
Ana Maria Dias Fachini, Antonio Carlos Zuliani, Luı́s Otávio Sarian, Júlio César Teixeira, Sérgio Carlos Barros Esteves, Helymar da Costa Machado, Luíz Carlos Zeferino,
Objective The present analysis determined the disease free survival (DFS) and overall survival (OS) at up to 14 years of follow-up in women who participated in our previous phase 3 randomized controlled clinical trial, in which women with stage IIIB squamous cervical cancer received either cisplatin plus RT or RT alone for treatment. The first study showed that the addition of cisplatin to RT offered a significant benefit in DFS, but not in OS. Methods The present analysis examined DFS and OS in 146 ...
Tópico(s): Cervical Cancer and HPV Research
2020 - Elsevier BV | Gynecologic Oncology

Ana C. Marcelino, Bruno Gozzi, Cássio Cardoso-Filho, Helymar da Costa Machado, Luíz Carlos Zeferino, Diama Bhadra Vale,
In Brazil, inequalities in access may interfere with cancer care. This study aimed to evaluate the influence of race on breast cancer mortality in the state of São Paulo, from 2000 to 2017, contextualizing with other causes of death.A population-based retrospective study using mortality rates, age and race as variables. Information on deaths was collected from the Ministry of Health Information System. Only white and black categories were used. Mortality rates were age-adjusted by the standard method. ...
Tópico(s): Cancer Risks and Factors
2021 - BioMed Central | BMC Cancer

Júlio César Teixeira, Carlos Afonso Maestri, Helymar da Costa Machado, Luíz Carlos Zeferino, Newton Sérgio de Carvalho,
Objective The aim of this study was to assess the time trends and pattern of cervical cancer diagnosed in the period from 2001 to 2012 by means of an opportunistic screening program from two developed regions in Brazil. Methods An observational study analyzing 3,364 cancer records (n = 1,646 from Campinas and n = 1,718 from Curitiba region) available in hospital-based cancer registries was done. An additional 1,836 records of CIN3/AIS from the region of Campinas was analyzed. The statistical analysis ...
Tópico(s): Women's cancer prevention and management
2018 - Thieme Medical Publishers (Germany) | Revista Brasileira Ginecologia e Obstetrícia
Tópico(s): Literature, Culture, and Criticism
2021 - | 19&20

Maria Terezinha Zeferino, Vivian Costa Fermo, Marcelo Brandt Fialho, Francisco Inácio Bastos,
Crack cocaine has been a major public health problem in Brazil due to the individual and social harms and risks deriving from its use. This article aims to assess the characteristics of drug scenes in the capital and Midwest of Santa Catarina state. The project used the Time-Location Sampling. Between January and June 2011, 41 crack cocaine scenes were mapped in capital of Santa Catarina, whereas 33 were mapped in the Midwest of that state. Such scenes were randomly selected to be observed, as well ...
Tópico(s): Substance Abuse Treatment and Outcomes
2017 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva

Thaise Honorato de Souza, Maria Terezinha Zeferino, Vivian Costa Fermo,
ABSTRACT This study investigated to understand how user embracement of users with acute illness or chronic worsened works, which has no scheduled service (spontaneous demand) from the perspective of workers of the reception service of health centers in a municipality in the southern region of Brazil. Descriptive exploratory qualitative study conducted in ten health centers in a municipality of Santa Catarina, Brazil. In data collection 17 workers from the reception of these health services were interviewed ...
Tópico(s): Health, Nursing, Elderly Care
2016 - Universidade Federal de Santa Catarina, Programa de Pós Graduação em Enfermagem | Texto & Contexto - Enfermagem

Michele Fernandes Rodrigues, Maximiliano Ribeiro Guerra, Angélica Vilela Rodrigues de ALVARENGA, Danillo Zeferino de Oliveira Souza, Rafaella Angélica Vieira e Silva COSTA, Sônia Maria Neumann Cupolilo,
ABSTRACT BACKGROUND: Helicobacter pylori infection is the most important risk factor for gastric atrophy and intestinal metaplasia, both considered gastric cancer precursor lesions. Therefore, the investigation of the occurrence of H. pylori infection, precursor lesions and associated factors guides the adoption of specific strategies for the control this type of cancer. OBJECTIVE: To evaluate the prevalence of H. pylori infection in patients undergoing upper digestive endoscopy, as well as the ...
Tópico(s): Eosinophilic Esophagitis
2019 - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) | Arquivos de Gastroenterologia

Marcos Danilo Costa de Almeida, João Antônio Pessoa da Silva, Felipe Fernando da Costa Tavares, Ludmila Leite Araújo, Jefferson de Souza Zeferino, Ruth Marlene Campomanes Santana,
In this work, a bio-based adhesive is prepared from Protium heptaphyllum resin. The resin is first characterized by 1H and 13C nuclear magnetic resonance spectroscopy and the bioadhesive is then prepared using a simple mixture of the resin with linseed oil, catalyzed by cobalt octanoate, to induce crosslinking. The precursors and bioadhesive obtained are characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The ...
Tópico(s): Synthetic Organic Chemistry Methods
2021 - Associação Brasileira de Polímeros | Polímeros

Michelle Garcia Discacciati, Ismael DCG. da Silva, Luisa L. Villa, Leandro Reis, Priscila Hayashi, Cecília Costa, Sílvia Helena Rabelo‐Santos, Luíz Carlos Zeferino,
This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL).This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months.Women with a negative or low-risk HPV status showed 100% CIN 2 regression. ...
Tópico(s): Cancer-related molecular mechanisms research
2014 - SAGE Publishing | Biomarker Insights

Gustavo Jacob Lourenço, Cássio Cardoso-Filho, Neiva Sellan Lopes Gonçales, Júlia Yoriko Shinzato, Luis Carlos Zeferino, Helvia Nascimento, Fernando Ferreira Costa, Maria Salete Costa Gurgel, Carmen Sílvia Passos Lima,
Tópico(s): Protease and Inhibitor Mechanisms
2006 - Springer Science+Business Media | Breast Cancer Research and Treatment
Ludhmila Abrahão Hajjar, Jean‐Louis Vincent, Filomena Regina Barbosa Gomes Galas, Andrew Rhodes, Giovanni Landoni, E Osawa, Renato Melo, M Sundin, Solimar Miranda Grande, Fábio Antônio Gaiotto, Pablo Maria Alberto Pomerantzeff, Luís Alberto Oliveira Dallan, Rafael Alves Franco, Rosana Ely Nakamura, Luiz Augusto Ferreira Lisboa, Juliano Pinheiro de Almeida, A Gerent, Dayenne Hianae Souza, Maria Alice Gaiane, Júlia Tizue Fukushima, Clarice Lee Park, Cristiane Maciel Zambolim, Graziela Santos Rocha Ferreira, Tânia Mara Varejão Strabelli, Felipe Lourenço Fernandes, Lígia Câmara, S Zeferino, Valter Garcia Santos, M Piccioni, Fábio Biscegli Jatene, José Otávio Costa Auler Júnior, Roberto Kalil Filho,
Vasoplegic syndrome is a common complication after cardiac surgery and impacts negatively on patient outcomes. The objective of this study was to evaluate whether vasopressin is superior to norepinephrine in reducing postoperative complications in patients with vasoplegic syndrome.This prospective, randomized, double-blind trial was conducted at the Heart Institute, University of Sao Paulo, Sao Paulo, Brazil, between January 2012 and March 2014. Patients with vasoplegic shock (defined as mean arterial ...
Tópico(s): Cardiac Arrest and Resuscitation
2016 - Lippincott Williams & Wilkins | Anesthesiology

Maria Cecília Ramiro Talarico, Rafaella Almeida Lima Nunes, Gabriela Ávila Fernandes Silva, Larissa Bastos Eloy da Costa, Marcella R. Cardoso, Sérgio Carlos Barros Esteves, Luı́s Otávio Sarian, Luíz Carlos Zeferino, Lara Termini,
High superoxide dismutase 2 (SOD2) expression is associated with a poor prognosis at many cancer sites, the presence of metastases, and more advanced cervical cancer. This study aims to determine whether SOD2 protein expression is associated with the prognosis of stage IIIB cervical carcinoma. Methods: sixty-three patients with stage IIIB squamous cell cervical carcinoma were included. The evaluation of SOD2 expression by immunohistochemistry was based on a positive cell ratio score and the staining ...
Tópico(s): Glutathione Transferases and Polymorphisms
2021 - Multidisciplinary Digital Publishing Institute | Antioxidants

Raimunda Sâmia Nogueira Brilhante, Débora de Souza Collares Maia Castelo‐Branco, Guilherme P. S. Duarte, Manoel de Araújo Neto Paiva, Carlos Eduardo Cordeiro Teixeira, João Paulo Otaviano Zeferino, André Jalles Monteiro, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha,
Twenty-two raptors from a rehabilitation centre were evaluated for the presence of yeasts prior to returning them to the wild, and the recovered Candida isolates were tested for in vitro antifungal susceptibility and phospholipase production. Samples were collected from the crop/lower esophagus and cloaca. In vitro antifungal susceptibility and phospholipase production of 21 Candida strains were assessed through broth microdilution and growth on egg yolk agar respectively. Twenty-seven isolates, ...
Tópico(s): Insects and Parasite Interactions
2012 - Wiley | Environmental Microbiology Reports

... e Animais – Vítor Meireles de Lima e João Zeferino da Costa – além, das possíveis relações com os métodos de ...
Tópico(s): Sociology and Education in Brazil
2019 - UNIVERSIDADE ESTADUAL DE CAMPINAS | Revista Visuais
... late 19th-century Rio de Janeiro, such as Zeferino da Costa, Rodolpho Bernardelli, Pedro Weingärtner and Henrique Bernardelli used ...
Tópico(s): History of Education Research in Brazil
2013 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Esboços histórias em contextos globais

Narriman Kênnia da Silva Barros, Cecília Costa, Rosane Ribeiro Figueiredo Alves, Luisa L. Villa, Sophie Derchain, Luíz Carlos Zeferino, Megmar Aparecida dos Santos Carneiro, Sílvia Helena Rabelo‐Santos,
Abstract High‐risk human papillomavirus (HPV) is considered the main etiological agent for cervical neoplasia. However, the presence of a single type HPV infection alone is unlikely to be sufficient to cause cervical cancer. There is epidemiologic evidence suggesting that HPV and Chlamydia trachomatis play a central role in the etiology of cervical intraepithelial neoplasia and subsequent cervical cancer. To evaluate the HPV prevalence and the seropositivity for C. trachomatis in women referred to ...
Tópico(s): Genital Health and Disease
2012 - Wiley | Journal of Medical Virology

Eliana Elizabet dos Santos, Nathalie Cruz Sena, Diego Balestrin, Elpı́dio Inácio Fernandes Filho, Liovando Marciano da Costa, Leiliane Bozzi Zeferino,
Fire behavior prediction models can assist environmental agencies with fire prevention and control. This study aimed to adjust a fire prediction model for the state of Minas Gerais, Brazil. Using the R program and hotspots provided by the National Institute for Space Research (INPE) for 2010, prediction of the probability of fires through the Random Forest algorithm was conducted using the Bootstrapping method. The model generated a prediction map with global kappa value of 0.65. External validation ...
Tópico(s): Environmental and biological studies
2020 - UNIVERSIDADE FEDERAL RURAL DO RIO DE JANEIRO | Floresta e Ambiente

Ricardo Filipe Alves Costa, Adhemar Longatto‐Filho, Céline Pinheiro, Luíz Carlos Zeferino, José Humberto Tavares Guerreiro Fregnani,
Background The Cervical Cancer Database of the Brazilian National Health Service (SISCOLO) contains information regarding all cervical cytological tests and, if properly explored, can be used as a tool for monitoring and managing the cervical cancer screening program. The aim of this study was to perform a historical analysis of the cervical cancer screening program in Brazil from 2006 to 2013. Material and Methods The data necessary to calculate quality indicators were obtained from the SISCOLO, ...
Tópico(s): Global Cancer Incidence and Screening
2015 - Public Library of Science | PLoS ONE

Júlio César Teixeira, Carlos Afonso Maestri, Helymar da Costa Machado, Luíz Carlos Zeferino, Newton Sérgio de Carvalho,
BACKGROUND: Brazilian opportunistic screening programs for cervical cancer have limited impact. In the regions of two cities (Campinas and Curitiba) with high human development indices, consistent information from 96-97% of all cervical cancer cases managed within the public healthcare system is available. OBJECTIVE: To estimate the incidence rate (IR) and temporal trends in these regions, covering 2001-2012. DESIGN AND SETTING: A population-based cohort study was conducted under the assumption that ...
Tópico(s): Women's cancer prevention and management
2019 - Medical Association of São Paulo | Sao Paulo Medical Journal

Gabriel Negreiros Salomão, Roberto Dall’Agnol, Prafulla Kumar Sahoo, Gabriel Soares de Almeida, Rafael Tarantino Amarante, Leiliane Bozzi Zeferino, João Paulo Nobre Lopes, Pedro Walfir Martins e Souza Filho, Normara Yane Mar da Costa, José Tasso Felix Guimarães, Marcio Sousa da Silva, Gabriel Caixeta Martins, Mayara Fraeda Barbosa Teixeira, Eduardo Duarte Marques, Rômulo Simões Angélica, Wilker Emmanoel Oliveira Araújo,
The expansion of areas of human occupation and the increase in economic activity and deforestation are negatively impacting the Amazon ecosystem. Situated in the Carajás Mineral Province in the southeastern Amazon, the Itacaiúnas River Watershed (IRW) encompasses several active mines and has a historical record of intense deforestation primarily linked with the expansion of pasturelands, but also of urban areas, and mining activities. Industrial mining projects are subjected to strict environmental ...
Tópico(s): Mercury impact and mitigation studies
2023 - Elsevier BV | Environmental Pollution

Sílvia Helena Rabelo‐Santos, Sophie Derchain, Luisa L. Villa, Cecília Costa, Luı́s Otávio Sarian, Maria Cristina do Amaral Westin, Janet R. Kornegay, Luíz Carlos Zeferino,
This study was designed to analyze whether specific human papillomavirus (HPV) genotypes may predict histologic outcomes in women with glandular abnormalities in their cervical smears. Of the 160 women included, 111 were diagnosed with atypical glandular cells, 35 had both atypical glandular cells and high-grade squamous intraepithelial lesions, whereas 14 women had AIS, in 1 case associated with high-grade squamous intraepithelial lesions. All women underwent colposcopic examinations and biopsy ...
Tópico(s): Colorectal and Anal Carcinomas
2009 - Lippincott Williams & Wilkins | International Journal of Gynecological Pathology

Luíz Carlos Zeferino, Sílvia Helena Rabelo‐Santos, Luisa L. Villa, Luı́s Otávio Sarian, Cecília Costa, Maria Cristina do Amaral Westin, L. A. L. Angelo‐Andrade, Sophie Derchain,
This study analyzed whether HPV (human papillomavirus) testing contributes towards defining histological abnormalities in women with atypical glandular cells (AGC) diagnosed at cervical cytology.One hundred and eight women with conventional cervical cancer screening smears suggestive of AGC not otherwise specified (AGC-NOS) and favor neoplastic (AGC-FN) were consecutively enrolled. All women underwent colposcopic examinations and biopsy was performed according to the cytopathologic and/or colposcopic ...
Tópico(s): Global Cancer Incidence and Screening
2011 - Elsevier BV | European Journal of Obstetrics & Gynecology and Reproductive Biology

Sílvia Helena Rabelo‐Santos, Lara Termini, Enrique Boccardo, Sophie Derchain, Adhemar Longatto‐Filho, Maria Antonieta Andreoli, Cecília Costa, Rafaella Almeida Lima Nunes, L. A. L. Angelo‐Andrade, Luisa L. Villa, Luíz Carlos Zeferino,
// Silvia Helena Rabelo-Santos 1 , Lara Termini 2 , Enrique Boccardo 3 , Sophie Derchain 4 , Adhemar Longatto-Filho 5, 6 , Maria Antonieta Andreoli 7 , Maria Cecília Costa 2 , Rafaella Almeida Lima Nunes 2 , Liliana Aparecida Lucci Ângelo-Andrade 8 , Luisa Lina Villa 2, 9 and Luiz Carlos Zeferino 4 1 School of Pharmacy, Federal University of Goiás (UFG – Universidade Federal de Goiás), Goiás, Brazil 2 Innovation in Cancer Laboratory, Center of Translational Research in Oncology, Cancer Institute of São Paulo (ICESP - Instituto ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2018 - Impact Journals LLC | Oncotarget

Marcus Vinicius Martins de Menezes, Anna Letícia Oliveira Cestari, Orlando José de Almeida, Marcelo Alvarenga, Glauce Aparecida Pinto, Maria Salete Costa Gurgel, Gustavo A. de Souza, Luíz Carlos Zeferino,
CONTEXT AND OBJECTIVE: Breast cancer is thought to derive from progressively aberrant, non-invasive breast lesions, but it is not known exactly how invasive breast cancer develops from these lesions. The aim of this study was to verify the changes in c-erbB-2 and p53 protein expression between non-neoplastic ducts, ductal carcinoma in situ and invasive ductal carcinoma found in the same breast. DESIGN AND SETTING: This was a cross-sectional study at Centro de Atenção Integral à Saúde da Mulher, ...
Tópico(s): Cancer-related Molecular Pathways
2006 - Medical Association of São Paulo | Sao Paulo Medical Journal
Fernando P. Silva, André P. Schmidt, Lívia Stocco Sanches Valentin, Kátia Osternack Pinto, S Zeferino, Jean Pierre Oses, Carolina David Wiener, Denise Aya Otsuki, Adriano B. L. Tort, Luis Valmor Portela, Diogo O. Souza, José Otávio Costa Auler Júnior, Maria José Carvalho Carmona,
BACKGROUND Postoperative cognitive dysfunction (POCD) may be related to the systemic inflammatory response and an increase in serum markers of brain injury such as S100B protein and neuron-specific enolase (NSE). OBJECTIVE The study aims to evaluate the association between POCD and serum levels of S100B and NSE after coronary artery bypass grafting surgery (CABG). DESIGN Prospective observational study. SETTING Single university teaching hospital. PATIENTS We investigated 88 patients undergoing CABG. ...
Tópico(s): Anesthesia and Neurotoxicity Research
2016 - Lippincott Williams & Wilkins | European Journal of Anaesthesiology

Ricardo Filipe Alves Costa, Adhemar Longatto‐Filho, Fabiana de Lima Vazquez, Céline Pinheiro, Luíz Carlos Zeferino, José Humberto Tavares Guerreiro Fregnani,
Quality indicators for the Brazilian cervical cancer screening programme can provide a perspective on its effectiveness in Brazilian macro-regions and states. The aim of this study was to perform a trend analysis of the cervical cancer screening program's quality indicators, according to Brazilian regions and states, from 2006 to 2013. Using information from approximately 62,000,000 exams obtained from the Information System of Cervical Cancer Screening (SISCOLO), joinpoint analysis was used to calculate ...
Tópico(s): Women's cancer prevention and management
2018 - BioMed Central | BMC Cancer

Michelle Garcia Discacciati, Fabrícia Gimenes, Paula Comune Pennacchi, Fernanda Faião‐Flores, Luíz Carlos Zeferino, Sophie Derchain, Júlio César Teixeira, Cecília Costa, Marco Antonio Zonta, Lara Termini, Enrique Boccardo, Adhemar Longatto‐Filho, Márcia Edilaine Lopes Consolaro, Luisa L. Villa, Silvya Stuchi Maria‐Engler,
Abstract Background: Matrix metalloproteinases (MMP) are important enzymes in the tumor microenvironment associated with progression of cervical intraepithelial neoplasia (CIN) toward squamous cell carcinoma (SCC) of the cervix. However, the role of MMPs in the inflammatory process associated with Chlamydia trachomatis infection concomitant with the carcinogenic process driven by HPV has not yet been addressed. In the present study, we analyzed the state of the MMP-9–RECK axis in cervical carcinogenesis. ...
Tópico(s): TGF-β signaling in diseases
2015 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention

Maria Terezinha Zeferino, Vivian Costa Fermo, Marcelo Brandt Fialho, Akwatu Kenthi, Francisco Inácio Bastos,
ABSTRACT Objective: to describe the characteristics of the crack cocaine use scene, its surroundings and consequences. Method: this study was based on the Time-location Sampling methodology. Between January and June 2011, 41 crack use scenes were mapped in Florianópolis (Brazil). After randomly selecting the scenes to be observed, the days and shifts for in-depth observation were selected by lottery, for a total of 98 scenes/shifts, this atep was performed between December 2011 and March 2012. The ...
Tópico(s): Substance Abuse Treatment and Outcomes
2019 - Universidade Federal de Santa Catarina, Programa de Pós Graduação em Enfermagem | Texto & Contexto - Enfermagem

Graziela Santos Rocha Ferreira, Juliano Pinheiro de Almeida, Giovanni Landoni, Jean‐Louis Vincent, Evgeny Fominskiy, Filomena Regina Barbosa Gomes Galas, Fábio Antônio Gaiotto, Luís Alberto Oliveira Dallan, Rafael Alves Franco, Luiz Augusto Ferreira Lisboa, Luís Roberto Palma Dallan, Júlia Tizue Fukushima, Stéphanie Itala Rizk, Clarice Lee Park, Tânia Mara Varejão Strabelli, Silvia G. Lage, Lígia Câmara, S Zeferino, Jaquelline Maria Jardim, Elisandra Cristina Trevisan Calvo Arita, Juliana Caldas, Silvia Moreira Ayub‐Ferreira, José Otávio Costa Auler Júnior, Roberto Kalil Filho, Fábio Biscegli Jatene, Ludhmila Abrahão Hajjar,
The aim of this study was to evaluate the efficacy of perioperative intra-aortic balloon pump use in high-risk cardiac surgery patients.A single-center randomized controlled trial and a meta-analysis of randomized controlled trials.Heart Institute of São Paulo University.High-risk patients undergoing elective coronary artery bypass surgery.Patients were randomized to receive preskin incision intra-aortic balloon pump insertion after anesthesia induction versus no intra-aortic balloon pump use.The ...
Tópico(s): Cardiac Ischemia and Reperfusion
2018 - Lippincott Williams & Wilkins | Critical Care Medicine

Maria Gabriela Loffredo D’Ottaviano, Michelle Garcia Discacciati, Maria Antonieta Andreoli, Cecília Costa, Lara Termini, Sílvia Helena Rabelo‐Santos, Luisa L. Villa, Luíz Carlos Zeferino,
Purpose . To describe the acquisition, persistence, and clearance of HPV infection in women with CIN 2 followed up for 12 months. Methods . Thirty-seven women with CIN 2 biopsy, who have proven referral to cervical smear showing low-grade squamous intraepithelial lesions or atypical squamous cells of undetermined significance and tested for HPV, were followed up for one year with cervical smear, colposcopy, and HPV test every three months. HPV DNA was detected by the polymerase chain reaction and genotyping ...
Tópico(s): Reproductive tract infections research
2013 - Hindawi Publishing Corporation | Obstetrics and Gynecology International