β-ADRENOCEPTOR SENSITIVITY FOLLOWING PSYCHOTROPIC DRUG TREATMENT
1979; Elsevier BV; Linguagem: Inglês
10.1016/b978-1-4832-8363-0.50180-4
AutoresSoham Chanda, Vinod Sharma, Swati Banerjee,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoChronic administration of antidepressants led to a decrease in the density of βAR in rat brain. In contrast, psychomotor stimulants induce an enhancement of βAR levels. Only desipramine, doxepin and amphetamine inhibited norepinephrine (NE) uptake. Although the level of NE may have an important role in controlling βAR density, this is not the only mechanism for the regulation of βAR concentration.
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