Janusz Kozak, Zbigniew Górski,
Fatigue strength determination of ship structural jointsSpectacular accidents at sea which have happened for a few last years show that hull structures of contemporary sea-going ships are not perfect and must be systematically improved. Fatigue strength is one of the groups of strength problems which affect design of contemporary ship's structures and greatly contribute in their improvement process. In this paper several approaches to estimation of fatigue life of hull structural elements are presented. ...
Tópico(s): Probabilistic and Robust Engineering Design
2011 - De Gruyter Open | Polish Maritime Research
T. Piotrowski, Paweł Rózga, Ryszard Kozak, Zbigniew Szymanski,
The article describes a case study when the voltage collapse during lightning impulse tests of new power transformers was noticed and when the repeated tests finished with a positive result. The step-by-step process of reaching the conclusion on the basis of dissolved gas analysis (DGA) as a key method of the investigations was presented. The considerations on the possible source of the analysis showed that the Duval triangle method, used in the analysis of the concentration of gases dissolved in ...
Tópico(s): Lightning and Electromagnetic Phenomena
2020 - Multidisciplinary Digital Publishing Institute | Energies
Robert Janowski, Maciej Kozak, Elżbieta Jankowska, Zbigniew Grzonka, Mariusz Jaskólski,
The three-dimensional structure of two polymorphs of a ZLFG-CH2-papain covalent complex has been determined by X-ray crystallography. The structures indicate that: (i) the methylene carbon atom of the inhibitor is covalently bound to the Sgamma atom of Cys25 of papain; (ii) the hydrophobic S2 pocket formed by Pro68, Val133, Val157, and Asp158 is occupied by the inhibitor's phenylalanyl P2 side chain; (iii) extensive hydrogen bonding and hydrophobic interactions are responsible for the interaction of ...
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2004 - Wiley | Journal of Peptide Research
Robert Janowski, Maciej Kozak, Elżbieta Jankowska, Zbigniew Grzonka, Anders Grubb, Magnus Abrahamson, Mariusz Jaskólski,
The crystal structure of human cystatin C, a protein with amyloidogenic properties and a potent inhibitor of cysteine proteases, reveals how the protein refolds to produce very tight two-fold symmetric dimers while retaining the secondary structure of the monomeric form. The dimerization occurs through three-dimensional domain swapping, a mechanism for forming oligomeric proteins. The reconstituted monomer-like domains are similar to chicken cystatin except for one inhibitory loop that unfolds to ...
Tópico(s): Trace Elements in Health
2001 - Nature Portfolio | Nature Structural & Molecular Biology
Maciej Kozak, Elżbieta Jankowska, Robert Janowski, Zbigniew Grzonka, Anders Grubb, Marcia Alvarez Fernandez, Magnus Abrahamson, Mariusz Jaskólski,
Human cystatin C, a protein with amyloidogenic properties and a potent inhibitor of papain-like mammalian proteases, has been produced in its full-length form by recombinant techniques and crystallized in two polymorphic forms: cubic and tetragonal. A selenomethionyl derivative of the protein, obtained by Escherichia coli expression and with complete Met→Se-Met substitution confirmed by mass spectrometry, amino-acid analysis and X-ray absorption spectra, was crystallized in the cubic form. A truncated ...
Tópico(s): Porphyrin Metabolism and Disorders
1999 - Wiley | Acta Crystallographica Section D Biological Crystallography
Krzysztof Pawełek, John J. Kozak, Zbigniew J. Grzywna,
Tópico(s): Nanopore and Nanochannel Transport Studies
2010 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Jolanta Szenajch, B Jasiński, A. Kozak, Jadwiga Kulik, M Chomicka, Jerzy Strużyna, Zbigniew Nowecki, Piotr Rutkowski, W. Ruka, W Kupść, Janusz A. Siedlecki, W Wiktor-Jędrzejczak,
Szenajch, J.; Jasinski, B.; Kozak, A.; Kulik, J.; Chomicka, M.; Struzyna, J.; Nowecki, Z.; Rutkowski, P.; Ruka, W.; Kupsc, W.; Siedlecki, J.; Wiktor-Jedrzejczak, W. Author Information
Tópico(s): Melanoma and MAPK Pathways
2002 - Lippincott Williams & Wilkins | Melanoma Research
Krzysztof Milewski, Andrzej Małecki, Dominika Orszulik-Baron, Mateusz Kachel, Piotr Hirnle, Marek Orczyk, Rafał Dunal, Grzegorz Mikołajowski, Adam Janas, Zbigniew Nowak, Karol Kozak, Wojciech Roskiewicz, Katarzyna Nierwińska, Andrzej Izworski, Adam Rybicki, Piotr Buszman, Ryszard Piotrowicz, Paweł Buszman,
Despite proven efficacy of cardiac rehabilitation (CR) in reducing the all-cause mortality in patients after myocardial revascularization, the penetration of CR, due to patient-related factors and referral rates remains limited. To improve the outcomes, home-based tele-rehabilitation (TR) has been proposed recently. In theory TR enhances the effects of standard CR procedures due to implementation of an intelligent monitoring system designed to ensure optimal training through on-demand transmission ...
Tópico(s): Stroke Rehabilitation and Recovery
2018 - Via Medica | Cardiology Journal
Zbigniew Kobus, R. Nadulski, Kamil Wilczyński, Marta Kozak, T. Guz, Leszek Rydzak,
The primary objective of the study was to determine the effect of process conditions on extraction efficiency and the total amount of released polyphenols and antioxidant activity (AA) in black chokeberry juice. The study samples were fruits of black chokeberry (Aronia melanocarpa (Michx.) Elliott) cv. Galicjanka. In the study, two kinds of presses—piston press and twin gear juice extractor—were used, and two raw material pretreatment methods—freezing and thawing and enzymatic liquefaction—were applied. ...
Tópico(s): Botanical Research and Applications
2019 - Public Library of Science | PLoS ONE
Cezary Czaplewski, Zbigniew Grzonka, Mariusz Jaskólski, Franciszek Kasprzykowski, Maciej Kozak, E Politowska, Jerzy Ciarkowski,
Papain from Carica papaya, an easily available cysteine protease, is the best-studied representative of this family of enzymes. The three dimensional structure of papain is very similar to that of other cysteine proteases of either plant (actinidin, caricain, papaya protease IV) or animal (cathepsins B, K, L, H) origin. As abnormalities in the activities of mammalian cysteine proteases accompany a variety of diseases, there has been a long-lasting interest in the development of potent and selective ...
Tópico(s): Protein Tyrosine Phosphatases
1999 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Janusz Kozak, Zbigniew Górski,
Tópico(s): Mechanical Engineering Research and Applications
2011 - Polish Society of Mechanical Engineers and Technicians | Welding Technology Review
Małgorzata Kowalczewska, Anna A. Brożyna, Wojciech Jóźwicki, Krzysztof Pławski, Michał Przybyszewski, Sylwia Wrotek, Zbigniew Bartuzi, Wiesław Kozak,
... Jóźwicki, Krzysztof Pławski, Michał Przybyszewski, Sylwia Wrotek, and Zbigniew Bartuzi et al. 2014. "Analysis of the involvement of cytokines in allergy and breast cancer association". Contemporary Oncology/Współczesna Onkologia 18 (6): 396-402. doi:10.5114/wo.2014.47903. Harvard Kowalczewska, M., Brożyna, A., Jóźwicki, W., Pławski, K., Przybyszewski, M., Wrotek, S., Bartuzi, Z., and Kozak, W. (2014). Analysis of the involvement of cytokines ...
Tópico(s): Asthma and respiratory diseases
2014 - Termedia Publishing House | Współczesna Onkologia
D. Gareth Evans, Kelly‐Anne Phillips, Roger L. Milne, Robert Fruscio, Cezary Cybulski, Jacek Gronwald, Jan Lubiński, Tomasz Huzarski, Zerin Hyder, Claire Forde, Kelly Metcalfe, Leigha Senter, Jeffrey N. Weitzel, Nadine Tung, Dana Zakalik, Maria Ekholm, Ping Sun, Steven A. Narod, Maria Błasińska-Morawiec, Maria Chosia, Kazimierz Drosik, S. Gozdecka-Grodecka, Stanisław Góźdż, Ewa Grzybowska, Arkadiusz Jeziorski, Aldona Karczewska, Radzisław Kordek, Agnieszka Synowiec, Beata Kozak‐Klonowska, Katarzyna Lamperska, Dariusz Lange, Andrzej Maćkiewicz, Jerzy Mituś, Stanislas Niepsuj, Oleg Oszurek, K Gugała, Zbigniew Morawiec, Tomasz Mierzwa, Michał Posmyk, Janusz Ryś, Cezary Szczylik, Michał Uciński, Krzysztof Urbański, Bernard Waśko, Piotr Wandzel, Michael Friedlander, Sue Anne McLachlan, Stephanie Nesci, Sandra Picken, Sarah O’Connor, Lucy Stanhope, Andrea Eisen, Kevin Sweet, Raymond H. Kim, William D. Foulkes, Pål Møller, Susan L. Neuhausen, Carey A. Cullinane, Charis Eng, Peter Ainsworth, Fergus Couch, Christian F. Singer, Beth Y. Karlan, Wendy McKinnon, Marie Wood,
The impact of various breast-cancer treatments on patients with a BRCA2 mutation has not been studied. We sought to estimate the impact of bilateral oophorectomy and other treatments on breast cancer-specific survival among patients with a germline BRCA2 mutation. We identified 664 women with stage I–III breast cancer and a BRCA2 mutation by combining five different datasets (retrospective and prospective). Subjects were followed for 7.2 years from diagnosis to death from breast cancer. Tumour characteristics ...
Tópico(s): Breast Cancer Treatment Studies
2021 - Springer Nature | British Journal of Cancer
Mirosław Zimnoch, Paulina Wach, Łukasz Chmura, Zbigniew Gorczyca, K. Różański, Jolanta Godłowska, J. E. Mazur, Krzysztof Kozak, Amela Jeričević,
Abstract. Concentration of radon (222Rn) in the near-ground atmosphere has been measured quasi-continuously from January 2005 to December 2009 at two continental sites in Europe: Heidelberg (south-west Germany) and Krakow (southern Poland). The atmosphere was sampled at ca. 30 and 20 m above the local ground. Both stations were equipped with identical instruments. Regular observations of 222Rn were supplemented by measurements of surface fluxes of this gas in the Krakow urban area, using two different ...
Tópico(s): Atmospheric chemistry and aerosols
2014 - Copernicus Publications | Atmospheric chemistry and physics
Chosen by Robert Liddington, Christin Frederick, Stephen D. Fuller, Sophie Jackson,
... through three-dimensional domain swapping. Robert Janowski, Maciej Kozak, Elzbieta Jankowska, Zbigniew Grzonka, Anders Grubb, Magnus Abrahamson, and Mariusz Jaskolski ( ...
Tópico(s): Respiratory viral infections research
2001 - Elsevier BV | Structure
Maciej Kozak, E Kozian, Zbigniew Grzonka, Mariusz Jaskólski,
A new crystal form of papain from the latex of Carica papaya, complexed with an inhibitor (Z-Arg-Leu-Val-Gly-CHN2) was obtained by the vapor-diffusion method using a methanol/ethanol mixture as a precipitant. The slat-like crystals are monoclinic, space group P2(1), with unit cell parameters a = 42.6 A, b = 49.8 A, c = 50.5 A, A = 111.9 degrees, and contain one molecule in the asymmetric unit. The crystals are stable in the X-ray beam and diffract beyond 1.8 A. A molecular model has been placed in the unit ...
Tópico(s): Phytochemistry and biological activities of Ficus species
1997 - Polish Biochemical Society | Acta Biochimica Polonica
Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Bohdan Górski, Paweł Domagała, Cezary Cybulski, Oleg Oszurek, Marek Szwiec, K Gugała, Małgorzata Stawicka, Zbigniew Morawiec, Tomasz Mierzwa, Hanna Janiszewska, Ewa Kilar, Elżbieta Marczyk, Beata Kozak‐Klonowska, Monika Siołek, Dariusz Surdyka, Rafał Wiśniowski, Michał Posmyk, Ping Sun, Jan Lubiński, Steven A. Narod,
To estimate 10-year overall survival (OS) rates for patients with early-onset breast cancer, with and without a BRCA1 mutation, and to identify prognostic factors among those with BRCA1-positive breast cancer.A total of 3,345 women with stage I to III breast cancer, age ≤ 50 years, were tested for three founder mutations in BRCA1. Information on tumor characteristics and treatments received was retrieved from medical records. Dates of death were obtained from the vital statistics registry. Survival ...
Tópico(s): DNA Repair Mechanisms
2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Michael S. Chmielewski, Zbigniew Serafin, Dorota Kamińska, Katarzyna Skrobisz, Oliwia Kozak, Piotr Olczyk, Przemysław Rutkowski, Marcin Adamczak, Edyta Szurowska, Magdalena Krajewska,
Radiological procedures utilising intravascular contrast media (ICM) are fundamental to modern medicine, enhancing diagnostics and treatment in diverse medical fields. However, the application of ICM has been constrained in patients with compromised kidney function due to perceived nephrotoxic risks, called contrast-induced nephropathy or contrast-induced acute kidney injury. Historical evidence marked ICM as a possible contributor to kidney damage. This led to restrictive guidelines advocating limited ...
Tópico(s): Trauma, Hemostasis, Coagulopathy, Resuscitation
2024 - Polish Medical Society of Radiology | Polish Journal of Radiology
Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Cezary Cybulski, Oleg Oszurek, Marek Szwiec, K Gugała, Małgorzata Stawicka, Zbigniew Morawiec, Tomasz Mierzwa, Michał Falco, H Janiszewska, Ewa Kilar, Elżbieta Marczyk, Beata Kozak‐Klonowska, Monika Siołek, Dariusz Surdyka, Rafał Wiśniowski, Michał Posmyk, Paweł Domagała, Peng Sun, Jan Lubiński, Steven A. Narod,
Tópico(s): Ovarian cancer diagnosis and treatment
2016 - Springer Science+Business Media | Breast Cancer Research and Treatment
Janusz Kozak, Zbigniew Górski,
Fatigue cracks occurring in ship structures are formed in areas particularly susceptible to variable loads, i.e. areas of stress concentration, which include welded joints. In the case of fatigue cracking of complex welded structures, which include ship hulls, the cracking process can be divided into two stages: propagation of the crack in the direction of thickness and the development of the crack across its width. In addition, some of the fatigue cracks develop unseen and cannot be noticed by ...
Tópico(s): Fatigue and fracture mechanics
2015 - Taylor & Francis | Welding International
Krzysztof Wycisk, Aneta Tarczewska, Magdalena Kaus‐Drobek, Michał Dadlez, Rafał Hołubowicz, Zbigniew Pietras, Andrzej Dziembowski, Michał Taube, Maciej Kozak, Marek Orłowski, Andrzej Ożyhar,
Nuclear receptors (NRs) are a family of ligand-dependent transcription factors activated by lipophilic compounds. NRs share a common structure comprising three domains: a variable N-terminal domain (NTD), a highly conserved globular DNA-binding domain and a ligand-binding domain. There are numerous papers describing the molecular details of the latter two globular domains. However, very little is known about the structure-function relationship of the NTD, especially as an intrinsically disordered ...
Tópico(s): Heat shock proteins research
2018 - Elsevier BV | The Journal of Steroid Biochemistry and Molecular Biology
Jolanta Jaśkowska, Przemysław Zaręba, Anna K. Drabczyk, Agnieszka Kozak, Izabela D. Madura, Zbigniew Majka, Edyta Pindelska,
New pharmaceutically acceptable salts of trazodone (trazodone hydrogen bromide and trazodone 1-hydroxy-2-naphthonic acid) for the treatment of central nervous system disorders are synthesized and described. Although trazodone salts are poorly crystalline, single-crystal X-ray diffraction data for trazodone 1-hydroxy-2-naphthonic acid were collected and analyzed as well as compared to the previously described crystal structure of commercially available trazodone hydrochloride. The powder samples of ...
Tópico(s): Coordination Chemistry and Organometallics
2021 - Multidisciplinary Digital Publishing Institute | Molecules
Joanna Tomiczek‐Szwiec, Marek Szwiec, Michał Falco, Cezary Cybulski, Dominika Wokołorczyk, Anna Jakubowska, Jacek Gronwald, Małgorzata Stawicka, Dariusz Godlewski, Ewa Kilar, Elżbieta Marczyk, Monika Siołek, Rafał Wiśniowski, Olga Haus, Robert Sibilski, Lubomir Bodnar, Ping Sun, Steven A. Narod, Jan Lubiński, Tomasz Huzarski, Maria Błasińska-Morawiec, Maria Chosia, Kazimierz Drosik, S. Gozdecka-Grodecka, Stanisław Góźdż, Ewa Grzybowska, Arkadiusz Jeziorski, Aldona Karczewska, Radzisław Kordek, Agnieszka Synowiec, Beata Kozak‐Klonowska, Katarzyna Lamperska, Dariusz Lange, Andrzej Maćkiewicz, Jerzy Mituś, Stanisław Niepsuj, Oleg Oszurek, K Gugała, Zbigniew Morawiec, Tomasz Mierzwa, Michał Posmyk, Janusz Ryś, Cezary Szczylik, Michał Uciński, Krzysztof Urbański, Bernard Waśko, Piotr Wandzel,
To estimate the impact of oophorectomy and other treatments on the survival of breast cancer patients with a CHEK2 mutation.Women with Stage I-III breast cancer who were treated at 17 hospitals in Poland were tested for four founder mutations in the CHEK2 gene. 974 women (10%) were positive for a CHEK2 mutation. Control patients without a CHEK2 mutation were selected from a database of patients treated over the same time period. Information on treatments received and distant recurrences were retrieved ...
Tópico(s): Male Breast Health Studies
2022 - Springer Nature | British Journal of Cancer
Michał Rażew, Zbigniew Warkocki, Michał Taube, Adam Kolondra, Mariusz Czarnocki‐Cieciura, Elżbieta Nowak, Karolina Łabędzka-Dmoch, Aleksandra Kawinska, Jakub Piątkowski, Paweł Golik, Maciej Kozak, Andrzej Dziembowski, Marcin Nowotny,
Abstract Nuclease and helicase activities play pivotal roles in various aspects of RNA processing and degradation. These two activities are often present in multi-subunit complexes from nucleic acid metabolism. In the mitochondrial exoribonuclease complex (mtEXO) both enzymatic activities are tightly coupled making it an excellent minimal system to study helicase–exoribonuclease coordination. mtEXO is composed of Dss1 3′-to-5′ exoribonuclease and Suv3 helicase. It is the master regulator of mitochondrial ...
Tópico(s): DNA Repair Mechanisms
2018 - Nature Portfolio | Nature Communications
Algimantas Grigelis, Zbigniew Wójcik, Wojciech Narębski, Leonora Živilė Gelumbauskaitė, Jan Kozák,
Summary In the late eighteenth and early nineteenth centuries the Polish geoscientist, philosopher, and statesman Stanisław Staszic (1755–1826) conducted an extensive geological survey of Poland and adjacent areas. In 1815, he completed a book (in Polish), On the geology of the Carpathians and other mountains and lowlands of Poland, complemented by a well-made geological map of Central and Eastern Europe. Early in the nineteenth century, Staszic refined the idea of 'geological mapping', though initially ...
Tópico(s): Geological Formations and Processes Exploration
2011 - Taylor & Francis | Annals of Science
Zbigniew Grzonka, Elżbieta Jankowska, Franciszek Kasprzykowski, Regina Kasprzykowska, Leszek Łankiewicz, Wiesław Wiczk, Ewa Wieczerzak, Jerzy Ciarkowski, Piotr Drabik, Robert Janowski, Maciej Kozak, Mariusz Jaskólski, Anders Grubb,
Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally ...
Tópico(s): Oral and gingival health research
2001 - Polish Biochemical Society | Acta Biochimica Polonica
Paweł Sobczak, Kazimierz Zawiślak, Marta Kozak, Jacek Mazur, Marian Panasiewicz, Zbigniew Kobus, Wioletta Żukiewicz-Sobczak,
The paper presents characteristics of mixtures of soya bean extrusion process with wheat and corn and soya beans’ meals with these cereals. On the Polish market, soybeans come mostly from traditional crops, for this reason its cultivation is much more expensive than soybeans derived from GM crops. Refuse soybean contains a large amount of fat that can be used as an additive enriching animal feed fat. It is however essential first soybeans processing. The extrusion process is one of the processing ...
Tópico(s): Agriculture, Plant Science, Crop Management
2015 - Elsevier BV | Agriculture and Agricultural Science Procedia
Zbigniew Tucholski, Bartosz Kozak,
The Power Plant Complex of the State Powder and Crushing Materials Factory in Zagożdżon-Pionki The article describes the former power plant complex at the State Powder and Crushing Materials Factory in Zagożdżon (now Pionki), dating back to the mid-1920s. It begins with an introduction outlining the company’s history, followed by a presentation of the history of the power plant and accompanying facilities, with a focus on the evolution of technical equipment and related architectural layers. Subsequently, ...
Tópico(s): Renewable energy and sustainable power systems
2023 - Wydawnictwo Uniwersytetu Jagiellońskiego | Kwartalnik Historii Nauki i Techniki
Ł. Jęczmionek, Marek Kozák, Xymena Badura, Zbigniew Stępień, Leszek Ziemiański, Grażyna Żak, Wojciech Krasodomski, G. Wcisło,
Direct hydroconversion of vegetable oils (by a one-stage process) and hydroconversion of vegetable oil zeoformates (by a two-stage process) lead to hydroraffinates that contain trace elements. The concentrations of these trace elements must be below the inductively coupled plasma optical emission spectrometry determination limit, in accordance with the recommendations and requirements specified in the relevant legislation (Worldwide Fuel Charter). In this work, it was found that some trace elements ( ...
Tópico(s): Catalysis and Hydrodesulfurization Studies
2017 - American Chemical Society | Energy & Fuels
Mariusz Jaskólski, Robert Janowski, Maciej Kozak, Elżbieta Jankowska, Zbigniew Grzonka, Anders Grubb, M. Alvarez Fernandez, Magnus Abrahamson,
Tópico(s): Reproductive Biology and Fertility
2000 - Wiley | Acta Crystallographica Section A Foundations of Crystallography