A Quantitatively Controlled Method to Study Prospectively Interstitial Cystitis and Demonstrate the Efficacy of Pentosanpolysulfate
1993; Lippincott Williams & Wilkins; Volume: 150; Issue: 3 Linguagem: Inglês
10.1016/s0022-5347(17)35629-x
ISSN1527-3792
AutoresC. Lowell Parsons, George S. Benson, Stacy J. Childs, Philip M. Hanno, Grannum R. Sant, George D. Webster,
Tópico(s)Urological Disorders and Treatments
ResumoNo AccessJournal of Urology1 Sep 1993A Quantitatively Controlled Method to Study Prospectively Interstitial Cystitis and Demonstrate the Efficacy of Pentosanpolysulfate C. Lowell Parsons, George Benson, Stacy J. Childs, Philip Hanno, Grannum R. Sant, and George Webster C. Lowell ParsonsC. Lowell Parsons , George BensonGeorge Benson , Stacy J. ChildsStacy J. Childs , Philip HannoPhilip Hanno , Grannum R. SantGrannum R. Sant , and George WebsterGeorge Webster View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35629-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A randomized, prospective, double-blind, placebo-controlled study was conducted at 7 clinical centers on 148 patients. Patients received orally either 100mg. pentosanpolysulfate (a synthetic polysaccharide) 3 times per day or a placebo. Of the patients on drug therapy 32% showed significant improvement compared to 16% of those on placebo (p = 0.01). This study provides a model to assess this disease quantitatively in a prospective manner using a method whereby the patients globally assess their symptoms as either worse or improved by 0, 25, 50, 75 or 100%. Patients on drug therapy also experienced a significant decrease in pain and urgency (p = 0.04 and 0.01) on analogue scales when compared to placebo and also more drug patients showed an average increase of more than 20ml. in voided volume than did placebo patients (p = 0.02). All adverse effects were minor, with 7 in the drug group and 10 in the placebo group. The results support the concept that some patients with the interstitial cystitis syndrome may have abnormal bladder surface glycosaminoglycans. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByNickel J, Herschorn S, Whitmore K, Forrest J, Hu P, Friedman A and Baseman A (2018) Pentosan Polysulfate Sodium for Treatment of Interstitial Cystitis/Bladder Pain Syndrome: Insights from a Randomized, Double-Blind, Placebo Controlled StudyJournal of Urology, VOL. 193, NO. 3, (857-862), Online publication date: 1-Mar-2015.Bosch P (2018) A Randomized, Double-Blind, Placebo Controlled Trial of Adalimumab for Interstitial Cystitis/Bladder Pain SyndromeJournal of Urology, VOL. 191, NO. 1, (77-82), Online publication date: 1-Jan-2014.Parsons C (2014) Should Local Anesthetic Bladder Cocktails Include Sodium Bicarbonate?Journal of Urology, VOL. 191, NO. 4, (895-896), Online publication date: 1-Apr-2014.Janssen D, van Wijk X, Jansen K, van 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Volume 150Issue 3September 1993Page: 845-848 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.Keywordsbladder diseasescystitispentosan sulfuric polyesterMetricsAuthor Information C. Lowell Parsons More articles by this author George Benson More articles by this author Stacy J. Childs More articles by this author Philip Hanno More articles by this author Grannum R. Sant More articles by this author George Webster More articles by this author Expand All Advertisement PDF DownloadLoading ...
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