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Reduction of Cisplatin Nephrotoxicity by Selenium: Does Metallothionein Play a Role?

1988; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-642-73113-6_27

0171-9750

Glenn S. Baldew, K. J. Volkers, C.J.A. van den Hamer,

Drug Transport and Resistance Mechanisms

Cisplatin is an important antineoplastic drug widely used against several tumors, especially those of the testis and ovaries (Prestayko et al. 1980). The dose-limiting side-effect of cisplatin chemotherapy is its nephrotoxicity, mainly consisting of degeneration of proximal tubules (Walker and Gale 1981); the mechanism of this nephrotoxicity is still unknown. Many attempts have been made to reduce cisplatin-induced nephrotoxicity. An interesting approach in this respect is the use of selenium. Selenium has been shown to prevent cadmium toxicity in animals (Parizek et al. 1974) and a protective effect of selenium against cisplatin lethality in mice has been described (Berry et al. 1984). It is not known how selenium exerts its protective effect against cisplatin.