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Clonazepam and phenobarbital in tardive dyskinesia

1981; American Psychiatric Association; Volume: 138; Issue: 2 Linguagem: Inglês

10.1176/ajp.138.2.189

1535-7228

A Bobruff, G. Gárdos, Daniel Tarsy, Richard Rapkin, Jonathan Cole, P Moore,

Epilepsy research and treatment

Back to table of contents Previous article Next article No AccessClonazepam and phenobarbital in tardive dyskinesiaPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.138.2.189AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractBenzodiazepines have several advantages over other antidyskinetic drugs in treating tardive dyskinesia. The authors conducted a controlled study of clonazepam versus the active placebo of phenobarbital in 21 psychiatric patients with tardive dyskinesia. Both drugs significantly reduced dyskinetic movements: clonazepam had a stronger effect on orofacial dyskinesia, and phenobarbital was more effective for limbs and axial movements. Clonazepam was also more effective for drug-free patients and those receiving low doses of neuroleptics than for all patients given phenobarbital and for clonazepam patients taking high doses of neuroleptics. The authors suggest that future treatment studies focus on the effects of antidyskinetic drugs on distinct body regions. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byMovement disorders of the mouth: a review of the common phenomenologies29 July 2022 | Journal of Neurology, Vol. 269, No. 11Antiseizure Drugs and Movement Disorders21 July 2022 | CNS Drugs, Vol. 36, No. 8N-methyl-D-aspartate receptor antibody and the choroid plexus in schizophrenia patients with tardive dyskinesiaJournal of Psychiatric Research, Vol. 142Tardive Dyskinesia: Treatment Update16 August 2019 | Current Neurology and Neuroscience Reports, Vol. 19, No. 9Benzodiazepines for antipsychotic-induced tardive dyskinesia20 January 2018 | Cochrane Database of Systematic Reviews, Vol. 2018, No. 1CNS Drugs, Vol. 32, No. 2Journal of the Neurological Sciences, Vol. 389Health Technology Assessment, Vol. 21, No. 43Psychiatry and Clinical Neurosciences, Vol. 69, No. 6Benzodiazepines for schizophrenia14 November 2012 | Cochrane Database of Systematic Reviews, Vol. 7Current Treatment Options in Neurology, Vol. 13, No. 3Epilepsy & Behavior, Vol. 21, No. 1Cochrane Database of Systematic ReviewsTardive Dyskinesia in the Era of Typical and Atypical Antipsychotics. Part 2: Incidence and Management Strategies in Patients with Schizophrenia1 October 2005 | The Canadian Journal of Psychiatry, Vol. 50, No. 11Current Treatment Options in Neurology, Vol. 2, No. 3Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 22, No. 4Irish Journal of Psychological Medicine, Vol. 10, No. 3Benzodiazepines: Abuse and New Use1 April 1991 | The Canadian Journal of Psychiatry, Vol. 36, No. 3Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 4Pharmacology Biochemistry and Behavior, Vol. 29, No. 3Movement Disorders Induced by Psychotherapeutic Agents, Vol. 2Psychiatry and Clinical Neurosciences, Vol. 39, No. 2Alprazolam Reversal of Reserpine-Induced Depression in Patients with Compensated Tardive Dyskinesia30 August 2016 | Drug Intelligence & Clinical Pharmacy, Vol. 18, No. 4Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 7, No. 2-3Brain Research Bulletin, Vol. 11, No. 2Journal of Neurology, Neurosurgery & Psychiatry, Vol. 46, No. 6Clonazepam treatment of chronic schizophrenia: negative results in a double-blind, placebo-controlled trial1 April 2006 | American Journal of Psychiatry, Vol. 139, No. 12, Vol. 17 Volume 138Issue 2 February 1981Pages 189-193 Metrics PDF download History Published online 1 April 2006 Published in print 1 February 1981