Kazuaki A. Homma, Satoshi Okuzumi, T. Nakamoto, Yuta Ueda,
Abstract The poor stickiness of silicate dust grains is a major obstacle to the formation of rocky planetesimals. In this study, we examine the possibility that silicate grains with an organic mantle, which we call Organic-mantled Grains (OMGs), form planetesimals through direct coagulation. Organic mantles are commonly found in interplanetary dust particles, and laboratory experiments show that they are softer than silicates, in particular in warm environments. This, combined with the theory of ...
Tópico(s): Stellar, planetary, and galactic studies
2019 - IOP Publishing | The Astrophysical Journal
Takashi Okitsu, Maho Itoh, Ayaka Inui, Emiko Muta, Ryota Nakamoto, Yuta Adachi, Akimori Wada, Manabu Hatano,
Abstract Ynamides are recognized as electron‐rich π‐components and show high reactivity toward electrophiles such as iodonium salts. Here we report the iodocyclization of ene‐ynamides and arene‐ynamides leading to naphthalenes and phenanthrenes. We found these reactions were completed within 3 seconds by using I(coll) 2 PF 6 as an iodonium reagent, and cyclized products were obtained in good to high yields. To the best of our knowledge, this method is the most rapid synthesis known to date of polycyclic ...
Tópico(s): Cyclization and Aryne Chemistry
2022 - Wiley | Asian Journal of Organic Chemistry
Daisuke Nakamoto, Shuko Nojiri, Chie Taguchi, Yuta Kawakami, Satoshi Miyazawa, Manabu Kuroki, Yuji Nishizaki,
Japan has responded to the spread of COVID-19 through declaration of a state of emergency to regulate human mobility. Although the declaration was enforced by the government for prefectures, there is limited evidence as to whether the public complied with requests for voluntary stay at home. In this study, we evaluated the impact of declaring a state of emergency on human mobility during the COVID-19 pandemic in Japan.We utilized daily human mobility data for 47 prefectures in Japan. Data were collected ...
Tópico(s): COVID-19 Digital Contact Tracing
2022 - Elsevier BV | Clinical Epidemiology and Global Health
Hironari Tanaka, S. Yamamoto, Arichika Nakamura, Yuta Nakashoji, Naoaki Okura, Norimitsu Nakamoto, Kazuhiko Tsukagoshi, Masahiko Hashimoto,
A fully autonomous method of creating highly monodispersed emulsion droplets with a low sample dead volume was realized using a degassed poly(dimethylsiloxane) (PDMS) microfluidic chip possessing a simple T-junction channel geometry with two inlet reservoirs for oil and water to be loaded and one outlet reservoir for the collection of generated droplets. Autonomous transport of oil and water phases in the channel was executed by permeation of air confined inside the outlet reservoir into the degassed ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2015 - American Chemical Society | Analytical Chemistry
Wataru Nakamoto, Ryohei Hayami, Shun Aizawa, Yuta Miyase, Shintaro Fujii, Kazuki Yamamoto, Takahiro Gunji,
Self-cleaning materials with photoinduced hydrophilicity have received significant attention. These materials have been applied to rigid and flat substrates such as glasses and ceramics; however, their utilization on flexible substrates is necessary for their future applications. Herein, the preparation of a flexible and transparent self-cleaning film with photoinduced hydrophilicity is reported. The self-cleaning film was developed using three layers, namely, TiO2 as a cleaning layer, phosphonic- ...
Tópico(s): Marine Biology and Environmental Chemistry
2020 - Elsevier BV | Thin Solid Films
Hironari Takehara, Yuta Nakamoto, Narihito Ikeda, Kiyotaka Sasagawa, Makito Haruta, Toshihiko Noda, Takashi Tokuda, Jun Ohta,
In digital enzyme-linked immunosorbent assay, which is used for biomarker detection and diagnosis, the concentration of target biomarkers is estimated by counting the number of fluorescence chambers in the microchamber array. We propose a compact system for counting fluorescent chambers. Our system consists of three components: a micro-reaction chamber array, an absorption filter for attenuating excitation light, and a photodetector. The absorption filter has a micro-light-pipe array (m-LPA) structure. ...
Tópico(s): CCD and CMOS Imaging Sensors
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Biomedical Circuits and Systems
Mami Iima, Masako Kataoka, Maya Honda, Akane Ohashi, Ayami Ohno Kishimoto, Rie Ota, Ryuji Uozumi, Yuta Urushibata, Thorsten Feiweier, Masakazu Toi, Yuji Nakamoto,
Introduction The aim of this study was to investigate the variation of apparent diffusion coefficient (ADC) values with diffusion time according to breast tumor type and prognostic biomarkers expression. Materials and Methods A total of 201 patients with known or suspected breast tumors were prospectively enrolled in this study, and 132 breast tumors (86 malignant and 46 benign) were analyzed. Diffusion-weighted imaging scans with 2 diffusion times were acquired on a clinical 3-T magnetic resonance ...
Tópico(s): Breast Lesions and Carcinomas
2021 - Lippincott Williams & Wilkins | Investigative Radiology
Masahiro Shinoda, Hirotoshi Ebinuma, Osamu Itano, Yoshiyuki Yamagishi, Hideaki Obara, Minoru Kitago, Nobuhiro Nakamoto, Taizo Hibi, Hiroshi Yagi, Yuta Abe, Kentaro Matsubara, Po–Sung Chu, Yuko Wakayama, Nobuhito Taniki, Akihiro Yamaguchi, Ryusuke Amemiya, Rei Miyake, Takamasa Mizota, Takanori Kanai∥, Yuko Kitagawa,
Simeprevir (SMV) is a protease inhibitor which demonstrates good tolerability and high antiviral response in patients with hepatitis C. The clinical outcomes of triple therapy using simeprevir, pegylated interferon and ribavirin (SMV/PEG IFN/RBV) for recurrent hepatitis C after living donor liver transplantation (LDLT) have not been well reported. In this study, we assessed the outcomes of patients with recurrent hepatitis C (genotype 1) after LDLT who received triple therapy at our hospital.SMV/PEG ...
Tópico(s): Liver Disease Diagnosis and Treatment
2016 - Wiley | Hepatology Research
Hiroto Yoshida, Yuki Izumi, Yuta Hiraoka, Kazuki Nakanishi, Masaaki Nakamoto, Sayaka Hatano, Manabu Abe,
A new dimethyl(phenyl)silylborane having a naphthalene-1,8-diaminato (dan) substituent on the boron center, PhMe2Si-B(dan), was synthesized. Owing to the diminished boron Lewis acidity, it is highly stable toward air. Synthetic application of the silylborane to catalytic silylboration and silylation of alkynes is also described.
Tópico(s): Coordination Chemistry and Organometallics
2022 - Royal Society of Chemistry | Dalton Transactions
Krishna Pandu Wicaksono, Yasutaka Fushimi, Satoshi Nakajima, Akihiko Sakata, Sachi Okuchi, Takuya Hinoda, Sonoko Oshima, Sayo Otani, Hiroshi Tagawa, Yuta Urushibata, Yuji Nakamoto,
To assess the accuracy, repeatability, and reproducibility of T1 and T2 relaxation time measurements by three-dimensional magnetic resonance fingerprinting (3D MRF) using various dictionary resolutions.The ISMRM/NIST phantom was scanned daily for 10 days in two 3 T MR scanners using a 3D MRF sequence reconstructed using four dictionaries with varying step sizes and one dictionary with wider ranges. Thirty-nine healthy volunteers were enrolled: 20 subjects underwent whole-brain MRF scans in both scanners ...
Tópico(s): MRI in cancer diagnosis
2022 - Springer Science+Business Media | European Radiology
Akira Fujimoto, Kota Yoshida, Tomohiro Higaki, Yuta Kimura, Masami Nakamoto, Yukiyasu Kashiwagi, Mari Yamamoto, Masashi Saitoh, Toshinobu Ohno, S. Furuta,
To clarify the electrical transport properties of nanostructured thin films, tin-doped indium oxide (ITO) nanoparticle (NP) solution-processed films were fabricated. An air-atmosphere, simple chemical thermolysis method was used to grow the ITO NPs, and the structural and electrical properties of spin-coated granular ITO NP films were investigated. X-ray diffraction measurements showed clear observation of the cubic indium oxide (222) diffraction peak, and films with a smaller Sn concentration were ...
Tópico(s): Quantum and electron transport phenomena
2013 - Physical Society of Japan | Journal of the Physical Society of Japan
Takashi Munemasa, Taro Mukaibo, Yusuke Kondo, Chihiro Masaki, Yuichiro Kusuda, Yuta Miyagi, Shintaro Tsuka, Ryuji Hosokawa, Tetsuji Nakamoto,
Hypofunction of different organs in the body is associated with diabetes, including in the oral cavity. Diabetes is often associated with xerostomia, but the underlying mechanism is not well characterized. Thus, the mechanisms underlying diabetes-induced xerostomia were investigated in this study in KK-A y mice as an experimental model of type 2 diabetes.The mechanisms involved in diabetes-induced xerostomia were investigated using the ex vivo glandular perfusion technique, histological analysis, ...
Tópico(s): Neuropeptides and Animal Physiology
2017 - Wiley | Journal of Diabetes
Yukio Kawashima, Yuta Onishi, Norihisa Tatarazako, Hirotaka Yamamoto, Masaaki Koshio, Tomohiro Oka, Yoshifumi Horie, Haruna Watanabe, Takashi Nakamoto, Jun Yamamoto, Hidenori Ishikawa, Tomomi Sato, Kunihiko Yamazaki, Taisen Iguchi,
In June 2016, the Ministry of the Environment of Japan announced a program "EXTEND2016" on the implementation of testing and assessment for endocrine active chemicals, consisting of a two-tiered strategy. The aim of the Tier 1 screening and the Tier 2 testing is to identify the impacts on the endocrine system and to characterize the adverse effects to aquatic animals by endocrine disrupting chemicals detected in the aquatic environment in Japan. For the consistent assessment of the effects on reproduction ...
Tópico(s): Reproductive biology and impacts on aquatic species
2021 - Wiley | Journal of Applied Toxicology
Masashi Hirano, Kazuyuki Kitamura, Ikuo Kato, Chizuko Yanaihara, Ken‐ichi Iwamoto, Makiko Sekiyama, Chiho Watanabe, Takashi Nakamoto, Nobukazu Miyamoto, Yuta Onishi, Koji Arizono,
Abstract Dichlorodiphenyltrichloroethane (DDT) is one of the persistent organic pollutants (POPs) widely found in the environment and in the general population. In this study, a direct competitive enzyme immunoassay (EIA) has been developed for the quantitative analysis of DDT. To generate a specific polyclonal antibody for EIA, p, p′-DDT was conjugated to porcine thyroglobulin for rabbit immunization. At optimized EIA conditions, the standard curves ranged from 0.137 to 100 ng/mL with the quantification ...
Tópico(s): Analytical chemistry methods development
2007 - Taylor & Francis | Journal of Environmental Science and Health Part B
Akira Mima, Takahiro Nakamoto, YUTA SAITO, Keishi Matsumoto, Shinji Lee,
Background/Aim: Vildagliptin is one of the dipeptidyl peptidase-4 (DPP-4) inhibitors that have been shown to improve hyperglycemia in clinical trials among patients with type 2 diabetes. However, few studies have examined the efficacy of vildagliptin in patients with diabetic kidney disease (DKD). Patients and Methods: Eight patients with DKD received oral vildagliptin 50-100 mg/day. The duration of diabetes was 6.7±5.9 years and observation period was 23.6±9.8 months. Changes in fasting blood glucose, ...
Tópico(s): Hormonal Regulation and Hypertension
2024 - Stanford University Highwire Press | In Vivo
Akira Mima, Takeo Matsuki, Takahiro Nakamoto, Yuta Saito, Takaaki Morikawa, Sakura Kure, Shinji Lee,
A 77-year-old man was referred to our department because of macrohematuria, oliguria, and a serum creatinine level of 2.47 mg/dL during boron neutron capture therapy (BNCT) for oropharyngeal cancer. At baseline, his creatinine level had been 0.98 mg/dL. The vital signs and physical examination were normal. A urinalysis showed protein and numerous red cells per high-power field, and needle-shaped crystals were observed. A plane computed tomography showed hematoma within the extensive ureter. However, ...
Tópico(s): Folate and B Vitamins Research
2024 - Cureus, Inc. | Cureus
Azusa Nagao, Kunihiko Kido, Yoichi Nakamoto, Yuta Yoshida, Katsuyuki Fukutake,
Background: In previous studies, we reported that regular semi-annual POCUS over three years led to modifications in prophylaxis, contributing to the disappearance of synovitis, improvement in the annual bleeding rate, and joint function in hemophilia patients. Most modifications involved increasing doses, shortening intervals, and changing to new drugs. With ongoing AI technology development to offer accurate POCUS delivery, often dubbed as provider-dependent, we foresee active modifications of ...
Tópico(s): Systemic Sclerosis and Related Diseases
2023 - Elsevier BV | Blood
Atsuhiro Nakamoto, Yuta Omizo,
Let G be a quadrangulation on the projective plane P , i.e., a map of a simple graph on P such that each face is quadrilateral. For a vertex v ∈ V ( G ) of degree 3 with neighbors v 1 , v 3 , v 5 , a Y-rotation is to delete three edges v v 1 , v v 3 , v v 5 and add v v 2 , v v 4 , v v 6 , where the union of three faces incident to v is surrounded by a closed walk v 1 v 2 v 3 v 4 v 5 v 6 . We say that G is k -minimal if its shortest noncontractible cycle is of length k and if any face contraction yields a noncontractible cycle ...
Tópico(s): semigroups and automata theory
2021 - Elsevier BV | Discrete Applied Mathematics
Jinichiro Koga, Kota Ojiro, Ayumi Yanagida, Takahisa Suto, Hideaki Hiki, Yuki Inoue, Chihiro Sakai, Kohei Nakamoto, Yuta Fujisawa, Ayaka Orihara, Haruka Murakami, Shintaro Hirasawa, Kengo Nakajima, Tomoko Sakazawa, Hisakazu Yamane,
In animals, the health effects of ingested cacao proteins are unknown because the proteins are difficult to extract and purify from cacao beans. This study aimed to develop an extraction and purification method for cacao proteins and reveal the effect of ingestion of cacao proteins on defecation and intestinal microbiota in mice. Three groups of mice were fed a control diet (AIN-93 G), a cacao lignin diet (AIN-93 G containing 1.22% cacao lignin), or a cacao protein and lignin diet (AIN-93 G containing ...
Tópico(s): Food Chemistry and Fat Analysis
2022 - Elsevier BV | Current Developments in Nutrition
Yuta Segawa, Masahiro Inoue, Akihiro Nakamoto, Satoshi Umehara,
To safely handle hydrogen as an energy carrier, it is important to understand the behaviour of hydrogen. There are many methods available for measuring hydrogen concentration using conventional sensors; however, it is difficult to detect hydrogen gas from a distance. Here, we observed hydrogen behaviour over a narrow region of space with a Raman scattered light sensor. Generally, there is some delay in conventional sensors; however, there was almost no delay with the use of our sensor. We used 1- ...
Tópico(s): Advanced Chemical Sensor Technologies
2018 - Elsevier BV | International Journal of Hydrogen Energy
Yuta Kawakami, Shuko Nojiri, Daisuke Nakamoto, Yoshiki Irie, Satoshi Miyazawa, Manabu Kuroki, Yuji Nishizaki,
The Japanese government adopted policies to control human mobility in 2020 to prevent the spread of severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). The present study examined the impact of human mobility on COVID-19 cases at the prefectural level in Japan by devising an indicator to have a relationship between the number of infected people and on human mobility. We calculated origin-destination travel mobility within prefectures in Japan from March ...
Tópico(s): Data-Driven Disease Surveillance
2023 - Nature Portfolio | Scientific Reports
Koji Furukawa, Atsushi Shima, Daisuke Kambe, Akira Nishida, Ikko Wada, Haruhi Sakamaki, Kenji Yoshimura, Yuta Terada, Yusuke Sakato, Masahiro Mitsuhashi, Masanori Sawamura, Etsuro Nakanishi, Yosuke Taruno, Hodaka Yamakado, Yasutaka Fushimi, Tomohisa Okada, Yuji Nakamoto, Ryōsuke Takahashi, Nobukatsu Sawamoto,
Objective The motor severity in Parkinson disease (PD) is believed to parallel dopaminergic terminal degeneration in the striatum, although the terminal was reported to be virtually absent by 4 years postdiagnosis. Meanwhile, neuromelanin‐laden dopamine neuron loss in the substantia nigra (SN) elucidated a variability at early stages and gradual loss with less variability 10 years postdiagnosis. Here, we aimed to clarify the correlation between motor impairments and striatal dopaminergic terminal ...
Tópico(s): Genetic Neurodegenerative Diseases
2022 - Wiley | Annals of Neurology
Yasushi Hasegawa, Hideaki Obara, Po–Sung Chu, Masahiro Shinoda, Minoru Kitago, Yuta Abe, Hiroshi Yagi, Kentaro Matsubara, Nobuhiro Nakamoto, Yuko Kitagawa,
The main causes of liver cirrhosis have changed over the past decade. In Japan, the number of deceased donors is increasing but is still insufficient relative to the number of patients awaiting a liver transplant. In the present study we aimed to assess the outcomes of candidates for liver transplantation.This was a retrospective study of adult patients who visited our department for consultation regarding liver transplantation from January 2009 to December 2020. Of a total of 601 patients, 336 ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2022 - Wiley | Journal of Hepato-Biliary-Pancreatic Sciences
Yuta NAKAMOTO, Yuki KOZAWA, Gakuto HIRAZAWA, Takeshi Nishiwaki, Hideo Tsutamori,
Tópico(s): Microstructure and Mechanical Properties of Steels
2024 - The Japan Society for Technology and Plasticity | Journal of the Japan Society for Technology of Plasticity
Akira Mima, Yuta Saito, Keishi Matsumoto, Takahiro Nakamoto, Shinji Lee,
Diabetic kidney disease (DKD) is an important complication of diabetes as it results in end-stage renal disease; hence, several drugs have been developed for its treatment. However, even with treatment with renin-angiotensin system inhibitors and sodium-glucose cotransporter-2 inhibitors, the residual risk of DKD remains. While this risk is an issue, the renoprotective effects of finerenone, a novel non-steroidal mineralocorticoid receptor antagonist, are becoming evident. High proteinuria increases ...
Tópico(s): Diabetes Treatment and Management
2024 - Elsevier BV | Metabolism Open
Yuta Yoshimoto, Kazuo Azuma, Atsushi Miya, Eiichi Makino, Hidekazu Nakamoto, Nobutaka Abe, Masashi Kaburagi, Hisaki Ueda, Kohei Kuroda, Takeshi Tsuka, Akihiko Sugiyama, Tomohiro Imagawa, Yusuke Murahata, Norihiko Ito, Tomohiro Osaki, Tadashi Shimizu, Yoshiharu Okamoto,
Cryoablation is a minimally invasive cancer treatment. In this study, the effects of cryoablation on normal rabbit bone were evaluated using imaging and histopathological examinations. Cryoablation was performed using a Cryo-Hit (Galil Medical, Yokneam, Israel). Under anesthesia, one cryoablation needle was inserted at the center of the femur (day 0). To create an ice ball (2 × 3 cm), two 10-min freeze cycles were performed, separated by a 5-min thaw cycle. During cryoablation, changes in the bone and ...
Tópico(s): Bone health and treatments
2014 - Elsevier BV | Cryobiology
Hiroyuki Watanabe, Yuta Tarumizu, Sho Kaide, Yoichi Shimizu, Shimpei Iikuni, Yuji Nakamoto, Masahiro Ono,
Noninvasive imaging of tau aggregates with a positron emission tomography (PET) tracer is useful for the diagnosis and staging of Alzheimer's disease (AD). Recently, we found that benzimidazopyridine (BIP) is an attractive scaffold for developing PET and single photon computed emission tomography tracers targeting tau aggregates. In this study, we designed and synthesized five novel 18F-labeled compounds with various substituted groups or atoms at the 7-position of the BIP scaffold. In in vitro autoradiographic ...
Tópico(s): Lanthanide and Transition Metal Complexes
2021 - American Chemical Society | ACS Medicinal Chemistry Letters
Shuko Nojiri, Yuta Kawakami, Daisuke Nakamoto, Manabu Kuroki, Yuji Nishizaki,
On an ecological scale, the lag time between coronavirus disease 2019 (COVID-19) infection and related fatality has varied between epidemic waves and prefectures in Japan. The variability in lag time across areas of Japan during the seven distinct waves can help derive a more appropriate estimation of the weekly confirmed case fatality rate (CFR) of COVID-19.To estimate the 7-day moving average CFR across area block levels in Japan from February 2020 to July 2022 using the lag time between COVID-19 ...
Tópico(s): COVID-19 Clinical Research Studies
2023 - Elsevier BV | IJID Regions
Akane Ohashi, Masako Kataoka, Mami Iima, Maya Honda, Rie Ota, Yuta Urushibata, Dominik Nickel, Masakazu Toi, Sophia Zackrisson, Yuji Nakamoto,
Ultrafast (UF) dynamic contrast-enhanced (DCE)-MRI offers the potential for a faster and, therefore, less expensive examination of breast lesions; however, there are no reports that have evaluated whether UF DCE-MRI can be used the same as conventional DCE-MRI in the reading of morphological information. This study evaluated the agreement in morphological information obtained from malignant breast mass lesions between UF DCE-MRI and conventional DCE-MRI. UF DCE-MRI data were obtained over the first ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2023 - Multidisciplinary Digital Publishing Institute | Diagnostics
Akane Ohashi, Masako Kataoka, Mami Iima, Maya Honda, Rie Ota, Yuta Urushibata, Dominik Nickel, Masakazu Toi, Sophia Zackrisson, Yuji Nakamoto,
Tópico(s): Breast Cancer Treatment Studies
2023 - Springer Science+Business Media | European Radiology