-4) that assemble into specific homo- and heterocomplexes. The FtsH2/FtsH3 complex is involved in photoprotection but the physiological roles of the other complexes, notably the essential FtsH1/FtsH3 complex, remain unclear. Here we show that the FtsH1 and FtsH3 proteases are involved in the acclimation of cells to iron deficiency. A mutant conditionally depleted in FtsH3 was unable to induce normal ...
Tópico(s): Aquatic Ecosystems and Phytoplankton Dynamics
2014 - Wiley | Molecular Microbiology
Koji Kawamura, Hidenori Wada, Ryo Yamasaki, Yu Ishihara, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Tomohito Machishima, Kiriko Terasako, Shun‐ichi Kimura, Misato Kikuchi, Hideki Nakasone, Rie Yamazaki, Junya Kanda, Shinichi Kako, Aki Tanihara, Junji Nishida, Yoshinobu Kanda,
Currently, acyclovir (ACV) at 1000 mg/day is widely used as prophylaxis in the early phase of hematopoietic stem cell transplant (HSCT) in Japan. However, low-dose ACV (200 mg/day) has been shown to prevent varicella zoster virus reactivation in the middle and late phases of HSCT.Therefore, in this study, we decreased the dose of ACV to 200 mg/day in the early phase after HSCT. We analyzed 93 consecutive herpes simplex virus (HSV)-seropositive patients who underwent allogeneic HSCT for the first time ...
Tópico(s): Polyomavirus and related diseases
2013 - Wiley | Transplant Infectious Disease
Kousei Ohshima, Masaki Mogi, Hirotomo Nakaoka, Jun Iwanami, Li‐Juan Min, Harumi Kan‐no, Kana Tsukuda, Toshiyuki Chisaka, Hui‐Yu Bai, Xiaoli Wang, Akiyoshi Ogimoto, Jitsuo Higaki, Masatsugu Horiuchi,
Cross talk between the angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/Ang II type 1 (AT 1 ) receptor axis and the ACE2/Ang-(1–7)/Mas axis plays a role in the pathogenesis of cardiovascular remodeling. Furthermore, possible stimulation of the Ang II type 2 (AT 2 ) receptor by Ang-(1–7) has been highlighted as a new pathway. Therefore, we examined the possibility of whether the ACE2/Ang-(1–7)/Mas axis and Ang-(1–7)/AT 2 receptor axis are involved in the inhibitory effects of AT 1 receptor blockers ...
Tópico(s): Hormonal Regulation and Hypertension
2013 - Lippincott Williams & Wilkins | Hypertension
Kayo Kuroyanagi, Min‐Sook Kang, Tsuyoshi Goto, Shizuka Hirai, Kana Ohyama, Tatsuya Kusudo, Rina Yu, Masamichi Yano, Takao Sasaki, Nobuyuki Takahashi, Teruo Kawada,
Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-α and PPARγ. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments ...
Tópico(s): Adipose Tissue and Metabolism
2007 - Elsevier BV | Biochemical and Biophysical Research Communications
Rim Nefissi Ouertani, Yu Natsui, Kana Miyata, Atsushi Oda, Yoshihiro Hase, Mayu Nakagawa, Abdelwahed Ghorbel, Tsuyoshi Mizoguchi,
The photoperiodic response is one of the adaptation mechanisms to seasonal changes of lengths of day and night. The circadian clock plays pivotal roles in this process. In Arabidopsis, LHY, CCA1, ELF3, and other clock proteins play major roles in maintaining circadian rhythms. lhy;cca1 double mutants with severe defects in circadian rhythms showed accelerated flowering under short days (SDs), but delayed flowering under continuous light (LL). The protein level of the floral repressor SVP increased ...
Tópico(s): Photosynthetic Processes and Mechanisms
2011 - Oxford University Press | Journal of Experimental Botany
Anna Di Nardo, Yu-Ling Chang, Shahrzad Alimohammadi, Kana Masuda‐Kuroki, Zhenping Wang, Krishna Sriram, Paul A. Insel,
Activation and degranulation of mast cells (MCs) is an essential aspect of innate and adaptive immunity. Skin MCs, the most exposed to the external environment, are at risk of quickly degranulating with potentially severe consequences. Here, we define how MCs assume a tolerant phenotype via crosstalk with dermal fibroblasts (dFBs) and how this phenotype reduces unnecessary inflammation when in contact with beneficial commensal bacteria. We explore the interaction of human MCs (HMCs) and dFBs in the ...
Tópico(s): Dermatology and Skin Diseases
2023 - Cell Press | Cell Reports
Kana Shimada, Taka-aki Okabe, Yu Mikami, Miki Hattori, Masatoshi Fujita, Chiharu Kishimoto,
We systematically investigated serial efficacy of granulocyte colony-stimulating factor (G-CSF) therapy upon experimental autoimmune myocarditis (EAM) in rats treated with and without the inhibition of nitric oxide (NO) with the analyses of tissue regeneration. G-CSF could mobilize multipotent progenitor cells of bone marrow into the peripheral blood and may improve ventricular function. A rat model of porcine myosin-induced EAM was used. After the immunization of myosin, G-CSF (10 μg/kg/day) or saline ...
Tópico(s): Transplantation: Methods and Outcomes
2010 - Elsevier BV | Journal of Molecular and Cellular Cardiology
Shinya Furukawa, Yoshio Ikeda, Sen Yagi, Teruki Miyake, Kana Shiraishi, Kazuhiro Tange, Yu Hashimoto, Kenichirou Mori, Tomoyuki Ninomiya, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Aki Hasebe, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoichi Hiasa,
Monocytes play an important role in innate immunity. Some epidemiological evidence indicates an association between peripheral blood monocytes and ulcerative colitis (UC). The association between peripheral blood monocytes and mucosal healing (MH), however, remains unclear. We evaluated this issue in patients with UC.Study subjects consisted of 272 Japanese patients with UC. Monocyte counts were taken in the morning after overnight fasting. Monocyte count was divided into tertiles based on the distribution ...
Tópico(s): IL-33, ST2, and ILC Pathways
2021 - Lippincott Williams & Wilkins | Clinical and Translational Gastroenterology
Toshihisa Hiraiwa, Kazuhiro Moriyama, Kana Matsumoto, Yasuyo Shimomura, Yu Kato, Chizuru Yamashita, Yoshitaka Hara, Takahiro Kawaji, Yasuyoshi Kurimoto, Tomoyuki Nakamura, Naohide Kuriyama, Junpei Shibata, Hidefumi Komura, Kunihiko Morita, Osamu Nishida,
<b><i>Introduction:</i></b> Renal replacement therapy (RRT) is widely used in the treatment of septic acute kidney injury. However, little is known about how the adsorption properties of hemofilters used in RRT affect antibiotic concentration. Because a cytokine-adsorption membrane is frequently used in RRT, it is important to determine the antibiotic adsorption capacity of this membrane. <b><i>Objective:</i></b> The present study aimed to investigate the ...
Tópico(s): Dialysis and Renal Disease Management
2020 - Karger Publishers | Blood Purification
Kana Ikemoto, Shinya Kobayashi, Yu Haranosono, Seiko Kozai, Tomoyuki Wada, Hideki Tokushige, Akio Kawamura,
Abstract Background We aimed to demonstrate the contribution of anti-inflammatory and anti-virulence effects of azithromycin (AZM) in ocular surface infection treatment. Methods Staphylococcus aureus was injected into the corneal stroma of rabbits to induce keratitis. AZM at concentrations of 0.01, 0.1, and 1% was instilled into the eye twice daily. The eyes were examined using a slit lamp and scored. The viable bacteria in the cornea were counted at 48 h post infection. To evaluate the anti-inflammatory ...
Tópico(s): Immune Response and Inflammation
2020 - BioMed Central | BMC Ophthalmology
Jian Zhang, Zhong‐Mei Yang, Yu Huang, Kana Wang, Yao Xie, Nian Yang,
To investigate the role of the lncRNA growth arrest special 5 (GAS5) in ovarian clear cell carcinoma (OCCC), we measured the expression of GAS5 and miR-31-5p in OCCC tissue samples and OCCC cell lines using RT-qPCR. MTT and colony formation assays were used to measure cell viability and colony formation ability. Cell invasion was determined by Transwell assays. The binding between GAS5 and miR-31-5p as well as miR-31-5p and ARID1A was determined by dual-luciferase reporter assays. The ARID1A protein ...
Tópico(s): RNA modifications and cancer
2021 - Wiley | The Kaohsiung Journal of Medical Sciences
Chiaki Maeyashiki, Shigeru Oshima, Kana Otsubo, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe,
Genome-wide association studies have identified autophagy-related susceptibility genes for inflammatory bowel disease (IBD); however, whether autophagy regulators can be utilized as therapeutic targets remains unclear. To identify novel microtubule-associated protein 1 light chain 3 (LC3)-interacting proteins in intestinal epithelial cells (IECs), we isolated primary IECs from green fluorescent protein (GFP)-LC3 mice. We performed immunoprecipitation with a GFP antibody and then analyzed co-immunoprecipitates ...
Tópico(s): Gut microbiota and health
2017 - Elsevier BV | Biochemical and Biophysical Research Communications
Hideki Nakasone, Y Tanaka, Rie Yamazaki, Kiriko Terasako, Miki Sato, Kana Sakamoto, Ryo Yamasaki, Hidenori Wada, Yu Ishihara, Koji Kawamura, Tomohito Machishima, Masahiro Ashizawa, S-i Kimura, Misato Kikuchi, Aki Tanihara, Junya Kanda, Shinichi Kako, Junji Nishida, Yoshinobu Kanda,
Cellular immunity is important for the control of CMV infection after allogeneic hematopoietic cell transplantation (Allo-HCT). However, the actual in vivo dynamics of CMV-specific cytotoxic T cell (CMV-CTL) clones are still unclear. We conducted clone monitoring of tetramer+ CMV-CTLs in HLA-A*2402-positive donor–patient pairs, using a direct single-cell analysis that enabled the simultaneous identification and quantification of CTL clones. Clone dynamics were assessed in three cases with or without ...
Tópico(s): Immune Cell Function and Interaction
2013 - Springer Nature | Bone Marrow Transplantation
Miki Sato, Shinichi Kako, Kana Matsumoto, Kumi Oshima, Yu Akahoshi, Hirofumi Nakano, Tomotaka Ugai, Ryoko Yamasaki, Hidenori Wada, Yuko Ishihara, Kana Sakamoto, Koji Kawamura, Masahiro Ashizawa, Kiriko Terasako‐Saito, Shun-ichi Kimura, Hideki Nakasone, Misato Kikuchi, Aki Tanihara, Rie Yamazaki, Yukië Tanaka, Junya Kanda, Junji Nishida, Kunihiko Morita, Yoshinobu Kanda,
Tópico(s): Acute Myeloid Leukemia Research
2015 - Springer Science+Business Media | International Journal of Hematology
Yuta Hiraike, Hironori Waki, Jing Yu, Masahiro Nakamura, Kana Miyake, Gaku Nagano, Ryo Nakaki, Ken Suzuki, Hirofumi Kobayashi, Shogo Yamamoto, Wei Sun, Tomohisa Aoyama, Yusuke Hirota, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Andrew P. White, Yu‐Hua Tseng, Aaron M. Cypess, Therese Juhlin Larsen, Naja Z. Jespersen, Camilla Schéele, Shuichi Tsutsumi, Hiroyuki Aburatani, Toshimasa Yamauchi, Takashi Kadowaki,
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2017 - Nature Portfolio | Nature Cell Biology
Shujie Xie, Xiang Li, Yan Jia, Hua Yu, Shuhuai Chen, Kana Chen,
Abstract Introduction Tumor‐associated macrophages, a major component of the tumor microenvironment, undergo polarization into M2 macrophages (M2), and thereby exert an immunosuppressive effect to induce cancer metastasis. This study strives to uncover a molecular mechanism underlying this event in hepatocellular carcinoma (HCC). Methods Proteasome subunit alpha 5 (PSMA5) expression in liver hepatocellular carcinoma (LIHC) tissues and its association with LIHC patients were predicted using StarBase. ...
Tópico(s): Ferroptosis and cancer prognosis
2024 - Wiley | Immunity Inflammation and Disease
Kana Saito, Yu Kaiho, Toru Tamii, Tadaho Nakamura, Eri Kameyama, Masanori Yamauchi,
Tópico(s): Blood transfusion and management
2019 - Springer Science+Business Media | Journal of Anesthesia