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... coma victim back to life A Living Death Zolpidem, marketed in the United Kingdom as Stilnoct, is ...
2006 - Gale Group | TDA
Xuechan Lyu, YeGang Hu, Yan Zhao, Haihong Wang, Jiang Du, Jijun Wang, Haifeng Jiang,
Initially, zolpidem, a non-benzodiazepine hypnotic agent, was considered to have fewer adverse reactions than traditional benzodiazepines. However, after zolpidem was approved for medical use, an increasing number ... dependence that presented a paradoxical 'euphoric' effect of zolpidem. This article reports the case of a female zolpidem-dependent patient who presented with 6 years of daily use of 400-1400 mg of zolpidem. She reported subjective effects of euphoria, intense craving ... inability to stop drug ingestion. Her diagnoses were zolpidem dependence and a depressive episode induced by substance ...
Tópico(s): Neuroscience and Neuropharmacology Research
2022 - BMJ | General Psychiatry
Zexuan Hao, Xiaoyu Xia, Yang Bai, Yong Wang, Weibei Dou,
... challenges in neuroscience. Previous studies have shown that zolpidem produces paradoxical recovery and induces similar change patterns ... and dynamic EEG analysis techniques to fully uncover zolpidem-induced alterations in eight patients with DOC and ... power and weakened alpha-band functional connectivity) after zolpidem administration, albeit none zolpidem responders. Based on the current evidence, previously published electrophysiological features are not neural markers for zolpidem responders. Moreover, we found that the temporal dynamics ...
Tópico(s): EEG and Brain-Computer Interfaces
2022 - Frontiers Media | Frontiers in Neuroscience
Yuichi Inoue, Maika Nishida, Naoki Kubota, Michinori Koebis, Takehiro Taninaga, Kenzo Muramoto, Kohei Ishikawa, Margaret Moline,
... InvestigationsComparison of the treatment effectiveness between lemborexant and zolpidem tartrate extended-release for insomnia disorder subtypes defined ... determined by polysomnography—to treatment with lemborexant and zolpidem tartrate extended-release 6.25 mg (zolpidem ER), compared with placebo.Methods:Study E2006-G000- ... and wake after sleep onset (WASO) vs placebo; zolpidem ER also provided significant benefit for TST and ... placebo. In the I-NSD subgroup, lemborexant and zolpidem ER provided significant benefit for TST and WASO ...
Tópico(s): Circadian rhythm and melatonin
2022 - American Academy of Sleep Medicine | Journal of Clinical Sleep Medicine
Marion Istvan, Pascal Caillet, Morgane Rousselet, Marylène Guerlais, Edouard‐Jules Laforgue, Marie Gérardin, Pascale Jolliet, Fanny Feuillet, Caroline Victorri‐Vigneau,
In recent years, zolpidem has been the subject of numerous reports of misuse, abuse and dependence. In view of these risks, the French ... of this regulatory measure on the prescription of zolpidem and other sedative medications (zopiclone, benzodiazepines and antihistamines) in long-term users of zolpidem and associated factors.We performed a historical cohort ... were enacted. We analysed the reimbursement trajectories of zolpidem, zopiclone, benzodiazepines and antihistamines (hydroxyzine and alimemazine) up ...
Tópico(s): Blood Pressure and Hypertension Studies
2021 - Wiley | British Journal of Clinical Pharmacology
Amber N. Edinoff, Natalie W. Wu, Yahya T. Ghaffar, Rosemary Prejean, Rachel Gremillion, Mark Cogburn, Azem A. Chami, Adam M. Kaye, Alan D. Kaye,
... resulting side effects. Non-benzodiazepine hypnotics such as zolpidem, eszopiclone, zaleplon are the most used as adjunctive ... of the most used of these hypnotics is zolpidem. However, zolpidem has a wide variety of adverse effects and ... special considerations noted in the literature. Recent Findings Zolpidem has been associated with an increased risk of ... risk (RR) for hip fractures in patients taking zolpidem was described as 1.92 (95% CI 1. ... of 24 previous studies of sleepwalking associated with zolpidem demonstrated that the association was not dependent on ...
Tópico(s): Circadian rhythm and melatonin
2021 - PAGEPress (Italy) | Health psychology research
Ludovico Messineo, Sophie G. Carter, Luigi Taranto‐Montemurro, Alan Chiang, Andrew Vakulin, Robert Adams, Jayne C. Carberry, Danny J. Eckert,
... We sought to investigate the additional effect of zolpidem with Ato‐Oxy on sleep efficiency (primary outcome), ... Methods Twelve participants with OSA received 10 mg zolpidem plus Ato‐Oxy (80‐5 mg, respectively) or ... a driving simulation task. Results The addition of zolpidem increased sleep efficiency by 9% ± 13% (80.9% ± ... O, p = 0.004) versus Ato‐Oxy + placebo. Zolpidem did not systematically change OSA severity. Combination therapy was well tolerated, and zolpidem did not worsen next‐day sleepiness. However, median ...
Tópico(s): Sleep and related disorders
2021 - Wiley | Respirology
Niti Mittal, Rakesh Mittal, Manish Gupta,
Background: Being a nonbenzodiazepine, zolpidem is believed to have a favorable side-effect profile and is widely prescribed for insomnia. However, in the past few ... complex sleep behaviors (CSBs), have been reported with zolpidem. Objective: To conduct a systematic review of zolpidem-associated CSBs. Data Sources: An electronic search was ... observational or interventional study) reporting CSBs associated with zolpidem. Results: In this review, we present aggregate summarized data from 148 patients presenting with zolpidem-induced CSBs (79 patients from 23 case reports ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2021 - SAGE Publishing | Indian Journal of Psychological Medicine
Margaret Moline, Gary Zammit, Jocelyn Y. Cheng, Carlos Perdomo, Dinesh Kumar, David Mayleben,
... of the effect of lemborexant with placebo and zolpidem tartrate extended release on sleep architecture in older ... the impact of lemborexant compared with placebo and zolpidem tartrate extended release on objective sleep architecture parameters, ... multicenter, randomized, double-blind, placebo-controlled, active comparator (zolpidem)–controlled, parallel-group study comparing 2 dose levels ... total sleep time compared with both placebo and zolpidem. Significant increases from baseline in rapid eye movement ...
Tópico(s): Restless Legs Syndrome Research
2021 - American Academy of Sleep Medicine | Journal of Clinical Sleep Medicine
Ting Xiang, Yixian Cai, Zhijin Hong, Jiyang Pan,
... used to evaluate the effectiveness and safety of Zolpidem in the treatment of insomnia disorder for one ... sleep onset. And to evaluate the safety of Zolpidem in the treatment of insomnia. Total of 6 ... Our analysis results showed that compared with placebo, zolpidem treatment for one month was more effective in ... no significant statistical difference in adverse events between Zolpidem and placebo after one month of treatment. Our meta-analysis showed that zolpidem is an effective and safe therapy option to ...
Tópico(s): Circadian rhythm and melatonin
2021 - Elsevier BV | Sleep Medicine
Meredith E. Rumble, W. Vaughn McCall, Daniel Dickson, Andrew D. Krystal, Peter B. Rosenquist, Ruth M. Benca,
... control trial primarily examining whether cautious use of zolpidem extended-release or placebo reduced suicidal ideation. All ... controlled trial primarily examining whether cautious use of zolpidem ER or placebo and an open-label selective ... serotonin reuptake inhibitors and the double-blinded randomization (zolpidem extended-release [ER] or placebo) occurred at the ... and demonstrated that the group allocated to receive zolpidem ER had greater improvement in suicidality as measured ... recruitment (November 2012), all participants were randomized to zolpidem ER 12.5 mg or placebo. In February ...
Tópico(s): Circadian rhythm and melatonin
2020 - American Academy of Sleep Medicine | Journal of Clinical Sleep Medicine
Patricia Murphy, Dinesh Kumar, Gary Zammit, Russell Rosenberg, Margaret Moline,
Free AccessScientific InvestigationsSafety of lemborexant versus placebo and zolpidem: effects on auditory awakening threshold, postural stability, and ... was to evaluate the effect of lemborexant versus zolpidem tartrate extended release 6.25 mg (ZOL) or ... Evaluate the Effect of Lemborexant Versus Placebo and Zolpidem on Postural Stability, Auditory Awakening Threshold, and Cognitive ... Moline M. Safety of lemborexant versus placebo and zolpidem: effects on auditory awakening threshold, postural stability, and ...
Tópico(s): Cardiovascular Health and Disease Prevention
2020 - American Academy of Sleep Medicine | Journal of Clinical Sleep Medicine
Rafael Leal Monteiro Paraiso, Rachel H. Rose, Nikoletta Fotaki, Mark McAllister, Jennifer Dressman,
Zolpidem is a non-benzodiazepine hypnotic agent which has been shown to be effective in inducing and ... was to create a PBPK/PD model for zolpidem and establish a clinically relevant "safe space" for dissolution of zolpidem from the commercial immediate release (IR) formulation. A ... to verify the negative food effect ascribed to zolpidem and consider its ramifications in terms of the " ... an integrated PBPK/PD model for immediate release zolpidem tablets was constructed in Simcyp®. This model was ... impact on the PK and PD profiles of zolpidem would be minimal. According to the FDA, the ...
Tópico(s): Analytical Chemistry and Chromatography
2020 - Elsevier BV | European Journal of Pharmaceutical Sciences
Tiffany C. Ho, Alyssa Jimenez, I. Ramos Sánchez, Christina Seeger, Merlyn Joseph,
Zolpidem is associated with sleep-related eating disorder (SRED). We compiled case reports and performed a descriptive ... CINAHL, and SciFinder was performed using search terms "Zolpidem," "Feeding and Eating Disorders/chemically induced," "Dyssomnias," "sleep ... SRED onset was most commonly seen with daily zolpidem doses of 10 mg or higher (95% of ... nightly in 57.5% of patients. Discontinuation of zolpidem resolved SRED in all patients (n = 36). SRED associated with zolpidem can occur with any dose, but was most ...
Tópico(s): Sleep and Wakefulness Research
2020 - Elsevier BV | Sleep Medicine X
Zinat Alimohammadi, Shabnam Pourmoslemi,
... aimed to develop a method for determination of zolpidem as a widely used hypotonic in human plasma ... MIP-SPE) method was used for extraction of zolpidem and concentrating it in the sample to be ... zeta potential analyzer. Extraction time and pH of zolpidem aqueous solution were optimized and capacity of MIP for adsorbing zolpidem was determined. A HPLC-fluorescence detector method was validated and used for analysis of zolpidem samples extracted from plasma. The method was linear ... 04 ng/ml, respectively. Extraction and analysis of zolpidem from spiked human plasma samples determined zolpidem with ...
Tópico(s): Analytical chemistry methods development
2020 - Elsevier BV | Microchemical Journal
Charles M. Morin, Jack D. Edinger, Simon Beaulieu‐Bonneau, Hans Ivers, Andrew D. Krystal, Bernard Guay, Lynda Bélanger, Ann Cartwright, Bryan Simmons, Manon Lamy, Mindy Busby,
... involving either behavioral therapy (BT; n = 104) or zolpidem (zolpidem; n = 107), and patients who did not remit received a second treatment involving either medication (zolpidem or trazodone) or psychological therapy (BT or cognitive ... mood disorder. First-stage therapy with BT or zolpidem produced equivalent weighted percentages of responders (BT, 45.5%; zolpidem, 49.7%; OR, 1.18; 95% CI, 0.60-2.33) and remitters (BT, 38.03%; zolpidem, 30.3%; OR, 1.41; 95% CI, 0. ... the 2 conditions, starting with BT (BT to zolpidem, 40.6% to 62.7%; OR, 2.46; ...
Tópico(s): Youth Substance Use and School Attendance
2020 - American Medical Association | JAMA Psychiatry
Ludovico Messineo, Danny J. Eckert, Richard Lim, Alan Chiang, Ali Azarbarzin, Sophie G. Carter, Jayne C. Carberry,
... severity, with variable success. Here we show that zolpidem increases the respiratory arousal threshold by ∼15%, an ... muscle responsiveness during transient manipulations of airway pressure, zolpidem did not alter pharyngeal muscle responsiveness during natural ... sleepiness and alertness. These novel findings indicate that zolpidem was well tolerated and effective in promoting sleep ... airway pressure (CPAP) manipulations indicated that the hypnotic zolpidem increases the arousal threshold and genioglossus responsiveness in ...
Tópico(s): Sleep and Wakefulness Research
2020 - Wiley | The Journal of Physiology
Magdalene M. Assimon, Jennifer E. Flythe,
Background and objectives Zolpidem, a nonbenzodiazepine hypnotic, and trazodone, a sedating antidepressant, are the most common medications used to treat insomnia in the ... the risk of falls and fractures. Despite widespread zolpidem and trazodone use, little is known about the ... to investigate the association between the initiation of zolpidem versus trazodone therapy and the 30-day risk ... of 31,055 patients were included: 18,941 zolpidem initiators (61%) and 12,114 trazodone initiators (39%). ... follow-up period, 101 fall-related fractures occurred. Zolpidem versus trazodone initiation was associated with a higher ...
Tópico(s): Blood Pressure and Hypertension Studies
2020 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Chul‐Hyun Cho, Hee‐Jung Jee, Yoon-Ju Nam, Hyonggin An, Leen Kim, Heon‐Jeong Lee,
... concerns about abuse and unnecessary chronic administration of zolpidem, and zolpidem’s relation to suicide risk. To investigate the temporal association of zolpidem with the risk of suicide, we conducted a ... used to investigate the correlation over time between zolpidem medication and suicide. Over intervals commencing after 80 ... of suicides associated with the use of the zolpidem was 2.01 (95% CI: 1.58–2. ... 001). The mean cumulative number of days of zolpidem prescription was significantly longer in the suicide group ...
Tópico(s): Bipolar Disorder and Treatment
2020 - Nature Portfolio | Scientific Reports
Russell Rosenberg, Patricia Murphy, Gary Zammit, David Mayleben, Dinesh Kumar, Shobha Dhadda, Gleb Filippov, Antonia LoPresti, Margaret Moline,
... the orexin receptor antagonist lemborexant with placebo and zolpidem tartrate extended release in participants with insomnia disorder. ... also had sleep onset difficulties.Participants received placebo, zolpidem tartrate extended release (6.25 mg), or lemborexant ( ... the second half of the night compared with zolpidem therapy.Among 1006 participants randomized (placebo, n = 208; zolpidem, n = 263; lemborexant 5 mg, n = 266; and ... the night (least squares mean treatment difference vs zolpidem for lemborexant 5 mg, -6.7 min; 95% ...
Tópico(s): Restless Legs Syndrome Research
2019 - American Medical Association | JAMA Network Open
Hyewon Kim, Yuwon Kim, Woojae Myung, Maurizio Fava, David Mischoulon, Unjoo Lee, Hyosang Lee, Eun Jin Na, Kwan Woo Choi, Myung‐Hee Shin, Hong Jin Jeon,
Abstract Objectives To investigate the association between zolpidem prescription and suicide attempts in people with depression Methods A nationwide, population-based electronic medical records database from the Health Insurance Review & Assessment ... attempts in people with depression before and after zolpidem prescription using self-controlled case series design. Results ... behavior during the risk periods before and after zolpidem prescription increased compared with those at the baseline. ... increased and peaked immediately before the prescription of zolpidem. The IRR was 70.06 (95% CI: 25. ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2019 - Oxford University Press | SLEEP
Jayne C. Carberry, Ronald R. Grunstein, Danny J. Eckert,
... phenotypic causes of obstructive sleep apnea indicate that zolpidem has therapeutic potential for certain patients. Specifically, zolpidem increases the threshold for arousal threshold and pharyngeal ... However, the effects of a standard dose of zolpidem (10 mg) on obstructive sleep apnea severity and ... night sleep study in which 10 mg of zolpidem was given just prior to sleep. Tolerability, next‐day sleepiness and the effects of zolpidem on polysomnography variables were assessed. Zolpidem was well tolerated and significantly improved the sleep ...
Tópico(s): Sleep and related disorders
2019 - Wiley | Journal of Sleep Research
Tatiana Borodina, И. В. Марченко, Daria B. Trushina, Yulia A. Volkova, Валерий З. Ширинян, И. В. Заварзин, Е. А. Кондрахин, Г. И. Ковалев, M. V. Kovalchuk, Т. В. Букреева,
Anxiolytic drug zolpidem was incorporated into the microcontainers based on mesoporous calcium carbonate particles modified by diethylaminoethyl-dextran/hyaluronic acid shell. The release of zolpidem in saline solution and in polymer film modelling nasal mucosa was investigated. The anxiolytic effect of zolpidem upon intranasal administration of microcontainers and free medicine ... on mice.The structures of all compounds during zolpidem synthesis were established using nuclear magnetic resonance spectroscopy. ...
Tópico(s): Epilepsy research and treatment
2018 - Oxford University Press | Journal of Pharmacy and Pharmacology
Koutaro Hasegawa, Amin Wurita, Hideki Nozawa, Itaru Yamagishi, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki,
... which a male in his 20s self-administered zolpidem intravenously. The victim was found dead lying on ... disposal syringe containing small-volume solution dissolving crushed zolpidem tablets was found. The postmortem interval was estimated ... pancreas and skeletal muscle. For the extractions of zolpidem, zolpidem phenyl-4-carboxylic acid, deuterated internal standards zolpidem-d7 and zolpidem phenyl-4-carboxylic acid-d4, a modified QuEChERS ...
Tópico(s): Pharmacology and Obesity Treatment
2018 - Elsevier BV | Forensic Science International
Maja Jazvinšćak Jembrek, Vedrana Radovanović, Josipa Vlainić, Lidija Vuković, Nikolina Hanžić,
... pathways. We investigated the neuroprotective effect of hypnotic zolpidem, a drug that exerts its central effects at ... complex, against glutamate-induced toxicity in P19 neurons. Zolpidem prevented death of P19 neurons exposed to glutamate, ... and Bax expression, and caspase-3/7 activity. Zolpidem effects were mediated by marked over-activation of ... functions upstream of Akt. The beneficial effect of zolpidem on neuronal survival was not prevented by flumazenil, ... and F0F1-ATPase, prevented the beneficial effect of zolpidem, indicating that the mechanism of zolpidem action involves ...
Tópico(s): Anesthesia and Neurotoxicity Research
2018 - Elsevier BV | Toxicology
Ramona Shayegani, Kangwon Song, Megan E. Amuan, Carlos A. Jaramillo, Blessen C. Eapen, Mary Jo Pugh,
... exists regarding the adverse effects and rate of zolpidem use, especially long-term use, limited information is available concerning patterns of zolpidem use. Objective To examine the prevalence and correlates of zolpidem exposure in Iraq and Afghanistan Veterans (IAVs). Methods A retrospective cohort study of zolpidem prescriptions was performed with National Veterans Health Administration ( ... prevalence of long term (>30 days), high-dose zolpidem exposure (>10mg immediate-release; >12.5mg extended-release) ...
Tópico(s): Treatment of Major Depression
2018 - Public Library of Science | PLoS ONE
Alicia Nevriana, Jette Möller, Lucie Laflamme, Joel Monárrez‐Espino,
Previous studies on the effect of zolpidem or zopiclone use on the risk of road traffic crashes (RTCs) have shown mixed results.Our objective was to determine the association between zolpidem or zopiclone use (as separate drugs or combined) ... categorized into new, occasional, and frequent use of zolpidem only, zopiclone only, and combined zolpidem and zopiclone. For the case-crossover study, newly dispensed zolpidem or zopiclone users were assessed during the 28 ... the highest odds were seen among newly initiated zolpidem-only users involved in single-vehicle crashes (adjusted ...
Tópico(s): Cannabis and Cannabinoid Research
2017 - Adis, Springer Healthcare | CNS Drugs
Hui‐Ting Cheng, Fang‐Ju Lin, Steven R. Erickson, Jin‐Liern Hong, Chung‐Hsuen Wu,
To evaluate the association between zolpidem use and the risk of Alzheimer's disease among older people.A retrospective cohort study using data from 2001 to 2011 ... January 2002 to December 2004 (the enrollment period).Zolpidem users were identified as patients who used zolpidem during the enrollment period. The index date was the date of the first zolpidem prescription. Dosage of zolpidem use was defined using cumulative defined daily dose ( ... models were used to evaluate the association between zolpidem use and the incidence of Alzheimer's disease. ...
Tópico(s): Schizophrenia research and treatment
2017 - Wiley | Journal of the American Geriatrics Society
Shih‐Wei Lai, Cheng‐Li Lin, Kuan‐Fu Liao,
Background/Objectives. Previous studies showed that zolpidem use could be associated with increased cancer risk, but the role of zolpidem on hepatocellular carcinoma (HCC) risk remains undetermined. The study ... to examine the association between HCC risk and zolpidem use in Taiwan. Methods. Using the database from ... group, from 2000 to 2011. Ever use of zolpidem was defined as a subject who had at least a prescription for zolpidem before the index date. Never use was defined ... subject who did not have a prescription for zolpidem before the index date. The association between HCC ...
Tópico(s): Berberine and alkaloids research
2017 - Frontiers Media | Frontiers in Pharmacology
Seyyed Majid Eslami, Maryam Ghasemi, Taraneh Bahremand, Majid Momeny, Mahdi Gholami, Mohammad Sharifzadeh, Ahmad Reza Dehpour,
This study aims to investigate the role of zolpidem in lithium-pilocarpine induced status epilepticus (SE) and ... in adult male Wistar rats. Different doses of zolpidem (0.1, 1, 2, 5, 10mg/kg) were ... arginine and L-NAME were injected 15min before zolpidem. Afterward, we identified the particular NO isoform mediating the effect of zolpidem by injecting aminoguanidine (AG) and 7-Nitroindazole (7-NI) 15min prior to zolpidem. Moreover, in both 6 and 24h after pilocarpine ... reverse transcription-PCR (qRT-PCR). Pre-treatment with zolpidem significantly prevented the onset of SE in a ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2017 - Elsevier BV | European Journal of Pharmacology