Edyta Wieczorek, Edyta Reszka, Wojciech Wąsowicz, Adam Grzegorczyk, Tomasz Konecki, Marek Sosnowski, Zbigniew Jabłonowski,
Breakdown of the extracellular matrix by matrix metalloproteinases (MMPs), as we know, is one of mechanisms involved and required in tumor invasion. MMP7 is a negative prognostic factor of various malignances, while MMP8 exhibits an inhibitory effect on tumorigenesis and metastasis. We evaluated the potential association of functional polymorphisms in the promoter of the MMP7 (rs11568818) and MMP8 (rs11225395) genes and bladder cancer (BCa) risk.The study included 241 BCa cases and 199 healthy population ...
Tópico(s): Peptidase Inhibition and Analysis
2013 - | Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication
Katarzyna Mizia‐Stec, Piotr Pysz, Marek Jasiński, Tomasz Adamczyk, Agnieszka Drzewiecka-Gerber, Artur Chmiel, Michał Krejca, Andrzej Bochenek, Stanisław Woś, Maciej Sosnowski, Zbigniew Gąsior, Maria Trusz‐Gluza, Michał Tendera,
Precise measurements of aortic complex diameters are essential for preoperative examinations of patients with aortic stenosis (AS) scheduled for aortic valve (AV) replacement. We aimed to prospectively compare the accuracy of transthoracic echocardiography (TTE), transoesophageal echocardiography (TEE) and multi-slice computed tomography (MSCT) measurements of the AV complex and to analyze the role of the multi-modality aortic annulus diameter (AAd) assessment in the selection of the optimal prosthesis ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2011 - Springer Science+Business Media | The International Journal of Cardiovascular Imaging
Natan M. Bornstein, Jeffrey L. Saver, Hans‐Christoph Diener, Philip B. Gorelick, Ashfaq Shuaib, Yoram Solberg, Thomas Devlin, Thomas Leung, Carlos A. Molina, David Školoudík, Jan Fiksa, Derk Krieger, Grethe Andersen, J. Berrouschot, Carsten Hobohm, Dietmar Schneider, B. Griewing, Matthias Endres, Karl-Georg Hausler, Hubert Kimmig, Peter A. Ringleb, Christian Weimar, Matthias Schilling, Martin Köhrmann, Andreas Hetzel, Manfred Kaps, Raymond Tak Fai Cheung, Piotr Sobolewski, Walenty Nyke, Anna Członkowska, Adam Stępień, Brola Waldemar, Agnieszka Słowik, Stelmasiakiem Zbigniewem, I Lubiński, Pedro Cardona Portela, Tomas Segure, Joan Martí‐Fàbregas, Marı́a Pilar Alonso, Antonio Núñez, Miguel Blanco Miguel, Anna Campello, Joaquin Arenillas, Nash Marshall, David Chiu, Harish Shownkeen, Marilyn Rymer, Souvik Sen, Martin Roubec, Martin Kuliha, Ctirad Lakomý, David Tyl, David Kemlink, Ondřej Doležal, Petra Reková, Veronika Krejčí, Anders Christensen, Bo Belhage, Christian Maschmann, C Larsen, Frank Pott, Hanne Christensen, Jakob Marstrand, Jens Kjellberg Nielsen, Per Meden, Svend Prytz, Sverre Rosenbaum, Jens Sörensen, Kaare Meier, Kare Schmift Ettrup, Kristina Dupont Hougaard, Paul Von Wietzel, Anett Stoll, Hans Schwetlick, Hendirk Pradel, Alexander Hemprich, Andreas Schulz, Bernhard Frerich, Carsten Hobohm, Christopher M. Weise, Dominik Michalski, Felix Schaller, Franziska Schiefke, Jens Helmrich, Johann Pelz, Martin Schnieder, Martin Schneider, Peter Matzen, Rudiger Langos, Stephan Müller-Duerwald, Sven Lukhaup, Ute Bauer, Wolfgang Kloppig, Erich Hiermann, Gregor Mucha, Hassan Soda, Renate Weinhardt, Teresa Mucha, Volker Ziegler, Alexander Abbushi, Benjamin Hotter, Benjamin Winter, Birgit Anthofer, Cornelia Noack, Dinah Laubisch, Gerd Heldge Schneider, Gerhard J. Jungehülsing, Heiko Mueller, Jens P. Dreier, Jochen B. Fiebach, Julia Flechsenhar, Kersten Villringer, Martin Ebinger, Michael Rozanski, Peter Vajkoczy, Randolf Klingebiel, Robert Steinicke, Sandra Pittl, Sarah Hoffmann, Stephan Maul, Thomas Krause, Thomas Liman, Thomas Plath, Tim Nowe, W. U. Schmidt, Carsten Fritzsch, Christopher Haas, Hans-Gerd Will, Katja Haußmann-Betz, Mohsen Bayat, Tomazs Pordzik, Andreas Hug, Christian Staff, Christoph Lichy, Georg Eggers, Manja Kloß, Martin Bendszus, Oliver Herrmann, Robin Seeberger, Soenke Schwarting, Stefan Rhode, Timolaos Rizos, Werner Hacke, Benedikt Frank, Bessi Bozkurt, Dagny Holle, Daniel S. Mueller, Dirk Koch, Hind Shanib, Joachim Sudendey, Johannes Brenck, Kolja Busch, Kristina Gartzen, Thomas Gasser, Tim Hagenacker, Boris Buerke, Gudrun Prigge, Jens Minnerup, Johannes Albers, Kai Wermker, Wolfram Schwindt, Bernd Kallmünzer Ringlestein, E.M. Hauer, Lorenz Breuer, Peter D. Schellinger, Rainer Kollmar, Roland Sauer, Stefan Schwab, Tobias Struffert, Anette Funfack, Anne Stechmann, Axel Schlaeger, Claus Laeppchen, Florian Schuchardt, Jan‐Helge Klingler, Janine Reis, Johann Lambeck, Mirko Friedrich, Mona Laible, Philip Wellermeyer, Sandra J. Beck, Sebastian Rutsch, Wolf‐Dirk Niesen, Christian Tanislav, H. Schaaf, Heiko Kerkmann, Ingo Schirotzek, Jens Allendörfer, S. Wolff, Alexander Yuk Lun Lau, Anne Yin Yan Chan, Deyond Y.W. Siu, Edward H Wong, George Kwok Chu Wong, Howan Leung, Ka Sing Wong, Xian Lun Zhu, Yannie Oi Yan Soo, Alan Choi Ting Tse, Gkk Leung, Kar Ming Leung, Kwan Ngai Hung, May Wai Mei Kwan, Mona Man Yu Tse, Philip Yat-hang Tse, P Chan, Raymand Lee, Richard Shek‐kwan Chang, Shirley Yin Yu Pang, Sonny Fong Kwong Hon, Tat Sun Cheng, Wai Man Lui, Windsor Wai Wo Mak, Anna Sobota, Baeta Wiater, Barbara Loch, Genowefa Wolak, Irena Łabudzka, Jan Dabal, Marcin Grzesik, Monika Sledzinska, Renata Hatalska‐Żerebiec, Wiktor Szczuchniak, Anna Gójska, Dariusz Nałęcz, Dariusz Gąsecki, Grzegorz Kozera, Łukasz Dylewicz, Marcin Niekra, Mariusz Kwarciany, Piotr Chomik, Piotr Skowron, Adam Kobayashi, Grzegorz Chabik, Grzegorz Makowicz, Jan Bembenek, Julia Jędrzejewska, Michał Karliński, Wojciech Czepiel, Bogdan Brodacki, Jacek Staszewski, Jarosław Kosek, Marcin Jadczak, Marta Durka-Kęsy, Krzysztof Kaluzny, Małgorzata Ziomek, Małgorzata Fudala, Zbigniew Sosnowski, Antoni Ferens, Elżbieta Szczygieł, Krzysztof Banaszkiewicz, Maciej Ziomek, Marcin Wnuk, Anna Szczepańska-Szerej, E Jach, Grazyna Elzbieta Maslanko, Joanna Wojczal, Piotr Luchowski, Andrzej Kowalczyk, J Jakubiak, Joanna Kopcewicz, Maciej Gajda, Małgorzata Wichlińska-Lubińska, David Rodríguez‐Luna, Estevo Santamarin, Jorge Pagola, Juan Lorente, Marc Ribó, Marta Rubiera, Olga Maisterra, Soccoro Pinero, Valera Catalina Iglesias, Gerard Plans, Helena Quesada, Marco Alberto Aparicio Caballero, Pedro Cardona Portela, Antonio Belinchon De Diego, David Sopelana‐Garay, Máximo Rafael García Rodriguez, Oscar Ayo Martin, Silvia Crusat Braña, Jorge García, Fernando Munoz Hernandez, Ignasi Catala, Josep Lluis Martí‐Vilalta, Rachel Delgado Mederos, Schmid Cristian de Quintana, Sergi Martínez‐Ramírez, Jaime Valcarcel Gonzalez, Jaime Masjuán, Jorge Diamantopoulus, Marta del Álamo, Pedro Domingo Poveda, Á. García Pastor, C. Fernández Carballal, Fernando Diaz,
Background and Purpose— Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, or large infarct core. Sphenopalatine ganglion (SPG) stimulation to enhance collateral flow and stabilize the blood-brain barrier offers an alternative, potentially more widely deliverable, therapy. Methods— In a randomized, sham-controlled, double-masked trial at 41 centers in 7 countries, ...
Lippincott Williams & Wilkins
N. Vynograd, I. Vynograd, Zbigniew Sosnowski,
Ninety men and women with recurrent genital HSV type 2 participated in a randomized, single-blind, masked investigator, controlled multi-centre study comparing the efficacy of ointment of Canadian propolis containing natural flavonoids with ointments of acyclovir and placebo (vehicle) on healing ability and capacity to remedy symptoms*. Thirty individuals were randomized to each group. Treatment was intended to start in the blister phase. All participants had HSV type 2 isolated, confirmed by serum ...
Tópico(s): Genital Health and Disease
2000 - Elsevier BV | Phytomedicine
Maciej Sosnowski, Zbigniew T. Czyż, Michał Tendera,
Abstract Background: Determinants of temporal lability in ventricular repolarisation are not fully recognised. We aimed to analyse the sources of RT variability by comparing normal subjects and patients after myocardial infarction (MI) with either depressed or preserved left ventricular (LV) function. Methods: One hundred and nine patients (27 women, 82 men, aged 51±9 years) were divided into three groups: 24 patients (pts) with an uncomplicated angiographically proven coronary heart disease (CHD‐group), ...
Tópico(s): Phonocardiography and Auscultation Techniques
2002 - Elsevier BV | European Journal of Heart Failure
Marcin Cichocki, Marek Sosnowski, Zbigniew Jabłonowski,
Angiomyolipoma (AML) is a rare benign renal tumor occurring in about 0.3 to 3% of the general population. Most frequently it takes the form of small single tumors occurring sporadically or accompanying tuberous sclerosis (Bourneville-Pringle disease). In some cases the tumor may reach a very large size and be a cause of various serious complications. This case description concerns a 26-year-old female patient, suffering from hypopituitarism, hypothyroidism and binocular blindness during the course ...
Tópico(s): Renal and related cancers
2014 - BioMed Central | European journal of medical research
Maciej Haberka, Maciej Sosnowski, Jolanta Zuziak-Pruska, Zbigniew Gąsior,
Epicardial and pericardial fat are well-established surrogate markers of cardiovascular diseases and complications. Extra-media thickness (EMT) is a novel ultrasound index corresponding to arterial adventitia and adipose tissue. We aimed to evaluate the association between carotid EMT and epicardial fat (EF) and pericardial fat (PF) and their relation to cardiovascular risk and metabolic syndrome (MS).One hundred consecutive patients (age: 51.7 ± 15.4 years; males 70%) scheduled for cardiac magnetic resonance ( ...
Tópico(s): Cardiovascular Health and Disease Prevention
2015 - Elsevier BV | Nutrition Metabolism and Cardiovascular Diseases
Maciej Sosnowski, Peter W. Macfarlane, Zbigniew T. Czyż, J Skrzypek-Wańha, Ewa Boczkowska-Gaik, Michał Tendera,
(1) to establish the normal limit of the heart rate variability (HRV) indices in a healthy population and in its four age-related subgroups, including a new HRV index, HRV fraction; and (2) to analyse the frequency and predictive value of abnormally low HRV in a population of post-infarction patients in respect to the cut-points chosen (raw or age-adjusted).Normal population of 296 healthy subjects (81 f, 215 m, aged 47+/-10 years) and post-infarction population of 298 patients (>3 months after acute ...
Tópico(s): ECG Monitoring and Analysis
2002 - Elsevier BV | International Journal of Cardiology
Piotr Lewitowicz, Jarosław Matykiewicz, Dorota Kozieł, Stanisław Głuszek, Zbigniew Sosnowski, Agata Horecka-Lewitowicz, Anna Nasierowska‐Guttmejer,
... Piotr, Jaroslaw Matykiewicz, Dorota Koziel, Stanislaw Z. Gluszek, Zbigniew Sosnowski, Agata Horecka-Lewitowicz, and Anna Nasierowska-Guttmejer. 2015. " ...
Tópico(s): Tumors and Oncological Cases
2015 - Termedia Publishing House | Polish Journal of Pathology
Stanisław Sosnowski, Stanisław Słomkowski, Stanisław Penczek, Zbigniew Florjańczyk,
Abstract The synthesis of highly uniform (1,08 ≤ M w / M n ≤ 1,13) telechelic poly(ε‐caprolactone) terminated at both ends with OH groups and its derivatization leading to poly(ε‐caprolactone) with pyrene end‐groups are described. The synthesis, carried out in THF at room temperature, involves initiation with (CH 3 CH 2 ) 2 AlO(CH 2 CH 2 O) 3 Al(CH 2 CH 3 ) 2 , leading to poly(ε‐caprolactone) macromolecules growing at both ends. The active centers were deactivated with acetic acid, giving macromolecules with ...
Tópico(s): Dendrimers and Hyperbranched Polymers
1991 - Wiley | Die Makromolekulare Chemie
Michał Tendera, Ewa Gaszewska-Żurek, Zofia Parma, Piotr Ponikowski, Ewa A. Jankowska, Kalina Kawecka−Jaszcz, Danuta Czarnecka, Maria Krzemińska‐Pakuła, Zbigniew Bednarkiewicz, Maciej Sosnowski, Michael Ochan Kilama, Rahul Agrawal,
Tópico(s): Cardiovascular Issues in Pregnancy
2012 - Springer Science+Business Media | Clinical Research in Cardiology
Edyta Reszka, Jolanta Gromadzińska, Ewa Jabłońska, Wojciech Wąsowicz, Zbigniew Jabłonowski, Marek Sosnowski,
Low concentrations of selenium (Se) in humans have been associated with risk of cancer. Selenoprotein mRNAs can potentially be regulated by Se status.Se status, GPx1 Pro198Leu and Sep15 1125G/A genetic polymorphism and human (h)GPx1, hGPx3, hSep15 and hSeP1 transcript levels in peripheral leukocytes of 33 males with bladder cancer and 47 healthy male controls were analysed.All the subjects expressed detectable selenoprotein mRNA concentrations in leukocytes. Significantly lower expression of hGPx1, ...
Tópico(s): Mercury impact and mitigation studies
2009 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
Maciej Sosnowski, Zbigniew T. Czyż, T Petelenz, Jacek M. Łęski, Michał Tendera,
Background: An application of the chaos theory to cardiology has gained growing interest during the last decade. It was shown that low dimensional chaos could be observed either in single cardiac cells, excitable cell assemblies, or in the whole heart and cardiovascular system. The aim of our study was to characterize the behavior of interbeat RT intervals variation in healthy subjects and in patients after myocardial infarction (Ml) in terms of the chaos theory. Methods: Twenty‐five healthy volunteers, ...
Tópico(s): Chaos control and synchronization
1997 - Wiley | Annals of Noninvasive Electrocardiology
Mateusz Czajkowski, Piotr Wierzbicki, Anna Kotulak‐Chrząszcz, Bartosz Małkiewicz, Roman Sosnowski, Zbigniew Kmieć, Marcin Matuszewski,
Background and Objectives: Penile cancer is a rare neoplasm in developed countries with an incidence of 0.8/100,000 per male inhabitant. Despite the development of personalized medicine and multimodal treatment, the outcome of penile cancer treatment is insufficient. Our study aimed to assess the levels of pro-inflammatory cytokines' mRNA such as interleukin 1-A (encoded by IL1A gene, alias IL-1A), interleukin 1-B (IL1B, IL-1B), interleukin 1 receptor antagonist (IL1RN, IL-1RN), interleukin 6 (IL6, ...
Tópico(s): Colorectal and Anal Carcinomas
2023 - Multidisciplinary Digital Publishing Institute | Medicina
Romuald Lango, Zbigniew Szkulmowski, Dariusz Maciejewski, Andrzej Sosnowski, Krzysztof Kusza,
Extracorporeal Membrane Oxygenation (ECMO) has become well established technique of the treatment of severe acute respiratory failure (Veno-Venous ECMO) or circulatory failure (Veno-Arterial ECMO) which enables effective blood oxygenation and carbon dioxide removal for several weeks. Veno-Venous ECMO (V-V ECMO ) is a lifesaving treatment of patients in whom severe ARDS makes artificial lung ventilation unlikely to provide satisfactory blood oxygenation for preventing further vital organs damage and progression ...
Tópico(s): Respiratory Support and Mechanisms
2017 - Via Medica | Anaesthesiology Intensive Therapy
Edyta Reszka, Zbigniew Jabłonowski, Edyta Wieczorek, Jolanta Gromadzińska, Marek Sosnowski, Wojciech Wąsowicz,
We explored association between GSTP1 Ile105Val (rs1695) polymorphism and GSTP1 mRNA expression in circulating blood leukocytes. GSTP1 transcripts level and polymorphism were determined by Real-Time PCR in 51 bladder cancer and 90 healthy men. Individuals with at least one GSTP1 Val105 variant allele possessed higher GSTP1 mRNA level in blood leukocytes compared to GSTP1 Ile105Ile carriers. GSTP1 Ile105Val gene polymorphism influences its expression in blood, regardless of cancer disease.
Tópico(s): Pharmacogenetics and Drug Metabolism
2011 - Elsevier BV | Clinical Biochemistry
Zbigniew Jabłonowski, Robert Kȩdzierski, E Miekoś, Marek Sosnowski,
To assess the effectiveness of visual laser ablation treatment with neodymium-doped yttrium aluminum garnet (Nd:YAG) laser in male patients with urethral strictures and to compare the effects with those obtained in patients treated with Sachse's optical urethrotomy.Fifty patients aged 22 to 83 (mean age 61.8) with primary (n = 26, 52%) and recurrent (n = 24, 48%) urethral strictures 0.3 to 2.4 cm long qualified for the study. The patients were randomized into two groups: 30 men treated using visual laser ...
Tópico(s): Urologic and reproductive health conditions
2010 - Mary Ann Liebert, Inc. | Photomedicine and Laser Surgery
Michał Petelenz, Joanna Musialik, P Besser, Maciej Gonciarz, Marek Sosnowski, Zbigniew T. Czyż, J Wilk, T Petelenz, Z Gonciarz,
Background and Study Aims: Cardiopulmonary complications have been reported during upper gastrointestinal endoscopy and endoscopic retrograde cholangiopancreatography (ERCP). The aim of this study was to evaluate the sympathovagal response to the stretching of the common bile duct caused by contrast medium injection during ERCP.
Tópico(s): Surgical Simulation and Training
2000 - Thieme Medical Publishers (Germany) | Endoscopy
Jarosław Sosnowski, Agnieszka Lukaszewicz, L Migalska, Maria Wojnowska, Zbigniew Polański,
research was performed on pachytene spermatocytes obtained from 8 male raccoon dogs and 10 male red foxes. cells were immunostained for visualization of synaptonemal complexes and sex chromosome chromatin. fluorescent microscope analysis revealed lack of pairing between the sex chromosomes. additionally, synaptonemal complex structures formed by the B chromosomes and their number in cell were determined. the data showed a large difference in the level of X and Y chromosome pairing failure in the ...
Tópico(s): Genetic Mapping and Diversity in Plants and Animals
2011 - De Gruyter | Annals of Animal Science
Zbigniew Jabłonowski, Edyta Reszka, Jolanta Gromadzińska, Wojciech Wąsowicz, Marek Sosnowski,
The aim of the study was to examine the frequency of methylation status in promoter regions of p16 and DAPK genes in patients with non-invasive bladder cancer.Forty-two patients (92.9% men, 73.8% smokers, 71.4% T1G1, 19.1% T1G2, 9.5% T1G3) and 36 healthy controls were studied. Isolation of genomic DNA from blood serum and methylation-specific PCR (MSP) were applied. Methylation status - methylated and unmethylated promoter regions of p16 and DAPK genes were analysed.Seventeen out of 42 patients (40.5%) ...
Tópico(s): Urological Disorders and Treatments
2011 - Termedia Publishing House | Archives of Medical Science
Cezary Cybulski, Bohdan Górski, Jacek Gronwald, Tomasz Huzarski, Tomasz Byrski, Tadeusz Dębniak, Anna Jakubowska, Dominika Wokołorczyk, Bartłomiej Gliniewicz, Andrzej Sikorski, Małgorzata Stawicka, Dariusz Godlewski, Zbigniew Kwias, Andrzej Antczak, K Krajka, Wojciech Lauer, Marek Sosnowski, Paulina Sikorska‐Radek, Krzysztof Bar, Robert Klijer, Romuald Zdrojowy, Bartosz Małkiewicz, Wen‐Chien Ko, Tomasz Borkowski, Marek Szwiec, Michał Posmyk, Steven A. Narod, Jan Lubiński,
Evidence to date that BRCA1 mutation carriers are at an increased risk of prostate cancer is mixed – both positive and negative studies have been published. To establish whether or not inherited variation in BRCA1 influences prostate cancer risk we genotyped 1793 men with prostate cancer in Poland and 4570 controls for three founder mutations (C61G, 4153delA and 5382insC). A BRCA1 mutation was present in 0.45% of the cases and 0.48% of the controls (odds ratio=0.9; P=1.0). The odds ratios varied substantially ...
Tópico(s): Genetic factors in colorectal cancer
2008 - Lippincott Williams & Wilkins | European Journal of Cancer Prevention
Cezary Cybulski, Dominika Wokołorczyk, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Bohdan Górski, Tadeusz Dębniak, Bartłomiej Masojć, Anna Jakubowska, Bartłomiej Gliniewicz, A. Sikorski, Małgorzata Stawicka, Dariusz Godlewski, Zbigniew Kwias, Andrzej Antczak, K Krajka, Wojciech Lauer, Marek Sosnowski, Paulina Sikorska‐Radek, Krzysztof Bar, Robert Klijer, Romuald Zdrojowy, Bartosz Małkiewicz, Wen‐Chien Ko, Tomasz Borkowski, Marek Szwiec, Steven A. Narod, Jan Lubiński,
Background: Germline mutations in the Chek2 kinase gene ( CHEK2 ) have been associated with a range of cancer types. Recently, a large deletion of exons 9 and 10 of CHEK2 was identified in several unrelated patients with breast cancer of Czech or Slovak origin. The geographical and ethnic extent of this founder allele has not yet been determined. Participants and methods: We assayed for the presence of this deletion, and of three other CHEK2 founder mutations, in 1864 patients with prostate cancer and 5496 controls ...
Tópico(s): Ovarian cancer diagnosis and treatment
2006 - BMJ | Journal of Medical Genetics
Zbigniew Purpurowicz, Marek Sosnowski,
The rapid development and invention of ever more technologically advanced ureterorenoscopes as well as other instruments used in fragmenting ureteral stones have made the traditional surgical treatment of ureterolithiasis very rare.
Tópico(s): Pediatric Urology and Nephrology Studies
2012 - | Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication
M. Traczyk, Edyta Borkowska, Marek Różniecki, Rafał Purpurowicz, Adam Jędrzejczyk, Piotr Marks, Michał Pietrusiński, Zbigniew Jabłonowski, Marek Sosnowski, Bogdan Kałużewski,
analysis of T81C polymorphism in H-RAS gene
Tópico(s): Ubiquitin and proteasome pathways
2012 - | Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication
Edyta Borkowska, Andrzej Kruk, Adam Jędrzejczyk, Marek Różniecki, Zbigniew Jabłonowski, M. Traczyk, Maria Constantinou, Monika Banaszkiewicz, Michał Pietrusiński, Marek Sosnowski, Freddie C. Hamdy, Stefán Péter, James W.F. Catto, Bogdan Kałużewski,
Abstract Kohonen self‐organizing maps ( SOM s) are unsupervised A rtificial N eural N etworks ( ANNs ) that are good for low‐density data visualization. They easily deal with complex and nonlinear relationships between variables. We evaluated molecular events that characterize high‐ and low‐grade BC pathways in the tumors from 104 patients. We compared the ability of statistical clustering with a SOM to stratify tumors according to the risk of progression to more advanced disease. In univariable analysis, ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2014 - Wiley | Cancer Medicine
Edyta Wieczorek, Edyta Reszka, Zbigniew Jabłonowski, Ewa Jabłońska, Magdalena Beata Król, Adam Grzegorczyk, Jolanta Gromadzińska, Marek Sosnowski, Wojciech Wąsowicz,
Objectives To elucidate genetic polymorphisms of the matrix metalloproteinases ( MMPs ) MMP 1 (rs1799750) , MMP 2 (rs243865) , MMP 9 (rs3918242) , MMP 12 (rs2276109) and tissue inhibitors of MMPs ( TIMPs ) TIMP 1 (rs2070584) and TIMP 3 (rs9619311) genes that may be involved in susceptibility to bladder cancer ( BC ). Patients and Methods We enrolled 241 patients with BC and 199 controls. Genomic DNA samples were extracted from peripheral blood and polymorphisms were analysed by high‐resolution melting analysis and by real‐ ...
Tópico(s): Bladder and Urothelial Cancer Treatments
2013 - Wiley | BJU International
Muthiah Vaduganathan, Robert A. Harrington, Gregg W. Stone, Efthymios Deliargyris, Philippe Gabríel Steg, C. Michael Gibson, Christian W. Hamm, Matthew J. Price, Alberto Menozzi, Jayne Prats, Steven Elkin, Kenneth W. Mahaffey, Harvey D. White, Deepak L. Bhatt, Fernando Cura, M Ballarino, Aníbal Damonte, Diego Grinfeld, Carlos Alejandro Álvarez, Alberto Ocaña, A. Farshid, Brendan Gunalingam, Craig Jeurgens, Harry C. Lowe, H. Hallani, G. Nelson, Gishel New, Ronald Dick, Jeffrey Lefkovits, Stephen W. Duffy, Nick Bett, Raibhan Yadav, P. Garrahy, Ron Lehman, Philip E. Aylward, John D. Horowitz, M. Worthley, D. Cross, Jaime Rankin, Peter Thompson, Phil Roberts-Thomson, D. Cross, Rohan Jayasinghe, Con Aroney, Kurt Huber, F Leisch, Johann Altenberger, Georg Gaul, Thomas Neunteufl, Franz Weidinger, Herwig Schuchlenz, H. Wéber, Werner Benzer, Paulo Roberto Ferreira ROSSI, Breno Oliveira Almeida, Antônio Francisco Godinho, Fábio Vilas‐Boas, Luciano Janussi Vacanti, Renato Giestas Serpa, José Antonio Jatene, Gilmar Reis, Jamil Abdalla Saad, Marcos Maynar-Mariño, Roberto Botelho, Constantino Costantini, Ricardo Wang, Dalton Bertolim Précoma, M Rati, L. C. Bodanese, Euler Roberto Fernandes Manenti, João Paulo Zouvi, Rogério Tumelero, Arthur Herdy, Eulógio Martinez Filho, Antônio Carlos Carvalho, Roberto Alexandre Franken, Lawrence Title, Charles Lazzam, François Reeves, Tamaz Shaburishvili, Gulnara Chapidze, Merab Mamatsashvili, Irakli Khintibidze, Kurt Huber, Hans‐Georg Olbrich, Sabine Genth‐Zotz, S Moebius-Winkler, Michael Buerke, Stefan Hoffmann, Peter W. Radke, Helge Moellmann, Hugo A. Katus, HANS-FRIEDRICH VOEHRINGER, Christian Hengstenberg, Volker Klauß, Johannes Brachmann, Aftab Ahmad Khan, Sampath Kumar, P.P. Mohanan, Praveen Chandra, M. Bhaskar Rao, S. S. Ramesh, Keyur Parikh, Arun Srinivas, Nakul Sinha, G. K. Surya Prakash, Shirish Hiremath, Anil Mishra, Sanjeeb Roy, Kamal Sethi, Ashwani Mehta, Tejas Patel, Suman Bhandari, Milind Gadkari, Milind Gadkari, Stefano De Servi, Giuseppe Musumeci, Alberto Menozzi, Bernardo Cortese, Giancarlo Marenzi, Raffaele De Caterina, Ralph Stewart, Gerard Devlin, Scott A. Harding, John F. Elliott, Gerard T. Wilkins, D. Scott, Sławomir Dobrzycki, Waldemar Dorniak, Dariusz Dudek, Zbigniew Gąsior, Jarosław Hiczkiewicz, Zdzisława Kornacewicz‐Jach, Leszek Kubik, Krzysztof Kuc, Jerzy Kuźniar, Walentyna Mazurek, Jakub Ostrowski, Michał Tendera, Andrzej Wiśniewski, Elżbieta Zinka, Krzysztof Żmudka, Jana Pawła, Maciej Kośmider, Seweryna, Andrés Íñiguez, Rafael Melgares, Francisco Javier Goicolea, José Hernández, Javier Zueco, Igor Kraiz, Mykola Vatutin, Anatoliy Polyakov, Y.N. Sokolov, Kenneth W. House, Charles Campbell, Timothy Trageser, Kenneth W. Baran, Neal S. Kleiman, Roberto Medina, Roger Hill, M. Zubair Jafar, David Drenning, Herbert Ladley, Adil Al‐Nahhas, Alan Niederman, Amit Goyal, William B. Abernethy, Naseem Jaffrani, Richard Zelman, B J Negus, José Marquez, Ehtisham Mahmud, William J. French, John Paulowski, Charles V. Pollack, M Mines, Robert Federici, Marc J. Schweiger, Kalim Habet, Ofsman Quintana, Thomas W. Nygaard, Steve Orlow, Douglas Spriggs, Ivan Chavez, M. Warner, Richard Paulus, David Cochran, Cary Hirsch, Ajay Virmani, Peter Soukas, Nalin Srivastava, Laurent Ferrier, Annapoorna Kini, Mark A. Greenberg, Hartmut Herrmann, Valerian Fernandes, Barry Bertolet, Ron Waksman, Joseph B. Henderson, Harinder Gogia, Maged Amine, Kourosh Mastali, Thomas Stuckey, Peter Hui, Luigi Pacifico, Todd Caulfield, Wilson Ginete, William L. Ballard, Robert Iwaoka, Joseph Stella, Vijay K. Misra, Costa Andreou, Michele Voeltz, Wayne Batchelor, Cezar Staniloae, Sanford J. Gips, Jeffrey Kramer, Paul Mahoney, John Wang, Prospero Gogo, David G. Rizik, David G. Rizik, Rex J. Winters, G. Hunter Mackenzie, Stephen J. Jenkins, Paul Teirstein, Pierre P. Leimgruber, J. Christopher Scott, Seth Krauss, Steven Rohrbeck, Robert G. Martin, Gustavo Grieco, Louis Cannon, Don Westerhausen, F. David Fortuin, Steven P. Schulman, Joel Cohn, Brent McLaurin, Jorge Saucedo, Robert Wozniak, J. J. Hall, Kevin Marzo, Merrill Krolick, Lawrence W. Gimple, Eric Hockstad, Arsenio Rodriguez, John Kao, Adhir Shroff, Michael Attubato, Ramon Quesada, Ernesto Rivera, Larry S. Dean, Russell Raymond, Thomas M. Amidon, David Lee, Spencer King, John S. Douglas, Abnash C. Jain, J Patrick Kleaveland, Mitchell Driesman, Krishna Kumar, Glen J. Kowalchuk, Behzad Taghizadeh, Lawrence A. Barr, Keith Benzuly, Tarek Helmy, Duane S. Pinto, Joseph Aragon, Reginald Low, Phillip A. Horwitz, Thomas D. LeGalley, Dominick J. Angiolillo, Rajesh Sachdeva, Kenneth M. Kent, Luis Gruberg, Richard G. Bach, Thomas Pow, Charles O’Shaughnessy, Shing Chiu Wong, Saeed R. Shaikh, Arthur Reitman, Mark E. Lawrence, Fernando Cura, Alejandro García Escudero, Carlos Poy, Miguel Miceli, Antonio Pocoví, Hugo Londero, Jorge Baccaro, L. Z. Polonetsky, Aliaksey Karotkin, Leanid Shubau, Eduardo da Rosa Maffini, Bruno Martins Machado, José Airton,
Cangrelor, an intravenous, reversible P2Y12 antagonist, is approved for use in patients undergoing percutaneous coronary intervention (PCI). This study sought to evaluate the efficacy and safety of cangrelor compared with clopidogrel in subgroups that did and did not receive glycoprotein IIb/IIIa inhibitors (GPIs). This pooled, patient-level analysis of the 3 CHAMPION (Cangrelor versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition) trials analyzed all randomized patients who ...
Elsevier BV
Edyta Wieczorek, Zbigniew Jabłonowski, Bartłomiej Tomasik, Jolanta Gromadzińska, Ewa Jabłońska, Tomasz Konecki, Wojciech Fendler, Marek Sosnowski, Wojciech Wąsowicz, Edyta Reszka,
The aim of this study was to evaluate the possible role in and contribution of antioxidant enzymes to bladder cancer (BC) etiology and recurrence after transurethral resection (TUR). We enrolled 40 patients with BC who underwent TUR and 100 sex- and age-matched healthy controls. The analysis was performed at diagnosis and recurrence, taking into account the time of recurrence. Gene expression of catalase (CAT), glutathione peroxidase 1 (GPX1) and manganese superoxide dismutase (SOD2) was determined in ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2017 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
Edyta Wieczorek, Zbigniew Jabłonowski, Bartłomiej Tomasik, Tomasz Konecki, Ewa Jabłońska, Jolanta Gromadzińska, Wojciech Fendler, Marek Sosnowski, Wojciech Wąsowicz, Edyta Reszka,
To investigate the clinical correlates and prognostic utility of MMP , VEGF and TIMP genes expression in bladder cancer (BCa) recurrence. Expression of MMP1 , MMP2 , MMP9 , VEGFA and TIMP1 , TIMP3 was analyzed by qRT-PCR using SYBR Green in peripheral blood leukocytes (PBLs) of BCa patients at two time points (diagnosis (n = 40), and first recurrence (n = 40)) and an age-matched group of healthy controls (n = 100). Plasma concentrations of MMP1 (pro- and active forms) were measured using ELISA in BCa patients. The expression ...
Tópico(s): Cancer, Lipids, and Metabolism
2015 - Elsevier BV | Clinical Biochemistry
Edyta Reszka, Zbigniew Jabłonowski, Edyta Wieczorek, Ewa Jabłońska, Magdalena Beata Król, Jolanta Gromadzińska, Adam Grzegorczyk, Marek Sosnowski, Wojciech Wąsowicz,
NRF2 transcription factor is involved in modulation of various antioxidant and metabolic genes and, therefore, may modulate anti-carcinogenic potential. Association between polymorphisms of NRF2 and five NRF2-regulated genes and urinary bladder cancer (BC) risk was analyzed.
Tópico(s): Bladder and Urothelial Cancer Treatments
2014 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology