A Begell House é uma editora que publica nos campos de ciências térmicas, física, engenharia de fluidos, telecomunicações e ciências biomédicas. Em resposta ao ofício assinado pelo presidente da CAPES, Benedito Aguiar, onde as entidades científicas são convocadas a liberar sem restrições ferramentas referentes ao novo coronavírus, a corporação identificou e removeu o controle de acesso a dois artigos pertinentes ao estudo da atual pandemia.

“Estamos verificando com nossos editores de periódicos biomédicos outros conteúdos relacionados que possam ser úteis”, afirmou Meghan Rohrmann, profissional de marketing e vendas da editora. Dessa forma, a lista pode ser atualizada a qualquer momento com novos recursos da Begell House sobre o covid-19.

Periódico: Critical Reviews in Immunology
Artigo: The Pathogenesis of Murine Coronavirus Infection of the Central Nervous System
Autores: Martin P. Hosking e Thomas E. Lane
Abstract:
Mouse hepatitis virus (MHV) is a positive-strand RNA virus that causes an acute encephalomyelitis that later resolves into a chronic fulminating demyelinating disease. Cytokine production, chemokine secretion, and immune cell infiltration into the central nervous system are critical to control viral replication during acute infection. Despite potent antiviral T-lymphocyte activity, sterile immunity is not achieved, and MHV chronically persists within oligodendrocytes. Continued infiltration and activation of the immune system, a result of the lingering viral antigen and RNA within oligodendrocytes, lead directly to the development of an immune-mediated demyelination that bears remarkable similarities, both clinically and histologically, to the human demyelinating disease multiple sclerosis. MHV offers a unique model system for studying host defense during acute viral infection and immune-mediated demyelination during chronic infection.
Acesse aqui

Periódico: Forum on Immunopathological Diseases and Therapeutics
Artigo: Coronaviral Ion Channels as Target for Chinese Herbal Medicine
Autores: Bing Sun, Daniel Sauter, Kai Wang, Silvia Schwarz, Thomas Efferth, Wei Lu e Wolfgang Schwarz
Abstract:
A variety of viruses encode for proteins that can form ion channels in the membrane of infected cells. For example, the protein coded by the open-reading-frame 3a of SARS coronavirus (SARS-CoV) has been demonstrated to form a cation-selective channel that may become expressed in the infected cell, and its activation is then involved in virus release. Chinese herbal drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and therefore they are a source for the development of novel therapeutic agents. Various drugs found in Chinese herbs are well known as anticancer agents and also have antiviral potency. In one study we tested some of them with respect to their potency to block the 3a channel. Application of the anthraquinone emodin was used as adjunct therapy in treatment of SARS, and we have demonstrated that it can inhibit the 3a ion channel as well as virus release with a K1/2 value of approximately 20 µM. Also the flavonols kaempferole and kaempferole glycosides may be potent inhibitors of the 3a channels. On the other hand, the favonol quercitin seems not to be effective. In addition, the flavanon naringenin and the isoflavon genistein were ineffective in inhibiting 3a-mediated currents. Antiviral activity of the artemisinin derivative artesunate is well documented, but we did not detect any inhibition of 3a-mediated currents. We suggest that viral ion channels, in general, may be good targets for the development of antiviral agents, and that, in particular, emodin and kaempferol gycosides are good candidates for 3a channel proteins in coronaviruses.
Acesse aqui

Acesso pelo Portal de Periódicos CAPES
Usuários de instituições participantes do Portal de Periódicos CAPES têm à disposição as plataformas:

- Begell House Digital Library
- Begell House Digital Library – eBook
- Begell House Multimedia

O conteúdo deve ser localizado pela opção buscar base.

A comunidade acadêmica também pode recorrer à consulta no link buscar periódico. Nessa alternativa, é possível selecionar o editor/fornecedor Begell House ou ainda inserir o nome da publicação ou o código ISSN.

Verifique o conteúdo do Portal de Periódicos disponível para sua instituição

O Portal de Periódicos autoriza a reprodução parcial ou total de seus textos informativos desde que seja citada a fonte: "Portal de Periódicos CAPES"