Ryosuke Satoh, Yasuhiro Matsumura, Akitomo Tanaka, Makoto Takada, Yuna Ito, Kanako Hagihara, Masahiro Inari, Ayako Kita, Akira Fukao, Toshinobu Fujiwara, Shinya Hirai, Tokio Tani, Reiko Sugiura,
RNA-binding proteins (RBPs) play important roles in the posttranscriptional regulation of gene expression, including mRNA stability, transport and translation. Fission yeast rnc1+ encodes a K Homology (KH)-type RBP, which binds and stabilizes the Pmp1 MAPK phosphatase mRNA thereby suppressing the Cl- hypersensitivity of calcineurin deletion and MAPK signaling mutants. Here, we analyzed the spatial regulation of Rnc1 and discovered a putative nuclear export signal (NES)Rnc1 , which dictates the cytoplasmic ...
Tópico(s): Genomics and Chromatin Dynamics
2017 - Wiley | Molecular Microbiology
Kiminori Sugino, Mitsuji Nagahama, Wataru Kitagawa, Keiko Ohkuwa, Takashi Uruno, Kenichi Matsuzu, Akifumi Suzuki, Chie Masaki, Junko Akaishi, Kiyomi Y. Hames, Chisato Tomoda, Yuna Ogimi, Koichi Ito,
New insights in thyroid cancer biology propelled the development of targeted therapies as salvage treatment for radioiodine-refractory differentiated thyroid cancer (RR-DTC), and the tyrosine kinase inhibitor (TKI) lenvatinib has recently become available as a new line of therapy for RR-DTC. The aim of this study is to investigate clinical factors related to the efficacy of TKI therapy in recurrent RR-DTC patients and identify the optimal timing for the start of TKI therapy. The subjects consisted ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2017 - Japan Endocrine Society | Endocrine Journal
Mutsumi Akahane, Yuki Enoki, Reika Saiki, Yukitaka Hayashi, Kana Hiraoka, Kyoka Honma, Marina Itagaki, Mai Gotoda, Kozue Shinoda, Satomi Hanyu, Yuna Hamamura, Taichi Miyajima, Chihiro Ito, Kazuaki Taguchi, Shunsuke Uno, Yoshifumi Uwamino, Osamu Iketani, Naoki Hasegawa, Kazuaki Matsumoto,
ObjectivesThe long-term stability of antimicrobials dissolved in infusion solution is necessary to establish and spread the outpatient parenteral antimicrobial therapy (OPAT). In this study, we evaluated the stability of antimicrobial agents dissolved in infusion solutions.MethodsThe antimicrobial agents were dissolved in infusion solutions and kept at 25 °C and 31.1 °C for 24 h or 4 °C for 10 days in a polypropylene tube or an elastomeric infusion pump. The stability was measured by high-performance ...
Tópico(s): Anesthesia and Sedative Agents
2020 - Elsevier BV | International Journal of Infectious Diseases
Hisayuki Yokoyama, Naoto Takahashi, Yuna Katsuoka, Mitsue Inomata, Toshihiro Ito, Kuniaki Meguro, Yoshihiro Kameoka, Riko Tsumanuma, Kazunori Murai, Hideyoshi Noji, Kenichi Ishizawa, Shigeki Ito, Yasushi Onishi, Hideo Harigae,
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2017 - Springer Science+Business Media | International Journal of Hematology
Yuna Roh, Tatsuro Ishibashi, Naotsugu Ito, H Inomata,
• We electron-microscopically studied 15 specimens of upper limbal conjunctiva obtained from 14 patients with exfoliation syndrome and clinical evidence of glaucoma. Of 15 specimens, four (three patients) contained exfoliation materials in the stroma of the conjunctiva. These exfoliation materials of immature, intermediate, and mature forms were composed of abnormal microfibrils lying adjacent to the fibroblasts and located in close proximity to the elastic and collagen fibers. These observations suggest ...
Tópico(s): Corneal surgery and disorders
1987 - American Medical Association | Archives of Ophthalmology
Moe Kawashima, Toyoaki Sawano, Michio Murakami, Nobuaki Moriyama, Kenmei Kitazawa, Yuna Uchi, Saori Nonaka, Naomi Ito, Hiroaki Saito, Toshiki Abe, Mamoru Sakakibara, Kazuko Yagiuchi, Mako Otsuki, Arinobu Hori, Akihiko Ozaki, Chika Yamamoto, Tianchen Zhao, Taiga Uchiyama, Tomoyoshi Oikawa, Shin‐Ichi Niwa, Masaharu Tsubokura,
The health of the vulnerable populations receiving the Long-Term Care (LTC) Insurance Programs was threatened by the direct and indirect effects of disasters. The 2011 Great East Japan Earthquake and Tsunami and the explosion at the Fukushima Daiichi nuclear power plant (FDNPP) forced 164,865 people's evacuation and caused many disaster-related deaths. We examined the relationship between these deaths and LTC certification. Data were collected from 520 people who were living in Minamisoma City during ...
Tópico(s): Geriatric Care and Nursing Homes
2023 - Elsevier BV | International Journal of Disaster Risk Reduction
Hiroshi Ito, Yuna Tomura, Jura Oshida, Sayato Fukui, Taisuke Kodama, Daiki Kobayashi,
The number of studies that verify whether Gram stain can help to reduce the use of broad-spectrum antibiotics is relatively limited compared to those evaluating its concordance with culture test results. Thereby, we aimed to evaluate the effectiveness of Gram staining in the reduction of broad-spectrum antibiotics and its impact on clinical outcomes. We systematically reviewed studies having used Gram stain to guide antibiotic selection and evaluated performance measures between 1996 and 2022. We ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2023 - Elsevier BV | Infectious Diseases Now
Kiminori Sugino, Mitsuji Nagahama, Wataru Kitagawa, Keiko Ohkuwa, Takashi Uruno, Kenichi Matsuzu, Akifumi Suzuki, Chisato Tomoda, Kiyomi Y. Hames, Junko Akaishi, Chie Masaki, Yuna Ogimi, Tomonori Yabuta, Koichi Ito,
The extent of thyroidectomy in Graves' disease remains controversial. In our institution, long-term euthyroidism without thyroxin replacement therapy has been the aim, and it has long been the standard surgical procedure used to treat Graves' disease in many institutions, including our hospital. Based our several clinical studies, it was concluded that subtotal thyroidectomy is not suitable as a standard surgical procedure for the treatment of Graves' disease. In 2009, the surgical strategy for ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2018 - Japan Endocrine Society | Endocrine Journal
Akihiro Saito, Shotaro Shinjo, Ito Daiki, Yuko Doi, Akira Sato, Yuna Wakabayashi, Juma Honda, Yuka Arai, Tsubasa Maeda, Takuji Ohyama, Kyoko Higuchi,
Leaf iron (Fe) contents in Fe-deficiency-tolerant plants are not necessarily higher than that in Fe-deficiency-susceptible ones, suggesting an unknown mechanism involved in saving and allowing the efficient use of minimal Fe. To quantitatively evaluate the difference in Fe economy for photosynthesis, we compared the ratio of CO2 assimilation rate to Fe content in newly developed leaves as a novel index of photosynthetic iron-use efficiency (PIUE) among 23 different barley (Hordeum vulgare L.) varieties. ...
Tópico(s): Plant Stress Responses and Tolerance
2021 - Multidisciplinary Digital Publishing Institute | Plants
Yuna Naraoka, Yo Mabuchi, Yosuke Yoneyama, Eriko Grace Suto, Daisuke Hisamatsu, Mami Ikeda, Risa Ito, Tetsuya Nakamura, Takanori Takebe, Chihiro Akazawa,
The current process of meat production using livestock has significant effects on the global environment, including high emissions of greenhouse gases. In recent years, cultured meat has attracted attention as a way to acquire animal proteins. However, the lack of markers that isolate proliferating cells from bovine tissues and the complex structure of the meat make it difficult to culture meat in a dish. In this study, we screened 246 cell-surface antibodies by fluorescence-activated cell sorting ...
Tópico(s): 3D Printing in Biomedical Research
2021 - Multidisciplinary Digital Publishing Institute | Cells
Yasuhiro Nishikawa, Kohei Takemoto, Kana Matsuda, Tanaka Risa, Akira Arashima, Kanako Ito, Yuki Kamezawa, Yuna Hori, Osamu Hara,
Site-selective acylation of α-hydroxyl groups in amides has been achieved in the presence of other primary hydroxyl groups with intrinsic high reactivity. In this methodology, a relatively stable pyridine aldoxime ester was exploited as an acyl donor to suppress undesired acylation. The catalytic activation of a pyridine aldoxime ester with a Lewis acid produced a cationic complex, which preferentially attracted the Lewis basic α-hydroxyamide via a template effect, to thus facilitate o-acylation.
Tópico(s): Asymmetric Synthesis and Catalysis
2018 - American Chemical Society | Organic Letters
Ruriko Kitamura, Natsuko Miura, Michihiro Ito, Toshiyuki Takagi, Hideyuki Yamashiro, Yumi Nishikawa, Yuna Nishimura, Keita Kobayashi, Michihiko Kataoka,
Tópico(s): Microbial Community Ecology and Physiology
2021 - Springer Science+Business Media | Marine Biotechnology
Masateru Ishiguro, Yoonsoo P. Bach, Jooyeon Geem, Hiroyuki Naito, D. Kuroda, Myungshin Im, Myung Gyoon Lee, Jinguk Seo, Sunho Jin, Yuna G. Kwon, Tatsuharu Oono, Seiko Takagi, Mitsuteru Sato, Kiyoshi Kuramoto, Takashi Itô, Sunao Hasegawa, Fumi Yoshida, Tomoko Arai, Hiroshi Akitaya, Tomohiko Sekiguchi, Ryo Okazaki, Masataka Imai, K. Ohtsuka, Makoto Watanabe, Jun Takahashi, Maxime Devogéle, G. Fedorets, L. Siltala, Mikael Granvik,
The investigation of asteroids near the Sun is important for understanding the final evolutionary stage of primitive solar system objects. A near-Sun asteroid, (155140) 2005 UD, has orbital elements similar to those of (3200) Phaethon (the target asteroid for the JAXA's $DESTINY^+$ mission). We conducted photometric and polarimetric observations of 2005 UD and found that this asteroid exhibits a polarization phase curve similar to that of Phaethon over a wide range of observed solar phase angles ($ \alpha = ...
Tópico(s): Stellar, planetary, and galactic studies
2021 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Yasuhiro Kawasaki, T. Sumiyoshi, Yuna Higuchi, Toru Ito, Mie Takeuchi, M. Kurachi, M. Suzuki,
Tópico(s): Functional Brain Connectivity Studies
2008 - Elsevier BV | Schizophrenia Research
Kazumasa Tani, S Okada, Yuna Ito, Yurika Kawaguchi, Yuki Sakai, Yoshiaki Tsukizawa, Naoko Tanaka, Satomi Yokohata, Keiji Morikawa, Maiko Ueda, Madoka Sekino, Masae Yorimitsu, Naoko Ueno, Junichi Kodama,
Tópico(s): Maternal and fetal healthcare
2024 - Elsevier BV | Placenta
Hiroshi Ito, Yuna Tomura, Yuki Kitagawa, Toshiya Nakashima, Satoshi Kobanawa, Kento Uki, Jura Oshida, Taisuke Kodama, Sayato Fukui, Daiki Kobayashi,
AimAlthough sleep is essential for maintaining good health and well-being, sleep disorders are becoming increasingly prevalent. Probiotics may play a role in sleep regulation; therefore, this study aimed to provide a comprehensive overview of the effects of probiotics on sleep parameters.MethodsWe conducted a systematic literature review and meta-analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology. Relevant placebo-controlled randomized controlled ...
Tópico(s): Gut microbiota and health
2024 - Elsevier BV | Clinical Nutrition ESPEN
Kenji Suzuki, Yuna Kouchi, Tomohisa Hirota, Hiroaki Kato, Tomoaki Namioka, Hibiki Ito, Hyun-Jin Hong, Keiji Yashiro, Tatsuya Kawada, Keiichi Okai, Shinichi Hashimoto,
It is reported that CaTi1-xScxO3-δ (CTS, x=0.05, 0.1) shows higher oxide ionic conductivity than conventional solid electrolyte, 8YSZ. Since CTS has also low density (c.a. 4 kg/cm3) compared with 8YSZ (c.a. 6 kg/cm3), Ni-CTS anode cermet will contribute to weight saving of SOFC stacks for vehicle applications such as airplane APU. In this study, ionic conductivity of CTS is tried to be improved by optimization of Sc dopant concentration. Additionally, Ni-CTS anode formation processing is examined by ...
Tópico(s): Catalytic Processes in Materials Science
2019 - Institute of Physics | ECS Transactions
Takashi Itô, Masateru Ishiguro, Tomoko Arai, Masataka Imai, Tomohiko Sekiguchi, Yoonsoo P. Bach, Yuna G. Kwon, Masanori Kobayashi, Ryo Ishimaru, Hiroyuki Naito, Makoto Watanabe, Kiyoshi Kuramoto,
Abstract The near-Earth asteroid (3200) Phaethon is the parent body of the Geminid meteor stream. Phaethon is also an active asteroid with a very blue spectrum. We conducted polarimetric observations of this asteroid over a wide range of solar phase angles α during its close approach to the Earth in autumn 2016. Our observation revealed that Phaethon exhibits extremely large linear polarization: P = 50.0 ± 1.1% at α = 106.5°, and its maximum is even larger. The strong polarization implies that Phaethon’ ...
Tópico(s): Geology and Paleoclimatology Research
2018 - Nature Portfolio | Nature Communications
Junko Akaishi, Tetsuo Kondo, Kiminori Sugino, Yuna Ogimi, Chie Masaki, Kiyomi Y. Hames, Tomonori Yabuta, Chisato Tomoda, Akifumi Suzuki, Kenichi Matsuzu, Takashi Uruno, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Ryohei Katoh, Koichi Ito,
Tópico(s): Hedgehog Signaling Pathway Studies
2019 - Springer Science+Business Media | World Journal of Surgery
Junko Akaishi, Tetsuo Kondo, Kiminori Sugino, Yuna Ogimi, Chie Masaki, Kiyomi Y. Hames, Tomonori Yabuta, Chisato Tomoda, Akifumi Suzuki, Kenichi Matsuzu, Takashi Uruno, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Ryohei Katoh, Koichi Ito,
Tópico(s): Head and Neck Anomalies
2018 - Springer Science+Business Media | World Journal of Surgery
Chie Masaki, Kiminori Sugino, Naoko Saito, Yoshiyuki Saito, Tomoaki Tanaka, Yuna Ogimi, Tetsuyo Maeda, Tadatoshi Osaku, Junko Akaishi, Kiyomi Y. Hames, Chisato Tomoda, Akifumi Suzuki, Kenichi Matsuzu, Takashi Uruno, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Hiroshi Takami, Koichi Ito,
Although advanced thyroid carcinoma patients who cannot be cured by conventional therapy have lacked effective treatment, multitargeted tyrosine kinase inhibitors have recently become available. Phase 3 trials of lenvatinib showed a median time to objective response of 2 (95 % confidence interval (CI) 1.9-3.5) months, demonstrating that shrinks tumors rapidly. The phenomenon of immediate tumor shrink is known as early tumor shrinkage (ETS) which is related to clinical outcome in other malignancies. However, ...
Tópico(s): Cancer-related Molecular Pathways
2017 - Japan Endocrine Society | Endocrine Journal
Masahiro Nishimura, Aiko Nakato, Masanao Abe, Kana Nagashima, Hiromichi Soejima, Toru Yada, Kasumi Yogata, Akiko Miyazaki, Kentaro Hatakeda, Miwa Yoshitake, Ayako Iwamae, C. Pilorget, R. Brunetto, D. Loizeau, Jean‐Pierre Bibring, Lucie Riu, Koki Yumoto, Yuichiro Cho, Yuna Yabe, Seiji Sugita, Motoo Ito, Tatsuaki Okada, Shogo Tachibana, Tomohiro Usui,
Abstract The JAXA Astromaterials Science Research Group developed a web-based database system for the Hayabusa2-returned samples from C-type asteroid Ryugu. The Ryugu Sample Database System database (RS-DBS) is designed as an online catalog for users of wide scientific communities to choose their preferred samples and propose the sample loan through the JAXA Ryugu Sample Announcement of Opportunity. Ryugu samples can be sorted and given identification numbers as individual particles larger than 1 ...
Tópico(s): Isotope Analysis in Ecology
2023 - Springer Nature | Earth Planets and Space
Hiroki Yoshimura, Toyoaki Sawano, Michio Murakami, Yuna Uchi, Moe Kawashima, Kemmei Kitazawa, Saori Nonaka, Naomi Ito, Hiroaki Saito, Toshiki Abe, Nobuaki Moriyama, Mamoru Sakakibara, Kazuko Yagiuchi, Mako Otsuki, Arinobu Hori, Akihiko Ozaki, Chika Yamamoto, Tianchen Zhao, Taiga Uchiyama, Tomoyoshi Oikawa, Shin‐Ichi Niwa, Masaharu Tsubokura,
Abstract The medical situation during disasters often differs from that at usual times. Disasters can lead to significant mortality that can be difficult to monitor. The types of disaster-related deaths are largely unknown. In this study, we conducted a survey to categorize the disaster-related deaths caused by a radiation disaster. A total of 520 people living in Minamisoma City, Fukushima Prefecture, at the time of the Fukushima Daiichi Nuclear Power Plant accident, who were certified to have ...
Tópico(s): Disaster Response and Management
2024 - Nature Portfolio | Scientific Reports
Sayaka Ito, Yuna YAMAGUCHI, Sayaka Kubota, Yuki Yamamoto, Koji Kimura,
The oviductal epithelium consists of ciliated and non-ciliated cells, and their numbers vary depending on the segment of the oviduct and stage of the estrous cycle. Compared with the ampulla, fewer cyclic changes in the number of the two types of cells occur in the isthmus. Recently, we have reported that the epithelium in the ampullary oviduct is composed of many types of cells during different translational/transcriptional states, and their numbers change during the estrous cycle. However, detailed ...
Tópico(s): Renal and related cancers
2022 - Japanese Society of Animal Reproduction | Journal of Reproduction and Development
Chisato Tomoda, Yuna Ogimi, Fumi Saito, Chie Masaki, Junko Akaishi, Kenichi Matsuzu, Akifumi Suzuki, Takashi Uruno, Keiko Ohkuwa, Hiroshi Shibuyà, Wataru Kitagawa, Mitsuji Nagahama, Kiminori Sugino, Koichi Ito,
Metastatic differentiated thyroid carcinoma (DTC) is an uncommon cause of malignant pleural effusion (MPE) and the characteristics and clinical course have been rarely described. Herein, we report a retrospective review of the clinical course of 18 patients (15 women and 3 men) with MPE from DTC who underwent treatment at our institution between January 2005 and December 2014. MPE from DTC was diagnosed based on cytology and/or level of thyroglobulin in the pleural fluid. Pathologically, papillary ...
Tópico(s): Myasthenia Gravis and Thymoma
2015 - Japan Endocrine Society | Endocrine Journal
Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Lingling Kong, Ryutaro Yoshida, Norihiro Okamoto, Masato Kinoshita, Haruka Miyazaki, Yuna Ku, Eri Tokunaga, Yuki Ito, Daisuke Watanabe, Makoto Ooi, Masakazu Shinohara, Kengo Sasaki, Yoh Zen, Takenori Kotani, Takashi Matozaki, Zibin Tian, Yoshikatsu Kanai, Yuzo Kodama,
Abstract Background Amino acid transporters play an important role in supplying nutrition to cells and are associated with cell proliferation. L-type amino acid transporter 1 (LAT1) is highly expressed in many types of cancers and promotes tumor growth; however, how LAT1 affects tumor development is not fully understood. Methods To investigate the role of LAT1 in intestinal tumorigenesis, mice carrying LAT1 floxed alleles that also expressed Cre recombinase from the promoter of gene encoding Villin ...
Tópico(s): Polyamine Metabolism and Applications
2023 - Springer Science+Business Media | Journal of Gastroenterology
Daisuke Hisamatsu, Natsumi Itakura, Yo Mabuchi, Rion Ozaki, Eriko Grace Suto, Yuna Naraoka, Akari Ikeda, Lisa Ito, Chihiro Akazawa,
The incidence of inflammatory bowel diseases (IBD) is increasing worldwide. Mesenchymal stem/stromal cells (MSCs) have immunomodulatory functions and are a promising source for cell transplantation therapy for IBD. However, owing to their heterogeneous nature, their therapeutic efficacy in colitis is controversial and depends on the delivery route and form of transplanted cells. Cluster of differentiation (CD) 73 is widely expressed in MSCs and used to obtain a homogeneous MSC population. Herein, we ...
Tópico(s): Immune cells in cancer
2023 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Yuna Hirano, Noriko Kidera, Natsuko Ito Kondo, Jun Nishihiro,
Tópico(s): Environmental DNA in Biodiversity Studies
2020 - Springer Science+Business Media | Ichthyological Research
Akiteru Takamura, Sayori Ito, Kaori Maruyama, Yusuke Ryo, Manami Saito, Shuhei Fujimura, Yuna Ishiura, Ariyuki Hori,
Automated external defibrillators (AED) have been installed in schools in Japan since 2004, and the government strongly recommends teaching basic life support (BLS). We therefore examined the quality of BLS education and AED installation in schools.We conducted a prefecture-wide questionnaire survey of all primary and junior high schools in 2016, to assess BLS education and AED installation against the recommendations of the Japan Circulation Society. The results were analyzed using descriptive statistics ...
Tópico(s): Trauma Management and Diagnosis
2016 - Wiley | Pediatrics International
Haruka Miyazaki, Daisuke Watanabe, Yuki Ito, Norihiro Okamoto, Eri Tokunaga, Yuna Ku, Makoto Ooi, Namiko Hoshi, Yuzo Kodama,
Patients with inflammatory bowel disease (IBD) are recommended to receive the coronavirus disease 2019 (COVID-19) vaccine. However, a recent survey showed that patients with IBD are more hesitant to receive the vaccine than the general population. Detailed information on the side effects of the COVID-19 vaccine is necessary to encourage vaccination among patients with IBD. To investigate the frequency of side effects following COVID-19 vaccination in patients with IBD in Japan. Study design: a cross- ...
Tópico(s): Immune responses and vaccinations
2022 - Springer Science+Business Media | Digestive Diseases and Sciences