Ekrem Cengiz Seyhan, Sinem Nedime Sökücü, Sedat Altın, Gülşah Günlüoğlu, Sinan Trablus, Doç. Dr. Şerif Yilmaz, Kaya Köksalan, Halim İşsever,
... population is recommended. The QuantiFERON-TB Gold assay (QFT-G) may be more accurate than the tuberculin ... of LTBI. We prospectively compared the results of QFT-G to TST in HD patients.We examined 100 patients and performed TST and QFT-G tests. Data obtained from patients and medical ... three of 100 patients (43%) had a positive QFT-G test result and 34 (34%) had a positive TST test result. Overall agreement between the QFT-G and the TST was 65% (concordance [k]= ... test results were seen in 13 TST-positive/QFT-G-negative patients and in 22 TST-negative/ ...
Tópico(s): Diagnosis and treatment of tuberculosis
2009 - Wiley | Transplant Infectious Disease
Roland Diel, R. Loddenkemper, Albert Nienhaus,
... and the QuantiFERON-TB Gold In-Tube Assay (QFT-IT) among definitely confirmed TB cases. We searched ... 95% CI, 0.78-0.83) for the QFT-IT and 88% (95% CI, 0.85-0. ... 95% CI, 0.86-0.91) for the QFT-IT and T-Spot.TB, respectively, when restricted ... in developed countries. In contrast, specificity of the QFT-IT was 99% (95% CI, 0.98-1. ... 95% CI, 0.02-0.023) for the QFT-IT and 3.8% (95% CI, 0.035- ... and the QuantiFERON-TB Gold In-Tube Assay (QFT-IT) among definitely confirmed TB cases. We searched ... 95% CI, 0.78-0.83) for the QFT-IT and 88% (95% CI, 0.85-0. ...
Tópico(s): Pneumonia and Respiratory Infections
2009 - Elsevier BV | CHEST Journal
Eugenia Bruzzese, Marialuisa Bocchino, L.R. Assante, Maria Alessio, Barbara Bellofiore, Dario Bruzzese, Raffaele Iorio, Alessandro Matarese, Giuseppe Santoro, Pietro Vajro, Alfredo Guarino, Alessandro Sanduzzi,
... tests, the QuantiFERON TB Gold assay and the QFT in-tube (QFT-IT) assay (Cellestis, Carnegie, Australia). QFT-IT is the latest improvement in this technology ... head-to-head comparisons of TS-TB and QFT-IT performance to TST performance for TB infection- ... Performance and data analysis of TS-TB and QFT-IT were realized according to the instructions of ... of <0.05 was considered significant. TST and QFT-IT gave a positive result for one (1. ... P = 0.02). Mean analytical TS-TB and QFT-IT results are shown in Table Table22 and ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2009 - American Society for Microbiology | Journal of Clinical Microbiology
Marie A. de Perio, Joel Tsevat, Gary A. Roselle, Stephen M. Kralovic, Mark H. Eckman,
... the newer QuantiFERON-TB Gold in Tube test (QFT-GIT) requires less manual processing time than the QuantiFERON-TB Gold test (QFT-G). We compared the cost-effectiveness of the QFT-G, QFT-GIT, and TST for detecting LTBI in new ... previously. The incremental cost-effectiveness ratio of the QFT-G compared with the QFT-GIT was $14,092/QALY for non-BCG- ... least costly strategy. If the sensitivity of the QFT-GIT exceeds that of the QFT-G, then the QFT-GIT is the most effective and least costly strategy.Use of the QFT-G and QFT-GIT leads to superior clinical ...
Tópico(s): Infectious Diseases and Tuberculosis
2009 - American Medical Association | Archives of Internal Medicine
Niclas Winqvist, Per Björkman, Ann Norén, Håkan Miörner,
... to evaluate the performance of QuantiFERON®-TB Gold (QFT-G) in the investigation for suspected active TB, ... in high-incidence countries. Furthermore, factors associated with QFT-G results in patients with active TB were ... clinically suspected active TB, blood was obtained for QFT-G testing, in addition to routine investigations. Positive (PPV) and negative (NPV) predictive values for QFT-G were calculated, comparing patients with confirmed TB and those with other final diagnoses. QFT-G results in TB patients originating from countries ...
Tópico(s): Infectious Diseases and Tuberculosis
2009 - BioMed Central | BMC Infectious Diseases
Seung Heon Lee, Woo Jin Lew, Hee Jin Kim, Hyun-Kyung Lee, Young Min Lee, Chong Hee Cho, Eun Joo Lee, Dong Yeol Lee, Sung Weon Ryu, Soo Yeon Oh, Sin Ok Kim, Tae Sun Shim,
... TST) and the QuantiFERON-TB Gold In-Tube (QFT-GIT) test were performed in 214 contacts with ... chest radiographs. Rifampicin prophylaxis was initiated in TST+/QFT-GIT+ subjects, and the QFT-GIT test was repeated upon completion of 4 ... treatment. Among the 214 contacts, the TST and QFT-GIT test results were positive in 67.7% ... 3%, kappa=0.55, p<0.001). The QFT-GIT test was positive in 77% (97/126) ... good compliance. Among 74 subjects with valid serial QFT-GIT test results, IFN-gamma levels decreased in 97.3% (72/74) of the subjects and QFT-GIT test reversion (positive to negative) was achieved ...
Tópico(s): Infectious Diseases and Tuberculosis
2009 - Elsevier BV | Respiratory Medicine
Luca Richeldi, Monica Losi, Roberto D’Amico, Mario Luppi, Angela Ferrari, Cristina Mussini, Mauro Codeluppi, Stefania Cocchi, Francesca Prati, Valentina Paci, Marisa Meacci, Barbara Meccugni, Fabio Rumpianesi, Pietro Roversi, Stefania Cerri, Fabrizio Luppi, Giovanni Ferrara, Irene Latorre, Giorgio Enrico Gerunda, Giuseppe Torelli, Roberto Esposito, Leonardo M. Fabbri,
... Abingdon, UK] and QuantiFERON-TB Gold In-Tube (QFT-IT) [Cellestis Ltd; Carnegie, VIC, Australia] might improve ... with hematologic malignancies (HMs). TST, TS.TB, and QFT-IT were simultaneously performed, their results were compared, ... TS.TB (18.4%; p < 0.001) and QFT-IT (15.1%; p = 0.033). Significantly fewer ... compared with either TST (κ = 0.16) or QFT-IT (κ = 0.19). Indeterminate blood test results ... positive control values were significantly more frequent with QFT-IT (7.2%) than with TS.TB (0. ... Abingdon, UK] and QuantiFERON-TB Gold In-Tube (QFT-IT) [Cellestis Ltd; Carnegie, VIC, Australia] might improve ...
Tópico(s): Mycobacterium research and diagnosis
2009 - Elsevier BV | CHEST Journal
Brita Askeland Winje, Fredrik Oftung, Gro Ellen Korsvold, Turid Mannsåker, Ingvild Nesthus Ly, Ingunn Harstad, Anne Margarita Dyrhol-Riise, Einar Heldal,
... M. tuberculosis is considered rare. QuantiFERON®TB Gold (QFT) is a new and specific blood test for ... So far, there have been few reports of QFT used in screening of predominantly unexposed, healthy, TST- ... we aimed to (1) measure the prevalence of QFT positivity among TST positive children identified in the ... and clinical risk factors for tuberculosis infection and QFT positivity. This cross-sectional multi-centre study was ... and urban areas in Norway. Participation included a QFT test and a questionnaire regarding demographic and clinical ...
Tópico(s): Pneumonia and Respiratory Infections
2008 - BioMed Central | BMC Infectious Diseases
Yoshihiro Kobashi, Keiji Mouri, Shinichi Yagi, Yasushi Obase, Naoyuki Miyashita, Mikio Oka,
... study was to evaluate the QuantiFERON TB‐2G (QFT‐2G) results in patients with active extrapulmonary tuberculosis (E‐TB) to determine whether QFT‐2G test might be a reliable diagnostic method ... the tuberculin skin test (TST). Methods: TST and QFT‐2G tests were performed for 35 patients with ... the TST was 57% and that of the QFT‐2G test was 86%. For patients with probable ... the TST was 60%, whereas that of the QFT‐2G test was 80%. However, the positive rate of the TST was 51% and that of QFT‐2G test was 9% for patients that did ...
Tópico(s): Mycobacterium research and diagnosis
2008 - Wiley | Respirology
Nira R. Pollock, Antonio Campos‐Neto, Suely Sanae Kashino, Danielle R. Napolitano, Samuel M. Behar, Daniel S. Shin, Alex Sloutsky, Swati Joshi, Jasmine Guillet, Michael Y. Wong, Edward A. Nardell,
... hospital implemented use of the QuantiFERON-TB Gold (QFT-G) assay, a whole-blood interferon-gamma release ... test (TST) results were routinely tested with the QFT-G assay, to take advantage of its higher ... undertook a quality assurance review to evaluate the QFT-G test results in HCWs with multiple risk ... records for TST-positive HCWs tested with the QFT-G assay were reviewed. HCWs with 2 or ... increased risk" (IR). IR HCWs who had negative QFT-G test results underwent repeat QFT-G testing and were offered testing with a ...
Tópico(s): Mycobacterium research and diagnosis
2008 - Cambridge University Press | Infection Control and Hospital Epidemiology
Brita Askeland Winje, Fredrik Oftung, Gro Ellen Korsvold, Turid Mannsåker, Anette Skistad Jeppesen, Ingunn Harstad, Berit Tafjord Heier, Einar Heldal,
QuantiFERON®TB Gold (QFT) is a promising blood test for tuberculosis infection but with few data so far from immigrant screening. The aim of this study was to compare results of QFT and tuberculin skin test (TST) among newly arrived ... in Norway and to assess the role of QFT in routine diagnostic screening for latent tuberculosis infection. ... September 2005 to June 2006. Participation included a QFT test and a questionnaire in addition to the ... valid test results, 29% (264) had a positive QFT test whereas 50% (460) tested positive with TST ( ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2008 - BioMed Central | BMC Infectious Diseases
Susan Shin‐Jung Lee, Yung-Ching Liu, Tsi-Shu Huang, Yao-Shen Chen, Hung‐Chin Tsai, Shue-Ren Wann, Hsi-Hsun Lin,
... BCG-vaccinated health care workers. QuantiFERON-TB GOLD (QFT-G) is a sensitive and specific interferon-gamma ... by BCG vaccination. This study compared TST and QFT-G in the diagnosis of latent TB infection ... cases, but only 4 (10.2%) cases using QFT-G. TST conversion occurred in 2/6 (33. ... compared to 4/32(12.5%), cases using QFT-G. A higher proportion of QFT converters was associated with intimate contact, although not ... face contact >1 h was significantly associated with QFT-G conversion >or=0.7 IU/ml (OR ... 07, p=0.04). Agreement between TST and QFT-G was 18.0%, (kappa: -0.03). Concordance ...
Tópico(s): Pneumonia and Respiratory Infections
2008 - Informa | Scandinavian Journal of Infectious Diseases
Felix C. Ringshausen, Albert Nienhaus, Anja Schablon, Stephan F. Schlosser, G. Schultze‐Werninghaus, Gernot Rohde,
... and the IGRA QuantiFERON®-TB Gold In-Tube (QFT-GIT) at baseline. The QFT-GIT was repeated 18 weeks later in the median. QFT-GIT conversions (and reversions) were defined as baseline ... ml (and vice versa). Predictors of persistently positive QFT-GIT results were calculated by logistic regression analysis. ... 15 (8.2%) of 182 analyzed HCWs were QFT-GIT-positive at baseline and at follow-up, ... strong overall agreement between baseline and follow-up QFT-GIT results (κ = 0.70). Reversions (6/18, ... prior and recent TST results independently predicted persistent QFT-GIT positivity. Furthermore, the chance of having persistently ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2010 - BioMed Central | BMC Infectious Diseases
T. G. Connell, Marc Tebruegge, Nicole Ritz, Penelope A. Bryant, David Leslie, Nigel Curtis,
... indeterminate test results obtained with the QuantiFERON-TB (QFT) Gold In-Tube assay (35% of the study ... suspected TB disease or latent TB infection, a QFT assay (either the second generation Gold assay or ... et al we reviewed the results of all QFT assays from children attending the Royal Children's ... Reference Laboratory that has extensive experience in performing QFT assays, processing more than 4000 assays per year. ... according to manufacturer's instructions. Results from 875 QFT assays (449 [51%] QFT Gold and 426 [49%] ...
Tópico(s): Pneumonia and Respiratory Infections
2010 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Sumanth Gandra, William S. Scott, Vijaya Somaraju, Huaping Wang, Suzanne Wilton, Michelle Feigenbaum,
... tool TST with the QFTG in-tube assay (QFT-GIT) for annual screening of latent tuberculosis infection ... workers (HCWs). This study evaluated the effectiveness of QFT-GIT test as screening tool in HCWs at ... records of all HCWs who underwent screening with QFT-GIT from January 2008 through December 2008.Among the 6,530 HCWs screened with QFT-GIT from January through December 2008, 287 had ... HCWs had newly diagnosed latent tuberculosis infection by QFT-GIT. Of the 164 HCWs, 135 were retested by QFT-GIT and were simultaneously tested with TST within ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2010 - Cambridge University Press | Infection Control and Hospital Epidemiology
Payam Tabarsi, Masoud Mardani, Zohre Mohammadtaheri, Ehsan Chitsaz, Banafsheh Farokhzad, Fatemeh Hadavand, Latif Gachkar, Kambiz Nemati, Mohammad Reza Masjedi,
... data about the performance of QuantiFERON-TB Gold (QFT-G) test in detecting latent tuberculosis infection (LTBI) ... region. We intended to determine the performance of QFT-G compared to conventional tuberculin skin test (TST) ... sorbent assay (ELISA). The agreement between TST and QFT-G results were analyzed using Kappa test.A ... negative and 14 (28%) revealed positive TST. For QFT-G, 20 (40%) tested positive, 19 (38%) tested ... 200. Of the 14, TST + group, 12 had QFT-G +, only one case TST+/QFT-G-, and QFT-G was indeterminate in one ...
Tópico(s): Infectious Diseases and Tuberculosis
2010 - Medknow | Annals of Thoracic Medicine
Tania A. Thomas, Dinesh Mondal, Zannatun Noor, Lei Liu, Masud Alam, Rashidul Haque, Sayera Banu, Haiyan Sun, Kristine M. Peterson,
... to the QuantiFERON-TB Gold In-Tube assay (QFT-IT) and assess the effects of malnourishment and intestinal helminth infection on QFT-IT results.In this population-based cross-sectional ... screened children for latent tuberculosis infection with the QFT-IT and TST. We assess the agreement between the TST and QFT-IT, risk factors associated with indeterminate QFT-IT results, and magnitude of interferon γ (IFN- ... children and negative for 201 (66.6%) children. QFT-IT results were positive for 107 (35.4%) ... 0001) when excluding indeterminate results. Children with indeterminate QFT-IT results were separately compared with children with ...
Tópico(s): Child Nutrition and Water Access
2010 - American Academy of Pediatrics | PEDIATRICS
Kwok Chiu Chang, Chi Chiu Leung,
Background Clinical roles of QuantiFERON-TB Gold (QFT-G)/Gold in-Tube (QFT-G-IT) and T-SPOT.TB in tuberculosis require clarification. Methods MEDLINE and EMBASE were searched for relevant ... papers. Summary estimates of likelihood ratios (LR) of QFT-G/QFT-G-IT and T-SPOT.TB for latent ... 10.8 (5.3 to 21.8) for QFT-G/QFT-G-IT based on Japanese and other studies, ... 3.6 (2.3 to 5.6) for QFT-G, 2.1 (1.1 to 4.0) for QFT-G-IT and 4.7 (2.4 to ... 90% certainty threshold, LTBI is best diagnosed by QFT-G/QFT-G-IT and excluded by T-SPOT.TB ...
Tópico(s): Mycobacterium research and diagnosis
2010 - BMJ | Thorax
Anne Ma Dyrhol‐Riise, Gerd Gran, Tore Wentzel‐Larsen, Bjørn Blomberg, Christel Gill Haanshuus, Odd Mørkve,
... performance of the QuantiFERON®-TB Gold In-tube (QFT-TB) assay as diagnostic test and during follow- ... persons with suspected TB infection were tested with QFT-TB. Thoracic X-ray and sputum samples were ... rifampicin were given to patients with LTBI and QFT-TB tests were performed after three and 15 months. The QFT-TB test was positive in 30.8% (148/ ... with active TB with no inconclusive results. The QFT-TB test was more frequently positive in those ... 73) were all independently associated with a positive QFT-TB test. After preventive therapy, 35/40 (87. ...
Tópico(s): Diagnosis and treatment of tuberculosis
2010 - BioMed Central | BMC Infectious Diseases
Yoshihiro Kobashi, Yasushi Obase, Minoru Fukuda, Kouichiro Yoshida, Naoyuki Miyashita, Masashi Fujii, Mikio Oka,
... To evaluate the usefulness of QuantiFERON TB-2G (QFT-2G) for detecting latent tuberculosis infection (LTBI) in ... infectivity×contact duration) were investigated. The TST and QFT-2G test were performed on all subjects. Results ... TST was positive in 48 subjects (25%), the QFT-2G test was positive in only five subjects (3%). The correlation of the QFT-2G with TST results was not significant. There ... TST positive responses (22%), but there were no QFT-2G positive responses in subjects with a mild ... positive responses (31%), but two subjects showed positive QFT-2G results (4%) in the moderate contact score ...
Tópico(s): Pneumonia and Respiratory Infections
2007 - The Japanese Society of Internal Medicine | Internal Medicine
Gerald H. Mazurek, Stephen E. Weis, Patrick K. Moonan, Charles L. Daley, John Bernardo, Alfred Lardizabal, Randall Reves, Sean Toney, Laura Daniels, Philip LoBue,
... and 2 whole-blood IGRAs (QuantiFERON-TB assay [QFT] and QuantiFERON-TB Gold assay [QFT-G]) in situations in which infection is confirmed ... have tuberculosis were tested simultaneously with the TST, QFT, and QFT-G.M. tuberculosis was cultured from samples from ... confidence interval [CI], 62.5%-82.8%). The QFT indicated tuberculosis infection for 48 (69.6%) of ... and was indeterminate for 7 (10.1%). The QFT-G yielded positive results for 46 (66.7%) ... 9 subjects (13.0%). If subjects with indeterminate QFT-G results were excluded, 46 (76.7%) of ...
Tópico(s): Mycobacterium research and diagnosis
2007 - Oxford University Press | Clinical Infectious Diseases
Gerald H. Mazurek, Margan J. Zajdowicz, Arlene Hankinson, Dana Costigan, Sean Toney, J.S. Rothel, Laura Daniels, F. Brian Pascual, N. Shang, Lisa W. Keep, Philip LoBue,
... blood interferon-γ release assays (QuantiFERON-TB assay [QFT] and QuantiFERON-TB Gold assay [QFT-G]) and to identify factors associated with test ... tested for M. tuberculosis infection using the TST, QFT, and QFT-G. Results. Among the study subjects, 5.1% ... in an induration ⩾15 mm. Eleven percent of QFT results and 0.6% of QFT-G results were positive. Assuming recruits at low ... 10-mm cutoff value was used. The estimated QFT specificity was 92.3% (95% CI, 90.0%–94.5%), and the estimated QFT-G specificity was 99.8% (95% CI, 99. ...
Tópico(s): Infectious Diseases and Tuberculosis
2007 - Oxford University Press | Clinical Infectious Diseases
Roland Diel, Albert Nienhaus, R. Loddenkemper,
... of the new QuantiFERON-TB Gold In-Tube (QFT-G) [Cellestis; Carnegie, VIC, Australia] assay for screening ... values for the tuberculin skin test (TST), the QFT-G assay alone, or the QFT-G assay as a confirmatory test for the TST results. Results QFT-G assay-based treatment led to cost savings ... cutoff value compared to the results of the QFT-G assay alone reduced the total costs per ... 1 TB case was 22 for the two QFT-G assay-based procedures, 40 for the TST ... the sensitivity rates of the TST and the QFT-G assay were compounded, the QFT-G assay ...
Tópico(s): Infectious Diseases and Tuberculosis
2007 - Elsevier BV | CHEST Journal
Der‐Yuan Chen, Gwan‐Han Shen, Yi‐Ming Chen, Hsin‐Hua Chen, Chia‐Wei Hsieh, Joung‐Liang Lan,
... evaluated the utility of serial QuantiFERON-TB Gold (QFT-G) assays for detecting its emergence in RA ... patients who received anti-TNFα therapy and serial QFT-G assays were prospectively evaluated. QFT-G was performed by measuring IFNγ levels in ... test (TST) and 45 (18.6%) had positive QFT-G results, with another nine (3.7%) showing indeterminate QFT-G assay. Isoniazid prophylaxis was given to 37 patients with TST+/QFT-G+ results and 24 TST+/QFT-G− patients with TST induration diameter ≧10 mm. Four patients (three with baseline QFT-G+ results) developed tuberculosis within the first 3 ...
Tópico(s): Mycobacterium research and diagnosis
2011 - BMJ | Annals of the Rheumatic Diseases