Hongyi Li, Jiliang Cao, Xu Wu, Yun Deng, Na Ning, Chunxian Geng, Ting Lei, Ruizhen Lin, Ding‐Tao Wu, Shengpeng Wang, Peng Li, Yitao Wang,
... miscarriage and treat threatened abortion. Polysaccharides of ZYP (ZYPPs) play an essential role in the theraprutic effects ... compositions of ZYP and the complicated structure of ZYPPs have posed great challenges and barriers to the ... evaluation of ZYP. To identify and characterize the ZYPPs for better quality control of ZYP, a reliable ... to identify and discriminate the chemical structure of ZYPPs. Besides, the purpose of revealing the relationships between structure and biological activity of ZYPPs, their chemical characteristics, in vitro antioxidant and anti- ...
Tópico(s): Phytoestrogen effects and research
2020 - Elsevier BV | Journal of Ethnopharmacology
Gin S. Malhi, Carissa Coulston, Kristina Fritz, Lisa Lampe, Danielle Bargh, Michael Ablett, Bill Lyndon, R. J. SAPSFORD, Mike Theodoros, Derek Woolfall, Andrea van der Zypp, Malcolm Hopwood, Alex J. Mitchell,
Objective: Diagnosing depression in primary care settings is challenging. Patients are more likely to present with somatic symptoms, and typically with mild depression. Use of assessment scales is variable. In this context, it is uncertain how general practitioners (GPs) determine the severity of depressive illness in clinical practice. The aim of the current paper was to identify which symptoms are used by GPs when diagnosing depression and when determining severity. Method: A total of 1760 GPs ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2013 - SAGE Publishing | Australian & New Zealand Journal of Psychiatry
Khong Bee Kang, M. A. Sharmini Rajanayagam, Andrea van der Zypp, H. Majewski,
Tópico(s): Eicosanoids and Hypertension Pharmacology
2007 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Khong Bee Kang, Andrea van der Zypp, L Iannazzo, H. Majewski,
Cyclooxygenase (COX) catalyses the formation of prostanoids that are crucial in maintaining hemostasis and important in inflammation. Animal studies reveal that COX-1 and COX-2 expression increase in some cell types during aging. This study determined age-related changes in COX expression in platelets and monocytes. Platelets and mononuclear cells were isolated from healthy male human volunteers from 18 to 28 and from 55 to 65 years of age, as well as male rats 8 and 54 weeks old for comparison. ...
Tópico(s): Neuropeptides and Animal Physiology
2006 - Elsevier BV | Translational research
Andrea van der Zypp, Khong-Bee Kang, H. Majewski,
The signalling pathway involved in β-adrenoceptor relaxation was studied in aortas from rats either 8 or 54 weeks of age. The vasorelaxation produced by isoprenaline was almost completely abolished by endothelium removal in 54-week aortas, whereas in 8-week aortas, the effect was much smaller. The nitric oxide synthase inhibitor N-methyl-1-arginine acetate (l-NMMA) partially attenuated the isoprenaline induced relaxation to a similar extent in both age groups when the endothelium was intact, suggesting ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2000 - Elsevier BV | European Journal of Pharmacology
M. P. Rechtman, Andrea van der Zypp, H. Majewski,
We investigated the effects of amrinone on ischaemia-induced changes in myocardial function in isolated rat hearts. Isolated hearts from male Sprague–Dawley rats (150–275 g) were perfused with physiological salt solution at a constant flow rate. The effects of amrinone (30 μM) on left ventricular end diastolic pressure, positive and negative dP/dt, heart rate and coronary perfusion pressure were observed following global ischaemia and reperfusion. In normal hearts, amrinone had no effect on myocardial ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2000 - Elsevier BV | European Journal of Pharmacology
Andrea van der Zypp, H. Majewski,
1. The involvement of cGMP in vasodilatation produced by a range of nitrodilators was investigated using two different protein kinase G inhibitors, R(p) 8-bromoguanosine-3'5'-cyclic monophosphothioate (RBrcGMPS) and KT 5823. 2. The nitric oxide donors sodium nitroprusside (SNP), glyceryltrinitrate (GTN) and s-nitroso-acetylpenicillamine (SNAP), the endothelium-dependent vasodilator acetylcholine (ACh) as well as the cGMP analogues 8-(4-chlorophenylthio)-cGMP(CPTcGMP) and beta-phenyl-1-N2-etheno-8-bromo- ...
Tópico(s): Receptor Mechanisms and Signaling
1998 - Wiley | Clinical and Experimental Pharmacology and Physiology
Andrea van der Zypp, M. P. Rechtman, H. Majewski,
(1) The vasorelaxation produced by the phosphodiesterase 3 (PDE3) inhibitor, amrinone was investigated in isolated rat aorta denuded of endothelium. In the presence of extracellular Ca(2+), amrinone, milrinone and 3-isobutyl-1-methylxanthine (IBMX), relaxed endothelium-denuded rat aortic rings constricted with phenylephrine. While the actions of milrinone and IBMX were inhibited by the protein kinase G (PKG) inhibitor, Rp-8-Bromo guanosine-3',5' monophosphothioate (Rp-8-Br-cGMPS; 0.5 mM), that of amrinone ...
Tópico(s): Renin-Angiotensin System Studies
2000 - Elsevier BV | General Pharmacology The Vascular System
Khong Bee Kang, Andrea van der Zypp, H. Majewski,
1. Divergent evidence suggests that the intracellular signalling pathways for beta-adrenoceptor-mediated vascular relaxation involves either cAMP/protein kinase (PK) A or endothelial nitric oxide (NO) release and subsequent activation of cGMP/PKG. The present study identifies the relative roles of NO and cAMP, as well as dependence on the endothelium for beta-adrenoceptor-mediated relaxation of rat isolated aortas. 2. Cumulative concentration-response curves to isoprenaline (0.01-3 micromol/L) in phenylephrine ( ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2006 - Wiley | Clinical and Experimental Pharmacology and Physiology
Helena Teede, Andrea van der Zypp, H. Majewski,
Although gender and oestrogen treatment influence production of the vasorelaxant, NO, their influence on factors downstream in the NO signal-transduction pathway, specifically protein kinase G (PKG), remains unknown. We aimed to study the influence of sex hormones on PKG, along with the endothelial modulation of these effects, in rat thoracic aortic rings in two separate groups, control male and female rats and ovariectomized female rats after treatment with oestrogen or vehicle. Vessel preparations ...
Tópico(s): Receptor Mechanisms and Signaling
2001 - Portland Press | Clinical Science
Ian F. Musgrave, Andrea van der Zypp, MATHEW GRIGG, Colin J. Barrow,
A bstract : Agmatine and harmane have been proposed as endogenous ligands of imidazoline receptors. Agmatine has been reported to activate nitric oxide synthetase (NOS) in endothelial cells, so we sought to determine if agmatine or harmane and an analogue of harmane, propyl harmane, produced vasodilatation through an endothelium‐dependent mechanism. The experiments were performed in endothelium‐denuded and intact rat aortic rings preconstricted with phenylephrine (0.1 m M). Agmatine (0.3–1000 m M), harmane, ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2003 - Wiley | Annals of the New York Academy of Sciences
H. J. L. Maas, H. W. Antonisse, Akke J. van der Zypp, J.E. Groenendal, G. L. Kok,
Summary A programme to develop resistance to Marek's disease (MD) in chickens in two non‐inbred White Plymouth Rock (WPR) lines by breeding from survivors was initiated in 1968 and since then nine generations have been produced. In each generation only sires and dams which survived heavy exposure to virulent MD virus (MDV), Dutch strain K, either by inoculation (for the first two generations) or by contact‐exposure (for the following seven generations) were used. In this long term trial a high level ...
Tópico(s): Plant Pathogenic Bacteria Studies
1981 - Taylor & Francis | Avian Pathology
Helena TEEDE, Andrea VAN DER ZYPP, H. Majewski,
Although gender and oestrogen treatment influence production of the vasorelaxant, NO, their influence on factors downstream in the NO signal-transduction pathway, specifically protein kinase G (PKG), remains unknown. We aimed to study the influence of sex hormones on PKG, along with the endothelial modulation of these effects, in rat thoracic aortic rings in two separate groups, control male and female rats and ovariectomized female rats after treatment with oestrogen or vehicle. Vessel preparations ...
Tópico(s): Receptor Mechanisms and Signaling
2001 - Portland Press | Clinical Science
H. J. L. Maas, Akke J. van der Zypp, J. H. Groenendal, G. L. Kok,
Summary Two White Plymouth Rock lines (WPR), both developed into lines resistant for Marek's disease (MD), and one commercial WPR line, supposedly susceptible to the disease, were mated in a number of combinations to evaluate resistance to MD in their pure‐ and crossbred progeny. For this purpose the pedigreed 1‐day‐old progeny chicks were exposed to 3‐week‐old spreader chicks which had been inoculated at 1‐day‐old with virulent MD virus (MDV) and reared with them for the whole experimental period ...
Tópico(s): Plant Pathogens and Fungal Diseases
1982 - Taylor & Francis | Avian Pathology
Gin S. Malhi, Kristina Fritz, Carissa Coulston, Lisa Lampe, Danielle Bargh, Michael Ablett, Bill Lyndon, R. J. SAPSFORD, Mike Theodoros, Derek Woolfall, Andrea van der Zypp, Malcolm Hopwood,
The treatment of depression in primary care remains suboptimal for reasons that are complex and multifactorial. Typically GPs have to make difficult decisions in limited time and therefore, the aim of this study was to examine the management of depression of varying severity and the factors associated with treatment choices.Nested within a primary care educational initiative we conducted a survey of 1760 GPs. The GPs each identified four patients with clinical depression whom they had treated recently ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2013 - Elsevier BV | Journal of Affective Disorders