Pharmacokinetic properties of carprofen in humans.
1982; National Institutes of Health; Volume: 5; Issue: 4 Linguagem: Inglês
Autores Tópico(s)
Antibiotics Pharmacokinetics and Efficacy
ResumoIn this overview the pharmacokinetic behaviour of carprofen in healthy subjects is described. Carprofen is rapidly and completely absorbed. The maximum concentration in plasma is reached after 1 hour and the absolute bioavailability of the oral forms reaches values of over 90%. The elimination half-life is 10 hours. The multiple-dose kinetics could be predicted adequately, using pharmacokinetic parameters of the single-dose kinetics. A clear accumulation of carprofen in plasma was not observed. In clinical-therapeutic use the kinetics are not significantly influenced by food intake or by age.
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