... 10.1007/978-3-030-76433-3_8Jovan Filipović, Zoran Milosavljević, Jelena Ruso The impact of social and ...
Tópico(s): Urban and Rural Development Challenges
1985 - University of Chicago Press | Journal of Political Economy
Miloš Radović, Mohamed Ghalwash, Nenad Filipović, Zoran Obradović,
Feature selection, aiming to identify a subset of features among a possibly large set of features that are relevant for predicting a response, is an important preprocessing step in machine learning. In gene expression studies this is not a trivial task for several reasons, including potential temporal character of data. However, most feature selection approaches developed for microarray data cannot handle multivariate temporal data without previous data flattening, which results in loss of temporal ...
Tópico(s): Genetic and phenotypic traits in livestock
2017 - BioMed Central | BMC Bioinformatics
Milos Jordanski, Miloš Radović, Žarko Milošević, Nenad Filipović, Zoran Obradović,
Computer simulations based on the finite element method represent powerful tools for modeling blood flow through arteries. However, due to its computational complexity, this approach may be inappropriate when results are needed quickly. In order to reduce computational time, in this paper, we proposed an alternative machine learning based approach for calculation of wall shear stress (WSS) distribution, which may play an important role in mechanisms related to initiation and development of atherosclerosis. ...
Tópico(s): Cardiovascular Health and Disease Prevention
2016 - Institute of Electrical and Electronics Engineers | IEEE Journal of Biomedical and Health Informatics
Svetlana Antić, Igor Šaveljić, Dalibor Nikolić, Gordana Jovičić, Nenad Filipović, Zoran Rakočević, Marija Djurić,
It has been suggested that unerupted lower third molars (M3) increase the fragility of the mandibular angle and simultaneously decrease the risk of condylar fracture. However, it is unknown whether this applies regardless of the direction and point of impact of the traumatic force. The aim of this study was to investigate the impact of an unerupted M3 on the fragility of the angle and condyle in terms of a force acting from different directions and affecting different regions of the mandible. Computed ...
Tópico(s): Temporomandibular Joint Disorders
2016 - Elsevier BV | International Journal of Oral and Maxillofacial Surgery
Miloš Filipović, Zoran Marković, Jelena Đorović, Jasmina M. Dimitrić Marković, Bono Lučić, Dragan Amić,
The quantitative structure–activity relationship (QSAR) of the free radical scavenging potency of 21 selected hydroxybenzoic acids and simple phenolics was examined. We found that descriptors related to the energetics and structural aspects of free radical scavenging processes enable the development of reliable QSAR models that possess better statistical characteristics than the models developed using more than thousand molecular descriptors from the large Dragon set. The lack of standardized antioxidant ...
Tópico(s): Biochemical effects in animals
2015 - Elsevier BV | Comptes Rendus Chimie
Svetlana Antić, Arso M. Vukićević, Marko Milasinovic, Igor Šaveljić, Gordana Jovičić, Nenad Filipović, Zoran Rakočević, Marija Djurić,
The aim of the present study was to investigate the influences of the presence and position of a lower third molar (M3) on the fragility of mandibular angle and condyle, using finite element analysis. From computed tomographic scans of a human mandible with normally erupted M3, two additional virtual models were generated: a mandibular model with partially impacted M3 and a model without M3. Two cases of impact were considered: a frontal and a lateral blow. The results are based on the chromatic ...
Tópico(s): Traumatic Ocular and Foreign Body Injuries
2015 - Elsevier BV | Journal of Cranio-Maxillofacial Surgery
Radoslav Filipović, Zoran Obrenović, Ivan Stijepović, Ljubica Nikolić, Vladimir V. Srdić,
Silica particles, with controllable porosity, were synthesized using two different precursors, tetraethylortosilicate (TEOS) and sodium silicate, but without the addition of template. Characteristics of silica particles (aggregates) prepared by these two methods were compared. The pore structure was tuned only by changing the processing parameters, such as precursor concentration, base concentration, temperature and reaction time. The pore structure of prepared silica particles (aggregates) is strongly ...
Tópico(s): Layered Double Hydroxides Synthesis and Applications
2009 - Elsevier BV | Ceramics International
Matej Pičulin, Tim Smole, Bojan Žunkovič, Enja Kokalj, Marko Robnik‐Šikonja, Matjaž Kukar, Dimitrios I. Fotiadis, Vasileios C. Pezoulas, Nikolaos S. Tachos, Fausto Barlocco, Francesco Mazzarotto, Dejana Popović, Lars S. Maier, Lazar Velicki, Iacopo Olivotto, Guy A. MacGowan, Djordje G. Jakovljević, Nenad Filipović, Zoran Bosnić,
Cardiovascular disorders in general are responsible for 30% of deaths worldwide. Among them, hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease that is present in about 1 of 500 young adults and can cause sudden cardiac death (SCD).Although the current state-of-the-art methods model the risk of SCD for patients, to the best of our knowledge, no methods are available for modeling the patient's clinical status up to 10 years ahead. In this paper, we propose a novel machine learning (ML)-based ...
Tópico(s): Cardiac Structural Anomalies and Repair
2022 - JMIR Publications | JMIR Medical Informatics
Nicholas J. Vogelzang, Tomasz M. Beer, Winald R. Gerritsen, Stéphane Oudard, Paweł Wiechno, Bożena Kukiełka-Budny, Vladimír Šámal, Jaroslav Hájek, Susan Feyerabend, Vincent Khoo, Arnulf Stenzl, Tibor Csöszi, Zoran Filipovic, Frederico Gonçalves, А А Прохоров, Eric Cheung, Arif Hussain, Nuno Sousa, Amit Bahl, Syed A. Hussain, Harald Fricke, Pavla Kadlecová, Tomáš Scheiner, Roman Korolkiewicz, Jiřina Bartůňková, Radek Špíšek, Walter M. Stadler, Arthur Berg, Karl‐Heinz Kurth, Celestia S. Higano, Matti Aapro, Michael Krainer, Stephan Hruby, Johannes Meran, S. Polyakov, Jean‐Pascal Machiels, Thierry Roumeguère, Koen Ackaert, Nicolaas Lumen, Thierry Gil, Velko Minchev, Antoaneta Tomova, Borislav D. Dimitrov, Marchela Koleva, Antonio Juretić, Ana Fröbe, Željko Vojnović, Martin Drabek, L Jarolı́m, Tomáš Büchler, Eva Kindlová, Jan Schraml, Milada Zemanová, Prausova Jana, Bohuslav Melichar, Martina Chodacká, Jan Jansa, Gedske Daugaard, Nicolas Delonchamps, Brigitte Duclos, Stéphane Culine, G. Deplanque, Sylvestre Le Moulec, Peter Hammerer, Gerald Rodemer, Manuel Ritter, Axel S. Merseburger, Marc‐Oliver Grimm, Ilija Damjanoski, Manfred Wirth, Martin Burmester, Kurt Miller, Jan Herden, Bastian Keck, Christian Wuelfing, Alexander Winter, Martin Boegemann, Ingo Kausch von Schmeling, Paolo Fornara, E. Jaeger, G. Bodoky, Zsuzsanna Pápai, Géza Böszörményi-Nagy, Paola Vanella, Héctor Soto Parrà, Rodolfo Passalacqua, Francesco Ferraú, Michele Maio, Lucia Fratino, Enrico Cortesi, Gunta Purkalne, Jolita Asadauskienė, Rasa Jančiauskienė, Skaistė Tulytė, Alvydas Česas, Marco B. Polée, Brigitte C.M. Haberkorn, Fons van de Eertwegh, Pieter van den Berg, Aart Beeker, Peter Nieboer, Romuald Zdrojowy, Elżbieta Starosławska, Jacek Fijuth, Bożena Sikora-Kupis, Boguslawa Karaszewska, Isabel Fernandes, Gabriela Sousa, Tânia Rodrigues, Zoran Džamić, Nada Babović, B Cvetkovic, Roman Sokol, J Mikuláš, M Bonnet Gajdos, Marek Brezovsky, I. Minčík, J. Breza, José Ángel Arranz, Virginia Calvo, Gabriel Rubio, M. Sánchez Chapado, Pablo Gajete Boreu, A. Montesa, David Olmos, Begoña Mellado, Daniel Castellano, Javier Puente, Erika Thellenberg Karlsson, Johan Ahlgren, Hardev Pandha, Danish Mazhar, Maria Vilarino-Varela, Tony Elliott, Ian Pedley, Anjali Zarkar, Amy Law, Dennis Slater, Gary Karlin, Marijo Bilušić, Charles H. Redfern, Rakesh Gaur, Robert McCroskey, David T. Clarkson, Manish Agrawal, Mikhail Shtivelband, Luke T. Nordquist, Nagla Fawzy Abdel Karim, Ralph J. Hauke, Thomas W. Flaig, Haresh Jhangiani, Rakesh Singal, Brian S. Choi, Evangeline Reyes, John M. Corman, Clara Hwang, Leonard J. Appleman, Edward F. McClay, Mark T. Fleming, Vijay Gunuganti, Eric Cheung, Benjamin A. Gartrell, Alton Sartor, Stephen K. Williamson, Jitendra G. Gandhi, Ian D. Schnadig, John P. Burke, Stuart H. Bloom, Neal D. Shore, Tina Mayer, William Oh, Alan H. Bryce, Laurence Belkoff, Ulka N. Vaishampayan, Sanjiv S. Agarwala, Ömer Küçük, Apurv Agrawal, William D. Walsh, Bernard J. Poiesz, Lauren C. Harshman, Nancy A. Dawson, Sanjay Sharma,
Importance DCVAC/PCa is an active cellular immunotherapy designed to initiate an immune response against prostate cancer. Objective To evaluate the efficacy and safety of DCVAC/PCa plus chemotherapy followed by DCVAC/PCa maintenance treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). Design, Setting, and Participants The VIABLE double-blind, parallel-group, placebo-controlled, phase 3 randomized clinical trial enrolled patients with mCRPC among 177 hospital clinics in the US ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2022 - American Medical Association | JAMA Oncology
Zhuming Zhang, Qingjie Ding, Jinjun Liu, Jing Zhang, Nan Jiang, Xin‐Jie Chu, David Bartkovitz, Kin‐Chun Luk, Cheryl A. Janson, Christian Tovar, Zoran Filipovic, Brian Higgins, Kelli Glenn, Kathryn Packman, Lyubomir T. Vassilev, Bradford Graves,
The field of small-molecule inhibitors of protein-protein interactions is rapidly advancing and the specific area of inhibitors of the p53/MDM2 interaction is a prime example. Several groups have published on this topic and multiple compounds are in various stages of clinical development. Building on the strength of the discovery of RG7112, a Nutlin imidazoline-based compound, and RG7388, a pyrrolidine-based compound, we have developed additional scaffolds that provide opportunities for future development. ...
Tópico(s): Ubiquitin and proteasome pathways
2014 - Elsevier BV | Bioorganic & Medicinal Chemistry
Brian Higgins, Kelli Glenn, Antje‐Christine Walz, Christian Tovar, Zoran Filipovic, Sazzad Hussain, Edmund Lee, Kenneth Kolinsky, Shahid Tannu, Violeta Adames, Rosario Garrido, Michael Linn, Christophe Meille, David Heimbrook, Lyubomir T. Vassilev, Kathryn Packman,
Antitumor clinical activity has been demonstrated for the MDM2 antagonist RG7112, but patient tolerability for the necessary daily dosing was poor. Here, utilizing RG7388, a second-generation nutlin with superior selectivity and potency, we determine the feasibility of intermittent dosing to guide the selection of initial phase I scheduling regimens.A pharmacokinetic-pharmacodynamic (PKPD) model was developed on the basis of preclinical data to determine alternative dosing schedule requirements for ...
Tópico(s): Protein Degradation and Inhibitors
2014 - American Association for Cancer Research | Clinical Cancer Research
Christian Tovar, Bradford Graves, Kathryn Packman, Zoran Filipovic, Brian Higgins Mingxuan Xia, Christine Tardell, Rosario Garrido, Edmund Lee, Kenneth Kolinsky, Kwong-Him To, Michael Linn, Frank Podlaski, Peter M. Wovkulich, Binh Thanh Vu, Lyubomir T. Vassilev,
Abstract MDM2 negatively regulates p53 stability and many human tumors overproduce MDM2 as a mechanism to restrict p53 function. Thus, inhibitors of p53-MDM2 binding that can reactivate p53 in cancer cells may offer an effective approach for cancer therapy. RG7112 is a potent and selective member of the nutlin family of MDM2 antagonists currently in phase I clinical studies. RG7112 binds MDM2 with high affinity (KD ∼ 11 nmol/L), blocking its interactions with p53 in vitro. A crystal structure of the ...
Tópico(s): Microtubule and mitosis dynamics
2013 - American Association for Cancer Research | Cancer Research
Yong S. Chang, Bradford Graves, Vincent Guerlavais, Christian Tovar, Kathryn Packman, Kwong-Him To, Karen A. Olson, Kamala Kesavan, Pranoti Gangurde, Aditi Mukherjee, Theresa Baker, Krzysztof Darłak, Carl Elkin, Zoran Filipovic, Farooq Qureshi, Hongliang Cai, Pamela Berry, Eric Feyfant, Xiangguo Shi, James Horstick, D. Allen Annis, Anthony M. Manning, Nader Fotouhi, Huw M. Nash, Lyubomir T. Vassilev, Tomi K. Sawyer,
Significance Stapled α−helical peptides have emerged as a promising new modality for a wide range of therapeutic targets. Here, we describe the development of a stapled α−helical peptide lead molecule for the treatment of cancers that possess the intact p53 tumor suppressor protein but are resistant to drug therapy because of the overexpression of inhibitory proteins MDM2 and MDMX. The molecule ATSP-7041 is a highly potent dual inhibitor of both MDM2 and MDMX that is shown to effectively reactivate ...
Tópico(s): Ubiquitin and proteasome pathways
2013 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Qingjie Ding, Zhuming Zhang, Jinjun Liu, Nan Jiang, Jing Zhang, Tina Morgan Ross, Xin‐Jie Chu, David Bartkovitz, Frank Podlaski, Cheryl A. Janson, Christian Tovar, Zoran Filipovic, Brian Higgins, Kelli Glenn, Kathryn Packman, Lyubomir T. Vassilev, Bradford Graves,
Restoration of p53 activity by inhibition of the p53-MDM2 interaction has been considered an attractive approach for cancer treatment. However, the hydrophobic protein-protein interaction surface represents a significant challenge for the development of small-molecule inhibitors with desirable pharmacological profiles. RG7112 was the first small-molecule p53-MDM2 inhibitor in clinical development. Here, we report the discovery and characterization of a second generation clinical MDM2 inhibitor, ...
Tópico(s): Ubiquitin and proteasome pathways
2013 - American Chemical Society | Journal of Medicinal Chemistry
Zhuming Zhang, Xin‐Jie Chu, Jinjun Liu, Qingjie Ding, Jing Zhang, David Bartkovitz, Nan Jiang, Prabha Karnachi, Sung‐Sau So, Christian Tovar, Zoran Filipovic, Brian Higgins, Kelli Glenn, Kathryn Packman, Lyubomir T. Vassilev, Bradford Graves,
The development of small-molecule MDM2 inhibitors to restore dysfunctional p53 activities represents a novel approach for cancer treatment. In a previous communication, the efforts leading to the identification of a non-imidazoline MDM2 inhibitor, RG7388, was disclosed and revealed the desirable in vitro and in vivo pharmacological properties that this class of pyrrolidine-based inhibitors possesses. Given this richness and the critical need for a wide variety of chemical structures to ensure success ...
Tópico(s): Microtubule and mitosis dynamics
2013 - American Chemical Society | ACS Medicinal Chemistry Letters
Christian Tovar, James Rosinski, Zoran Filipovic, Brian Higgins, Kenneth Kolinsky, Holly Hilton, Xiaolan Zhao, Binh Thanh Vu, Weiguo Qing, Kathryn Packman, Ola Myklebost, David Heimbrook, Lyubomir T. Vassilev,
The p53 tumor suppressor retains its wild-type conformation and transcriptional activity in half of all human tumors, and its activation may offer a therapeutic benefit. However, p53 function could be compromised by defective signaling in the p53 pathway. Using a small-molecule MDM2 antagonist, nutlin-3, to probe downstream p53 signaling we find that the cell-cycle arrest function of the p53 pathway is preserved in multiple tumor-derived cell lines expressing wild-type p53, but many have a reduced ...
Tópico(s): Epigenetics and DNA Methylation
2006 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves, Daisy Carvajal, Frank Podlaski, Zoran Filipovic, Norman Kong, U. Kammlott, Christine Lukacs, Christian Klein, Nader Fotouhi, Emily A. Liu,
MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and stability. Overexpression of MDM2, found in many human tumors, effectively impairs p53 function. Inhibition of MDM2-p53 interaction can stabilize p53 and may offer a novel strategy for cancer therapy. Here, we identify potent and selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes. These compounds bind MDM2 ...
Tópico(s): Ubiquitin and proteasome pathways
2004 - American Association for the Advancement of Science | Science
Steven Kerr, Walter W. Wolyniec, Zoran Filipovic, Suzanne G. Nodop, Frank Braza, Raymond J. Winquist, Thomas C. Noonan,
We report on the development of a method for repeated monitoring of mucosal permeability that allows assessment of the severity of colitis and evaluation of treatment efficacy in HLA-B27 transgenic rats. We determined the extent to which intestinal permeability related to stool condition, colon weight, and histological pathology in precolitic and diseased rats up to 29 weeks old. Intestinal permeability was measured by the urinary excretion of iodixanol at 24 h after oral administration. Mean permeability ...
Tópico(s): IL-33, ST2, and ILC Pathways
1999 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Karin Ataman, M. Jehmlich, Sabine Kock, Sabine Neumann, Matthias Leischik, Zoran Filipovic, Hans‐Bernd Hopf,
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2002 - Springer Science+Business Media | Intensive Care Medicine
Vladeta Filipović, Zoran Milošević,
A new method for the optimal real‐time control of water transport in open channels, called DYN2, is presented. This method was developed for controlling a class of water conveyance systems where so‐called dynamic regulation (DR), proposed by the Société du Canal de Provence (France), is the basic control method. The DR concept is based on the heuristic policy, which compensates for downstream cumulative volume error. In DYN2, however, optimal control theory is applied to solve the water‐transport ...
Tópico(s): Water Systems and Optimization
1989 - American Society of Civil Engineers | Journal of Irrigation and Drainage Engineering
Brian Higgins, Christian Tovar, Kelli Glenn, Antje Walz, Zoran Filipovic, Yue Zhang, Markus Dangl, Bradford Graves, Lyubomir T. Vassilev, Kathryn Packman,
... Brian Higgins, Christian Tovar, Kelli Glenn, Antje Walz, Zoran Filipovic, Yu-E Zhang, Markus Dangl, Bradford Graves, Lyubomir ...
Tópico(s): Cancer-related Molecular Pathways
2013 - American Association for Cancer Research | Molecular Cancer Therapeutics
Milica Kovačević Filipović, Vesna Ilić, Zoran Vujčić, Biljana Dojnov, Marija Stevanov-Pavlović, Zora Mijačević, Tatjana Božić,
Serum amyloid A proteins (SAA) are very sensitive acute phase proteins, displaying multiple isoforms in plasma and different body fluids. They are currently under investigation as biomarkers of diseases. The aim of the present study was to compare the concentration and isoform expression of SAA in serum and milk of cows with bacteriologically negative milk (control group) and naturally occurring Staphylococcus aureus (S. aureus) subclinical mastitis (subclinical mastitis group). Somatic cell count (SCC) ...
Tópico(s): Celiac Disease Research and Management
2011 - Elsevier BV | Veterinary Immunology and Immunopathology
Svetlana Jeremić, Nenad Filipović, Aleksandar Peulić, Zoran Marković,
In this paper the conformational behavior and thermodynamics of radical scavenging action of alizarin (A) and alizarin red S (ARS) were investigated at the M06-2X/6-311++G(d,p) and M06-2X/cc-pVTZ levels of theory in the gas phase and water solution. For this purpose all BDE (bond dissociation enthalpy), IP (ionization potential), PDE (proton dissociation enthalpy), PA (proton affinity), and ETE (electron transfer enthalpy) values were calculated, implying that all radicals, anions, and radical cations ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2014 - Elsevier BV | Computational and Theoretical Chemistry
Brian Higgins, Christian Tovar, Kelli Glen, Aruna Railkar, Zoran Filipovic, Farooq Qureshi, Binh Thanh Vu, George K. Ehrlich, Dan Fishlock, Lin-Chi Chen, Steven A. Middleton, Gwen Nichols, Kathryn Packman, Lyubomir T. Vassilev,
... Brian Higgins, Christian Tovar, Kelli Glen, Aruna Railkar, Zoran Filipovic, Farooq Qureshi, Binh Vu, George Ehrlich, Dan Fishlock, ...
Tópico(s): Cancer-related Molecular Pathways
2015 - American Association for Cancer Research | Molecular Cancer Therapeutics
Tim Smole, Bojan Žunkovič, Matej Pičulin, Enja Kokalj, Marko Robnik‐Šikonja, Matjaž Kukar, Dimitrios I. Fotiadis, Vasileios C. Pezoulas, Nikolaos S. Tachos, Fausto Barlocco, Francesco Mazzarotto, Dejana Popović, Lars S. Maier, Lazar Velicki, Guy A. MacGowan, Iacopo Olivotto, Nenad Filipović, Djordje G. Jakovljević, Zoran Bosnić,
Machine learning (ML) and artificial intelligence are emerging as important components of precision medicine that enhance diagnosis and risk stratification. Risk stratification tools for hypertrophic cardiomyopathy (HCM) exist, but they are based on traditional statistical methods. The aim was to develop a novel machine learning risk stratification tool for the prediction of 5-year risk in HCM. The goal was to determine if its predictive accuracy is higher than the accuracy of the state-of-the-art ...
Tópico(s): Firm Innovation and Growth
2021 - Elsevier BV | Computers in Biology and Medicine
Vladimir Gašparović, Ina Filipović-Grčić, Marijan Merkler, Zoran Pišl,
Although at present there is no prospective randomized study which could show significantly better survival of patients on continuous procedures, the majority of intensivists advocate this technique of renal function replacement due to generally accepted opinion that it has less effect on circulation of already hemodynamically unstable patients. In our prospective randomized study with 104 patients, we also did not observe any difference in 28 days survival, in total survival, as well as in circulatory ...
Tópico(s): Sepsis Diagnosis and Treatment
2003 - Taylor & Francis | Renal Failure
Zhihong Huang, Zoran Filipovic, Nandakumar Mp, Chia Ung, Erika L. Troy, Raymond W. Colburn, Jennifer F. Iaci, Craig Hackett, Donald Button, Anthony O. Caggiano, Tom J. Parry,
Magnesium (Mg2+) homeostasis is impaired following spinal cord injury (SCI) and the loss of extracellular Mg2+ contributes to secondary injury by various mechanisms, including glutamate neurotoxicity. The neuroprotective effects of high dose Mg2+ supplementation have been reported in many animal models. Recent studies found that lower Mg2+ doses also improved neurologic outcomes when Mg2+ was formulated with polyethylene glycol (PEG), suggesting that a PEG/ Mg2+ formulation might increase Mg2+ delivery ...
Tópico(s): Magnesium in Health and Disease
2016 - Mary Ann Liebert, Inc. | Journal of Neurotrauma
Edina H. Avdović, Žiko Milanović, Dušica Simijonović, Marko Antonijević, Milena Milutinović, Danijela Nikodijević, Nenad Filipović, Zoran Marković, Radiša Vojinović,
In this study, green synthesis of two derivatives of coumarin-hydroxybenzohydrazide, (E)-2,4-dioxo-3-(1-(2-(2,3,4-trihydroxybenzoyl)hydrazyl)ethylidene)-chroman-7-yl acetate (C-HB1), and (E)-2,4-dioxo-3-(1-(2-(3,4,5-trihydroxybenzoyl)hydrazyl)ethylidene)chroman-7-yl acetate (C-HB2) is reported. Using vinegar and ethanol as a catalyst and solvent, the reactions were carried out between 3-acetyl-4-hydroxy-coumarin acetate and corresponding trihydroxybenzoyl hydrazide. The antioxidant potential of these ...
Tópico(s): Synthesis of Organic Compounds
2023 - Multidisciplinary Digital Publishing Institute | Antioxidants
Vesna Dragičević, Snežana Mladenović-Drinić, Milovan Stojiljković, Milomir Filipović, Zoran Dumanović, Dragan Kovačević,
Deficiencies of some mineral elements are causing serious health problems, which could be prevented by increase of mineral nutrients in food with supplementation, food fortification or plant breeding. From this point, experiment with 78 maize inbred lines was set up to determine maize lines with improved contents of Fe, Zn and Mn, as well as their relations with phytic acid, inorganic phosphorus and ?-carotene, as factors which affect their absorption. Obtained results suggest that investigated maize ...
Tópico(s): Cassava research and cyanide
2013 - Serbian Genetics Society | Genetika
Jelena Filipović, Zoran Miladinović, Lato Pezo, Vladimir Filipović, Vladimir Filipović, Aleksandra Jevtić-Vukmirović,
This paper deals with the characteristics of spelt pasta enriched with eggs. Eggs were added to spelt farina in the quantity of 0, 124 or 248 g/kg (equivalent to 0, 3 or 6 eggs, respectively). Post-hoc Tukey?s HSD test at 95% confidence limit showed significant differences between various samples. Relatively low coefficients of variation have been obtained for each applied assay (1.25-12.42%), which confirmed the high accuracy measurements and statistically significant results. Standard score analysis ...
Tópico(s): Heavy Metals in Plants
2014 - Association of Chemical Engineers of Serbia | Hemijska industrija