Hiroshi Nakazawa, Yuko Matsuoka, I. NAKAGAWA, Katsuhiko Miyoshi,
... isolation of aroyl(phosphonato)palladium complexes as intermediatesHiroshi Nakazawa, Yuko Matsuoka, Ikuko Nakagawa, and Katsuhiko MiyoshiCite this: Organometallics ...
Tópico(s): Ferrocene Chemistry and Applications
1992 - American Chemical Society | Organometallics
Hiroshi Nakazawa, Yuko Matsuoka, Hideaki Yamaguchi, Toshiaki Kuroiwa, Katsuhiko Miyoshi, Hayami Yoneda,
... of .alpha.-ketophosphonates promoted by a palladium complexHiroshi Nakazawa, Yuko Matsuoka, Hideaki Yamaguchi, Toshiaki Kuroiwa, Katsuhiko Miyoshi, and ...
Tópico(s): Organometallic Complex Synthesis and Catalysis
1989 - American Chemical Society | Organometallics
Yuko Akai, Yumiko Kurokawa, Norihiko Nakazawa, Yuko Murakami‐Tonami, Yuki Suzuki, Shige H. Yoshimura, Hiroshi Iwasaki, Yoshiharu Shiroiwa, Takahiro Nakamura, Eri Shibata, Mitsuhiro Yanagida,
Condensin is required for chromosome dynamics and diverse DNA metabolism. How condensin works, however, is not well understood. Condensin contains two structural maintenance of chromosomes (SMC) subunits with the terminal globular domains connected to coiled-coil that is interrupted by the central hinge. Heterotrimeric non-SMC subunits regulate SMC. We identified a novel fission yeast SMC hinge mutant, cut14-Y1 , which displayed defects in DNA damage repair and chromosome segregation. It contains an ...
Tópico(s): RNA Research and Splicing
2011 - Royal Society | Open Biology
Kayoko Kato, Yoshihiro Yoshimura, Hiroyuki Nakazawa, Yuko Ito, Hisao Oka,
Abstract Phthalate and adipate esters are present in relatively large amounts in the environment, resulting in their large blank values at analysis and making precise analysis difficult. We developed a highly sensitive analytical method for phthalate and adipate esters in plasma and beverages by lowering the blank values that interfere with analysis. The method uses a closed distillation cleanup system in which steam distillation and extraction are performed simultaneously. The recoveries from beverages ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2002 - Oxford University Press | Journal of AOAC International
Shinji Shimizu, Ryo Atsumi, Tsunenori Nakazawa, Yuko Fujimaki, Kenichi Sudo, Osamu Okazaki,
We have identified several novel metabolites of ticlopidine, a well known antiplatelet agent and have revealed its metabolic route in rats. The main biliary metabolite of ticlopidine was characterized as a glutathione (GSH) conjugate of ticlopidine S -oxide, in which conjugation had occurred at carbon 7a in the thienopyridine moiety. Quantitative analysis revealed that 29% of the dose was subjected to the formation of reactive intermediates followed by conjugation with GSH after oral administration ...
Tópico(s): Inflammatory mediators and NSAID effects
2009 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Hiromi Nakazawa, Yuko Ito, Eiji Matsumoto, Kenji Adachi, Nobuyuki Aoki, Yuichi Ochiai,
Polycrystalline In2O3 films with high crystallinity were prepared by annealing the amorphous In2O3 films deposited at room temperature by using dc/rf sputtering method. General electronic behaviors of both these amorphous and polycrystalline films have been investigated by means of Hall effect and resistivity measurements at temperatures between 4.2 and 300K. For the amorphous films, ionized impurity scattering dominates the electronic transport, and Hall mobility agrees well with the theory of ...
Tópico(s): Transition Metal Oxide Nanomaterials
2006 - American Institute of Physics | Journal of Applied Physics
Koichi Asahi, Kohji Ichimori, Hiroe Nakazawa, Yuko Izuhara, Reiko Inagi, Tsuyoshi Watanabe, T Miyata, Kiyoshi Kurokawa,
Tópico(s): Renin-Angiotensin System Studies
2000 - Elsevier BV | Kidney International
Mitsuru Nakazawa, Yuko Wada, Makoto Tamai,
Objective Mutations of the peripherin/RDS gene have been reported in several kinds of retinal dystrophy, and they show variation of manifestation. In some pedigrees, the same mutation can produce different phenotypic features, a factor that makes it difficult to deduce certain rules for genotype-phenotype correlations in the peripherin/RDS gene. The authors report the phenotypic features of a Japanese family with a mutation in codon 172 of the peripherin/RDS gene and compare them to previously reported ...
Tópico(s): Chronic Lymphocytic Leukemia Research
1995 - Lippincott Williams & Wilkins | Retina
Mitsuru Nakazawa, Yuko Wada, Sigrid Fuchs, Andreas Gal, Makoto Tamai,
To characterize clinical features of patients with Oguchi disease associated with a homozygous deletion of adenine at nucleotide 1147 (1147delA) in codon 309 in the arrestin gene.Mutation screening by single-strand conformation polymorphism analysis was done, followed by sequencing. Ophthalmologic testing included evaluation of visual acuity and color vision, fundus examination, electroretinography, fluorescein angiography, evaluation of kinetic visual field, and dark adaptometry. Nine patients with ...
Tópico(s): Retinal Diseases and Treatments
1997 - Lippincott Williams & Wilkins | Retina
M. Nakazawa, Yuko Kaneko, Tsutomu Takeuchi,
Tópico(s): Eosinophilic Disorders and Syndromes
2017 - Springer Science+Business Media | Clinical Rheumatology
Satoshi Takanashi, Naoshi Nishina, M. Nakazawa, Yuko Kaneko, Tsutomu Takeuchi,
To identify biomarkers for assessing myositis-associated interstitial lung disease (ILD).We reviewed consecutive patients from our institution who had been newly diagnosed with PM, DM, or clinically amyopathic DM during the years 2002-2017. The patients were divided into two groups according to the presence of ILD, and the ILD group was further subdivided into three groups according to the clinical courses of induction failure, relapse and non-relapse. Baseline and time-course changes in the parameters ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2018 - Oxford University Press | Lara D. Veeken
Yusuke Sano, Yoshito Koyanagi, Jing Hao Wong, Yusuke Murakami, Kohta Fujiwara, Mikiko Endo, Tomomi Aoi, Kazuki Hashimoto, Toru Nakazawa, Yuko Wada, Shinji Ueno, Dan Gao, Akira Murakami, Yoshihiro Hotta, Yasuhiro Ikeda, Koji M. Nishiguchi, Yukihide Momozawa, Koh‐Hei Sonoda, Masato Akiyama, Akihiro Fujimoto,
Despite the successful identification of causative genes and genetic variants of retinitis pigmentosa (RP), many patients have not been molecularly diagnosed. Our recent study using targeted short-read sequencing showed that the proportion of carriers of pathogenic variants in EYS , the cause of autosomal recessive RP, was unexpectedly high in Japanese patients with unsolved RP. This result suggested that causative genetic variants, which are difficult to detect by short-read sequencing, exist in such ...
Tópico(s): CRISPR and Genetic Engineering
2022 - BMJ | Journal of Medical Genetics
Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Tsunetoyo Namba, Takanori Ikeda, Yuko Nakazawa, Tomoya Ozawa, Makoto Ito, Minoru Horie, Natalia A. Trayanova,
Rationale: Electrogram-based catheter ablation, targeting complex fractionated atrial electrograms (CFAEs), is empirically known to be effective in halting persistent/permanent atrial fibrillation (AF). However, the mechanisms underlying CFAEs and electrogram-based ablation remain unclear. Objective: Because atrial fibrosis is associated with persistent/permanent AF, we hypothesized that electrotonic interactions between atrial myocytes and fibroblasts play an important role in CFAE genesis and electrogram- ...
Tópico(s): Cardiac Arrhythmias and Treatments
2011 - Lippincott Williams & Wilkins | Circulation Research
Hiroaki Tachi, Toshihiro Shiozawa, Chio Sakai, Mariko Kasuga, Kensuke Nakazawa, Yuko Morishima, Hiroaki Satoh, Nobuyuki Hizawa, Shingo Sakashita, Ikuo Sekine,
Interstitial lung disease (ILD) is one of the most serious side effects induced by EGFR tyrosine kinase inhibitors (TKIs). We report a case of ILD showing predominant eosinophilic infiltration that developed during osimertinib treatment. Stage IIB lung adenocarcinoma harboring an EGFR L858R mutation was diagnosed in a 77-year-old woman with no smoking history. Five years after left upper lobectomy, small nodules appeared on the bilateral lung fields in a regular chest radiographic examination. The ...
Tópico(s): Eosinophilic Disorders and Syndromes
2017 - Elsevier BV | Journal of Thoracic Oncology
Nobuaki Tanaka, Koichi Inoue, Atsushi Kobori, Kazuaki Kaitani, Takeshi Morimoto, Toshiya Kurotobi, Itsuro Morishima, Hirosuke Yamaji, Yumie Matsui, Yuko Nakazawa, Kengo Kusano, Masato Okada, Koji Tanaka, Yuko Hirao, Takafumi Oka, Yasushi Koyama, Atsunori Okamura, Katsuomi Iwakura, Kenshi Fujii, Takeshi Kimura, Satoshi Shizuta,
The impact of sex differences on the clinical outcomes of radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) is controversial. We investigated the sex differences regarding the efficacy and clinical outcomes of RFCA of AF.We conducted a large-scale, prospective, multicentre, observational study (Kansai Plus Atrial Fibrillation Registry). We enrolled 5010 consecutive patients who underwent an initial RFCA of AF at 26 centres (64 ± 10 years; non-paroxysmal AF, 35.7%). The median follow- ...
Tópico(s): Cardiac pacing and defibrillation studies
2020 - Oxford University Press | EP Europace
Nobuyuki Kato, Takahide Nakazawa, Yuko Ootsuyama, Kazuo Sugiyama, Showgo Ohkoshi, Kunitada Shimotohno,
Hypervariable region 1 (HVR1), located in the N‐terminal region of a putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV), contains immunological B‐cell epitopes which might be neutralizing epitopes. To clarify whether B‐cell epitopes within HVR1 are common among virus isolates or specific for the homologous virus isolate, we examined the reactivities of sera from 53 patients with chronic hepatitis or hepatocellular carcinoma/liver cirrhosis against two different HVR1 peptides (HVR11‐ ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1994 - Oxford University Press | Japanese Journal of Cancer Research
Yuko Nakazawa, Takashi Ashihara, Takayoshi Tsutamoto, Makoto Ito, Minoru Horie,
Background A considerable rate of atrial fibrillation (AF) recurrence is one of the major limitations of pulmonary vein isolation (PVI). Although endothelin-1 (ET-1) is involved in atrial remodeling, it is unknown whether plasma ET-1 level before PVI can be used as a predictive factor for AF recurrence. Objective The goal of this study was to clarify whether the plasma ET-1 level, before PVI, can be used as a predictive factor for AF recurrence after PVI. Methods Fifty-one patients without structural ...
Tópico(s): Cardiovascular Function and Risk Factors
2009 - Elsevier BV | Heart Rhythm
Hideki Itoh, Tomoko Sakaguchi, Wei‐Guang Ding, Eiichi Watanabe, Ichiro Watanabe, Yukiko Nishio, Takeru Makiyama, Seiko Ohno, Masaharu Akao, Yukei Higashi, Naoko Zenda, Tomoki Kubota, Chikara Mori, Katsunori Okajima, Tetsuya Haruna, Akashi Miyamoto, Mihoko Kawamura, Katsuya Ishida, Iori Nagaoka, Yuko Oka, Yuko Nakazawa, Takenori Yao, Hikari Jo, Yoshihisa Sugimoto, Takashi Ashihara, Hideki Hayashi, Makoto Ito, Keiji Imoto, Hiroshi Matsuura, Minoru Horie,
Background— Drugs with I Kr -blocking action cause secondary long-QT syndrome. Several cases have been associated with mutations of genes coding cardiac ion channels, but their frequency among patients affected by drug-induced long-QT syndrome (dLQTS) and the resultant molecular effects remain unknown. Methods and Results— Genetic testing was carried out for long-QT syndrome–related genes in 20 subjects with dLQTS and 176 subjects with congenital long-QT syndrome (cLQTS); electrophysiological characteristics ...
Tópico(s): Receptor Mechanisms and Signaling
2009 - Lippincott Williams & Wilkins | Circulation Arrhythmia and Electrophysiology
Yuko Nakazawa, S. A. Carter, Heinz‐Georg Nothofer, Ullrich Scherf, V. Y. Lee, R. Miller, J. C. Scott,
We study how changes in sidebranching in electroluminescent polymers affect the performance of polyfluorene-based light-emitting diodes with and without additional hole transport materials. We observe that light emission and device efficiency are determined more by the position of the exciton recombination zone than by changes in the polymer morphology induced by sidebranching. Consequently, we find that sidebranching mainly controls the relative emission between vibrational energy levels and has ...
Tópico(s): Conducting polymers and applications
2002 - American Institute of Physics | Applied Physics Letters
Hideki Itoh, Tomoko Sakaguchi, Takashi Ashihara, Wei-Guang Ding, Iori Nagaoka, Yuko Oka, Yuko Nakazawa, Takenori Yao, Hikari Jo, Makoto Ito, Kazufumi Nakamura, Tohru Ohe, Hiroshi Matsuura, Minoru Horie,
In a 34-year-old man showing short QT interval (QTc 329 ms), we identified a novel C-terminal KCNH2 mutation, R1135H. Using a heterologous expression system with CHO cells, the mutant channels were found to display a significantly slow deactivation, which resulted in a gain-of-function for reconstituted 'IKr' channels. This mutation could modify clinical phenotypes for this patient.
Tópico(s): Receptor Mechanisms and Signaling
2008 - Elsevier BV | International Journal of Cardiology
Lishu Li, Hideto Saigusa, Yuko Nakazawa, Tsuyoshi Nakamura, Taro Komachi, Satoshi Yamaguchi, Aimin Liu, Yuichi Sugisaki, Eiji Shinya, Hongmei Shen,
Summary We examined pathologically a bamboo nodule of the vocal fold by means of immunohistochemical studies and scanning electron microscopic examination. A 38-year-old female showed a high index of antinuclear antibodies without any systemic symptoms but had complained of progressive voice disorder for 9 months. She had used her voice excessively in her occupation and for singing. Hematoxylin and eosin staining showed submucosal edema with lymphocyte and neutrocyte infiltrations and hyaline degeneration. ...
Tópico(s): Dysphagia Assessment and Management
2010 - Elsevier BV | Journal of Voice
Stephanie V. Chasteen, Johanna Härter, Garry Rumbles, J. C. Scott, Yuko Nakazawa, Marcus Jones, H.‐H. Hörhold, H. Tillman, S. A. Carter,
We characterize and compare blended and bilayered heterojunctions of polymer photovoltaic devices using poly[oxa-1,4-phenylene-1,2-(1-cyano)-ethenylene-2,5-dioctyloxy-1,4-phenylene-1,2-(2-cyano)-ethenylene-1,4-phenylene] (CN-ether-PPV) and poly[2,5-dimethoxy-1,4-phenylene-1,2-ethenylene-2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene-1,2-ethenylene] (M3EH-PPV) as electron- and hole-transporting polymers, respectively. We find that both blended and bilayered structures have substantially improved current ...
Tópico(s): Perovskite Materials and Applications
2006 - American Institute of Physics | Journal of Applied Physics
Kazuaki Kaitani, Koichi Inoue, Atsushi Kobori, Yuko Nakazawa, Tomoya Ozawa, Toshiya Kurotobi, Itsuro Morishima, Fumiharu Miura, Tetsuya Watanabe, Masaharu Masuda, Masaki Naito, Hajime Fujimoto, Taku Nishida, Yoshio Furukawa, Takeshi Shirayama, Mariko Tanaka, Katsunori Okajima, Takenori Yao, Yasuyuki Egami, Kazuhiro Satomi, Takashi Noda, Koji Miyamoto, Tetsuya Haruna, Tetsuma Kawaji, Takashi Yoshizawa, Toshiaki Toyota, Mitsuhiko Yahata, Kentaro Nakai, Hiroaki Sugiyama, Yukei Higashi, Makoto Ito, Minoru Horie, Kengo Kusano, Wataru Shimizu, Shiro Kamakura, Takeshi Morimoto, Takeshi Kimura, Satoshi Shizuta,
Substantial portion of early arrhythmia recurrence after catheter ablation for atrial fibrillation (AF) is considered to be due to irritability in left atrium (LA) from the ablation procedure. We sought to evaluate whether 90-day use of antiarrhythmic drug (AAD) following AF ablation could reduce the incidence of early arrhythmia recurrence and thereby promote reverse remodelling of LA, leading to improved long-term clinical outcomes. A total of 2038 patients who had undergone radiofrequency catheter ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2015 - Oxford University Press | European Heart Journal
Atsushi Kobori, Satoshi Shizuta, Koichi Inoue, Kazuaki Kaitani, Takeshi Morimoto, Yuko Nakazawa, Tomoya Ozawa, Toshiya Kurotobi, Itsuro Morishima, Fumiharu Miura, Tetsuya Watanabe, Masaharu Masuda, Masaki Naito, Hajime Fujimoto, Taku Nishida, Yoshio Furukawa, Takeshi Shirayama, Mariko Tanaka, Katsunori Okajima, Takenori Yao, Yasuyuki Egami, Kazuhiro Satomi, Takashi Noda, Koji Miyamoto, Tetsuya Haruna, Tetsuma Kawaji, Takashi Yoshizawa, Toshiaki Toyota, Mitsuhiko Yahata, Kentaro Nakai, Hiroaki Sugiyama, Yukei Higashi, Makoto Ito, Minoru Horie, Kengo Kusano, Wataru Shimizu, Shiro Kamakura, Takeshi Kimura,
Most of recurrent atrial tachyarrhythmias after pulmonary vein isolation (PVI) for atrial fibrillation (AF) are due to reconnection of PVs. The aim of the present study was to evaluate whether elimination of adenosine triphosphate (ATP)-induced dormant PV conduction by additional energy applications during the first ablation procedure could reduce the incidence of recurrent atrial tachyarrhythmias. We randomly assigned 2113 patients with paroxysmal, persistent, or long-lasting AF to either ATP-guided ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2015 - Oxford University Press | European Heart Journal
Takaaki Fujii, Keiko Yanai, Shoko Tokuda, Yuko Nakazawa, Sasagu Kurozumi, Sayaka Obayashi, Reina Yajima, Tomoko Hirakata, Ken Shirabe,
18F-Fluorodeoxyglucose-positron-emission tomography (FDG-PET) is used to evaluate the glucose metabolic rates of tumors. Several studies have reported that high FDG uptake is predictive of poor prognosis and aggressive features in patients with breast cancer. FDG uptake is influenced by many factors, including inflammation. In this study, the relationship between FDG uptake and neutrophil/lymphocyte ratio (NLR), which is an indicator of systemic inflammation, was investigated.A retrospective investigation ...
Tópico(s): Breast Cancer Treatment Studies
2018 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
Takaaki Fujii, Tomoko Hirakata, Sasagu Kurozumi, Shoko Tokuda, Yuko Nakazawa, Sayaka Obayashi, Reina Yajima, Tetsunari Oyama, Ken Shirabe,
Vascular endothelial growth factor-A (VEGF-A), an important angiogenic factor, has been reported to effect cancer growth and development. Recent reports indicated that anti-VEGF therapy has an important effect of enhancing anti-tumor immunity in various cancers. In the current study, we investigated the relationship between VEGF-A expression and immunological factors, including programmed cell death ligand 1 (PD-L1) and the degrees of stromal tumor-infiltrating lymphocytes (TILs) in breast cancer.This ...
Tópico(s): Cancer Cells and Metastasis
2020 - Stanford University Highwire Press | In Vivo
Tomoko Hirakata, Takaaki Fujii, Sasagu Kurozumi, Ayaka Katayama, Chikako Honda, Keiko Yanai, Shoko Tokuda, Yuko Nakazawa, Sayaka Obayashi, Reina Yajima, Kyoichi Kaira, Tetsunari Oyama, Ken Shirabe,
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2020 - Springer Science+Business Media | Breast Cancer Research and Treatment
Takaaki Fujii, Shoko Tokuda, Yuko Nakazawa, Sasagu Kurozumi, Sayaka Obayashi, Reina Yajima, Ken Shirabe,
Background/Aim: We examined the relationship between preoperative serum albumin levels and long-term outcomes in patients with breast cancer. Patients and Methods: We retrospectively analyzed the records of 157 patients who underwent breast cancer surgery at a single institution. We divided the patients into those with <4.0 g/dl and those with ≥4.0 g/dl preoperative serum albumin. Results: The overall median follow-up period was 86.7 months. Among the 157 patients, 19 (12.1%) had decreased serum albumin ...
Tópico(s): Cancer, Lipids, and Metabolism
2020 - Stanford University Highwire Press | In Vivo
Misato Ogino, Takaaki Fujii, Yuko Nakazawa, Toru Higuchi, Yukio Koibuchi, Tetsunari Oyama, Jun Horiguchi, Ken Shirabe,
We evaluated the usefulness of topoisomerases (TOPs) expression as prognostic predictors in breast cancer.We retrospectively investigated sixty cases with primary breast cancer. We evaluated the tumor and non-tumor mRNA levels of TOP1 and TOP2α using quantitative reverse-transcription polymerase chain reaction. TOP1/TOP2α positivity was defined as the ratio of the mRNA expression of cancer/normal tissue of >1 for both TOP1 and TOP2α.TOP1 and TOP2α were markedly overexpressed in breast cancer tissues ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2020 - Stanford University Highwire Press | In Vivo
Yuko Nakazawa, Seshiru Nakazawa, Sasagu Kurozumi, Misato Ogino, Yukio Koibuchi, Hiroki Odawara, Tetsunari Oyama, Jun Horiguchi, Takaaki Fujii, Ken Shirabe,
Biomarkers that can accurately predict treatment response are required for indicating optimal neoadjuvant treatments. The current study assessed the predictive value of secreted protein acidic and rich in cysteine (SPARC) mRNA expression for the response to neoadjuvant nab-paclitaxel (nab-PTX) therapy in patients with breast cancer. It was hypothesized that SPARC expression can affect the response to albumin-bound taxanes, including nab-PTX since SPARC binds albumin with a high affinity. Pre-therapeutic ...
Tópico(s): Protease and Inhibitor Mechanisms
2020 - Spandidos Publishing | Oncology Letters