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Chapter 81 Therapeutic effects of human fetal dopamine cells transplanted in a patient with Parkinson's disease

1990; Elsevier BV; Linguagem: Inglês

10.1016/s0079-6123(08)62664-3

1875-7855

Curt R. Freed, Robert E. Breeze, Neil L. Rosenberg, Stuart A. Schneck, Trent H. Wells, John N. Barrett, Scott T. Grafton, John C. Mazziotta, David Eidelberg, David A. Rottenberg,

Neurogenetic and Muscular Disorders Research

This chapter examines the therapeutic effects of human fetal dopamine cells transplanted in a patient with Parkinson's disease. The patient was a 52 years old male with a 20 year history of Parkinson's disease that presented with left-sided symptoms. The left side remained the more impaired. The patient suffered from the on-off phenomenon and freezing spells. The patient underwent clinical evaluation by a neurologist using the Hoehn and Yahr scale and the Unified Parkinson's Disease Rating Scale (UPDRS) for motor performance and activities of daily living. The patient received broad-spectrum antibiotics at the time of surgery and for 10 days thereafter. Prophylactic phenytoin was also used. Beginning about 30 days and peaking at 60 days after surgery, the patient demonstrated bilateral increases in finger speed both before and after the first morning dose of drugs. There was a greater improvement in his response to drugs than in his basal performance. Data were analyzed in 2 month intervals and compared to pre-operative. Results of the two-way analysis of variance showed highly significant improvement in drug response after surgery for all periods.