Keita Mizuno, Toshiaki Kume, C. Muto, Yuki Takada‐Takatori, Yasuhiko Izumi, Hachiro Sugimoto, Akinori Akaike,
Oxidative stress plays pivotal roles in aging, neurodegenerative disease, and pathological conditions such as ischemia. We investigated the effect of sulforaphane and 6-(methysulfinyl) hexyl isothiocyanate (6-HITC), a naturally occurring isothiocyanate, on oxidative stress–induced cytotoxicity using primary neuronal cultures of rat striatum. Pretreatment with sulforaphane and 6-HITC significantly protected against H2O2- and paraquat-induced cytotoxicity in a concentration-dependent manner. Sulforaphane ...
Tópico(s): Sulfur Compounds in Biology
2011 - Elsevier BV | Journal of Pharmacological Sciences
T. Tamae, Mitsuru Sugawara, Katsuhisa Yoshida, O. Konno, T. Sasanuma, M. Muto, Yuki Shibazaki, T. Tanaka, M. Hirooka, Ken Yamada, T. Terasawa, S. Urasawa, T. Ichinohe, Shoichi Takahashi, H. Miyase, Yoshiyuki Kawazoe, S. Yamamoto, Y. Torizuka,
Abstract This paper describes the Tohoku University 150 MeV pulse stretcher and its operation and use. The ring accepts a pulsed beam from the electron linac and produces a continuous current. An extracted beam of 1 μA has been obtained with a duty factor of 80%. The energy spread of the extracted beam was measured to be 0.2%. The stretcher supplies this continuous beam for use in coincidence experiments. Presently (e, e′p) and tagged photon experiments are being successfully performed.
Tópico(s): Pulsed Power Technology Applications
1988 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment
Takashi Abe, Hachiro Inokuchi, Yuko Yamada, Akira Muto, Yuki Iwasaki, Toshimichi Ikemura,
The tRNA Gene Data Base Curated by Experts "tRNADB-CE" (http://trna.ie.niigata-u.ac.jp) was constructed by analyzing 1,966 complete and 5,272 draft genomes of prokaryotes, 171 viruses', 121 chloroplasts', and 12 eukaryotes' genomes plus fragment sequences obtained by metagenome studies of environmental samples. 595,115 tRNA genes in total, and thus two times of genes compiled previously, have been registered, for which sequence, clover-leaf structure, and results of sequence-similarity and oligonucleotide- ...
Tópico(s): RNA and protein synthesis mechanisms
2014 - Frontiers Media | Frontiers in Genetics
Masaaki Kotera, Yasuo Tabei, Yoshihiro Yamanishi, Ai Muto, Yuki Moriya, Toshiaki Tokimatsu, Susumu Goto,
Abstract Motivation: Metabolic pathway analysis is crucial not only in metabolic engineering but also in rational drug design. However, the biosynthetic/biodegradation pathways are known only for a small portion of metabolites, and a vast amount of pathways remain uncharacterized. Therefore, an important challenge in metabolomics is the de novo reconstruction of potential reaction networks on a metabolome-scale. Results: In this article, we develop a novel method to predict the multistep reaction ...
Tópico(s): Microbial Natural Products and Biosynthesis
2014 - Oxford University Press | Bioinformatics
Xinghui Li, Wei Gao, Hiroshi Muto, Yuki Shimizu, So Ito, Songyi Dian,
This paper presents a multi-axis surface encoder that can measure six-degree-of-freedom (six-DOF) translational displacement motions and angular motions of a planar motion stage. The six-DOF surface encoder is composed of a planar scale grating and an optical sensor head. A blue laser diode with a wavelength of 405 nm and an output power of 25 mW was employed as the light source of the sensor head. The light rays from the laser diode were collimated to a parallel beam with a diameter of 1.8 mm. The ...
Tópico(s): Optical measurement and interference techniques
2013 - Elsevier BV | Precision Engineering
Satoshi Muto, Yuki Owada, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Hiroyuki Suzuki, Mitsukazu Gotoh,
The functions of different regulatory T cell (Treg) types in cancer progression are unclear. Recently, expression of the transcription factor Helios was proposed as a marker for natural (non-induced) Tregs. The present study investigated the clinical significance of Helios expression in patients with non-small cell lung cancer (NSCLC). We enrolled 64 patients with NSCLC, of whom 45 were treated surgically and 19 received chemotherapy because of advanced/recurrent disease. Their peripheral blood mononuclear ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2015 - Spandidos Publishing | International Journal of Oncology
Hiroyuki Suzuki, Jun Osugi, Satoshi Muto, Yuki Matsumura, Mitsunori Higuchi, Mitsukazu Gotoh,
The present study compared the prognostic value of the Glasgow prognostic score (GPS), modified GPS (mGPS), high-sensitivity mGPS (HS-mGPS), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), prognostic index (PI), and prognostic nutritional index (PNI) in patients with resectable non-small cell lung cancer (NSCLC).This retrospective study included 327 consecutive patients with resectable NSCLC with a follow.-up period. >5. years. Initially, the HS-mGPS was directly compared with the GPS ...
Tópico(s): Cancer, Lipids, and Metabolism
2016 - BioMed Central | Journal of Cancer Research and Therapeutics
Yu Takahashi, Alisa Kongjaimun, Chiaki Muto, Yuki Kobayashi, Masahiko Kumagai, Hiroaki Sakai, Kazuhito Satou, Kuniko Teruya, Akino Shiroma, Makiko Shimoji, Takashi Hirano, Takehisa Isemura, Hiroki Saito, Akiko Baba-Kasai, Akito Kaga, Prakit Somta, Norihiko Tomooka, Ken Naito,
Loss of pod shattering is one of the most important domestication-related traits in legume crops. The non-shattering phenotypes have been achieved either by disturbed formation of abscission layer between the valves, or by loss of helical tension in sclerenchyma of endocarp, that split open the pods to disperse the seeds. During domestication, azuki bean (Vigna angularis) and yard-long bean (Vigna unguiculata cv-gr. Sesquipedalis) have reduced or lost the sclerenchyma and thus the shattering behavior ...
Tópico(s): Soybean genetics and cultivation
2020 - Frontiers Media | Frontiers in Genetics
Satoshi Muto, Yuki Ozaki, Hikaru Yamaguchi, Hayato Mine, Hironori Takagi, Masayuki Watanabe, Takuya Inoue, Takumi Yamaura, Mitsuro Fukuhara, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Hideaki Nanamiya, Jun‐ichi Imai, Takao Isogai, Shinya Watanabe, Hiroyuki Suzuki,
β‑catenin expression by tumor cells suppressed dendritic cell recruitment to the tumor microenvironment in a melanoma model, resulting in fewer tumor‑infiltrating lymphocytes. Immunohistochemistry was used in the present study to examine the association between the expression of β‑catenin and tumor infiltrating lymphocytes and CD11c + cells in 122 patients with non‑small cell lung cancer (NSCLC), who underwent radical surgery. β‑catenin was positive in 24% of NSCLC tumors compared with 59% of squamous ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2021 - Spandidos Publishing | Oncology Letters
Akinori Muto, Yuki Hirayama, Hayato Tokumoto, Akira Matsuoka, Koji Noishiki,
Lithium ions were extracted from aqueous solutions into cyclohexane containing di-(2-ethylhexyl)phosphoric acid (D2EHPA) through slug flow in millimeter-diameter glass and polytetrafluoroethylene (PTFE) tubes. The PTFE tube produced a higher initial mass transfer coefficient than the glass tube by increasing internal circulation in the organic phase, and maintained its specific surface area. Slug flow occurred in the PTFE tube when the interfacial tension between the aqueous and organic phases exceeded ...
Tópico(s): Electrowetting and Microfluidic Technologies
2016 - Taylor & Francis | Solvent Extraction and Ion Exchange
Yuki Muto, Takayuki Shiraiwa, Manabu Enoki,
Compression tests of directionally solidified (DS) Mg85Zn6Y9 alloys were conducted from surface observations and acoustic emission (AE) measurements. In the compression tests, deformation bands were generated in the early deformation stage. The number of microcracks started to increase from approximately 100 MPa and rapidly increased around the yielding point. Clustering analysis was applied to the extracted AE events in the compression tests. The AE events were divided into two clusters. The observation ...
Tópico(s): Aluminum Alloys Composites Properties
2017 - Elsevier BV | Materials Science and Engineering A
Hiroaki Yokoyama, Tetsuya Tobaru, Yuki Muto, Kenichi Hagiya, Ryosuke Higuchi, Mike Saji, Itaru Takamisawa, Jun Shimizu, Shuichiro Takanashi, Morimasa Takayama, Hirofumi Tomita, Harutoshi Tamura, Shinichiro Doi, Shinya Okazaki, Mitsuaki Isobe,
Japan is an aging society, and the number of nonagenarians with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) is increasing, but their outcomes have not been determined fully.We prospectively enrolled 767 consecutive patients who underwent TAVI in three Japanese institutions. Clinical characteristics and outcomes of nonagenarians (n = 94) were evaluated and compared with those of patients aged <90 years (n = 673).Prevalence of New York Heart Association (NYHA) class III/ ...
Tópico(s): Cardiac Imaging and Diagnostics
2019 - Wiley | Clinical Cardiology
Kentaro Oniki, Hirofumi Nohara, Ryunosuke Nakashima, Yui Obata, Narumi Muto, Yuki Sakamoto, Keiko Ueno-Shuto, Tadashi Imafuku, Yu Ishima, Hiroshi Watanabe, Toru Maruyama, Koji Otake, Yasuhiro Ogata, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto, Junji Saruwatari,
Oxidative stress and inflammation play a key role in the age-related decline in the respiratory function. Adipokine in relation to the metabolic and inflammatory systems is attracting growing interest in the field of respiratory dysfunction. The present clinical and experimental studies investigated the role of the disulfide bond-forming oxidoreductase A-like protein (DsbA-L) gene, which has antioxidant and adiponectin multimeric (i.e. activation) properties, on the respiratory function of the elderly. ...
Tópico(s): Exercise and Physiological Responses
2020 - Nature Portfolio | Scientific Reports
This paper proposes a method for generating user profile from user's TV watching behavior using sentiment analysis. Personalized technologies such as information recommendation are currently hot topic of Web intelligence. Among them, TV program recommendation is expected to be one of the practical applications in near future, as digital TV service and partner robots providing personalized support are getting into our living environment. The proposed method does not estimate user's interest in a ...
Tópico(s): Video Analysis and Summarization
2007 - IOS Press | Web Intelligence
Masayuki Watanabe, Tomohito Higashi, Kana Ozeki, Atsuko Y. Higashi, Kotaro Sugimoto, Hayato Mine, Hironori Takagi, Yuki Ozaki, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Yutaka Shio, Hiroyuki Suzuki, Hideki Chiba,
Abstract Malignant mesothelioma is a cancer with a poor survival rate. It is difficult to diagnose mesotheliomas because they show a variety of histological patterns similar to those of various other cancers. However, since currently used positive markers for mesotheliomas may show false positives or false negatives, a novel mesothelial positive marker is required. In the present study, we screened 25 claudins and found that claudin-15 is expressed in the mesothelial cells. We made new rat anti- ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2021 - Nature Portfolio | Scientific Reports
Futa Nakatani, Tomofumi Ienaga, Xiao Wu, Yusuke Tahara, Hidekazu Ikezaki, Hiroyuki Sano, Yuki Muto, Yuya Kaneda, Kiyoshi Toko,
The saltiness enhancement effect is the effect whereby saltiness is enhanced by adding specific substances to salt (sodium chloride). Since this effect can be used in the development of salt-reduced foods, a method to objectively evaluate the saltiness with this effect is required. A taste sensor with lipid/polymer membranes has been used to quantify the taste of food and beverages in recent years. The sensor electrodes of this taste sensor have the feature of selectively responding to each of the ...
Tópico(s): Electrochemical sensors and biosensors
2019 - Multidisciplinary Digital Publishing Institute | Sensors
Takumi Yamaura, Junji Ezaki, Naoyuki Okabe, Hironori Takagi, Yuki Ozaki, Takuya Inoue, Yuzuru Watanabe, Mitsuro Fukuhara, Satoshi Muto, Yuki Matsumura, Takeo Hasegawa, Mika Hoshino, Jun Osugi, Yutaka Shio, Satoshi Waguri, Hirosumi Tamura, Jun‐ichi Imai, Emi Ito, Yuka Yanagisawa, Reiko Honma, Shinya Watanabe, Hiroyuki Suzuki,
Lung adenocarcinoma (ADC) patients with tumors that harbor no targetable driver gene mutation, such as epidermal growth factor receptor (EGFR) gene mutations, have unfavorable prognosis, and thus, novel therapeutic targets are required. Family with sequence similarity 83, member B (FAM83B) is a biomarker for squamous cell lung cancer. FAM83B has also recently been shown to serve an important role in the EGFR signaling pathway. In the present study, the molecular and clinical impact of FAM83B in lung ...
Tópico(s): Cancer-related gene regulation
2017 - Spandidos Publishing | Oncology Letters
Takuya Inoue, Hironori Takagi, Yuki Owada, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Hiroshi Yokouchi, Kenya Kanazawa, Katsuya Ohbuchi, Takahisa Fukushima, Mitsuru Munakata, Hiroyuki Suzuki,
Cisplatin is a key drug in lung cancer therapy. However, cisplatin is also well known to induce gastrointestinal disorders, such as chemotherapy-induced nausea and vomiting, anorexia, and weight loss. These symptoms sometimes affect patients' quality of life and make continuation of chemotherapy difficult. Anorexia is a cause of concern for patients with cancer because a persistent loss of appetite progresses to cancer cachexia. Although evidence-based management for chemotherapy has recently been ...
Tópico(s): Cancer survivorship and care
2017 - Springer Science+Business Media | Trials
Jun Osugi, Yuka Kimura, Yuki Owada, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Athushi Yonechi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Hiroyuki Suzuki, Mitsukazu Gotoh,
Objective . The aim of this study was to investigate the prognostic value of MicroRNA-210 ( miR-210 ) expression in patients with non-small-cell lung cancer (NSCLC). Methods . We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results . miR-210 expression ...
Tópico(s): Cancer-related molecular mechanisms research
2015 - Hindawi Publishing Corporation | Journal of Oncology
Wei Gao, Yûsuke Saito, Hiroshi Muto, Yoshikazu Arai, Yuki Shimizu,
Tópico(s): Surface Roughness and Optical Measurements
2011 - Elsevier BV | CIRP Annals
Jun Osugi, Takumi Yamaura, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Mika Hoshino, Mitunori Higuchi, Hiroyuki Suzuki, Mitsukazu Gotoh,
Objective Metabolic alternations are deemed a hallmark of cancer cells. Among many metabolic pathways, glycolysis and lipogenesis are essential metabolic processes in cancer cells. In this study, we examined the prognostic impact of the combined expression of glycolysis-related glucose transporter 1 (GLUT1) and ATP-citrate lyase (ACLY), which are important molecules in lipogenesis, in patients with non-small cell lung cancer (NSCLC). Materials and methods GLUT1 and ACLY expression in 134 NSCLC specimens ...
Tópico(s): Metabolism, Diabetes, and Cancer
2015 - Elsevier BV | Lung Cancer
Kohei Muto, Naoko Matsui, Yuki Unai, Waka Sakai, Shotaro Haji, Kengo Udaka, Hirokazu Miki, Takahiro Furukawa, Masahiro Abe, Ryuji Kaji,
The immunologic effects of rituximab (RTX) in myasthenia gravis (MG) remain to be explored. We aimed to clarify immunologic reactions and their association with response to RTX in MG. Regulatory T cell and B cell profiles of MG patients were monitored. Two patients presenting with generalized MG with anti-acetylcholine receptor antibodies were treated with RTX. The treatment led to sustained clinical improvement, discontinuation of intravenous immunoglobulin or plasma exchange, and reduction of prednisolone ...
Tópico(s): Peripheral Neuropathies and Disorders
2017 - Elsevier BV | Neuromuscular Disorders
Mitsunori Higuchi, Hironori Takagi, Yuki Owada, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Atsushi Yonechi, Jun Osugi, Mika Hoshino, Yutaka Shio, Koichi Fujiu, Ryuzo Kanno, Akio Ohishi, Hiroyuki Suzuki, Mitsukazu Gotoh,
The present retrospective multi-center study aimed to evaluate the efficacy and feasibility of nanoparticle albumin-bound (nab)-paclitaxel plus carboplatin as a second or late-phase chemotherapy in patients with non-small cell lung cancer (NSCLC). A total of 25 patients with recurrent or advanced NSCLC who had received previous chemotherapy were treated with nab-paclitaxel (70-100 mg/m2, intravenously) on days 1, 8 and 15 every 28 days with a carboplatin area under the concentration-time curve of 4- ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2017 - Spandidos Publishing | Oncology Letters
Masaaki Kotera, Yosuke Nishimura, Zenichi Nakagawa, Ai Muto, Yuki Moriya, Shinobu Okamoto, Shuichi Kawashima, Toshiaki Katayama, Toshiaki Tokimatsu, Minoru Kanehisa, Susumu Goto,
Genomics is faced with the issue of many partially annotated putative enzyme-encoding genes for which activities have not yet been verified, while metabolomics is faced with the issue of many putative enzyme reactions for which full equations have not been verified. Knowledge of enzymes has been collected by IUBMB, and has been made public as the Enzyme List. To date, however, the terminology of the Enzyme List has not been assessed comprehensively by bioinformatics studies. Instead, most of the ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2014 - Imperial College Press | Journal of Bioinformatics and Computational Biology
... Doped Graphene for Electrochemical Oxygen ReductionMasaru Kato, Marika Muto, Naohiro Matsubara, Yohei Uemura and Yuki Wakisaka et al.9 April 2018 | ACS Applied ...
Tópico(s): Non-Destructive Testing Techniques
1996 - World Scientific | Series on synchrotron radiation techniques and applications
Yuki Yano-Ozawa, Nadine Lobsiger, Yu Muto, Takahiro Mori, Ken Yoshimura, Yuki Yano, Wendelin J. Stark, Mizuo Maeda, Tsuyoshi Asahi, Atsushi Ogawa, Tamotsu Zako,
Gold nanoparticles (AuNPs) are often used for biosensing. In particular, aptamer-modified AuNPs are often used for colorimetric molecular detection, where target molecule-induced AuNP aggregates can be recognized by a color change from red to blue. However, non-specific aggregation could be induced by various compounds, leading to false-positive results. In this work we employed high-density ssDNA modification on the AuNP surface to prevent non-specific aggregation. The covalently immobilized DNA ...
Tópico(s): Gold and Silver Nanoparticles Synthesis and Applications
2021 - Royal Society of Chemistry | RSC Advances
Hanako Saito, K. Taniwaka, Taichiro Muto, Yuki Morioka, Ryuzaburo Shinaha, Satoshi Mori, Y. Matsubara, Naoichi Sato, Kazuo Muto, Mutsuo Ishikawa, Junko Yura, M. Iwasa, Shohei Ogoshi, Kikuo Okamura, Hironobu Koseki, Toshitada Okuma,
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
1992 - Elsevier BV | Clinical Nutrition
T. Ohtsuki, Heimei Yuki, M. Muto, J. Kasagi, Kaoru Ohno,
The decay rate of $^{\mathrm{7}}\mathrm{B}\mathrm{e}$ electron capture was measured in ${\mathrm{C}}_{60}$ and Be metal with a reference method. The half-life of $^{\mathrm{7}}\mathrm{B}\mathrm{e}$ endohedral ${\mathrm{C}}_{\mathrm{60}}$ ($^{\mathrm{7}}\mathrm{B}\mathrm{e}\mathrm{@}{\mathrm{C}}_{\mathrm{60}}$) and $^{\mathrm{7}}\mathrm{B}\mathrm{e}$ in Be metal (Be metal ($^{\mathrm{7}}\mathrm{B}\mathrm{e}$)) is found to be $52.68\ifmmode\pm\else\textpm\fi{}0.05$ and $53.12\ifmmode\pm\else\textpm\fi{}0.05$ days, respectively. ...
Tópico(s): Carbon Nanotubes in Composites
2004 - American Physical Society | Physical Review Letters
Yuki Ozaki, Satoshi Muto, Hironori Takagi, Masayuki Watanabe, Takuya Inoue, Mitsuro Fukuhara, Takumi Yamaura, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Ohsugi, Mika Hoshino, Yutaka Shio, Daisuke Tanaka, Hideaki Nanamiya, Jun‐ichi Imai, Takao Isogai, Shinya Watanabe, Hiroyuki Suzuki,
Cancer treatment using immune checkpoint inhibitors is widely used, although biomarkers predictive of response are not well established. However, both the expressions of programmed cell death ligand 1 (PD-L1) and the tumor mutation burden (TMB) hold promise as such biomarkers for immune checkpoint inhibitors; however, its characteristics and clinical and immunological impacts have not been fully analyzed. We, therefore, evaluated the clinical and immunological parameters related to TMB to identify ...
Tópico(s): Lung Cancer Research Studies
2019 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Yuzo Obara, T. Ishikawa, H. Hama, F. Hinode, H. Kanda, Shigeru Kashiwagi, M. Miyabe, Toshiya Muto, K. Ozawa, Yuki Shimizu, A. O. Tokiyasu,
Tópico(s): Radiation Detection and Scintillator Technologies
2019 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment