Direct chromosomal analysis of human spermatozoa: preliminary results from 18 normal men.
1982; National Institutes of Health; Volume: 34; Issue: 3 Linguagem: Inglês
Autores
Renée H. Martin, Ching‐Shwun Lin, Wayne Balkan, K. Burns,
Tópico(s)Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
ResumoChromosomal analysis of 240 spermatozoa from 18 normal men was performed using in vitro fertilization of zona-free golden hamster eggs. The frequency of chromosome abnormalities in this population was 9.2% (22/240). Of the abnormal complements, 18 were aneuploid (13 hyperploid and five hypoploid) and four had a chromosome break. The sex ratio of Y-bearing to X-bearing sperm was .68. The frequency and type of sperm chromosome abnormalities is compared with those seen in spontaneous abortions.
Referência(s)