Wei Dong, Zhenglin Yang, Fan Yang, Jialiang Wang, Yan Zhuang, Chongren Xu, Bo Zhang, Xiao‐Li Tian, Dong Liu,
Numerous studies have revealed that Rap1 (Ras-proximate-1 or Ras-related protein 1), a small GTPase protein, plays a crucial role in mediating cAMP signaling in isolated cardiac tissues and cell lines. However, the involvement of Rap1 in the cardiac development in vivo is largely unknown. By injecting anti-sense morpholino oligonucleotides to knock down Rap1a and Rap1b in zebrafish embryos, and in combination with time-lapsed imaging, in situ hybridization, immunohistochemistry and transmission electron ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2012 - Public Library of Science | PLoS ONE
Emmy Y. Li, Yingpeng Liu, Xingkai Zhan, Yuanbo Liang, Xiu Juan Zhang, Chongren Zheng, Vishal Jhanji, Ping Xu, David F. Chang, Dennis S.C. Lam,
Objective To define the prevalence of blindness and visual impairment (VI) in people in rural Hainan using the rapid assessment of avoidable blindness (RAAB) and to report the outcomes of cataract surgery among the residents. Design Population-based, cross-sectional survey. Participants A total of 6482 rural residents of the Hainan province. Methods A total of 136 clusters, each of which consisted of 50 people aged ≥50 years, were selected through probability-proportionate-to-size sampling. Door-to-door visits ...
Tópico(s): Retinal Imaging and Analysis
2013 - Elsevier BV | Ophthalmology
Qunxiong Pan, Zijian Su, Jianhua Zhang, Chongren Wang, Shaoying Ke,
People's Republic of China is one of the countries with the highest incidence of gastric cancer, accounting for 45% of all new gastric cancer cases in the world. Therefore, strong prognostic markers are critical for the diagnosis and survival of Chinese patients suffering from gastric cancer. Recent studies have begun to unravel the mechanisms linking the host inflammatory response to tumor growth, invasion and metastasis in gastric cancers. Based on this relationship between inflammation and cancer ...
Tópico(s): Cancer, Lipids, and Metabolism
2015 - Dove Medical Press | OncoTargets and Therapy
Qunxiong Pan, Zijian Su, Jianhua Zhang, Chongren Wang, Shaoying Ke,
High Glasgow Prognostic Score (GPS) has been associated with poor prognosis in patients with lung, ovarian, colorectal and renal cancer, as well as hepatocellular carcinoma. The aim of this study was to investigate the prognostic value of GPS in patients with intrahepatic cholangiocarcinoma (ICC) undergoing partial hepatectomy. A total of 72 patients with pathologically confirmed ICC were classified according to their GPS scores assigned based on the preoperative levels of C-reactive protein (CRP) ...
Tópico(s): Gallbladder and Bile Duct Disorders
2017 - Spandidos Publishing | Molecular and Clinical Oncology
Fei Ling, Chaowei Zhang, Chongren Ai, Yaping Lv, Weihui Zhong,
A traceless directing group assisted Co-catalyzed C(sp2)-H carbonylation of ortho-arylanilines for the synthesis of free ( NH)-phenanthridinones in metal-based-oxidant-free fashion was accomplished. This protocol employs diisopropyl azodicarboxylate as the CO source and oxygen as the sole oxidant, and provides good yields with various functional tolerance. The methodology has been applied for the total synthesis of PARP inhibitor PJ-34. Furthermore, the kinetic isotopic effect experiments reveal the ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2018 - American Chemical Society | The Journal of Organic Chemistry
Zhuoying Wang, Chongren Wang, Dongqing Zuo, Tao Zhang, Fei Yin, Zifei Zhou, Hongsheng Wang, Jing Xu, Min Mao, Gangyang Wang, Yingqi Hua, Wei Sun, Zhengdong Cai,
Osteosarcoma (OS) is the most common primary bone malignancy in adolescents. One major obstacle for current OS treatment is drug-resistance. Raddeanin A (RA), an oleanane-type triterpenoid saponin, exerts anti-tumor effects in several tumor models, but the effect of RA in human drug-resistant OS remained to be elucidated. In the present study, we investigated the anti-tumor effects of RA in both drug-sensitive and drug-resistant OS cells and its underlying mechanism. RA inhibited cell proliferation ...
Tópico(s): Cancer-related molecular mechanisms research
2019 - Ivyspring International Publisher | International Journal of Biological Sciences
Wei Sun, Xiaojun Ma, Fan Zhang, Miao Weiliang, Chongren Wang, Zhengdong Cai,
Objective To explore the outcomes of surgical treatment of sacral neurogenic tumors Methods Between 1 J anuary 2003 and 31 D ecember 2012, data on 64 patients with sacral neurogenic tumors treated with surgery were retrospectively analyzed. The mean age of the 64 cases (35 males and 29 females) was 37.2 years (range, 21–69 years); 38 had neurilemmomas and 26 neurofibromas. Thirty‐four of the tumors involved S 1 and S 2 , 11 S 3 or lower, and 19 were single presacral soft tissue masses. Tumors were removed ...
Tópico(s): Soft tissue tumor case studies
2016 - Wiley | Orthopaedic Surgery
Chongren Wang, Zhengqi Chen, Wei Sun, Yisilamu Yasin, Chuanyin Zhang, Xiaojun Ma, Jian Chen, Jiakang Shen, Yingqi Hua, Zhengdong Cai,
Complete resection of pelvic bone tumors, especially recurrent and metastatic ones, is often impossible to achieve using conventional surgery. This study aimed to assess the benefits and adverse effects of computed tomography (CT)-guided radioiodine (125I) brachytherapy for inoperable recurrent and metastatic bone tumors of the pelvis. This was a retrospective study of 22 patients with confirmed pelvic bone tumors (10 females and 12 males; 15–84 years; 21 with primary pelvic tumor and one with pelvic ...
Tópico(s): Pelvic and Acetabular Injuries
2016 - BioMed Central | World Journal of Surgical Oncology
Hongsheng Wang, Wei Sun, Mengxiong Sun, Zeze Fu, Chenhao Zhou, Chongren Wang, Dongqing Zuo, Zifei Zhou, Gangyang Wang, Tao Zhang, Jing Xu, Jian Chen, Zhuoying Wang, Fei Yin, Zhenfeng Duan, Francis J. Hornicek, Zhengdong Cai, Yingqi Hua,
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. The abilities of chemotherapy resistance are major roadblock in the successful treatment of OS. The clarification of mechanism regarding cell survival during OS chemotherapy are important. Here, we examined HER4 expression by immunohistochemistry in a large series of OS tissues, and found HER4 expression correlated with tumor characteristics and patient survival rates. HER4 knockdown by shRNA inhibited ...
Tópico(s): FOXO transcription factor regulation
2018 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Hongwei Lv, Yanqiang Tang, Haihan Zhang, Siming Li, Zhiyong Fan,
Abstract This research aimed to determine whether the astragalus polysaccharide (AP) can improve the production performance and gut microbiota in Chongren hens.120 Chongren hens (240‐d old) were randomly allocated into 4 treatments with 30 hens and fed with a control basal diet (CON) or CON supplemented with the different levels of AP (100, 200, and 400 mg/kg) for 56 d. The egg production and feed conversion ratio were decreased ( p < .05) with the levels of AP. The yolk weight, yolk color, eggshell thickness, ...
Tópico(s): Agriculture, Soil, Plant Science
2021 - Wiley | Animal Science Journal
Xianxiu Qiu, Meigong Zhong, Yangfei Xiang, Chang Qua, Ying Pei, Ying‐Jun Zhang, Chongren Yang, Johann Gasteiger, Jun Xu, Zhong Liu, Yifei Wang,
Herpes simplex virus type 1 (HSV-1), a member of the Herpesviridae family, is a ubiquitous, contagious, hostadapted pathogen that causes a wide variety of disease states, such as herpes labialis (“cold sores”) and encephalitis. Recently, due to the appearance of acyclovir-resistant HSV-1 mutants, a rapidly growing area of research has been the identification of novel small molecules (whether found in traditional medicine or not) with antiviral activity. One group of these novel pre-drugs is gallic acylate ...
Tópico(s): Morinda citrifolia extract uses
2014 - Bentham Science Publishers | Medicinal Chemistry
Jianhao Zhao, Dennis S.C. Lam, Li Jia Chen, Yunxiu Wang, Chongren Zheng, Qiaoer Lin, Srinivas K. Rao, Dorothy S.P. Fan, Mingzhi Zhang, Ping Chung Leung, Robert Ritch,
To compare the effectiveness of 2-hour daily patching with the effectiveness of acupuncture in treating anisometropic amblyopia in children aged 7 to 12 years who have worn optimal spectacles for at least 16 weeks.In a single-center randomized controlled trial, 88 eligible children with an amblyopic eye who had a best spectacle-corrected visual acuity (BSCVA) of 0.3 to 0.8 logMAR at baseline were randomly assigned to receive 2 hours of patching of the sound eye daily or 5 sessions of acupuncture ...
Tópico(s): Acupuncture Treatment Research Studies
2010 - American Medical Association | Archives of Ophthalmology
Dennis S.C. Lam, Jianhao Zhao, Li Jia Chen, Yunxiu Wang, Chongren Zheng, Qiaoer Lin, Srinivas K. Rao, Dorothy S.P. Fan, Mingzhi Zhang, Ping Chung Leung, Robert Ritch,
Objectives To evaluate the safety and adjunctive effect of acupuncture added to refractive correction for anisometropic amblyopia in younger children. Design Prospective, randomized, controlled, crossover trial. Participants We included 83 children aged 3 to <7 years with untreated anisometropic amblyopia and baseline best-corrected visual acuity (BCVA) of 20/40 to 20/200 in the amblyopic eye. Methods Participants were randomized to receive spectacles alone (group 1; n = 42) or spectacles + acupuncture ( ...
Tópico(s): Glaucoma and retinal disorders
2011 - Elsevier BV | Ophthalmology
Qunxiong Pan, Jianhua Zhang, Zijian Su, Chongren Wang, Shaoying Ke,
Some prognostic evaluation systems were developed to postoperatively predict the outcome of hepatocellular carcinoma (HCC) patients, mainly based on the cancer itself and the underlying liver diseases. However, none of these prognostic evaluation systems have so far been universally accepted. A simple and feasible scoring system is still lacking for the prediction of prognosis of HCC patients following resection. We aimed to uncover the correlation between the preoperative Glasgow Prognostic Score ( ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2014 - Karger Publishers | Oncology Research and Treatment
Zifen HE, Guangchen Chen, Yinhui Zhang, Chongren Zhao, Pengfei He, Benjie Shi,
Classification of tobacco leaves by stalk position and color is a necessary prerequisite for tobacco accurate pricing and subsequent fine blending. The similarity of color, contour, and texture features limits the classification accuracy of current tobacco recognition technology, which is focusing on either a local feature or global feature extraction. To improve the feature fusion ability, we propose a tobacco classification model FSWPNet based on pyramid feature fusion through shifted window self- ...
Tópico(s): Advanced Chemical Sensor Technologies
2023 - Elsevier BV | Expert Systems with Applications
Mengxiong Sun, Zongyi Wang, Wei Sun, Ming Chen, Xiaojun Ma, Jiakang Shen, Zeze Fu, Dongqing Zuo, Gangyang Wang, Hongsheng Wang, Chongren Wang, Fei Yin, Zhuoying Wang, Chuanying Zhang, Yingqi Hua, Zhengdong Cai,
To retrospectively analyze and compare the relationship between the success rate of patient-derived xenograft (PDX) modeling of osteosarcoma and prognosis (3-year overall survival rate and disease-free survival rate) and incidence of lung metastasis.The sample group consisted of 57 osteosarcoma patients with definite pathological diagnoses from Shanghai General Hospital from 2015-2017. PDX models in 57 patients were analyzed by retrospective analyses. Among the patients currently inoculated, 20 were ...
Tópico(s): Cancer Cells and Metastasis
2022 - Wiley | Orthopaedic Surgery
Haisheng Hou, Xiangjun Gao, Lei Zhu, Peng Xie, Chongren Zhang,
The programmable metasurface element is able to achieve continuous controllable responses by loading controllable electronic devices. In this work, a reflective programmable element working at 5GHz is implemented with varactor diodes. By tuning the biasing DC voltage loaded on the varactor diodes, the capacitance can be changed, and then the reflected phases can be tuned. Simulated results show that the reflected phase can cover the 360° and amplitude of the reflective wave is more than 0.7. In ...
Tópico(s): Antenna Design and Analysis
2019 - IOP Publishing | IOP Conference Series Materials Science and Engineering
Yafei Jiang, Jinzeng Wang, Mengxiong Sun, Dongqing Zuo, Hongsheng Wang, Jiakang Shen, Wenyan Jiang, Haoran Mu, Xiaojun Ma, Fei Yin, Jun Lin, Chongren Wang, Shuting Yu, Lu Jiang, Gang Lv, Feng Liu, Linghang Xue, Kai Tian, Gangyang Wang, Zifei Zhou, Yu Lv, Zhuoying Wang, Tao Zhang, Jing Xu, Yang Liu, Kewen Zhao, Wei Sun, Yujie Tang, Zhengdong Cai, Shengyue Wang, Yingqi Hua,
Abstract Osteosarcoma (OS) is a primary malignant bone tumor that most commonly affects children, adolescents, and young adults. Here, we comprehensively analyze genomic, epigenomic and transcriptomic data from 121 OS patients. Somatic mutations are diverse within the cohort, and only TP53 is significantly mutated. Through unsupervised integrative clustering of the multi-omics data, we classify OS into four subtypes with distinct molecular features and clinical prognosis: (1) Immune activated (S-IA), ( ...
Tópico(s): CAR-T cell therapy research
2022 - Nature Portfolio | Nature Communications
Xiu Juan Zhang, Vishal Jhanji, Christopher Kai-Shun Leung, Emmy Y. Li, Yingpeng Liu, Chongren Zheng, David C. Musch, David F. Chang, Yuanbo Liang, Dennis S.C. Lam,
Aims: To identify the reasons for poor uptake of cataract surgery in a program of outreach screening and low-cost surgery in Pucheng County, a rural area in northwestern China.Methods: Detailed interviews with a semi-structured questionnaire were conducted by telephone or face-to-face for participants who had been advised to attend a low-cost cataract surgery program but did not schedule the surgery within 3 months after the initial screening.Results: Among 432 eligible subjects, 355 (82.2%) were ...
Tópico(s): Ophthalmology and Visual Impairment Studies
2014 - Taylor & Francis | Ophthalmic Epidemiology
Xiu Juan Zhang, Emmy Y. Li, Christopher Kai-Shun Leung, David C. Musch, Xin Tang, Chongren Zheng, Mingguang He, David F. Chang, Dennis S.C. Lam,
To estimate the prevalence and causes of blindness and visual impairment (VI), and report the outcomes of cataract surgery in Chaonan Region, Guangdong Province, southern China.Cross-sectional population-based survey.A total of 3484 participants including 1397 men (40.1%) and 2087 women (59.9%) aged ≥50 years were examined (94.2% response rate).A two-stage cluster sampling procedure was used to select 3700 participants aged ≥50 years from 74 clusters of Chaonan Region. Participants were examined according ...
Tópico(s): Glaucoma and retinal disorders
2017 - Public Library of Science | PLoS ONE
Dongqing Zuo, Zifei Zhou, Hongsheng Wang, Tao Zhang, Jie Zang, Fei Yin, Wei Sun, Jiepeng Chen, Lili Duan, Jing Xu, Zhuoying Wang, Chongren Wang, Binhui Lin, Zeze Fu, Yuxin Liao, Suoyuan Li, Mengxiong Sun, Yingqi Hua, Longpo Zheng, Zhengdong Cai,
Osteosarcoma (OS) is the most frequent primary malignant bone tumour. Alternol, a novel compound purified from microbial fermentation products exerts anti-tumour effects across several cancer types. The effect of alternol on human OS remains to be elucidated. We first evaluated the anti-tumour effect of alternol in several human OS cell lines in vitro and investigated its underlying mechanism. Alternol inhibited OS cell proliferation, migration and induced caspase-dependent apoptosis, G2/M cell cycle ...
Tópico(s): Phytochemical compounds biological activities
2016 - Wiley | Journal of Cellular and Molecular Medicine
Hang Sun, Hongxin Ding, Jianjun Wang, Emma Zhang, Yihua Fang, Zhenhua Li, Xiao Yu, Chongren Wang, Yifan Zhao, Kan Chen, Siwan Wen, Liang Li, Shan Shan, Hong Liu, Face Chen, Pu Su,
A tumor comprising of different types of tissues (such as hair, muscle, bone, etc.) is known as a teratoma. It is a type of germ cell (cells that make sperm or eggs) tumor. When these germ cells have rapid cancerous growth, then such a teratoma is called a malignant teratoma. We have studied the differences between gonadal and extra-gonadal malignant teratomas and the effects of chemotherapy in both genders. The samples of 3799 male and 1832 female patients with malignant teratoma samples, between ...
Tópico(s): Gestational Trophoblastic Disease Studies
2019 - BioMed Central | BMC Cancer
Gangyang Wang, Mengxiong Sun, Yafei Jiang, Tao Zhang, Wei Sun, Hongsheng Wang, Fei Yin, Zhuoying Wang, Weilin Sang, Jing Xu, Min Mao, Dongqing Zuo, Zifei Zhou, Chongren Wang, Zeze Fu, Zongyi Wang, Zhenfeng Duan, Yingqi Hua, Zhengdong Cai,
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, with highly aggressive behavior and early systemic metastasis. The survival rates for osteosarcoma remain unchanged over the past two decades. Studies aiming to find new or alternative therapies for patients with refractory osteosarcoma are urgently needed. Anlotinib, a novel multi‐targeted tyrosine kinase inhibitor (TKI), has exhibited encouraging clinical activity in NSLCC and soft tissue sarcoma, whereas ...
Tópico(s): Lung Cancer Research Studies
2019 - Wiley | International Journal of Cancer
Hongsheng Wang, Xinmeng Jin, Yangfeng Zhang, Zhuoying Wang, Tao Zhang, Jing Xu, Jiakang Shen, Pengfei Zan, Mengxiong Sun, Chongren Wang, Yingqi Hua, Xiaojun Ma, Wei Sun,
Osteosarcoma is the most common primary bone tumor, with a poor prognosis owing to the lack of efficient molecular-based targeted therapies. Previous studies have suggested an association between CD151 and distinct consequences in osteosarcoma tumorigenicity. However, the potential of CD151 as a therapeutic target has not yet been sufficiently explored. Here, we performed integrated transcriptomic and metabolomic analyses of osteosarcoma and identified sphingolipid metabolism as the top CD151-regulated ...
Tópico(s): Cellular Mechanics and Interactions
2022 - BioMed Central | Cell & Bioscience
Haichao Zhao, Changzhou Chen, Xidong Chen, Donglin Zhang, Jian Li, Chuanli Yang, Chongren Ren, Xiaojing Ren, Xifeng Fu, Yanjun Li, Jiefeng He, Haoliang Zhao,
The carbon catabolite repressor 4-negative on TATA (CCR4-NOT) complex, abbreviated CNOT, has deadenylation and 3'-5' exonuclease activity, mediates deadenylation in the degradation of RNA, initiates the exonuclease degradation pathway, and participates in tumor gene regulation. CNOT proteins comprise a family of global transcriptional regulators that are evolutionarily conserved in eukaryotic cells. Several subunit types of the CNOT complex have been discovered; however, little is known about the ...
Tópico(s): Ferroptosis and cancer prognosis
2020 - Mary Ann Liebert, Inc. | DNA and Cell Biology
Chongren Pei, Yuzhe Zhang, Jun Xiao, Qing‐Yu He, Wenyong Zhang, Ying Xu,
Tópico(s): Cancer, Hypoxia, and Metabolism
2025 - Elsevier BV | Genes & Diseases
Chongren Zhao, Yinhui Zhang, Zifen HE, Yunnan Deng, Ying Huang, Guangchen CHEN,
Aiming at the problem of spatial focus regions distribution dispersion and dislocation in feature pyramid networks and insufficient feature dependency acquisition in both spatial and channel dimensions, this paper proposes a spatial-temporal aggregated shuffle attention for video instance segmentation (STASA-VIS). First, an mixed subsampling (MS) module to embed activating features from the low-level target area of feature pyramid into the high-level is designed, so as to aggregate spatial information ...
Tópico(s): Image Enhancement Techniques
2023 - Institute of Electronics, Information and Communication Engineers | IEICE Transactions on Information and Systems
Ping Zhao, Ying‐Jun Zhang, Hirobumi Yamamoto, Chongren Yang,
Progress of the studies on chemistry, bioactivity and biosynthesis of prenylated flavonoids from Sophora flavecens Aiton. was reviewed.
Tópico(s): Medicinal Plants and Neuroprotection
2004 - National Science Library | Tianran chanwu yanjiu yu kaifa
Qunxiong Pan, Zijian Su, Jianhua Zhang, Chongren Wang, Shaoying Ke,
Background Several inflammation-based scores have been demonstrated to have prognostic value in many types of malignant solid tumours. However, there are no studies elucidating which of these prognostic scores is more suitable in predicting outcomes in patients with gastric cancer undergoing surgery. We aimed to compare the prognostic value of inflammation-based prognostic scores (Glasgow prognostic score [GPS], neutrophil lymphocyte ratio [NLR], platelet lymphocyte ratio [PLR], prognostic nutritional ...
Tópico(s): Metastasis and carcinoma case studies
2015 - Elsevier BV | European Journal of Cancer
Yan Zhou, Chang Xu, Houqiang Chen, Dandan Zhang, Yu Long, Fengming Yan, Chongren Xu, Rongjiang Wang,
In a previous study most males of the Glanville fritillary butterfly (Melitaea cinxia) were caught in valleys, whereas almost all females were distributed on slopes in the Tianshan Mountains, northwestern China. To help understand this phenomenon, male mate location behaviours were observed in different landscapes of the Tianshan Mountains. In valleys, males exhibited perching behaviour. On slopes, spatial distribution of males showed patrolling behaviour on meadows, but intermediate behaviour between ...
Tópico(s): Animal Behavior and Reproduction
2019 - | Entomologica Fennica