Vasoactive Intestinal Peptide and Immune Function
1991; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-12-043780-1.50012-9
Autores Tópico(s)Neuroendocrine Tumor Research Advances
ResumoThis chapter discusses vasoactive intestinal peptide (VIP) and immune function. The primary structure of human VIP shows substantial sequence similarity to a number of other human peptides, including PHM, secretin, and glucagon, a number of other common mammalian peptides including corticotropin-releasing factor and gastric inhibitory peptide, and the reptilian skin peptide helodermin. The structure of VIP is not related to other major neuropeptides such as SP or somatostatin. The sequence of VIP is more highly conserved through various mammals than is that of its immediate relatives. Synthesis of VIP is regulated both at transcription and afterward. The amino-acid sequence of the major VIP-related mRNA transcript in both neuroblastoma cells and the buccal tumor is a precursor peptide that contains both PHM and VIP. The VIP is a potent immunoregulatory signal that can influence a variety of lymphoid cell processes around which immune responses pivot. The efforts of many investigators have established the presence of VIP receptors on lymphoid cells of many phenotypes and the modulating effects that VIP has on a number of relevant immunological assays. In contrast, the opportunity for regulatory effects originating from the inflammatory cells might well be increased.
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