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Applications of the Drosophila Retina to Human Disease Modeling

2002; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-540-45398-7_15

1861-0412

Nancy M. Bonini, Mark Fortini,

Hippo pathway signaling and YAP/TAZ

The renowned Dutch naturalist Anton van Leeuwenhoek, an early inventor of the microscope, was fascinated by the new scientific perspectives afforded by his new apparatus. Writing just over three centuries ago, Leeuwenhoek marveled at the exquisite detail of the fly retina revealed by the microscope, and he commented upon its scientific implications: If we now see that provident Nature works in all Creatures, from the biggest to the smallest, almost in one and the same way, and if we remember that each round protuberance of the Eye is composed of many superposed scale-like parts, as I have said about the eye of the Dragon-Fly, and still is provided with it perfect roundness, which most ingenious structure exceeds anything we see on the Earth with the naked Eye, we must say again: Away with the opinion of Aristotle and all those who still follow him and want to maintain that flying Creatures or any other living Creature is generated from rotten matter and who are trying to obscure the Truth with their writings. (Leeuwenhoek 1695)