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The Duffy Blood Group System and Malaria

1995; Springer Nature; Linguagem: Inglês

10.1007/978-1-4757-9537-0_8

1078-0491

Asok Chaudhuri, A.O. Pogo,

Complement system in diseases

Cutbush et al. (1950) reported the presence of a new antibody in a hemophiliac man who had many blood transfusions during the previous 20 years. “Duffy” was the patient’s last name and the authors used this name for the new blood group system (Cutbush and Mollison, 1950). Fy u was designated as the gene responsible for the antigen, anti-Fy a the antibody, and Fy b the allele. They did not discover the anti-Fy b antibody but predicted that it would be found soon. The antibody was found a year later, in the serum of a Berlin woman who had three pregnancies but no transfusions (Ikin et al., 1951). Chown et al.(1965) reported a variant of Fy b having a weak expression of Fy b that they called Fy x Several Duffy antigens were found and subsequently termed Fy3 (Albrey et al., 1971), Fy4 (Behzad et al., 1973), and Fy5 (Colledge et al., 1973). More recently the murine monoclonal antibody anti-Fy6 identified the Fy6 antigen (Nichols et al., 1987).