Isamu Matsuda, Shizuaki Murata, Yūsuke Izumi,
... jasmonoid compounds from .gamma.-(trimethylsiloxy)butyronitrileIsamu Matsuda, Shizuaki Murata, and Yusuke IzumiCite this: J. Org. Chem. 1980, 45, 2, ...
Tópico(s): Insect and Pesticide Research
1980 - American Chemical Society | The Journal of Organic Chemistry
Yoshitada Murata, Yusuke Morino,
In an ordinary least-squares analysis of gas electron diffraction, the standard deviation for the most probable value of a parameter for a molecule depends on the interval of measurements As on a microphotometer recording, that is, on the number of observed points on an intensity curve.It is shown that a reasonable estimate of the standard deviation of a parameter can be obtained by taking into account the effect of 'correlation' among the points of observations.A general method and its simplified ...
Tópico(s): Calibration and Measurement Techniques
1966 - Wiley | Acta Crystallographica
Isamu Matsuda, Shizuaki Murata, Yūsuke Izumi,
Abstract α-Cyano carbanions which are generated from γ-trimethylsiloxy nitriles have been found to react with aldehydes to give α-(1-hydroxyalkyl)-γ-trimethylsiloxy nitriles (6). α-Ylidene γ-lactones (5) are derived from 6 in two steps; hydrolytic lactonization to α-(1-hydroxyalkyl) γ-lactones and dehydration. The stereochemistry of the lactones 5 with one exception have been found to be of the E form on the basis of the NMR spectra.
Tópico(s): Marine Sponges and Natural Products
1979 - Oxford University Press | Bulletin of the Chemical Society of Japan
Michio Murata, Yusuke Kasai, Yuichi Umegawa, Naohiro Matsushita, Hiroshi Tsuchikawa, Nobuaki Matsumori, Tohru Oishi,
Abstract Amphotericin B (AmB) exerts its pharmacological effects by forming a barrel-stave assembly in fungal membranes. To examine the interaction between AmB and ergosterol or cholesterol, 13C- and 19F-labeled covalent conjugates were prepared and subjected to solid-state NMR measurements. Using rotor-synchronous double resonance experiments such as REDOR and RDX, we estimated the distance between the fluorine atom and its nearest carbon in the heptaene moiety to be less than 8.6 Å, indicating ...
Tópico(s): Coordination Chemistry and Organometallics
2009 - International Union of Pure and Applied Chemistry | Pure and Applied Chemistry
Yasuhiro Ohki, Motosuke Imada, Ayuro Murata, Yusuke Sunada, Shun Ohta, Masaru Honda, Takahiro Sasamori, Norihiro Tokitoh, Motomi Katada, Kazuyuki Tatsumi,
High-yield synthesis of the iron−sulfur cluster [{N(SiMe3)2}{SC(NMe2)2}Fe4S3]2(μ6-S) {μ-N(SiMe3)2}2 (1), which reproduces the [8Fe-7S] core structure of the nitrogenase PN-cluster, has been achieved via two pathways: (1) Fe{N(SiMe3)2}2 + HSTip (Tip = 2,4,6-iPr3C6H2) + tetramethylthiourea (SC(NMe2)2) + elemental sulfur (S8); and (2) Fe3{N(SiMe3)2}2(μ-STip)4 (2) + HSTip + SC(NMe2)2 + S8. The thiourea and terminal amide ligands of 1 were found to be replaceable by thiolate ligands upon treatment with thiolate anions and thiols ...
Tópico(s): Electrocatalysts for Energy Conversion
2009 - American Chemical Society | Journal of the American Chemical Society
Wataru Satake, Yuko Nakabayashi, Ikuko Mizuta, Yushi Hirota, Chiyomi Ito, Michiaki Kubo, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Masahiko Watanabe, Atsushi Takeda, Hiroyuki Tomiyama, Kenji Nakashima, Kazuko Hasegawa, Fumiya Obata, Takeo Yoshikawa, Hideshi Kawakami, Saburo Sakoda, Mitsutoshi Yamamoto, Nobutaka Hattori, Miho Murata, Yusuke Nakamura, Tatsushi Toda,
Tópico(s): RNA regulation and disease
2009 - Nature Portfolio | Nature Genetics
Y. Ikeda, Makoto Handa, K Kawano, Tamihiro Kamata, Mitsuru Murata, Yusuke Araki, Hironobu Anbo, Y Kawai, Kazuhiro Watanabe, Ichiro Itagaki,
Exposure of platelets to shear stress leads to aggregation in the absence of exogenous agonists. We have now found that different adhesive proteins and platelet membrane glycoproteins are involved in aggregation depending on the shear stress conditions and the concentration of divalent cations in the medium. When blood is collected with trisodium citrate as anticoagulant, which causes a decrease in the levels of external ionized calcium ([Ca2+]o), platelet aggregation can be induced under low shear ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
1991 - American Society for Clinical Investigation | Journal of Clinical Investigation
Ayako Furukawa, Shinji Oikawa, Mariko Murata, Yusuke Hiraku, Shosuke Kawanishi,
Green tea catechins, especially (−)-epigallocatechin gallate (EGCG), are believed to mediate much of the cancer chemopreventive effects of tea. However, it was reported that green tea catechins enhanced colon carcinogenesis in rats. Experiments using 32P-labeled DNA fragments obtained from human cancer-related genes showed that catechins induced DNA damage in the presence of metals such as Cu(II) and Fe(III) complexes. In the presence of Fe(III)EDTA, the order of DNA damaging ability was EGCG ≈ (−)-epigallocatechin > (−)- ...
Tópico(s): Tannin, Tannase and Anticancer Activities
2003 - Elsevier BV | Biochemical Pharmacology
Vuthichai Ervithayasuporn, Junichi Abe, Xin Wang, Toshinori Matsushima, Hideyuki Murata, Yusuke Kawakami,
Two new classes of mono- and oligo(p-phenylene ethynylene)s grafted with polyhedral oligomeric silsesquioxanes (POSS) were synthesized via 'click' chemistry and palladium-catalyzed Sonogashira cross-coupling. These materials with cubic silsesquioxanes are very robust with excellent thermal stability in air (T5%loss>330 °C) and exhibited Tg>80 °C. All the compounds showed high photoluminescence with a range of blue emission and quantum yield up to 80% in the solution. Extended π conjugation molecules ...
Tópico(s): Organic Light-Emitting Diodes Research
2010 - Elsevier BV | Tetrahedron
Kazuma Murakami, Shinichi Yokoyama, Nakaba Murata, Yusuke Ozawa, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu,
Obesity is a risk factor for Alzheimer’s disease (AD), which is characterized by amyloid β depositions and cognitive dysfunction. Although insulin resistance is one of the phenotypes of obesity, its deleterious effects on AD progression remain to be fully elucidated. We previously reported that the suppression of insulin signaling in a mouse with a heterozygous mutation (P1195L) in the gene for the insulin receptor showed insulin resistance and hyperinsulinemia but did not develop diabetes mellitus [ ...
Tópico(s): Biochemical effects in animals
2011 - Elsevier BV | Biochemical and Biophysical Research Communications
Kazuma Murakami, Nakaba Murata, Yusuke Ozawa, Noriaki Kinoshita, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu,
Oxidative stress is related to the pathogenesis of Alzheimer's disease (AD) characterized by progressive memory impairment. Soluble amyloid-β (Aβ) oligomers cause cognitive loss and synaptic dysfunction rather than senile plaques in AD. The decline o
Tópico(s): Vitamin C and Antioxidants Research
2011 - IOS Press | Journal of Alzheimer s Disease
Feiye Guo, Ning Ma, Yoshiteru Horibe, Shosuke Kawanishi, Mariko Murata, Yusuke Hiraku,
Carbon nanotube (CNT) has a promising usage in the field of material science for industrial purposes because of its unique physicochemical property. However, intraperitoneal administration of CNT was reported to cause mesothelioma in experimental animals. Chronic inflammation may contribute to carcinogenesis induced by fibrous materials. 8-Nitroguanine is a mutagenic DNA lesion formed during inflammation and may play a role in CNT-induced carcinogenesis. In this study, we examined 8-nitroguanine ...
Tópico(s): Anesthesia and Neurotoxicity Research
2012 - Elsevier BV | Toxicology and Applied Pharmacology
Koichi Watashi, Naoto Ishii, Makoto Hijikata, Daisuke Inoue, Takayuki Murata, Yusuke Miyanari, Kunitada Shimotohno,
Viruses depend on host-derived factors for their efficient genome replication. Here, we demonstrate that a cellular peptidyl-prolyl cis-trans isomerase (PPIase), cyclophilin B (CyPB), is critical for the efficient replication of the hepatitis C virus (HCV) genome. CyPB interacted with the HCV RNA polymerase NS5B to directly stimulate its RNA binding activity. Both the RNA interference (RNAi)-mediated reduction of endogenous CyPB expression and the induced loss of NS5B binding to CyPB decreased the levels ...
Tópico(s): Hepatitis B Virus Studies
2005 - Elsevier BV | Molecular Cell
Takumi Azuma, Akihiro Murata, Yusuke Kobayashi, Tsubasa Inokuma, Yoshiji Takemoto,
A bifunctional aminoboronic acid has been used to facilitate for the first time the intramolecular aza- and oxa-Michael reactions of α,β-unsaturated carboxylic acids. The combination of an arylboronic acid with a chiral aminothiourea allowed for these reactions to proceed successfully in an enantioselective manner to afford the desired heterocycles in high yields and ee's (up to 96% ee). The overall utility of this dual catalytic system was demonstrated by a one-pot enantioselective synthesis of (+)- ...
Tópico(s): Asymmetric Hydrogenation and Catalysis
2014 - American Chemical Society | Organic Letters
Masakiyo Sakaguchi, Masami Watanabe, Rie Kinoshita, Haruki Kaku, Hideo Ueki, Junichiro Futami, Hitoshi Murata, Yusuke Inoue, Shun-Ai Li, Peng Huang, Endy Widya Putranto, I Made Winarsa Ruma, Yasutomo Nasu, Hiromi Kumon, Nam-ho Huh,
For expression of genes in mammalian cells, various vectors have been developed using promoters including CMV, EF-1α, and CAG promoters and have been widely used. However, such expression vectors sometimes fail to attain sufficient expression levels depending on the nature of cargo genes and/or on host cell types. In the present study, we aimed to develop a potent promoter system that enables high expression levels of cargo genes ubiquitously in many different cell types. We found that insertion ...
Tópico(s): CRISPR and Genetic Engineering
2014 - Springer Science+Business Media | Molecular Biotechnology
Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Mayumí Takáhashi, Noriaki Minakawa, Akira Matsuda, Hideyoshi Harashima,
Efficient delivery continues to be a challenge in microRNA (miRNA) therapeutics. We utilized a pH-sensitive multifunctional envelope-type nano device (MEND) containing a pH-sensitive lipid YSK05 (YSK05-MEND) to regulate liver specific miRNA-122 (miR-122). Anti-microRNA oligonucleotides including 2′-OMe and phosphorothioate modifications against miR-122 (AMO122) were encapsulated in the YSK05-MEND. Despite the lower uptake, the YSK05-MEND showed a higher activity in liver cancer cells than Lipofectamine2000 ( ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2013 - Elsevier BV | Journal of Controlled Release
Mayumí Takáhashi, Naoki Yamada, Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Noriaki Minakawa, Hideyoshi Harashima, Akira Matsuda,
Abstract MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. Previous studies, which characterized miRNA function, revealed their involvement in fundamental biological processes. Importantly, miRNA expression is deregulated in many human diseases. Specific inhibition of miRNAs using chemically modified anti-miRNA oligonucleotides (AMOs) can be a potential therapeutic strategy for diseases in which a specific miRNA is overexpressed. 2′-O-Methyl (2′-OMe)- ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2013 - Oxford University Press | Nucleic Acids Research
Katsuhisa Sakano, Shinji Oikawa, Mariko Murata, Yusuke Hiraku, Nakao Kojima, Shosuke Kawanishi,
2-Nitropropane (2-NP), a widely used industrial solvent, is carcinogenic to rats. To clarify the mechanism of carcinogenesis by 2-NP, we investigated DNA damage by 2-NP metabolites, N-isopropylhydroxylamine (IPHA) and hydroxylamine-O-sulfonic acid (HAS), using 32P-5′-end-labelled DNA fragments obtained from genes that are relevant to human cancer. In the presence of Fe(III) EDTA, both IPHA and HAS caused DNA damage at every nucleotide position without marked site preference. The damage was inhibited ...
Tópico(s): DNA and Nucleic Acid Chemistry
2001 - Elsevier BV | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Qing’an Li, Yasunari Kamada, Takao Maeda, Junsuke MURATA, Yusuke Nishida,
Tópico(s): Biomimetic flight and propulsion mechanisms
2016 - Elsevier BV | Energy
Qing’an Li, Yasunari Kamada, Takao Maeda, Junsuke MURATA, Yusuke Nishida,
The evaluation of the stall phenomenon around an airfoil of the Horizontal Axis Wind Turbine (HAWT) was investigated experimentally in turbulent inflows. In order to observe the aerodynamic characteristics, pressures acting on a single rotor surface were measured by a multiport scanner. Furthermore, in order to present flow visualization, blade surface tufts and oil film methods were used to gain insight on the flow characteristics of HAWT airfoil. In this experiment, aerodynamic forces and flow ...
Tópico(s): Wind and Air Flow Studies
2016 - Elsevier BV | Energy
Qing’an Li, Yasunari Kamada, Takao Maeda, Junsuke MURATA, Yusuke Nishida,
This paper presented the results of a study to investigate the effect of turbulent inflows on the blade performance of a Horizontal Axis Wind Turbine (HAWT) by employing the experimental measurement at low Reynolds numbers. In order to observe the stall phenomenon, pressures on the rotor surface were measured by a multiport pressure device. Furthermore, for understanding the effects of different turbulence intensities on the aerodynamic performance characteristics of HAWT airfoil, static turbulence ...
Tópico(s): Aerodynamics and Fluid Dynamics Research
2016 - Elsevier BV | Energy
Qing’an Li, Yasunari Kamada, Takao Maeda, Junsuke MURATA, Yusuke Nishida,
The present study aimed at highlighting the influence of turbulence on the dynamic stall characteristics of the Horizontal Axis Wind Turbine (HAWT) with wind tunnel experiments. UMY02-T01-26 airfoil that could efficiently perform at a high Reynolds number had been designed. The turbulence flow was generated by turbulence grids. To experimentally characterize these flows, HAWT blade surface pressures which were used to investigate the dynamic stall phenomenon were acquired by multiport pressure devices. ...
Tópico(s): Wind Energy Research and Development
2016 - Elsevier BV | Energy
Yoshiji Takemoto, Taryn L. March, Akihiro Murata, Yusuke Kobayashi,
The first enantioselective decarboxylative aldol addition with α-amido-substituted malonic acid half oxyesters (MAHOs) is described. The combined use of a newly designed bifunctional sulfonamide catalyst with pentafluorobenzoic acid as an additive afforded the β-hydroxy-α-amino acid derivatives in moderate to high yields and with high enantioselectivities.
Tópico(s): Chemical Synthesis and Analysis
2017 - Thieme Medical Publishers (Germany) | Synlett
Mari Murata, Yusuke Uchida, Taku Takami, Tomoki Ito, Ryosuke Anzai, Seiichi Sonotaki, Yoshihiko Murakami,
In the present study, we designed hydrogels for dual drug release: the hydrogels that covalently contained the polymeric micelles that possess different drug release properties. The hydrogels that were formed from polymeric micelles possessing a tightly packed (i.e., well-entangled) inner core exhibited a higher storage modulus than the hydrogels that were formed from the polymeric micelles possessing a loosely packed structure. Furthermore, we conducted release experiments and fluorescent observations ...
Tópico(s): Advancements in Transdermal Drug Delivery
2017 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Takuma Hashimoto, Yasuhiko Murata, Yusuke Urushihara, Soichiro Shiga, Kazuya Takeda, Yoshio Hosoi,
Solid tumors often contain hypoxic regions because an abnormal and inefficient tumor vasculature is unable to supply sufficient oxygen. Tissue hypoxia is generally defined as a low oxygen concentration of less than 2%. It is well known that tumor cells under severe hypoxia, where oxygen concentration is less than 0.1%, show radioresistance. It has been reported that cells under severe hypoxia show different responses from those under mild hypoxia, where oxygen concentration is 0.5–2.0%. In the present ...
Tópico(s): Autophagy in Disease and Therapy
2018 - Elsevier BV | Biochemical and Biophysical Research Communications
Keita Takahashi, Yuichiro Murata, Yusuke Tsubaki, T. Fujiwara, Hideto Maniwa, Naohisa Uehara,
When designing a low electromagnetic interference (EMI) power electronic converter with high packaging density, its internal near-field coupling to an EMI filter is critical. In this paper, we investigated the near-field coupling between a noise source and a single-phase EMI filter. First, we measured the common-mode (CM) and differential-mode (DM) couplings separately using a four-port network analyzer. The DM coupling when the EMI filter was exposed to a magnetic field was larger than that when it ...
Tópico(s): Electrostatic Discharge in Electronics
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Electromagnetic Compatibility
Hitoshi Takamatsu, Ken-ichi Yamamoto, Nahoko Tomonobu, Hitoshi Murata, Yusuke Inoue, Akira Yamauchi, I Wayan Sumardika, Youyi Chen, Rie Kinoshita, Masahiro Yamamura, Hideyo Fujiwara, Yosuke Mitsui, Kota Araki, Junichiro Futami, Ken Saito, H Iioka, I Made Winarsa Ruma, Endy Widya Putranto, Masahiro Nishibori, Eisaku Kondo, Yasuhiko Yamamoto, Shinichi Toyooka, Masakiyo Sakaguchi,
The fertile stroma in pancreatic ductal adenocarcinomas (PDACs) has been suspected to greatly contribute to PDAC progression. Since the main cell constituents of the stroma are fibroblasts, there is crosstalking(s) between PDAC cells and surrounding fibroblasts in the stroma, which induces a fibroblast proliferation burst. We have reported that several malignant cancer cells including PDAC cells secrete a pronounced level of S100A11, which in turn stimulates proliferation of cancer cells via the ...
Tópico(s): TGF-β signaling in diseases
2019 - Cognizant Communication Corporation | Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
Mika Murata, Yusuke Nakai, Kei Kawazu, Masumi Ishizaka, Hideyuki Kajiwara, Hiroshi Abe, Kasumi Takeuchi, Yuki Ichinose, Ichiro Mitsuhara, Atsushi Mochizuki, Shigemi Seo,
Jasmonic acid (JA) plays an important role in the induction of herbivore resistance in many plants. However, JA-independent herbivore resistance has been suggested. An herbivore-resistance-inducing substance was isolated from Tobacco mosaic virus-infected tobacco (Nicotiana tabacum) leaves in which a hypersensitive response (HR) was induced and identified as loliolide, which has been identified as a β-carotene metabolite. When applied to tomato (Solanum lycopersicum) leaves, loliolide decreased the ...
Tópico(s): Allelopathy and phytotoxic interactions
2019 - Oxford University Press | PLANT PHYSIOLOGY
Takayuki Murata, Yusuke Okuno, Yoshitaka Sato, Takahiro Watanabe, Hiroshi Kimura,
Epstein-Barr virus (EBV) is a causative agent of infectious mononucleosis and several malignancies involving lymphocytes and epithelial cells. We recently reported genomic analyses of chronic active EBV infection (CAEBV), a proliferative disorder of T and/or NK cells, as well as other lymphoid malignancies. We found that T and/or NK cells undergoing clonal expansion in CAEBV patients gain somatic driver mutations as the disorder progresses. Investigation of the viral genome revealed viral genomes ...
Tópico(s): Histiocytic Disorders and Treatments
2019 - Wiley | Reviews in Medical Virology
Sean Walkowiak, Liangliang Gao, Cécile Monat, Georg Haberer, Mulualem T. Kassa, Jemima Brinton, Ricardo H. Ramírez-González, Markus C. Kolodziej, Emily Delorean, Dinushika Thambugala, Valentyna Klymiuk, Brook Byrns, Heidrun Gundlach, Venkat Bandi, Jorge Núñez Siri, Kirby T. Nilsen, Catharine Aquino, Axel Himmelbach, Dario Copetti, Tomohiro Ban, Luca Venturini, Michael W. Bevan, Bernardo Clavijo, Dal-Hoe Koo, Jennifer Ens, Krystalee Wiebe, Amidou N’Diaye, A.K. Fritz, Carl Gutwin, Anne Fiebig, Nigel Fosker, Bin Xiao Fu, Gonzalo Garcia Accinelli, Keith A. Gardner, Nick Fradgley, Juan J. Gutiérrez-González, Gwyneth Halstead-Nussloch, Masaomi Hatakeyama, ChuShin Koh, Jasline Deek, Alejandro C. Costamagna, Pierre R. Fobert, Darren Heavens, Hiroyuki Kanamori, Kanako Kawaura, Fuminori Kobayashi, Ksenia V. Krasileva, Tony Kuo, Neil McKenzie, Kazuki Murata, Yusuke Nabeka, Timothy Paape, Sudharsan Padmarasu, Lawrence Percival‐Alwyn, Sateesh Kagale, Uwe Scholz, Jun Sese, Philomin Juliana, Ravi P. Singh, Rie Shimizu‐Inatsugi, David Swarbreck, James Cockram, Hikmet Budak, Toshiaki Tameshige, Tsuyoshi Tanaka, Hiroyuki Tsuji, Jonathan Wright, Jian Wu, Burkhard Steuernagel, Ian Small, Sylvie Cloutier, Gabriel Keeble‐Gagnère, Gary J. Muehlbauer, Josquin Tibbets, Shuhei Nasuda, Joanna Melonek, Pierre Hucl, Andrew Sharpe, Matthew D. Clark, Erik Legg, Arvind K. Bharti, Peter Langridge, Anthony Hall, Cristóbal Uauy, Martin Mascher, Simon G. Krattinger, Hirokazu Handa, Kentaro K. Shimizu, Assaf Distelfeld, K. J. Chalmers, Beat Keller, Klaus Mayer, Jesse Poland, Nils Stein, Curt A. McCartney, M. Spannagl, Thomas Wicker, Curtis Pozniak,
Abstract Advances in genomics have expedited the improvement of several agriculturally important crops but similar efforts in wheat ( Triticum spp.) have been more challenging. This is largely owing to the size and complexity of the wheat genome 1 , and the lack of genome-assembly data for multiple wheat lines 2,3 . Here we generated ten chromosome pseudomolecule and five scaffold assemblies of hexaploid wheat to explore the genomic diversity among wheat lines from global breeding programs. Comparative ...
Tópico(s): Genetics and Plant Breeding
2020 - Nature Portfolio | Nature