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Transurethral Microwave Thermotherapy for Management of Benign Prostatic Hyperplasia: Results of the United States Prostatron Cooperative Study

1993; Lippincott Williams & Wilkins; Volume: 150; Issue: 5 Part 2 Linguagem: Inglês

10.1016/s0022-5347(17)35852-4

1527-3792

Michael L. Blute, Kevin M. Tomera, Daniel K. Hellerstein, Charles F. McKiel, John H. Lynch, James Regan, Noel Sankey,

Pelvic floor disorders treatments

No AccessJournal of Urology1 Nov 1993Transurethral Microwave Thermotherapy for Management of Benign Prostatic Hyperplasia: Results of the United States Prostatron Cooperative Study Michael L. Blute, Kevin M. Tomera, Daniel K. Hellerstein, Charles F. Mckiel, John H. Lynch, James B. Regan, and Noel E. Sankey Michael L. BluteMichael L. Blute , Kevin M. TomeraKevin M. Tomera , Daniel K. HellersteinDaniel K. Hellerstein , Charles F. MckielCharles F. Mckiel , John H. LynchJohn H. Lynch , James B. ReganJames B. Regan , and Noel E. SankeyNoel E. Sankey View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35852-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The primary objective of the study was to determine the safety and efficacy of transurethral microwave thermotherapy for the treatment of symptomatic benign prostatic hyperplasia. From March to August 1991, 150 patients were entered into a multi-site study and treated with transurethral microwave thermotherapy under a Food and Drug Administration approved protocol. Only patients with symmetrical trilobar or bilobar prostatic hypertrophy, peak flow rate of less than 15cc per second (on 2 voided volumes of 150cc or greater) and a total Madsen symptom score of more than 8 were treated. Transurethral microwave thermotherapy was performed with a 20F catheter and 1,296 MHz. microwave antenna for 60 minutes. The mean power achieved for this single session was 32.1 watts, with a mean power at maximum urethral temperature of 41.1 watts. Mean urethral temperature was 44.3C and the mean rectal temperature was 42.2C. The rectal and urethral temperatures were continuously monitored. Mean peak urinary flow rates, Madsen symptom score, post-void residual volume and improvement in motivating symptom to seek treatment were measured at 6 weeks, and 3, 6 and 12 months. Mean peak urinary flow rates improved 33% at 12 months (p <0.0001). Overall, the mean Madsen symptom score improved 61% (p <0.0001). The obstructive score and the irritative score improved 67% and 43%, respectively. Of 17 patients 12 (71%) reported improvement in weak stream when that was the motivating symptom to seek treatment. Of 28 men 18 (64%) reported improvement in nocturia, while 11 of 30 (37%) reported improvement in daytime frequency and 12 of 17 (71%) reported improvement in urgency. There was no statistically significant difference in post-void residual volume at 12 months from baseline. The treatment was well tolerated by all patients, and side effects were considered mild and transitory. Our study demonstrates the safety, effectiveness, patient tolerability and durability of transurethral microwave thermotherapy. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByREICH O, BACHMANN A, SCHNEEDE P, ZAAK D, SULSER T and HOFSTETTER A (2018) EXPERIMENTAL COMPARISON OF HIGH POWER (80 W) POTASSIUM TITANYL PHOSPHATE LASER VAPORIZATION AND TRANSURETHRAL RESECTION OF THE PROSTATEJournal of Urology, VOL. 171, NO. 6 Part 1, (2502-2504), Online publication date: 1-Jun-2004.FRANCISCA E, d'ANCONA F, MEULEMAN E, DEBRUYNE F and de la ROSETTE J (2018) SEXUAL FUNCTION FOLLOWING HIGH ENERGY MICROWAVE THERMOTHERAPY: RESULTS OF A RANDOMIZED CONTROLLED STUDY COMPARING TRANSURETHRAL MICROWAVE THERMOTHERAPY TO TRANSURETHRAL PROSTATIC RESECTIONJournal of Urology, VOL. 161, NO. 2, (486-490), Online publication date: 1-Feb-1999.DJAVAN B, FAKHARI M, SHARIAT S, GHAWIDEL K and MARBERGER M (2018) A NOVEL INTRAURETHRAL PROSTATIC BRIDGE CATHETER FOR PREVENTION OF TEMPORARY PROSTATIC OBSTRUCTION FOLLOWING HIGH ENERGY TRANSURETHRAL MICROWAVE THERMOTHERAPY IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 161, NO. 1, (144-151), Online publication date: 1-Jan-1999.THALMANN G, GRABER S, BITTON A, BURKHARD F, GRUENIG O and STUDER U (2018) TRANSURETHRAL THERMOTHERAPY FOR BENIGN PROSTATIC HYPERPLASIA SIGNIFICANTLY DECREASES INFRAVESICAL OBSTRUCTION: RESULTS IN 134 PATIENTS AFTER 1 YEARJournal of Urology, VOL. 162, NO. 2, (387-393), Online publication date: 1-Aug-1999.Larson T, Collins J and Corica A (2018) DETAILED INTERSTITIAL TEMPERATURE MAPPING DURING TREATMENT WITH A NOVEL TRANSURETHRAL MICROWAVE THERMOABLATION SYSTEM IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 159, NO. 1, (258-264), Online publication date: 1-Jan-1998.DJAVAN B, SHARIAT S, SCHAFER B and MARBERGER M (2018) TOLERABILITY OF HIGH ENERGY TRANSURETHRAL MICROWAVE THERMOTHERAPY WITH TOPICAL URETHRAL ANESTHESIA: RESULTS OF A PROSPECTIVE, RANDOMIZED, SINGLE-BLINDED CLINICAL TRIALJournal of Urology, VOL. 160, NO. 3 Part 1, (772-776), Online publication date: 1-Sep-1998.Kaplan S, Laor E, Fatal M and Te A (2018) TRANSURETHRAL RESECTION OF THE PROSTATE VERSUS TRANSURETHRAL ELECTROVAPORIZATION OF THE PROSTATE: A BLINDED, PROSPECTIVE COMPARATIVE STUDY WITH 1-YEAR FOLLOWUPJournal of Urology, VOL. 159, NO. 2, (454-458), Online publication date: 1-Feb-1998.Ramsey E, Miller P and Parsons K (2018) A Novel Transurethral Microwave Thermal Ablation System to Treat Benign Prostatic Hyperplasia: Results of a Prospective Multicenter Clinical TrialJournal of Urology, VOL. 158, NO. 1, (112-119), Online publication date: 1-Jul-1997.De la Rosette J, D'ancona F and Debruyne F (2018) Current Status of Thermotherapy of the ProstateJournal of Urology, VOL. 157, NO. 2, (430-438), Online publication date: 1-Feb-1997.de la Rosette J, de Wildt M, Hofner K, Carter S, Debruyne F and Tubaro A (2018) High Energy Thermotherapy in the Treatment of Benign Prostatic Hyperplasia: Results of the European Benign Prostatic Hyperplasia Study GroupJournal of Urology, VOL. 156, NO. 1, (97-102), Online publication date: 1-Jul-1996.Tubaro A, St. Clair Carter S, de la Rosette J, Hofner K, Trucchi A, Ogden C, Miano L, Valenti M, Jonas U and Debruyne F (2018) The Prediction of Clinical Outcome from Transurethral Microwave Thermotherapy by Pressure-Flow Analysis: A European Multicenter StudyJournal of Urology, VOL. 153, NO. 5, (1526-1530), Online publication date: 1-May-1995.Cummings J, Parra R, Boullier J, Crawford K, Petrofsky J and Caulfield J (2018) Evaluation of Fluid Absorption During Laser Prostatectomy by Breath Ethanol TechniquesJournal of Urology, VOL. 154, NO. 6, (2080-2082), Online publication date: 1-Dec-1995.de Wildt M, Tubaro A, Hofner K, Carter S, de la Rosette J and Devonec M (2018) Responders and Nonresponders to Transurethral Microwave Thermotherapy: A Multicenter Retrospective AnalysisJournal of Urology, VOL. 154, NO. 5, (1775-1778), Online publication date: 1-Nov-1995.Kaplan S and Te A (2018) A Comparative Study of Transurethral Resection of the Prostate Using a Modified Electro-Vaporizing Loop and Transurethral Laser Vaporization of the ProstateJournal of Urology, VOL. 154, NO. 5, (1785-1790), Online publication date: 1-Nov-1995. Volume 150Issue 5 Part 2November 1993Page: 1591-1596 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.Keywordsprostatemicrowavesprostatic hypertrophyheatingMetricsAuthor Information Michael L. Blute More articles by this author Kevin M. Tomera More articles by this author Daniel K. Hellerstein More articles by this author Charles F. Mckiel More articles by this author John H. Lynch More articles by this author James B. Regan More articles by this author Noel E. Sankey More articles by this author Expand All Advertisement Loading ...